Blockade of spinal N- and P-type, but not L-type, calcium channels inhibits the excitability of rat dorsal horn neurones produced by subcutaneous formalin inflammation

Pain

Volumn 69, Issue 1-2, 1997, Pages 93-100

  Diaz, Alvaro ^a   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Central hyperexcitability; Formalin; Inflammatory pain; Rat; Spinal cord; Voltage sensitive calcium channels

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; OMEGA AGATOXIN; OMEGA CONOTOXIN; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; INFLAMMATION; INTRATHECAL DRUG ADMINISTRATION; NERVE CELL EXCITABILITY; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN;

ANIMALS; CALCIUM CHANNEL BLOCKERS; ELECTROPHYSIOLOGY; FORMALDEHYDE; INJECTIONS, SPINAL; INJECTIONS, SUBCUTANEOUS; ION CHANNEL GATING; NEURONS; OMEGA-AGATOXIN IVA; RATS; RATS, SPRAGUE-DAWLEY; SPIDER VENOMS; SPINAL CORD; SYNAPTIC TRANSMISSION; VERAPAMIL;

EID: 0031043244     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(96)03271-X     Document Type: Article

References (44)

1. Ahlijanian, M.K., Westenbroek, R.E. and Caterall, W.A., Subunit structure and localization of sensitive calcium channels in mammalian brain, spinal cord, and retina, Neuron, 4 (1990) 819-832.
2. Alagarsamy, S. and Johnson, M., Voltage-dependent calcium channel involvement in NMDA-induced activation of NOS, NeuroReport, 6 (1995) 2250-2254.
3. Anwyl, R., Modulation of vertebrate neuronal calcium channels by transmitters, Brain Res. Rev., 16 (1991) 265-281.
4. Bertolino, M. and Llinás, R.R., The central role of voltage-activated and receptor-operated calcium channels in neuronal cells, Ann. Rev. Pharmacol. Toxicol., 32 (1992) 399-421.
5. Bustamante, D., Miranda, H.F., Pelissier, T. and Paeile, C., Analgesic action of clonixin, nifedipine and morphine using the formalin test, Gen. Pharmacol., 20 (1989) 319-322.
6. Chaplan, S.R., Poorel, J.W. and Yaksh, T.L., Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia, J. Pharmacol. Exp. Ther., 269 (1994) 1117-1123.
7. Chapman, D.B. and Way, E.L., Modification of endorphin/enkephalin analgesia and stress induced analgesia by divalent cations, a cation chelator and an ionophore, Br. J. Pharmacol., 75 (1982) 89-96.
8. Coderre, T.J. and Melzack, R., The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury, J. Neurosci., 12 (1992) 3671-3675.
9. Coderre, T.J., Katz, Z., Vaccarino, A.L. and Melzack, R., Contribution of central neuroplasticity to pathological pain review of clinical and experimental evidence, Pain, 52 (1993) 259-285.
10. Contreras, E., Tamayo, L. and Amigo, M., Calcium channel antagonists increase morphine induced analgesia and antagonize morphine tolerance, Eur. J. Pharmacol., 148 (1988) 463-466.
11. Del Pozo, E., Caro, G. and Baeyens, J.M., Analgesic effects of several calcium channel blockers in mice, Eur. J. Pharmacol., 137 (1987) 155-160.
12. Dickenson, A.H. and Sullivan, A.F., Peripheral origins and central modulation of subcutaneous formalin-induced activity of dorsal horn neurones, Neurosci. Lett., 8 (1987a) 201-211.
13. Dickenson, A.H. and Sullivan, A.F., Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin, Pain, 30 (1987b) 349-360.
14. Dickie, B.G.M. and Davies, J.A., Calcium channel blocking agents and potassium-stimulated release of glutamate from cerebellar slices, Eur. J. Pharmacol., 229 (1992) 97-99.
15. Evans, A.R., Nicol, G.D. and Vasko, M.R., Differential regulation of evoked peptide release by voltage-sensitive calcium channels in rat sensory neurons, Brain Res., 712 (1996) 265-273.
16. 3H]-nitrendipine binding sites in rat spinal cord, J. Pharmacol. Exp. Ther., 247 (1988) 473-480.
17. Gohil, K., Bell, J.R., Ramachandran, J. and Miljanich, G.P., Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium channel antagonist, SNX-230 (ω-conopeptide MVIIC), Brain Res., 653 (1994) 258-266.
18. Gruner, W. and Silva, L.R., ω-Conotoxin sensitivity and presynaptic inhibition of glutamatergic sensory neurotransmission in vitro, J. Neurosci., 14 (1994) 2800-2808.
