The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine

Psychopharmacology

Volumn 127, Issue 1, 1996, Pages 1-9

  Singh, L ^a   Field, M J ^a   Ferris, P ^a   Hunter, J C ^a   Oles, R J ^a   Williams, R G ^a   Woodruff, G N ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Conflict test; D Serine; Elevated X maze; Glycine; Marmoset human threat test; Mouse light dark box; NMDA receptor; Rat formalin paw test

Indexed keywords

3 AMINO 1 HYDROXY 2 PYRROLIDINONE; 4 PHOSPHONOMETHYLPIPECOLIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; ANTICONVULSIVE AGENT; CARRAGEENAN; CHLORDIAZEPOXIDE; DEXTRO SERINE; FORMALDEHYDE; GABAPENTIN; GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR AGONIST; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PARTIAL AGONIST; RADIOLIGAND; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BEHAVIOR; BINDING SITE; BRAIN CORTEX; CONFLICT; CONTROLLED STUDY; DARKNESS; DRUG ANTAGONISM; DRUG MECHANISM; DRUG RECEPTOR BINDING; INTRAPERITONEAL DRUG ADMINISTRATION; LIGHT; MALE; MARMOSET; MAZE TEST; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; THREAT; TRANQUILIZING ACTIVITY;

EID: 0029795902     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02805968     Document Type: Article

References (29)

1. Bartoszyk GD, Reimann W (1985) Preclinical characterization of the anticonvulsant gabapentin. In: 16th Epilepsy International Congress. Abstracts (Ciba-Geigy, Basel), p 1
2. Broekkamp CL, Berendsen HH, Jenck F, Van-Delft AM (1989) Animal models for anxiety and response to serotonergic drugs. Psychopathology 22 [Suppl. 1]: 2-12
3. Coderre TJ, Vaccarino AL, Melzack R (1990) Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection. Brain Res 535:155-158
4. Costall B, Domeney AM, Gerrard PA, Kelly ME, Naylor RJ (1988) Zacopride: anxiolytic profile in rodent and primate models of anxiety. J Pharm Pharmacol 40:302-306
5. Costall B, Jones BJ, Kelly ME, Naylor RJ, Tomkins DM (1989) Exploration of mice in a black and white box: Validation as a model of anxiety. Pharmacol Biochem Behav 32:777-785
6. Davis SN, Lodge D (1987) Evidence for the involvement of N-methyl-D-aspartate receptors in "wind-up" of class 2 neurones in the dorsal horn of the rat. Brain Res 424:402-406
7. Dickenson AH, Sullivan AF (1987) Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology 26:1235-1238
8. Dickenson AH, Sullivan AF (1990) Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat. Brain Res 506:31-39
9. Dunn RW, Flangan DM, Martin LL, Kerman LL, Woods AT, Camacho F, Wilmot CA, Cornfeldt ML, Effland RC, Wood PL, Corbett R (1992) Stereoselective R (+) enantiomer of HA-966 displays anxiolytic effects in rodents. Eur J Pharmacol 214:207-214
10. 2δ subunit of a calcium channel. J Biol Chem 271:5768-5776
11. Goa KL, Sorkin EM (1993) Gabapentin: a review of its pharmacological properties and clinical potential in epilepsy. Drug Evaluation 46 [3]:409-427
12. Haley JE, Sullivan AF, Dickenson AH (1990) Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res 518:218-226
13. Hunter JC, Singh L (1994) Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat. Neurosci Lett 174:217-221
14. Kemp JA, Foster AC, Leeson PD, Priestly T, Tridgett R, Iversen LL, Woodruff GN (1988) 7-Chlorokynurenic acid is a selective-antagonist at the glycine modulalory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci USA 85: 6547-6550
15. Kilfoil T, Michel A, Montgomery D, Whiting, RL (1989) Effects of anxiolytic and anxiogenic drugs on exploratory activity in a simple model of anxiety in mice. Neuropharmacology 28: 901-905
16. King AE, Thompson SWN, Urban L, Woolf CJ (1988) An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice. Neurosci Lett 89:286-292
17. Mellick GA, Mellicy LB, Mellick LB (1995) Gabapentin in the management of reflex sympathetic dystrophy. J Pain Symptom Management 10:265-266
18. Nasstrom J, Karlsson U, Post C (1992) Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice. Eur J Pharmacol 212:21-29
19. Oles RJ, Singh L, Hughes G, Woodruff GN (1990) The anticonvulsant action of gabapentin involves the glycine/NMDA receptor. Soc Neurosci Abstr 16:321.6
20. Singh L, Donald AE, Foster AC, Hutson PH, Iversen LL, Iversen SD, Kemp JA, Leeson PD, Marshall GR, Oles RJ, Priestley T, Thorn L, Tricklebank MD, Vass CA, Williams BJ (1990a) Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. Proc Natl Acad Sci USA 87: 347-351
21. Singh L, Oles RJ, Tricklebank MD (1990b) Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex. Br J Pharmacol 99:285-288
22. B receptor antagonist. Br J Pharmacol 104:239-245
23. A/B receptor antagonists. Eur J Pharmacol 286:185-191
24. Skilling SR, Smullin DH, Larson AA (1988) Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation. J Neurochem 51:127-132
25. 3H]gabapentin binding to a novel site in the rat brain: homogenate binding studies. Eur J Pharmacol [Mol Pharmacol Sec] 244:293-301
26. Wheeler-Aceto H, Cowan A (1991) Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology 104:35-44
27. Woolf CJ, Thompson SWN (1991) The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: implications for post-injury pain hypersensitivity states. Pain 44:293-299
28. Xiao W-H, Bennett GI (1995) Gabapentin relieves abnormal pains in a rat model of painful peripheral neuropathy. Soc Neurosci Abstr 21:356.17
29. Zieglgansberger W, Herz A (1971) changes of cutaneous receptive fields of spino-cervical-tract neurons and other dorsal horn neurons by microelectrophoretically administered amino acids. Exp Brain Res 13:111-126