Inhibition of chondrogenesis by Wnt gene expression in vivo and in vitro

Developmental Biology

Volumn 185, Issue 1, 1997, Pages 104-118

  Rudnicki, Julie A ^a   Brown, Anthony M C ^a,b  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLASTEMA; CHICK EMBRYO; CHONDROGENESIS; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE TRANSFER; LIMB BUD; LIMB DEVELOPMENT; MESENCHYME; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SKELETON MALFORMATION;

EID: 0031149422     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1997.8536     Document Type: Article

References (77)

1. Ahrens P. B., Solursh M., Reiter R. S. Stage-related capacity for limb chondrogenesis in cell culture. Dev. Biol. 60:1977;69-82.
2. Aulthouse A. L., Solursh M. The detection of a precartilage, blastema-specific marker. Dev. Biol. 120:1987;377-384.
3. Bader D. M., Masaki T., Fischman D. A. Immunochemical analysis of myosin heavy chain expression during avian myogenesis in vivo and in vitro. J. Cell Biol. 95:1982;763-770.
4. Bhanot P., Brink M., Samos C. H., Hsieh J.-C., Wang Y., Macke J. P., Andrew D., Nathans J., Nusse R. Dfz2, a new member of the frizzled family inDrosophila, Nature. 382:1996;225-230.
5. Bradbury J. M., Edwards P. A. W., Niemeyer C. C., Dale T. C. Wnt-4 expression induces a pregnancy-like growth pattern in reconstructed mammary glands in virgin mice. Dev. Biol. 170:1995;553-563.
6. Bradley R. S., Brown A. M. C. A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells. Mol. Cell. Biol. 15:1995;4616-4622.
7. Bradley R. S., Cowin P., Brown A. M. C. Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin levels and an increase in cell-cell adhesion. J. Cell Biol. 123:1993;1857-1865.
8. Brown A. M. C., Papkoff J., Fung Y. K. T., Shackleford G. M., Varmus H. E. Identification of protein products encoded by the proto-oncogene int-1. Mol. Cell. Biol. 7:1987;3971-3977.
9. Castagnola P., Dozin B., Moro G., Cancedda R. Changes in the expression of collagen genes show two stages in chondrocyte differentiation in vitro. J. Cell Biol. 106:1988;461-467.
10. Chen P., Carrington J. L., Paralkar V. M., Pierce G. F., Reddi A. H. Chick limb bud mesodermal cell chondrogenesis: Inhibition by isoforms of platelet-derived growth factor and reversal by recombinant bone morphogenetic protein. Exp. Cell Res. 200:1992;110-117.
11. Chen P., Yu Y. M., Reddi A. H. Chondrogenesis in chick limb bud mesodermal cells: Reciprocal modulation by activin and inhibin. Exp. Cell Res. 206:1993;119-127.
12. Coelho C. N. D., Kosher R. A. Gap junctional communication during limb cartilage differentiation. Dev. Biol. 144:1991;47-53.
13. Dealy C. N., Roth A., Ferrari D., Brown A. M. C., Kosher R. A. Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes. Mech. Dev. 43:1993;175-186.
14. Dessau W., VonDerMark H., VonDerMark K., Fischer S. Changes in the patterns of collagens and fibronectin during limb-bud chondrogenesis. J. Embryol. Exp. Morphol. 57:1980;51-60.
15. Dickinson M. E., Krumlauf R., McMahon A. P. Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development. 120:1994;1453-1471.
16. Du S. J., Purcell S. M., Christian J. L., Moon R. T. Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins inXenopus. Mol. Cell. Biol. 15:1995;2625-2634.
17. Edwards P. A. W., Hiby S. E., Papkoff J., Bradbury J. M. Hyperplasia of mouse mammary epithelium induced by expression of the Wnt-1 (int-1) oncogene in reconstituted mammary gland. Oncogene. 7:1992;2041-2051.
18. Erlebacher A., Filvaroff E. H., Gitelman S. E., Derynck R. Toward a molecular understanding of skeletal development. Cell. 80:1995;371-378.
19. Fallon J. F., Lopez A., Ros M. A., Savage M. P., Olwin B. B., Simandl B. K. FGF-2: Apical ectodermal ridge growth signal for chick limb bud development. Science. 264:1994;104-107.
20. Fekete D. M., Cepko C. L. Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo. Mol. Cell. Biol. 13:1993;2604-2613.
21. Gavin B. J., McMahon J. A., McMahon A. P. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes. Dev. 4:1990;2319-2332.
22. Hamburger V., Hamilton H. L. A series of normal stages in the development of the chick embryo. J. Morphol. 88:1951;49-92.
