Postherpetic neuralgia - Pathogenesis, treatment, and prevention

New England Journal of Medicine

Volumn 335, Issue 1, 1996, Pages 32-42

  Kost, Rhonda G ^a   Straus, Stephen E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMITRIPTYLINE; ANALGESIC AGENT; ANESTHETIC AGENT; CAPSAICIN; ETHER DERIVATIVE; IBUPROFEN; LIDOCAINE; LORAZEPAM; MEPIVACAINE; PRILOCAINE; VALPROIC ACID;

DISEASE COURSE; HERPES ZOSTER; HISTOPATHOLOGY; HUMAN; INCIDENCE; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PAIN; PATHOGENESIS; POSTHERPETIC NEURALGIA; PRIORITY JOURNAL; REVIEW; TOPICAL DRUG ADMINISTRATION; TREATMENT PLANNING;

ANTIVIRAL AGENTS; CAPSAICIN; CENTRAL NERVOUS SYSTEM AGENTS; DRUG THERAPY, COMBINATION; GLUCOCORTICOIDS; HERPES ZOSTER; HUMANS; NEURALGIA;

EID: 0030015461     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199607043350107     Document Type: Review

References (110)

1. Hope-Simpson RE. Postherpetic neuralgia. J R Coll Gen Pract 1975; 25:571-5.
2. Ragozzino MW, Melton LJ III, Kurland LT, Chu CP, Perry HO. Population-based study of herpes zoster and its sequelae. Medicine (Baltimore) 1982;61:310-6.
3. Burgoon CF Jr, Burgoon JS, Baldridge GD. The natural history of herpes zoster. JAMA 1957;164:265-9.
4. Glynn C, Crockford G, Gavaghan D, Cardno P, Price D, Miller J. Epidemiology of shingles. J R Soc Med 1990;83:617-9.
5. Rogers RS III, Tindall JP. Geriatric herpes zoster. J Am Geriatr Soc 1971;19:495-504.
6. Huff JC, Bean B, Balfour HH Jr, et al. Therapy of herpes zoster with oral acyclovir. Am J Med 1988;85:84-9.
7. . Wood MJ, Ogan PH, McKendrick MW, Care CD, McGill JI, Webb EM. Efficacy of oral acyclovir treatment of acute herpes zoster. Am J Med 1988; 85:79-83.
8. Gilden DH, Dueland AN, Cohrs R, Martin JR, Kleinschmidt-DeMasters BK, Mahalingam R. Preherpetic neuralgia. Neurology 1991;41:1215-8.
9. Gilden DH, Dueland AN, Devlin ME, Mahalingam R, Cohrs R. Varicella-zoster virus reactivation without rash. J Infect Dis 1992;166:Suppl 1: S30-S34.
10. Watson CPN. Postherpetic neuralgia. Neurol Clin 1989;7:231-48.
11. Nurmikko T, Bowsher D. Somatosensory findings in postherpetic neuralgia. J Neurol Neurosurg Psychiatry 1990;53:135-41.
12. Rowbotham MC, Fields HL. Post-herpetic neuralgia: the relation of pain complaint, sensory disturbance, and skin temperature. Pain 1989;39: 12944.
13. Idem. Topical lidocaine reduces pain in post-herpetic neuralgia. Pain 1989;38:297-301.
14. Eide PK, Jorum E, Stubhaug A, Bremnes J, Breivik H. Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo. Pain 1994;58:347-54.
15. Dworkin RH, Hartstein G, Rosner HL, Walther RR, Sweeney EW, Brand L. A high-risk method for studying psychosocial antecedents of chronic pain: the prospective investigation of herpes zoster. J Abnorm Psychol 1992;101:200-5.
16. de Moragas JM, Kierland RR. The outcome of patients with herpes zoster. Arch Dermatol 1957;75:193-6.
17. Hope-Simpson RE. The nature of herpes zoster a long-term study and a new hypothesis. Proc R Soc Med 1965;58:9-20.
18. Guess HA, Broughton DD, Melton LJ III, Kurland LT. Epidemiology of herpes zoster in children and adolescents: a population-based study. Pediatrics 1985;76:512-7.
