BMP signaling pathways in cartilage and bone formation

Critical Reviews in Eukaryotic Gene Expression

Volumn 11, Issue 1-3, 2001, Pages 23-45

  Hoffmann, A ^a   Gross, G ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

BMP; Bone; Cartilage; Chondrocyte; Osteoblast; Smad

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; SMAD PROTEIN; SONIC HEDGEHOG PROTEIN;

BONE DEVELOPMENT; CHONDROGENESIS; EMBRYO DEVELOPMENT; GENE EXPRESSION; GROWTH PLATE; HUMAN; LIMB DEVELOPMENT; MESENCHYME CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN CROSS LINKING; REVIEW; SIGNAL TRANSDUCTION; STEM CELL;

ERINACEIDAE;

EID: 0034777917     PISSN: 10454403     EISSN: None     Source Type: Journal    
DOI: 10.1615/critreveukargeneexpr.v11.i1-3.20     Document Type: Review

References (181)

1. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells. A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium
2. Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2
3. Expression of human bone morphogenetic proteins -2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages
4. The effect of the ectoderm on the dorsoventral pattern of epidermis, muscles and joints in the developing chick leg: A new model
5. The ectodermal control in chick limb development: Wnt-7a, Shh, Bmp-2 and Bmp-4 expression and the effect of FGF-4 on gene expression
6. Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-β through stress-activated protein kinase c-Jun N-terminal kinase (SAPK/JNK) signaling pathway
7. Activation of signaling by the activin receptor complex
8. Smad6 as a transcriptional corepressor
9. A novel mesoderm inducer, Madr2 functions in the activin signal transduction pathway
10. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-β superfamily
11. In vitro study of cartilage induction in T/T mice
12. A new member of the frizzled family from Drosophila functions as a Wingless receptor
13. Sox9 is required for cartilage formation
14. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
15. Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis
16. Antagonistic effects of FGF4 on BMP induction of apoptosis and chondrogenesis in the chick limb bud
17. Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning
18. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin
19. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
20. Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages
21. Shaping limbs by apoptosis
22. Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors
23. Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function
24. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
25. Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression
26. 1mRNA expression
27. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
28. Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development
29. Fibroblast growth factor receptor 3 is a negative regulator of bone growth
30. Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development
31. A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signaling and Bmp signaling
32. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
33. Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb
34. Bone morphogenetic protein-2 (BMP-2) inhibits muscle development and promotes cartilage formation in chick limb bud cultures
35. Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos
36. Chondrogenesis in chick embryo somites in vitro
37. Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes
38. Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
39. Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by hedgehog homolog
40. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation
41. Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation
42. Wnt3a-/like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice
43. Role of TGF betas and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod
44. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
45. Bone-inducing activity of mature BMP-2b produced from a hybrid BMP-2a/2b precursor
46. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of immunoglobulin germline Calpha promoter
47. The role of p38 MAP kinase in TGF-beta1-induced signal transduction in human neutrophils
48. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
49. TGF-β signaling from cell membrane to nucleus through SMAD proteins
50. Retinoic acid signaling is required during early chick limb development
51. Expression of FGFR3 with the G380R achondroplasia mutation inhibits proliferation and maturation of CFK2 chondrocytic cells
52. Stimulation of DNA and protein synthesis in epiphyseal growth plate chondrocytes by fibroblast growth factors. Interactions with other peptide growth factors
53. Bone morphogenetic proteins (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1 cells in vitro
54. Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1
55. Bone morphogenetic proteins: Multi-functional regulators of vertebrate development
56. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postim-plantation development
57. Growth plate formation, structure and function
58. Smad6 inhibits signaling by the TGF-β superfamily
59. A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos
60. TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300
61. Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription
62. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
63. Ectopic expression of sonic hedgehog alters dorsal-ventral patterning of somites
64. The BMP2 signaling mediator Smad1 participates predominantly in osteogenic and not in chondrogenic differentiation in mesenchymal progenitors C3H10T1/2
65. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide
66. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene
67. The genetic transformation of bone biology
68. Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation
69. BMP signaling during bone pattern determination in the developing limb
70. Regulation of chondrocyte differentiation by Cbfal
71. Drosophila MAD binds to DNA and directly mediates activation of vestigial by decapentaplegic
72. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6
73. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
74. A mechanism of repression of TGF beta/Smad signaling by oncogenic Ras
75. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth
76. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
77. Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia
78. A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors
79. Smads bind directly to the Jun family of AP-1 transcription factors
80. A human Mad protein acting as a BMP-regulated transcriptional activator
81. Carboxy-terminally truncated Gli3 proteins associate with Smads
82. Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: Mapping of ligand binding and GAG attachment sites
83. Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2
84. Cartilage-derived morphogenetic protein-1
85. Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development
86. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
87. The roles of FGFs in the early development of vertebrate limbs
88. TGF-β signal transduction
89. The TGF-β family and its composite receptors
90. Controlling TGF-β signaling
91. Transcriptional contol by the TGF-beta/Smad signaling system
92. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
93. The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
94. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: Interactions with the osteocalcin gene promoter
95. Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed
96. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
97. Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway
98. Sonic hedge-hog promotes somitic chondrogenesis by altering the cellular response to BMP signaling
99. Induction of osteogenic differentiation by hedgehog proteins
100. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling
101. Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
102. Antagonistic interactions between FGF and BMP signaling pathways: A mechanism for positioning the sites of tooth formation
103. Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
104. Interaction between Wnt and TFG-beta signaling pathways during formation of Spemann's organizer
105. FGF-4 and BMP-2 have opposite effects on limb growth
106. Smad2 role in mesoderm formation, left-right patterning and craniofacial development
107. Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
108. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
109. Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: Potentiation and binding to type IV collagen
110. Identification of a palmitic acid-modified form of human sonic hedgehog
111. Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-β superfamily. Selective effects of the bone morphogenetic proteins
112. Differential expression of the chicken Pax-1 and Pax-9 gene: In situ hybridization and immunohistochemical analysis
113. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
114. Specificity, diversity, and regulation in TGF-beta superfamily signaling
115. Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone
116. Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
117. Cholesterol modification of hedgehog signaling proteins in animal development
118. The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis
119. Regulation of cartilage and bone differentiation by bone morphogenetic proteins
120. New mode of DNA binding of multi-zinc finger transcription factors: Delta EF1 family members bind with two hands to two target sites
121. Sonic hedgehog mediates the polarizing activity of the ZPA
122. Cloning and characterization of a human type II receptor for bone morphogenetic proteins
123. Inhibition of chondrogenesis by wnt gene expression in vivo and in vitro
124. The works of GLI and the power of hedge-hog
125. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
126. Developmental patterns of cartilage
127. AFT-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
128. Restrained chondrocyre proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice
129. Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling
130. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling
131. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
132. TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction
133. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
134. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signaling
135. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
136. Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction
137. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
138. DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple linages
139. Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation
140. A zinc finger transcription factor, alphaA-crystallin binding protein 1, is a negative regulator of the chondrocyte-specific enhancer of the alpha1(II) collagen gene
141. Characterization of type I receptors for transforming growth factor-β and activin
142. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
143. Morphogen gradients in vertebrate limb development
144. Limb development: An international model for vertebrate pattern formation
145. Expression and function of Pax 1 during development of the pectoral girdle
146. SARA, a FYVE domain protein that recruits Smad2 to the TGF beta receptor
147. Inhibition of transforming growth factor-beta/SMAD signaling by the interferon-gamma/STAT pathway
148. Bone cell differentiation and growth factors
149. Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome
150. Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells
151. SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5′-CACCT sequences in candidate target genes
152. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
153. Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin
154. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
155. Bone morphogenetic protein causes commitment and differentiation in C3H1OT1/2 and 3T3 cells
156. The role of the neural tube and notochord in development of the axial skeleton of the chick
157. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation
158. Smads and early developmental signaling by the TGFβ superfamily
159. Functions of fibroblast growth factors and their receptors
160. Vertebrate limb development and malformations
161. Bone morphogenetic proteins
162. Mechanism of activation of the TGF-β receptor
163. Inhibitory effects of basic fibroblast growth factor on chondrocyte differentiation
164. Structural basis of Smad2 recognition by the Smad anchor for receptor activation
165. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
166. T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification
167. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β
168. Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
169. The dishevelled protein is modified by wingless signaling in Drosophila
170. Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through Smad proteins
171. Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators
172. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
173. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
174. The type IBMP receptor BMPRIB is required for chondrogenesis in the mouse limb
175. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
176. Cloning and expression of a rat Smad1: Regulation by TGF beta and modulation by the Ras/MEK pathway
177. Parathyroid hormone [PTH(1-34)] and parathyroid hormone-related protein [PTHrP(1-34)] promote reversion of hypertrophic chondrocytes to a prehypertrophic proliferating phenotype and prevent terminal differentiation of osteoblast-like cells
178. A RUNX2/PEB2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia
179. Smad3 mutant mice develop metastatic colorectal cancer
180. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage