Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients

Diabetes

Volumn 48, Issue 1, 1999, Pages 206-208

  Otabe, Shuichi ^a   Clement, Karine ^a,c   Dubois, Séverine ^a   Lepretre, Fréderic ^a   Pelloux, Véronique ^c   Leibel, Rudolph ^d   Chung, Wendy ^d   Boutin, Philippe ^a   Guy Grand, Bernard ^a,c   Froguel, Philippe ^a,b,c,e   Vasseur, Francis ^a,b  

^a INSTITUT DE BIOLOGIE DE LILLE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c HÔTEL DIEU   (France)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 3;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FRANCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ADULT; AGED; BLOOD GLUCOSE; CARRIER PROTEINS; DIABETES MELLITUS; FEMALE; GENETIC SCREENING; HUMANS; ION CHANNELS; MALE; MIDDLE AGED; MITOCHONDRIAL PROTEINS; MUTATION; OBESITY; OBESITY, MORBID; REFERENCE VALUES; VARIATION (GENETICS);

EID: 0032932815     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Nicholls DG, Locke RM: Thermogenic mechanisms in brown fat. Physiol Rev 64:1-64, 1984
2. Klingenberg M: Mechanism and evolution of the uncoupling protein of brown adipose tissue. Trends Biochem Sci 15:108-112, 1990
3. Himms-Hagen J, Ricquier D: Brown Adipose Tissue. Bray G, Bouchard C, James WPT, Eds. New York, Marcel Dekker, 1997, p. 415-441
4. Garruti G, Ricquier D: Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans. Int J Obes Relat Metab Disord 16:383-390, 1992
5. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi MC, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH: Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia Nat Genet 15:269-272, 1997
6. Solanes G, Vidal PA, Grujic D, Flier JS, Lowell BB: The human uncoupling protein-3 gene: genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. J Biol Chem 272:25433-25436, 1997
7. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB: UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 235:79-82, 1997
8. Boss O, Samec S, Paoloni GA, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino JP: Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett 408:39-42, 1997
9. Bouchard C, Pérusse L, Chagnon YC, Warden C, Ricquier D: Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum Mol Genet 6:1887-1889, 1997
10. Otabe S, Clement K, Rich N, Warden C, Pecqueur C, Neverova M, Raimbault S, Guy-Grand B, Basdevant A, Ricquier D, Froguel P, Vasseur F: Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians. Diabetes 47:840-842, 1998
11. Urhammer SA, Dalgaard LT, Sørensen TLA, Møller AM, Andersen T, Tybjaerg-Hansen A, Hansen T, Clausen JO, Vestergaard H, Pedersen O: Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance. Diabetologia 40:1227-1230, 1997
12. Boutin P, Chèvre JC, Hani EH, Gomis R, Pardini VC, Guillausseau P-J, Vaxillaire M, Velho G, Froguel P: An automated fluorescent single-strand conformation polymorphism technique for screening mutations in the hepatocyte nuclear factor-1α gene (maturity-onset diabetes of the young). Diabetes 46:2108-2109, 1997
13. Bouillaud F, Arechagal I, Petit PX, Raimbault S, Levi MC, Casteilla L, Laurent M, Rial E, Ricquier D: A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein. Embo J 13:1990-1997, 1994
14. Urhammer SA, Dalgaard LT, Sørensen TLA, Tybjaerg-Hansen A, Echwald S, Andersen T, Clausen JO, Pedersen O: Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity. Diabetologia 41:241-244, 1998
15. Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S, Manning B, Strosberg AD, Stern MP, Raben N: Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med 333:343-347, 1995
16. Hamann A, Flier JS, Lowell BB: Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 137:21-29, 1996
17. 3-adrenergic agonists, and leptin. J Biol Chem 272:24129-24132, 1997