19. Molin L. Aspects of the natural history of herpes zoster: a follow-up investigation of outpatient material. Acta Derm Venereol (Stockh) 1969; 49:569-83.
20. Rusthoven JJ, Ahlgren P, Elhakim T, et al. Varicella-zoster infection in adult cancer patients: a population study. Arch Intern Med 1988;148: 1561-6.
21. Hardy I, Gershon AA, Steinberg SP, LaRussa P, Varicella Vaccine Collaborative Study Group. The incidence of zoster after immunization with live attenuated varicella vaccine: a study in children with leukemia. N Engl J Med 1991;325:1545-50.
22. Freidman-Kein AE, Lafleur FL, Gendler E, et al. Herpes zoster: a possible early clinical sign for development of acquired immunodeficiency syndrome in high-risk individuals. J Am Acad Dermatol 1986;14:1023-8.
23. Watson CPN, Watt VR, Chipman M, Birkett N, Evans RJ. The prognosis with postherpetic neuralgia. Pain 1991;46:V95-9.
24. Brown GR. Herpes zoster: correlation of age, sex, distribution, neuralgia, and associated disorders. South Med J 1976;69:576-8.
25. Eaglstein WH, Katz R, Brown JA. The effects of early corticosteroid therapy on the skin eruption and pain of herpes zoster. JAMA 1970;211: 1681-3.
26. Riopelle JM, Naraghi M, Grush KP. Chronic neuralgia incidence following local anesthetic therapy for herpes zoster. Arch Dermatol 1984; 120:747-50.
27. Wood M. Understanding zoster-associated pain. In: How can the burden of zoster-associated pain be reduced? Recommendations from the IHMF Workshop, Washington, D.C., 15 May 1993. Worthing, United Kingdom: PPS Europe, 1993:3-11.
28. Epstein E. Treatment of zoster and postzoster neuralgia by the intralesional injection of triamcinolone: a computer analysis of 199 cases. Int J Dermatol 1976;15:762-9.
29. Balfour HH Jr. Varicella zoster virus infections in immunocompromised hosts: a review of the natural history and management. Am J Med 1988;85:68-73.
30. Clemmensen OJ, Andersen KE. ACTH versus prednisone and placebo in herpes zoster treatment. Clin Exp Dermatol 1984;9:557-63.
31. Cobo LM, Foulks GN, Liesegang T, et al. Oral acyclovir in the treatment of acute herpes zoster ophthalmicus. Ophthalmology 1986;93:763-70.
32. Harding SP, Lipton JR, Wells JCD. Natural history of herpes zoster ophthalmicus: predictors of postherpetic neuralgia and ocular involvement. Br J Ophthalmol 1987;71:353-8.
33. Garland J. Varicella following exposure to herpes zoster. N Engl J Med 1943;228:336-7.
34. Weller TH. Varicella and herpes zoster: a perspective and overview. J Infect Dis 1992;166:Suppl 1:S1-S6.
35. Straus SE, Reinhold W, Smith HA, et al. Endonuclease analysis of viral DNA from varicella and subsequent zoster infections in the same patient. N Engl J Med 1984;311:1362-4.
36. Gershon AA, Steinberg SP. Cellular and humoral immune responses to varicella-zoster virus in immunocompromised patients during and after varicella-zoster infections. Infect Immun 1979;25:170-4.
37. Burke BL, Steele RW, Beard OW, Wood JS, Cain TD, Marmer DJ. Immune responses to varicella-zoster in the aged. Arch Intern Med 1982;142: 291-3.
38. Meier JL, Straus SE. Comparative biology of latent varicella-zoster virus and herpes simplex virus infections. J Infect Dis 1992;166:Suppl 1:S13-S23.
39. Head H, Campbell AW. The pathology of herpes zoster and its bearing on sensory localisation. Brain 1900;23:353-523.
40. Ebert MH. Histologic changes in sensory nerves of the skin in herpes zoster. Arch Dermatol Syphilol 1949;50:641-8.
41. Muller SA, Winkelmann RK. Cutaneous nerve changes in zoster. J Invest Dermatol 1969;52:71-7.
42. Watson CPN, Deck JH, Morshead C, Van der Kooy D, Evans RJ. Post-herpetic neuralgia: further post-mortem studies of cases with and without pain. Pain 1991;44:105-17.
43. Watson CPN, Morshead C, Van der Kooy D, Deck J, Evans RJ. Post-herpetic neuralgia: post-mortem analysis of a case. Pain 1988;34:129-38.
44. Denny-Brown D, Adams RD, Fitzgerald PJ. Pathologic features of herpes zoster: a note on "geniculate herpes." Arch Neurol Psychiatry 1944; 51:216-31.
45. Zacks SI, Langfitt TW, Elliott FA. Herpetic neuritis: a light and electron microscopic study. Neurology 1964;14:744-50.
46. Wall PD. Neuropathic pain and injured nerve: central mechanisms. Br Med Bull 1991;47:631-43.
47. Bennett GJ. Hypotheses on the pathogenesis of herpes zoster-associated pain. Ann Neurol 1994;35:Suppl:S38-S41.
48. Devor M. Central changes mediating neuropathic pain. In: Dubner R, Gebhart GF, Bond MR, eds. Proceedings of the Vth World Congress on Pain. Amsterdam: Elsevier Science, 1988:114-28.
49. Portenoy RK, Duma C, Foley KM. Acute herpetic and postherpetic neuralgia: clinical review and current management. Ann Neurol 1986;20: 651-64.
50. Loeser JD. Herpes zoster and postherpetic neuralgia. Pain 1986;25: 149-64.
51. Max MB, Schafer SC, Culnane M, Dubner R, Graccly RH. Association of pain relief with drug side effects in postherpetic neuralgia: a single-dose study of clonidine, codeine, ibuprofen, and placebo. Clin Pharmacol Ther 1988;43:363-71.
52. Rowbotham MC, Reisner-Keller LA, Fields HL. Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurol-ogy 1991;41:1024-8.
53. Portenoy RK, Foley KM, Inturrisi CE. The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions. Pain 1990;43:273-86.
54. De Benedittis G, Besaria F, Lorenzetti A. A new topical treatment for acute herpetic neuralgia and post-herpetic neuralgia: the aspirin/diethyl ether mixture: an open-label study plus a double-blind controlled clinical trial. Pain 1992;48:383-90. [Erratum, Pain 1992;50:245.]
55. Milligan KA, Atkinson RE, Schofield PA. Lignocaine-prilocaine cream in postherpetic neuralgia. BMJ 1989;298:253.
56. Stow PJ, Glynn CJ, Minor B. EMLA cream in the treatment of post-herpetic neuralgia: efficacy and pharmacokinetic profile. Pain 1989;39: 301-5.
57. Rowbotham MC, Davies PS, Fields HL. Topical lidocaine gel relieves postherpetic neuralgia. Ann Neurol 1995;37:246-53.
58. Watson CPN, Evans RJ, Watt VR, Birkett N. Post-herpetic neuralgia: 208 cases. Pain 1988;35:289-97.
59. Dan K, Higa K, Noda B. Nerve block for herpetic pain. In: Fields HL, Dubner R, Cervero F, eds. Proceedings of the Fourth World Congress on Pain, Seattle. Vol. 9 of Advances in pain research and therapy. New York: Raven Press, 1985:831-8.
60. Colding A. The effect of regional sympathetic blocks in the treatment of herpes zoster: a survey of 300 cases. Acta Anaesth Scand 1969;13:133-41.
61. Fine PG. Nerve blocks, herpes zoster, and postherpetic neuralgia. In: Watson CPN, ed. Herpes zoster and postherpetic neuralgia. Vol. 8 of Pain research and clinical management. Amsterdam: Elsevier Science, 1993:173-83.
62. Jessell TM, Iversen LL, Cuello AC. Capsaicin-induced depletion of substance P from primary sensory neurones. Brain Res 1978;152:183-8.
63. Watson CP, Evans RJ, Watt VR. Post-herpetic neuralgia and topical capsaicin. Pain 1988;33:333-40.
64. Bernstein JE, Bickers DR, Dahl MV, Roshal JY. Treatment of chronic postherpetic neuralgia with topical capsaicin: a preliminary study. J Am Acad Dermatol 1987;17:93-6.
