The effect of intrathecal gabapentin and 3-isobutyl γ-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat

Anesthesia and Analgesia

Volumn 86, Issue 2, 1998, Pages 348-354

  Jun, Jong Hun ^a   Yaksh, Tony L ^b  

^a Hanyang University College of Medicine   (South Korea)

^b University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID DERIVATIVE; GABAPENTIN; PREGABALIN; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG RECEPTOR BINDING; ESCAPE BEHAVIOR; GABAERGIC SYSTEM; HINDLIMB; HYPERALGESIA; INTRATHECAL DRUG ADMINISTRATION; MALE; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; THERMAL INJURY;

EID: 0009672955     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199802000-00025     Document Type: Article

References (33)

1. Mellick GA, Mellick LB. Gabapentin in the management of reflex sympathetic dystrophy [letter]. J Pain Sympt Manage 1995;10:265-6.
2. Mellick LB, Mellick GA. Successful treatment of reflex sympathetic dystrophy with gabapentin [letter]. Am J Emerg Med 1995;13:96.
3. Rosner H, Rubin L, Kestenbaum A. Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain 1996;12:56-8.
4. Hwang JH, Yaksh TL. The effect of intrathecal gabapentin on tactile-evoked allodynia in a surgically-induced neuropathic pain model in the rat. Reg Anesth 1997;22:249-56.
5. Singh L, Field MJ, Ferris P, et al. The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology 1996;127:1-9.
6. Taylor CP, Vartanian MG, Andruszkiewicz R, et al. 3-Alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents. Epilepsy Res 1992;11:103-10.
7. Taylor CP. Mechanism of action of new anti-epileptic drugs. In: Chadwick D, ed. New trends in epilepsy management: the role of gabapentin. London: Royal Society of Medical Services, 1993: 13-40.
8. Taylor CP, Vartanian MG, Yuen PW, et al. Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin. Epilepsy Res 1993;14:11-5.
9. Singh L, Field MJ, Ferris P, et al. The antiepileptic agent gabapentin (neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology 1996;127:1-9.
10. Kemp JA, Leeson PD. The glycine site of the NMDA receptor: five years on. Trends Pharmacol Sei 1993;14:20-5.
11. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976;17:1031-6.
12. Dirig DM, Hua XY, Yaksh TL. Temperature dependency of basal and evoked release of amino acids and calcitonin gene-related peptide from rat dorsal spinal cord. J Neurosci 1997;17: 4406-14.
13. Hargreaves K, Dubner R, Brown F, et al. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988;32:77-88.
14. Tallarida RJ, Murray RB. Manual of pharmacologic calculations with computer programs. 2nd Ed. New York: Springer-Verlag, 1987.
15. Taylor CP. Gabapentin: mechanisms of action. In: Levy RH, Mattson RH, Meldrum BS, eds. Antiepileptic drugs. 4th Ed. New York: Raven Press, 1995:829-41.
16. Goa KL, Sorkin EM. Gabapentin: a review of its pharmacological properties and clinical potential in epilepsy. Drugs 1993;46: 409-27.
17. Satzinger G. Antiepileptics from gamma-aminobutyric acid. Arzneimittel Forschung 1994;44:261-6.
18. Taylor CP. Emerging perspectives on the mechanism of action of gabapentin. Neurology 1994;44:S10-6.
19. Loescher W, Honack D, Taylor CP. Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. Neurosci Lett 1991;128:150-4.
20. Gotz E, Feuerstein TJ, Lais A, et al. Effects of gabapentin on release of gamma-aminobutyric acid from slices of rat neostriatum. Arzneimittel Forschung 1993;43:636-8.
21. Kocsis JD, Honmou O. Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve. Neurosci Lett 1994; 169:181-4.
22. Yaksh TL, Chaplan SR, Malmberg AB. Future directions in the pharmacological management of hyperalgesic and allodynic pain states: the NMDA receptor. In: Chiang CN, Finnegan LP, eds. Medications development for the treatment of pregnant addicts and their infants. Rockville, MD: United States Department of Health and Human Services, 1995:84-102.
23. Malmberg AB, Yaksh TL. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in anesthetized rats. J Neurosci 1994;15:2768-76.
24. Yang LC, Marsala M, Yaksh TL. Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: a chronic microdialysis study. Pain 1996;67:345-54.
25. Marsala M, Yang L-C, Lee Y-W, Yaksh TL. Chronic nerve compression results in a delayed but persistent increase in spinal glutamate release in the unanesthetized rat. IASP. In press.
26. Oles RJ, Singh L, Hughes J, et al. The anticonvulsant actions of gabapentin involves the glycine/NMDA receptor. Soc Neurosci Abstr 1990;6:783.
27. Rock DM, Kelly KM, Macdonald RL. Gabapentin actions on ligand-and voltage-gated responses in cultured rodent neurons. Epilepsy Res 1993;16:89-98.
28. Goldlust A, Su TZ, Welty DF, et al. Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA. Epilepsy Res 1995;22:1-11.
29. Matsui T, Sekiguchi M, Hashimoto A, et al. Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J Neurochem 1995;65:454-8.
30. Brugge F, Wicki U, Nassenstein-Elton D, et al. Modulation of the NMDA receptor by D-serine in the cortex and the spinal cord in vitro. Eur J Pharmacol 1990;191:29-38.
31. Pralong E, Millar JD, Lodge D. Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro. Neurosci Lett 1992;136:56-8.
32. Kolhekar R, Meller ST, Gebhart GF. N-methyl-D-aspartate receptor-mediated changes in thermal nociception. allosteric modulation at glycine and polyamine recognition sites. Neuroscience 1994;63:925-36.
33. Gee NS, Brown JP, Dissanayake VU, et al. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2 delta subunit of a calcium channel. J Biol Chem 1996;271:5768-76.