Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 292, Issue 2, 2000, Pages 743-751

  Kaneko, Megumi ^a,b   Mestre, Christine ^a,c   Sánchez, Edgard H ^a   Hammond, Donna L ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORMALDEHYDE; GABAPENTIN; HALOTHANE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOREACTIVITY; MALE; NERVE CELL EXCITABILITY; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SENSITIZATION; SPINAL CORD;

ACETIC ACIDS; AMINES; ANALGESICS; ANIMALS; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FOOT; FORMALDEHYDE; GAMMA-AMINOBUTYRIC ACID; HINDLIMB; IMMUNOHISTOCHEMISTRY; INJECTIONS, SPINAL; MALE; NEURONS; NOCICEPTORS; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TIME FACTORS;

EID: 0033984866     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Abbadie C, Honoré P, Fournié-Zaluski M-C, Roques BP and Besson J-M (1994) Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation. Eur J Pharmacol 268: 215-227.
2. Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, LaMoreaux L and Garofalo E (1998) Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: A randomized controlled trial. J Am Med Assoc 280:1831-1836.
3. Chapman V, Honoré P, Buritova J and Besson J-M (1995) The contribution of NMDA receptor activation to spinal c-Fos expression in a model of inflammatory pain. Br J Pharmacol 116:1628-1634.
4. Coderre TJ and Melzack R (1992) The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. J Neurosci 12:3665-3670.
5. Field MJ, Holloman EF, McCleary S, Hughes J and Siagh L (1997a) Evaluation of gabapentin and S-(+)-isobutylgaba in a rat model of postoperative pain. J Pharmacol Exp Ther 282:1242-1246.
6. Field MJ, McCleary S, Hughes J and Singh L (1999) Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat. Pain 80:391-398.
7. Field MJ, Oles RJ, Lewis AS, McCleary S, Hughes J and Singh L (1997b) Gabapentin (Neurotin) and S-(+)-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br J Pharmacol 121:1513-1522.
8. Finney DJ (1964) Statistical Method in Biological Assay, Hafner Publishing Co., New York.
9. Goa KL and Sorkin EM (1993) Gabapentin: A review of its pharmacological properties and clinical potential in epilepsy. Drugs 46:409-427.
10. Gogas KR, Cho HJ, Botchkina GI, Levine JD and Basbaum AI (1996a) Inhibition of noxious stimulus-evoked pain behaviors and neuronal fos-like immunoreactivity in the spinal cord of the rat by supraspinal morphine. Pain 85:9-15.
11. Gogas KR, Levine JD and Basbaum AI (1996W Differential contribution of descending controls to the antinociceptive actions of kappa and mu opioids: An analysis of formalin-evoked c-fos expression. J Pharmacol Exp Ther 276:801-809.
12. Hammond DL, Wang H, Nakashima N and Basbaum AI (1998) Differential effects of intrathecally administered δ and μ opioid receptor agonists on formalin-evoked nociception and the expression of Fos-immunoreactivity in the spinal cord of the rat. J Pharmacol Exp Ther 284:378-387.
13. Honoré P, Buritova J and Besson JM (1995) Carrageenin-evoked c-Fos expression in rat lumbar spinal cord: The effects of indomethacin. Eur J Pharmacol 272:249-259.
14. Huang W and Simpson RK Jr (1999) Noxious thermal stimulation of c-fos activity induced in rat lumbar spinal cord is reduced by AP-5 but not by glycine. Neurosci Lett 269:1-4.
15. Hunter JC, Gogas KR, Hedley LR, Jacobson LO, Kassotakis L, Thompson J and Fontana DJ (1997) The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. Eur J Pharmacol 324:153-160.
16. Hwang JH and Yaksh TL (1997) Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat. Reg Anesth 22:249-256.