65. Watson CPN, Tyler KL, Bickers DR, Millikan LE, Smith S, Coleman E. A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther 1993;15:510-26.
66. Fields HL, Martin JB. Pain: psthophysiology and management. In: Isselbacher KJ, Braunwald E, Martin JB, et al., eds. Harrison's principles of internal medicine. 13th ed. New York: McGraw-Hill, 1994:49-55.
67. Dubner R, Bennett GJ. Spinal and trigeminal mechanism of nociception. Annu Rev Neurosci 1983;6:381-418.
68. Watson CP, Evans RJ, Reed K, Merskey H, Goldsmith L, Warsh J. Amitriptyline versus placebo in postherpetic neuralgia. Neurology 1982;32: 671-3.
69. Watson CPN, Evans RJ. A comparative trial of amitriptyline and zimel idine in post-herpetic neuralgia. Pain 1985;23:387-94.
70. Max MB, Schafer SC, Culnane M, Smoller B, Dubner R, Gracely RH. Amitriptyline, but not lorazepam, relieves postherpetic neuralgia. Neurology 1988;38:1427-32.
71. Watson CPN, Chipman M, Reed K, Evans RJ, Birkett N. Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial. Pain 1992;48:29-36.
72. Kishore-Kumar R, Max MB, Schafer SC, et al. Desipramine relieves postherpetic neuralgia. Clin Pharmacol Ther 1990;47:305-12.
73. Kishore-Kumar R, Schafer SC, Lawlor BA, Murphy DL, Max MB. Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain. Pain 1989;37:223-7.
74. Nathan PW. Chlorprothixene (Taractan) in post-herpetic neuralgia and other severe chronic pains. Pain 1978;5:367-71.
75. Killian JM, Fromm GH. Carbamazepine in the treatment of neuralgia: use of side effect. Arch Neurol 1968;19:129-36.
76. Gerson GR, Jones RB, Luscombe DK Studies on the concomitant use of carbamazepine and clomipramine for the relief of post-herpetic neuralgia. Postgrad Med J 1977;53:Suppl 4:104-9.
77. Taub A. Relief of postherpetic neuralgia with psychotropic drugs. J Neurosurg 1973;39:235-9.
78. Taub A, Collins WF Jr. Observations of the treatment of denervation dysesthesia with psychotropic drugs: postherpetic neuralgia, anesthesia dolorosa, peripheral neuropathy. In: Bonica JJ, ed. International symposium on pain. Vol. 4 of Advances in neurology. New York: Raven Press, 1974:309-15.
79. Merskey H, Hester RA. The treatment of chronic pain with psychotropic drugs. Postgrad Med J 1972;48:594-8.
80. Swerdlow M. Anticonvulsant drugs and chronic pain. Clin Neuropharmacol 1984;7:51-82.
81. Idem. The treatment of 'shooting' pain. Postgrad Med J 1980;56:159-61.
82. Hatangdi VS, Boas RA, Richards EG. Postherpetic neuralgia: management with antiepileptic and tricyclic drugs. In: Borica JJ, Albe-Fessard DG, eds. Proceedings of the First World Congress on Pain. Vol. 1 of Advances in pain research and therapy. New York: Raven Press, 1976:583-7
83. Mazars GJ, Merienne L, Cioloca C. Comparative study of electrical stimulation of posterior thalamic nuclei, periaqueductal gray, and other midline mesencephalic structures in man. In: Bonica JJ, Liebeskind JC, Albe-Fessard DG, eds. Proceedings of the Second World Congress on Pain. Vol. 3 of Advances in pain research and therapy. New York: Raven Press, 1979:541-6.
84. Pain of spinal origin. In: White JC, Sweet WH. Pain and the neurosurgeon: a forty-year experience. Springfield, III.: Charles C Thomas, 1969: 435-79.
85. North RB, Levy RM. Consensus conference on the neurosurgical management of pain. Neurosurgery 1994;34:756-61.
86. Nathan PW, Wall PD. Treatment of post-herpetic neuralgia by prolonged electric stimulation. BMJ 1974;3:645-7
87. Tavemer D. Alleviation of post-herpetic neuralgia. Lancet 1960;2: 671-3.
88. Lewith GT, Field J, Machin D. Acupuncture compared with placebo in post-herpetic pain. Pain 1983;17:361-8.
89. Crue BL Jr. Neuritis, neuropathy, and neuralgia. In: Tollison CD, ed. Handbook of pain management. 2nd ed. Baltimore: Williams & Wilkins, 1994:377-85.
