Gabapentin in the treatment of neuropathic pain

Reviews in Contemporary Pharmacotherapy

Volumn 12, Issue 3-4, 2001, Pages 125-211

  Johnson, F N ^a   Johnson, R D ^a   Armer, M L ^a  

^a LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANTICONVULSIVE AGENT; BICUCULLINE; CALCIUM CHANNEL; GABAPENTIN; LIDOCAINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALOXONE; PLACEBO; SODIUM CHANNEL; SUBSTANCE P;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; CASE REPORT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEMALE; GABAERGIC SYSTEM; HUMAN; INFECTION; INJURY; MALE; MONOAMINERGIC SYSTEM; NEUROPATHY; NEUROTRANSMISSION; NONHUMAN; PAIN; RAT; REVIEW; SIDE EFFECT;

EID: 0034773991     PISSN: 09548602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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302. Substance P-evoked release of amino acid transmitters from the newborn rat spinal cord
303. Anatomical distribution and ultrastructural organization of the GABAergic system in the rat spinal cord. An immunocytochemical study using anti-GABA antibodies
304. Hyperalgesia mediated by spinal glutamate or substance P-receptor blocked by spinal cyclooxygenase inhibition
305. Voltage-sensitive calcium channels in spinal nociceptive processing: Blockade of N- and P-type channels inhibits formalininduced nociception
306. Anti-nociceptive effects of the GMI ganglioside deivative AGF 44 on the formalin test in normal and diabetic rats
307. Pharmacologic treatment of herpes zoster and postherpetic neuralgia
308. Gabapentin is effective in treating painful tonic spasms in multiple sclerosis
309. Mechanisms of hyperalgesia and morphine tolerance: A current view of their possible interactions
310. Gabapentin for painful diabetic neuropathy
311. + channels
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313. Gabapentin in migraine prophylaxis: A preliminary open label study
314. + channels
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316. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood
317. Amitriptyline, but not lorazepam, relieves postherpetic neuralgia
318. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy
319. Formalin induced biphasic activity in C-fibers in the rat
320. The application of gabapentin in the management of neuropathic pain in children and adolescents
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322. Investigation of peripheral neuropathy
323. A receptors
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325. Erythromelalgia pain managed with gabapentin
326. Gabapentin treatment of neuropathic pain in a 12-year-old girl
327. Subsets of vulvodynia
328. Dysesthetic ('essential') vulvodynia
329. Receptive fields of lamina I projection cells move to incorporate a nearby region of injury
330. Anticonvulsant drugs for management of pain: A systematic review
331. A systematic review of antidepressants in neuropathic pain
332. Spinal mediators of hyperalgesia
333. The role of nitric oxide in the development and maintenance of hyperalgesia produced by intraplantar carrageenan in the rat
334. Successful treatment of reflex sympathetic dystrophy with gabapentin
335. Reflex sympathetic dystrophy treated with gabapentin
336. The use of gabapentin in the treatment of reflex sympathetic dystrophy and a phobic disorder
337. Gabapentin in the management of reflex sympathetic dystrophy
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339. The short-form McGill Pain Questionnaire
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341. Treatment of postherpetic neuralgia
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367. La carbamazepina en el tratamiento de neuropatia diabetica
368. Reflex sympathetic dystrophy: A disease of medical understanding
369. Mechanical hyperalgesias in neuropathic pain patients: Dynamic and static subtypes
370. The triple cold syndrome: Cold hyperalgesia, cold hypoaesthesia and cold skin in peripheral nerve disease
371. Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain
372. The anticonvulsant action of gabapentin involves the glycine/NMDA receptor
373. Calcium channel diversity and neurotransmitter release: The omega-conotoxins and omegaagatoxins
374. +-evoked release of met-enkephalin from rat striatum in vitro: Effect of putative neurotransmitters and morphine
375. Gabapentin for the treatment of dysesthetic pain after reconstructive surgery
376. High affinity GABA receptors autoradiographic localization
377. Responses of spinothalamic tract cells to mechanical and thermal stimulation in skin of rats with peripheral neuropathy
378. Role of spinal nitric oxide in antiallodynic effect of intrathecal clonidine in neuropathic rats
379. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats
380. Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia
381. Relief of cluster-tic syndrome by the combination of lithium and carbamazepine
382. Poliomyelitis and the postpolio syndrome
383. Effect of electroconvulsive shock treatment on the opioidmediated inhibition of serotonin release in rat hippocampal slices