17. Jones DL and Sorkin LS (1998) Systemic gabapentin and S(+)-3-isobutyl-γ-aminobutyric acid block secondary hyperalgesia. Brain Res 810:93-99.
18. A receptors in formalin-induced nociception in the rat. J Pharmacol Exp Ther 282:928-938.
19. Kehl LJ, Gogas KR, Lichtblau L, Pollock CH, Mayes M, Basbaum AI and Wilcox GL (1991) The NMDA antagonist MK801 reduces noxious stimulus-evoked FOS expression in the spinal cord dorsal horn, in Proceedings of the VIth World Congress on Pain (Bond MR, Charlton CE and Woolf CJ eds) pp 307-311, Elsevier, Amsterdam.
20. Mellick LB and Mellick GA (1995) Successful treatment of reflex sympathetic dystrophy with gabapentin. Am J Emerg Med 13:96.
21. Pan H-L, Eisenach JC and Chen S-R (1999) Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol Exp Ther 288:1026-1030.
22. Partridge BJ, Chaplan SR, Sakamoto E and Yaksh TL (1998) Characterization of the effects of gabapentin and 3-isobutyl-γ-aminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology 88:196-205.
23. Pertovaara A, Bravo R and Herdegen T (1993) Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation. Neuroscience 54:117-126.
24. Presley RW, Menétrey D, Levine JD and Basbaum AI (1990) Systemic morphine suppresses noxious stimulus-evoked fos protein-like immunoreactivity in the rat spinal cord. J Neurosci 10:323-335.
25. Rosenberg JM, Harrell C, Ristic H, Werner RA and de Rosayro AM (1997) The effect of gabapentin on neuropathic pain. Clin J Pain 13:251-255.
26. Rowbotham M, Harden N, Stacey B, Bernstein P and Magnus-Miller L (1998) Gabapentin for the treatment of postherpetic neuralgia: A randomized controlled trial. J Am Med Assoc 280:1837-1842.
27. Samkoff LM, Daras M, Tuchman AJ and Koppel BS (1997) Amelioration of refractory dysesthetic limb pain in multiple sclerosis by gabapentin. Neurology 49:304-305.
28. Segal AZ and Rordorf G (1996) Gabapentin as a novel treatment for postherpetic neuralgia. Neurology 4:1175-1176.
29. Shimoyama N, Shimoyama M, Davis AM, Inturrisi CE and Elliott KJ (1997) Spinal gabapentin is antinociceptive in the rat formalin test. Neurosci Lett 222:65-67.
30. Singh L, Field MJ, Ferris P, Hunter JC, Oles RJ, Williams RG and Woodruff GN (1996) The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology 127:1-9.
31. Taylor CP, Gee NS, Su T-Z, Kocsis JD, Welty DF, Brown JP, Dooley DJ, Boden P and Singh L (1998) A summary of the mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 29:233-249.
32. Tölle TR, Castro-Lopes JM, Coimbra A and Zieglgansberger W (1990) Opiates modify induction of c-fos proto-oncogene in the spinal cord of the rat following noxious stimulation. Neurosci Lett 111:46-51.
33. Vaccarino AL, Marek P, Kest B, Weber E, Keana JFW and Liebeskind JC (1993) NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin. Brain Res 815:331-334.
34. Welty DF, Schiekek GP, Vartanian MG and Taylor CP (1993) Gabapentin antinconvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate. Epilepsy Res 18:175-181.
35. Willcockson HH, Taylor-Blake B and Light AR (1995) Induction of fos-like immunoreactivity by electrocutaneous stimulation of the rat hindpaw. Somatosens Motor Res 12:151-161.
36. Xiao W-H and Bennett GJ (1996) Gabapentin has an antinociceptive effect mediated via a spinal site of action in a rat model of painful peripheral neuropathy. Analgesia 2:267-273.
37. Yamamoto T and Yaksh TL (1992) Comparison of the antinociceptive effects of preand posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology 77:757-763.
38. Yoon MH and Yaksh TL (1999) The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat. Anesth Analg 89:434-439.