Neurochemical actions of gabapentin in mouse brain

Epilepsy Research

Volumn 27, Issue 3, 1997, Pages 175-180

  Leach, John Paul ^a   Sills, Graeme J ^a   Butler, Elaine ^a   Forrest, Gerard ^a   Thompson, George G ^a   Brodie, Martin J ^a  

^a WESTERN INFIRMARY   (United Kingdom)

Author keywords

Chronic treatment antiepileptic drugs; Epilepsy; GABA; GABA T; Gabapentin; GAD; Glutamate; Glutamine

Indexed keywords

4 AMINOBUTYRIC ACID; GABAPENTIN; GLUTAMATE DECARBOXYLASE; GLUTAMIC ACID; GLUTAMINE;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN PROTECTION; CONCENTRATION RESPONSE; DOSE RESPONSE; ENZYME ANALYSIS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL;

ACETIC ACIDS; AMINES; ANIMALS; ANTICONVULSANTS; BRAIN; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; MALE; MICE; MICE, INBRED ICR;

EID: 0030789542     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(97)01034-6     Document Type: Article

References (22)

1. Anhut, H., Ashman, P., Feuerstein, T.J., et al., Gabapentin (Neurontin) as add-on therapy in patients with partial seizures: a double-blind, placebo-controlled study, Epilepsia, 35 (1994) 795-801.
2. Bartoszyk, G.D. and Hamer, M., The genetic animal model of reflex epilepsy in the Mongolian gerbil: differential efficacy of new anticonvulsive drugs and prototypic antiepileptics, Pharmacol. Res. Commun., 19 (1987) 429-440.
3. Bartoszyk, G.D., Meyerson, N., Reimann, W., Satzinger, G. and von Hodenberg, A., Gabapentin. In: B.S. Meldrum and R.J. Porter (Eds.), Current Problems in Epilepsy 4: New Anticonvulsant Drugs, John Libbey, London, 1986, pp. 147-163.
4. Dichter, M.A. and Brodie, M.J., New antiepileptic drugs, New Engl. J. Med., 334 (1996) 1583-1590.
5. Foot, M. and Wallace, J., Gabapentin. In: F. Pisani, E. Perucca, G. Avanzini and A. Richens (Eds.), New Antiepileptic Drugs. Epilepsy Res., Suppl. 3, Elsevier, Amsterdam, 1991, pp. 109-114.
6. 2δ subunit of a calcium channel, J. Biol. Chem., 271 (1996) 5768-5776.
7. Goa, K.L. and Sorkin, E.M., Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy, Drugs, 46 (1993) 409-427.
8. Goldlust, A., Su, T-Z., Welty, D.F., Taylor, C.P. and Oxender, D.L., Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways glutamate and GABA, Epilepsy Res., 22 (1995) 1-11.
9. Halonen, T., Pitkänen, A., Saano, V. and Riekkinen, P.J., Effects of vigabatrin (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats, Epilepsia, 32 (1991) 242-249.
10. Honmou, O., Kocsis, J.D. and Richerson, G.B., Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro, Epilepsy Res., 20 (1995) 193-202.
11. Löscher, W., Hönack, D. and Taylor, C.P., Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain, Neurosci. Lett., 128 (1991) 150-154.
12. McLean, M.J., Gabapentin, Epilepsia, 36 (1995) S73-S86.
13. Petroff, O.A.C., Rothman, D.L., Behar, K.L., Lamoreux, D. and Mattson, R.H., The effect of gabapentin on brain GABA in patients with epilepsy, Ann. Neurol., 39 (1996) 95-99.
14. Rock, D.M., Kelly, K.M. and Macdonald, R.L., Gabapentin actions on ligand and voltagegated responses in cultures rodent neurons, Epilepsy Res., 16 (1993) 89-98.
15. Rogawski, M. and Porter, R., Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds, Pharmacol. Rev., 42 (1990) 223-286.
16. Sills, G.J., Leach, J.P., Fraser, C.M., Forrest, G., Patsalos, P.N. and Brodie, M.J., Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain, Eur. J. Pharmacol., in press.
17. Stewart, B.H., Kugler, A.R., Thompson, P.R. and Bockbrader, H.N., A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma, Pharmacol. Res., 10 (1993) 276-281.
18. Taylor, C.P., Gabapentin - Mechanisms of Action. In: R.H. Levy, R.H. Mattson and B.S. Meldrum (Eds.), Antiepileptic Drugs, Raven Press, New York, 1995, pp. 829-841.
19. Taylor, C.P., Vartanian, M.G., Andruszkiewicz, R. and Silverman, R.B., 3-Alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents, Epilepsy Res., 11 (1992) 103-110.
20. UK Gabapentin Study Group, Gabapentin in partial epilepsy, Lancet, 335 (1990) 1114-1117.
21. US Gabapentin Study Group No. 5, Gabapentin as add-on therapy in refractory partial epilepsy: a double-blind, placebo-controlled, parallel group study, Neurology, 43 (1993) 2292-2298.
22. Wamil, A.W. and McLean, M.J., Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture, Epilepsy Res., 17 (1994) 1-11.