384. Distribution of glycine, GABA, aspartate, and glutamate in the rat spinal cord
385. Pain in the Guillain-Barré syndrome: A clinical review
386. Sodium valproate in trigeminal neuralgia
387. Gabapentin therapy for diabetic neuropathic pain
388. 2-adrenoceptor agonist, in various pain tests
389. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy
390. Two distinct mechanisms, differentially affected by excitatory amino acids, trigger GABA release from fetal mouse striatal neurons in primary culture
391. Diabetes mellitus and its degenerative complications: A prospective study of 4,400 patients observed between 1947 and 1973
392. Efficacy and safety of gabapentin in different neuropathic syndromes
393. Gabapentin in acute painful diabetic neuropathy
394. Cancer pain: Pathophysiology and syndromes
395. Recent advances in multiple sclerosis
396. Photochemically induced graded spinal cord infarction: Behavioral, electrophysiological, and morphological correlates
397. Reduction of 3,4-diaminopyridine-induced biogenic amine synthesis and release in rat brain by gabapentin
398. Formalin-evoked activity in identified primary afferent fibres: Systemic lidocaine suppresses phase-2 activity
399. Pain affect encoded in human anterior cingulate but not somatosensory cortex
400. Evidence for different mechanisms of primary and secondary hyperalgesia following heat injury to the glabrous skin
401. A method for measurement of analgesic activity on inflamed tissue
402. Gabapentin augments whole blood serotonin in healthy young men
403. Experimental pathophysiological correlates of clinical symptomatology in peripheral neuropathic pain syndromes
404. Interstitial cystitis: A patient's perspective
405. Thrombocythemia as a cause of erythromelalgia
406. The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat
407. Inhibition by GABA, baclofen, and gabapentin of dopamine release from rabbit caudate nucleus: Are there common or different sites of action?
408. The effects of a noncompetitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation
409. Gabapentin in the treatment of pain after traumatic avulsion of the brachial plexus or after leg amputatution at the hip joint
410. Role of HIV in the pathogenesis of distal symmetrical peripheral polyneuropathy
411. Nociceptive responses to altered GABAergic activity at the spinal cord
412. Gabapentin modifies extracellular opioid content in amygdala: A microdialysis study
413. Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons
414. Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds
415. Aetiology of migraine and prevention with carbamazepine (Tegretol): Results of a double-blind crossover study
416. Comparison of paroxetine and nortriptyline in depressed patients with ischaemic heart disease
417. Carbamazepine in the treatment of non-seizure disorders: Trigeminal neuralgia, other painful disorders, and affective disorders
418. The effect of gabapentin on neuropathic pain
419. Gabapentin adjunctive therapy in neuropathic pain states
420. Cytomegalovirus multifocal neuropathy in AIDS: Analysis of 15 consecutive cases
421. Low dose gabapentin for shoulder-hand syndrome induced by phenobarbital: A three-month study
422. Topical lidocaine reduces pain in post-herpetic neuralgia
423. Topical lidocaine gel relieves postherpetic neuralgia
424. Gabapentin for the treatment of postherpetic neuralgia a randomized controlled trial
425. Gabapentin for postherpetic neuralgia
426. Neurochemistry and neural circuitry in the dorsal horn
427. Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine: Double-blind crossover study
428. Actions of calcitonin-gene-related peptide on rat spinal dorsal horn neurons
429. Phase I trial of the murine monoclonal anti-GD2 antibody 14G2a in metastatic melanoma
430. Amelioration of refractory dysesthetic limb pain in multiple sclerosis by gabapentin
431. The role of the mast cell in interstitial cystitis
432. Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury
433. Adrenergic excitation of cutaneous nociceptors in chronically inflamed rats
434. Comparative effectiveness of anti-epileptic preparations in treatment of patients with neuralgia of the trigeminal nerve
435. D-Baclofen is an antagonist at baclofen receptors mediating antinociception in the spinal cord
436. Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons
437. Treatment of facial pain with gabapentin: Case reports
438. Treatment of central pain with gabapentin: Case reports
439. Gabapentin for painful diabetic neuropathy
440. Gabapentin decreases monoamine release without affecting acetylcholine release in the brain
441. Reflex sympathetic dystrophy: A review
442. 2+ currents elicited by action potential waveforms in acutely isolated adult rat dorsal root ganglion neurons
443. Spinal cord stimulation, conception, pregnancy, and labor: Case study in a complex regional pain syndrome patient
444. Gabapentin as a novel treatment for postherpetic neuralgia