90. Keczkes K, Basheer AM. Do corticosteroids prevent post-herpetic neuralgia? Br J Dermatol 1980;102:551-5.
91. Esmann V, Geil JP, Kroon S, et al. Prednisolone does not prevent post-herpetic neuralgia. Lancet 1987;2:126-9.
92. Whitley RJ, Weiss H, Gnann J, et al. The efficacy of steroid and acyclovir therapy of herpes zoster in the elderly. J Invest Med 1995;43:Suppl 2:252A. abstract.
93. Bonica JJ, Buckley FP. Regional anesthesia with local anesthetics. In: Bonica JJ, ed. The management of pain. 2nd ed. Vol. 2. Philadelphia: Lea & Febiger, 1990:1883-966.
94. Winnie AP, Hartwell PW. Relationship between time of treatment of acute herpes zoster with sympathetic blockade and prevention of post-herpetic neuralgia: clinical support for a new theory of the mechanism by which sympathetic blockade provides therapeutic benefit. Reg Anesth 1993;18:277-82.
95. Tenicela R, Lovasik D, Eaglstein W. Treatment of herpes zoster with sympathetic blocks. Clin J Pain 1985;1;63-7.
96. Nurmikko T, Wells C, Bowsher D. Pain and allodynia in postherpetic neuralgia: role of somatic and sympathetic nervous systems. Acta Neurol Scand 1991;84:146-52.
97. McKendrick MW, McGill JI, White JE, Wood MJ. Oral acyclovir in acute herpes zoster. BMJ 1986;293:1529-32.
98. Huff JC. Oral acyclovir therapy of acute herpes zoster: a multicenter study. Res Clin Forums 1987;9:37-45.
99. McKendrick MW, McGill JI, Wood MJ. Lack of effect of acyclovir on postherpetic neuralgia. BMJ 1989;298:431.
100. Morton P, Thomson AN. Oral acyclovir in the treatment of herpes zoster in general practice. N Z Med J 1989;102:93-5.
101. Harding SP, Porter SM. Oral acyclovir in herpes zoster ophthalmicus. Curr Eye Res 1991;10:Suppl:177-82.
102. Wood MJ, Johnson RW, McKendrick MW, Taylor J, Mandai BK, Crooks J. A randomized trial of acyclovir for 7 days or 21 days with and without prednisolone for treatment of acute herpes zoster. N Engl J Med 1994;330:896-900.
103. Tyring S, Barbarash RA, Nahlik JE, et al. Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia: a randomized, double-blind placebo-controlled trial. Ann Intern Med 1995;123:89-96.
104. deGreef H. Famciclovir, a new oral antiherpes drug: results of the first controlled clinical study demonstrating its efficacy and safety in the treatment of uncomplicated herpes zoster in immunocompetent patients. Int J Antimicrob Agents 1995;4:241-6.
105. Beutner KR, Friedman DJ, Forszpaniak C, Andersen PL, Wood MJ. Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrob Agents Chemother 1995;39: 1546-53.
106. Crooks RJ, Jones DA, Fiddian AP. Zoster-associated chronic pain: an overview of clinical trials with acyclovir. Scand J Infect Dis Suppl 1991;80: 62-8.
107. Merselis JG Jr, Kaye D, Hook EW. Disseminated herpes zoster: a report of 17 cases. Arch Intern Med 1964;113:679-86.
108. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993;52:259-85.
109. Levin MJ, Murray M, Rotbart HA, Zerbe GO, White CJ, Hayward AR. Immune response of elderly individuals to a live attenuated varicella vaccine. J Infect Dis 1992;166:253-9.
110. Hayward A, Villanueba E, Cosyns M, Levin M. Varicella-zoster virus (VZV)-specific cytotoxicity after immunization of nonimmune adults with Oka strain attenuated VZV vaccine. J Infect Dis 1992;166:260-4.