23. Hammond W. S., Yntema C. L. Depletions of pharyngeal arch cartilages following extirpation of cranial neural crest in chick embryos. Acta Anat. 56:1964;21-34.
24. Herzlinger D., Qiao J., Cohen D., Ramakrishna N. R., Brown A. M. C. Induction of kidney epithelial morphogenesis by cells expressing Wnt-1. Dev. Biol. 166:1994;815-819.
25. Hinck L., Nelson W. J., Papkoff J. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing β-catenin binding to the cell adhesion protein cadherin. J. Cell Biol. 124:1994;729-741.
26. Jiang T.-X., Yi J.-R., Ying S.-Y., Chong C.-M. Activin enhances chondrogenesis of limb bud cells: Stimulation of precartilaginous mesenchymal condensations and expression of N-CAM. Dev. Biol. 155:1993;545-557.
27. Jove R., Garber E. A., Iba H., Hanafusa H. Biochemical properties of pp60v-src mutants that induce different cell transformation parameters. J. Virol. 60:1986;849-857.
28. Kato Y., Iwamoto M. Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation. J. Biol. Chem. 265:1990;5903-5909.
29. Leonard C. M., Fuld H. M., Frenz D. A., Downie S. A., Massague J., Newman S. A. Role of transforming growth factor-β in chondrogenic pattern formation in the embryonic limb: Stimulation of mesenchymal condensation and fibronectin gene expression by exogeneous TGF-β and evidence for endogenous TGF-β-like activity. Dev. Biol. 145:1991;99-109.
30. McMahon A. P., Joyner A. L., Bradley A., McMahon J. A. The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell. 69:1992;581-595.
31. McMahon A. P., Moon R. T. Ectopic expression of the proto-oncogene int-1 inXenopus. Cell. 58:1989;1075-1084.
32. Moon R. T., De Marais A., Olson D. J. Responses to Wnt signals in vertebrate embryos may involve changes in cell adhesion and cell movement. J. Cell. Sci. Suppl. 17:1993;183-188.
33. Morgan B. A., Izpisua-Belmonte J.-C., Duboule D., Tabin C. J. Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature. 358:1992;236-239.
34. Munsterberg A. E., Kitajewski J., Bumcrot D. A., McMahon A. P., Lassar A. B. Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev. 9:1995;2911-2922.
35. Niswander L., Martin G. R. FGF-4 and BMP-2 have opposite effects on limb growth. Nature. 361:1993;68-71.
36. Niswander L., Tickle C., Vogel A., Booth I., Martin G. R. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell. 75:1993;579-587.
37. Nusse R., Varmus H. E. Wnt genes. Cell. 69:1992;1073-1087.
38. Oberlender S. A., Tuan R. S. Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis. Development. 120:1994;177-187.
39. Oberlender S. A., Tuan R. S. Spatiotemporal profile of N-cadherin expression in the developing limb mesenchyme. Cell Adhes. Comm. 2:1994;521-537.
40. Olson D. J., Christian J. L., Moon R. T. Effect of Wnt-1 and related proteins on gap junctional communication inXenopus. Science. 252:1991;1173-1176.
41. Parr B. A., McMahon A. P. Wnt genes and vertebrate development. Curr. Opin. Genet. Dev. 4:1994;523-528.
42. Parr B. A., McMahon A. P. Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature. 374:1995;350-353.
43. Parr B. A., Shea M. J., Vassileva G., McMahon A. P. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development. 119:1993;247-261.
44. Petropoulos C. J., Hughes S. H. Replication-competent retrovirus vectors for the transfer and expression of gene cassettes in avian cells. J. Virol. 65:1991;3728-3737.
45. Potts W. M., Olsen M., Boettiger D., Vogt V. M. Epitope mapping of monoclonal antibodies to gag protein p19 of avian sarcoma and leukaemia viruses. J. Gen. Virol. 68:1987;3177-3182.
46. Reddi A. H. Bone and cartilage differentiation. Curr. Opin. Genet. Dev. 4:1994;737-744.
47. Riddle R. D., Ensini M., Nelson C., Tsuchida T., Jessell T. M., Tabin C. Induction of the LIM homeobox containing gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell. 83:1995;631-640.
48. Riddle R. D., Johnson R. L., Laufer E., Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell. 75:1993;1401-1416.
49. Riley B. B., Savage M. P., Simandl B. K., Olwin B. B., Fallon J. F. Retroviral expression of FGF-2 (bFGF) affects patterning in chick limb bud. Development. 118:1993;95-104.
50. Shackleford G. M., Varmus H. E. Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos. Cell. 50:1987;89-95.