445. Gabapentin for painful diabetic neuropathy
446. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
447. A case of myokymia-cramp syndrome successfully treated with gabapentin
448. Gabapentin for muscle cramps: An open-label trial
449. Gabapentin enhances the antinociceptive effects of spinal morphine in the rat tail flick test
450. Spinal gabapentin is anfinociceptive in the rat formalin test
451. Gabapentin enhances the antinociceptive effect of spinal morphine in the rat tail-flick test
452. Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn
453. Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy
454. Chronic peripheral nerve section results in a rearrangement of the central axonal arborizations of axotomized Aβ primary afferent neurons in the rat spinal cord
455. Effects of sympathetic stimulation of C-fibre response after peripheral nerve compression: An experimental study in the rabbit common peroneal nerve
456. Tricyclic antidepressants and dextromethorphan bind with higher affinity to the phencyclidine receptor in the absence of magnesium and L-glutamate
457. Neurogenic hyperalgesia: Central neural correlates in responses of spinothalamic tract neurons
458. Nucleoside analogue-associated peripheral neuropathy in human immunodeficiency virus infection
459. A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathy
460. Tramadol relieves pain and allodynia in polyneuropathy: A randomised, double-blind, controlled trial
461. Painful symptoms reported by ambulatory HIV infected men in a longitudinal study
462. The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by Dserine
463. Experience with gabapentin for neuropathic pain in the head and neck: Report of ten cases
464. Gabapentin for idiopathic trigeminal neuralgia: Report of two cases
465. Alterations of regional gamma-aminobutyric acid receptors in morphine tolerant mice
466. Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation
467. Experimental peripheral neuropathy decreases the dose of substance P required to increase excitatory amino acid release in the CSF of the rat spinal cord
468. An animal model of pain produced by systemic administration of an immunotherapeutic anti-ganglioside antibody
469. Centrally administered nonNMDA but not NMDA receptor antagonists block peripheral knee joint inflammation pain
470. Joint inflammation and hyperalgesia are reduced by spinal bicuculline
471. The role of dorsal root reflexes in neurogenic inflammation
472. Erythermalgia (erythromelalgia) of the extremities: A syndrome characterized by redness, heat and pain
473. Increased sensitivity to the antinociceptive activity of (±)-baclofen in an animal model of chronic neuropathy, but not chronic inflammation hyperalgesia
474. Gabapentin is effective in treating paroxysmal symptoms in multiple sclerosis
475. An open-label trial of gabapentin treatment of paroxysmal symptoms in multiple sclerosis patients
476. Gabapentin is effective in treating nocturnal painful spasms in multiple sclerosis
477. Gabapentin and neuropathic pain states: A case series report
478. Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan-induced inflammation
479. Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation
480. Complex regional pain syndrome (Type I, RSD; Type II, causalgia): Controversies
481. Gabapentin inhibits calcium currents in isolated rat brain neurons
482. Acute and chronic pain syndromes in multiple sclerosis
483. Gabapentin as an analgesic in CRPS, type 1
484. A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma
485. Transport of gabapentin, a gamma-amino acid drug, by system alpha-amino acid transporters: A comparative study in astrocytes, synaptosomes, and CHO cells
486. Gabapentin in chronic neuropathic pain (preliminary results)
487. Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: Effects of a chronic constriction injury, transection, and strychnine
488. 3H]gabapentin binding site in rat brain: Homogenate binding studies
489. A review of the preclinical pharmacology of tiagabine: A potent and selective anticonvulsant GABA uptake inhibitor
490. Anticonvulsant drugs used in the treament of lancinating pain. A comparison
491. Crampfasciculation syndrome: A treatable hyperexcitable peripheral nerve disorder
492. Extra-territorial pain in rats with a peripheral mononeuropathy. Mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve
493. Neuropathic pain sensations are differentially sensitive to dextrorphan
494. Mechanisms of action of new anti-epileptic drugs
495. Emerging perspectives on the mechanism of action of gabapentin
496. Gabapentin: Mechanisms of action
497. Mechanisms of action of gabapentin
498. Phenobarbital rheumatism in primary brain tumor patients
499. In vitro and in vivo electrophysiological effects of the anticonvulsant gabapentin
500. 3-Alkyl GABA and 3-alkylglutamic acid analogues: Two new classes of anticonvulsant agents
501. Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labelled by tritiated gabapentin
502. A summary of mechanistic hypotheses of gabapentin pharmacology
503. 3H]Gabapentin may label a system-L-like neutral amino acid carrier in brain
504. Dose-dependent antagonism of spinal opioid receptor agonists by natoxone and natrindole: Additional evidence for δ-opioid receptor subtypes in the rat
505. The formalin test: An evaluation of the method
506. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans
507. Modern concepts of pain and hyperalgesia: Beyond the polymodal C-nociceptor
508. Calcium channels coupled to glutamate release identified by ω-aga-IVA
509. Acute and continuous morphine administration on the gammaaminobutyric acid system in the mouse
510. P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses
511. NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin
512. Neuropathic pain after anti-HIV gene therapy successfully treated with gabapentin
513. Somatosensory, proprioceptive and sympathetic activity in human peripheral nerve
514. Gabapentin in idiopathic trigeminal neuralgia
515. Use of gabapentin to treat taxane-induced myalgias
516. Neurontin (gabapentin, GBP) improved quality of life (QOL) in patients with painful diabetic peripheral neuropathy
517. Pharmacokinetics and metabolism of gabapentin in rat, dog and man
518. Management of erythrometalgia with epidural bupivicaine and fentanyl and oral gabapentin
519. Reflex sympathetic dystrophy
520. GABA, GABA receptors and benzodiazepine receptors in the human spinal cord: An autoradiographic and immunohistochemical study at the light and electron microscopic levels
521. Electrical stimulation of the upper thoracic portion of the sympathetic chain in man
522. Porperties of afferent nerve impulses originating from a neuroma
523. Calcium and sodium channel antagonists for the treatment of pain
524. Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture
525. Multiple cellular actions of gabapentin
526. The treatment of neuropathic pain: Antidepressants and opioids
527. Photochemically induced spinal cord injury in the rat
528. Post-herpetic neuralgia: Postmortem analysis of a case
529. Nortriptyline versus amitriptyline in postherpetic neuralgia. A randomized trial
530. Gabapentin anticonvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate
531. Pharmacokinetics and pharmacodynamics of CI-1008 (pregabalin) and gabapentin in rats using maximal electroshock
532. Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with anticonvulsant action
533. Use of gabapentin in pain management
534. Use of gabapentin in the treatment of childhood reflex sympathetic dystrophy
535. Standardization of the rat paw formalin test for the evaluation of analgesics
536. 2, β subunits of a novel human neuronal calcium channel subtype
537. Reaction thresholds to pressure in oedematous hind paw of rats: Response to analgesic drugs
538. Evidence for a central component of post-injury pain hypersensitivity
539. Recent advances in the pathophysiology of acute pain
540. The pathophysiology of chronic pain - Increased sensitivity to low threshold Aβ-fibre inputs
541. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: Implications for the treatment of post-injury pain hypersensitivity states
542. Relative effectiveness of C-primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat
543. Peripheral nerve injury triggers central sprouting of myelinated afferents
544. Gabapentin relieves abnormal pain in a rat model of painful peripheral neuropathy
545. Gabapentin has an antinociceptive effect mediated via a spinal site of action in a rat model of painful peripheral neuropathy
546. Chronic pain-related syndrome in rats after ischemic spinal cord lesion: A possible animal model for pain in patients with spinal cord injury
547. Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, α-adrenergic agonists and baclofen
548. Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists
549. Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and nonopioid receptors
550. Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy
551. Comparison of the antinociceptive effects of pre- and post-treatment with intrathecal morphine and MK-801, and NMDA antagonist, on the formalin test in the rat
552. Effects of intrathecal strychnine and bicuculline on nerve compression induced thermal hyperesthesia and selective antagonism by MK-801
553. Release of cold-induced burning pain by block of cold-specific afferent input
554. Pain following spinal cord injury: The clinical problem and experimental studies
555. Evaluation of interaction between gabapentin and ibuprofen on the formalin test in rats
556. The effect of intrathecal gabapentin on pain behavior and hemodynamics in the formalin test in the rat
557. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model
558. Diabetic neuropathy: Symptoms, signs and assessment
559. Lamotrigine (Lamictal) in refractory trigeminal neuralgia: Results from a double-blind placebo-controlled crossover study
560. Postpoliomyelitis pain treated with gabapentin
561. B receptor antagonist L-365,260 in rat spinal cord