51. Sidow A. Diversification of the Wnt gene family on the ancestral lineage of vertebrates. Proc. Natl. Acad. Sci. USA. 89:1992;5098-5102.
52. Smolich B. D., McMahon J. A., McMahon A. P., Papkoff J. Wnt family proteins are secreted and associated with the cell surface. Mol. Biol. Cell. 4:1993;1267-1275.
53. Sokol S., Christian J. L., Moon R. T., Melton D. A. Injected Wnt RNA induces a complete body axis inXenopus. Cell. 67:1991;741-752.
54. Solursh M. Ectoderm as a determinant of early tissue pattern in the limb bud. Cell. Differ. 15:1984;17-24.
55. Solursh M. Extracellular Matrix in Early Limb Development. 1991;Plenum, New York.
56. Solursh M., Singley C. T., Reiter R. S. The influence of epithelia on cartilage and loose connective tissue formation by limb mesenchyme cultures. Dev. Biol. 86:1981;471-482.
57. Stark K., Vainio S., Vassileva G., McMahon A. P. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature. 372:1994;679-683.
58. Stern H. M., Brown A. M. C., Hauschka S. D. Myogenesis in paraxial mesoderm: Preferential induction by dorsal neural tube and by cells expressing Wnt-1. Development. 121:1995;3675-3686.
59. Swalla B. J., Owens E. M., Linsenmayer T. F., Solursh M. Two distinct classes of prechondrogenic cell types in the embryonic limb bud. Dev. Biol. 97:1983;59-69.
60. Swalla B. J., Solursh M. The independence of myogenesis and chondrogenesis in micromass cultures of chick wing buds. Dev. Biol. 116:1986;31-38.
61. Tabin C. The initiation of the limb bud: Growth factors, Hox genes, and retinoids. Cell. 80:1995;671-674.
62. Tabin C. J. Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development. Cell. 66:1991;199-217.
63. Tavella S., Raffo P., Tacchetti C., Cancedda R., Castagnola P. N-CAM and N-cadherin expression duringin vitro. Exp. Cell Res. 215:1994;354-362.
64. Thomas K. R., Capecchi M. R. Targeted disruption of the murine int-1 protooncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature. 346:1990;847-850.
65. Tsukamoto A. S., Grosschedl R., Guzman R. C., Parslow T., Varmus H. E. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell. 55:1988;619-625.
66. Van Leeuwen F., Samos C. H., Nusse R. Biological activity of soluble wingless protein in culturedDrosophila. Nature. 368:1994;342-344.
67. Wang Y., Macke J. P., Abella B. S., Andreasson K., Worley P., Gilbert D. J., Copeland N. G., Jenkins N. A., Nathans J. A large family of putative transmembrane receptors homologous to the product of theDrosophila. J. Biol. Chem. 271:1996;4468-4476.
68. Weber-Hall S. J., Phippard D. J., Niemeyer C. C., Dale T. C. Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland. Differentiation. 57:1994;205-214.
69. Wedden S. E., Lewin-Smith M. R., Tickle C. The patterns of chondrogenesis of cells from facial primordia of chick embryos in micromass culture. Dev. Biol. 117:1986;71-82.
70. Wedden S. E., Lewin-Smith M. R., Tickle C. The effects of retinoids on cartilage differentiation in micromass cultures of chick facial primordia and the relationship to a specific facial defect. Dev. Biol. 122:1987;78-89.
71. Widelitz R. B., Jiang T.-X., Murray B. A., Chuong C.-M. Adhesion molecules in skeletogenesis. II. Neural cell adhesion molecules mediate precartilaginous mesenchymal condensations and enhance chondrogenesis. J. Cell. Phys. 156:1993;399-411.
72. Wilkinson D. G., Bailes J. A., McMahon A. P. Expression of the proto-oncogene int-1 is limited to specific neural cells in the developing mouse embryo. Cell. 50:1987;79-88.
73. Wong G. T., Gavin B. J., McMahon A. P. Differential transformation of mammary epithelial cells by Wnt genes. Mol. Cell. Biol. 14:1994;6278-6286.
74. Yang Y., Niswander L. Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning. Cell. 80:1995;939-947.
75. Zakany J., Duboule D. Correlation of expression of Wnt-1 in developing limbs with abnormalities in growth and skeletal patterning. Nature. 362:1993;546-549.
76. Zanetti N. C., Dress V. M., Solursh M. Comparison between ectoderm-conditioned medium and fibronectin in their effects on chondrogenesis by limb bud mesenchymal cells. Dev. Biol. 139:1990;383-395.
77. Zanetti N. C., Solursh M. Epithelial effects on limb chondrogenesis involve extracellular matrix and cell shape. Dev. Biol. 113:1986;110-118.