19. Gürdal, H., Sara, Y. and Tuluny, F.C., Effects of calcium channel blockers on formalin-induced nociception and inflammation in rats, Pharmacology, 44 (1992) 290-296.
20. Haley, J.E., Sullivan, A.F. and Dickenson, A.H., Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat, Brain Res., 518 (1990) 218-226.
21. Haley, J.E., Dickenson, A.H. and Schachter, M., Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception, Neuropharmacology, 31 (1992) 251-258.
22. Holz IV, G.G., Dunlap, K. and Kream, R.M., Characterization of the electrically evoked release of substance P from dorsal root ganglion neurons: methods and dihydropyridine sensitivity, J. Neurosci., 8 (1988) 468-471.
23. Hunter, J.C. and Singh, L., Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat, Neurosci. Lett., 174 (1994) 217-221.
24. 125I]ω-Conotoxin in rat brain, Eur. J. Pharmacol., 146 (1988) 181-183.
25. Maggi, C.A., Giuliani, S., Santicioli, P., Tramontana, M. and Meli, A., Effect of omega conotoxin on reflex responses mediated by activation of capsaicin-sensitive nerves of the rat urinary bladder and peptide release from the rat spinal cord, Neuroscience, 34 (1990) 243-250.
26. Malmberg, A.B. and Yaksh, T.L., Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception, J. Neurosci., 14 (1994) 4882-4890.
27. Malmberg, A., B and Yaksh, T.L., Effect of continuous intrathecal infusion of w-conopeptides, N-type calcium channels blockers, on behaviour and antinociception in the formalin and hot-plate tests in rats, Pain, 60 (1995) 83-90.
28. McCleskey, A., Fox, A.P., Cruz, L.J., Olivera, B.M., Tsien, R.W. and Yoshikami, D., ω-Conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not in muscle, Proc. Natl. Acad. Sci. USA, 84 (1987) 4327-4331.
29. Meller, S.T. and Gebhart, G.F., Nitric oxide (NO) and nociceptive processing in the spinal cord, Pain, 52 (1993) 127-136.
30. Miljanich, G.P. and Ramachandran, J., Antagonists of neuronal calcium channels: structure, function, and therapeutic implications, Ann. Rev. Pharmacol. Toxicol., 35 (1995) 707-734.
31. Millan, M.J. and Seguin, L., Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice, Neurosci. Lett., 178 (1994) 139-143.
32. Mintz, I.M., Adams, M.E. and Bean, B.P., P-type calcium channels in rat central and peripheral neurons, Neuron, 9 (1992) 85-95.
33. 2+ channels blockers, Eur. J. Pharmacol., 217 (1992) 137-141.
34. Murphy, T.H., Worley, P.F. and Baraban, J.M., L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes, Neuron, 7 (1991) 625-635.
35. Olivera, B.M., Milianich, G.P., Ramachandran, J. and Adams, M.E., Calcium channel diversity and neurotransmitter release: the ω-Conotoxins and ω-Agatoxins, Annu. Rev. Biochem., 63 (1994) 823-867.
36. Perney, T.M., Hirning, L.D., Leeman, S.E. and Miller, R.J., Multiple calcium channels mediate neurotransmitter release from peripheral neurons, Proc. Natl. Acad. Sci. USA, 83 (1986) 6656-6659.
37. 2+ channel coupled to glutamate exocytosis, Eur. J. Pharmacol., 226 (1992) 343-350.
38. Porro, C.A. and Cavazzuti, M., Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model, Prog. Neurobiol., 41 (1993) 565-607.
39. Ryu, P.D. and Randic, M., Low- and high-voltage activated calcium currents in rat spinal dorsal horn neurons, J. Neurophysiol., 63 (1990) 273-285.
40. Santicioli, P., Del Bianco, E., Tramontana, M., Geppetti, P. and Maggi, C.A., Release of calcitonin gene-related peptide like immunoreactivity induced by electrical field stimulation from rat spinal afferents is mediated by conotoxin-sensitive calcium channels, Neurosci. Lett., 136 (1992) 161-164.
41. Sorkin, L.S., NMDA evokes an L-NAME sensitive spinal release of glutamate and citrulline, NeuroReport, 4 (1993) 479-482.
42. Spedding, M. and Paoletti, R., Classification of calcium channels and the sites of action of drugs modifying channel function, Pharmacol. Rev., 44 (1992) 363-376.
43. Vaccarino, A.L., Marek, P., Kest, B., Weber, E., Keana, J.F. and Liebeskind, J.C., NMDA receptor antagonists, MK-801 and ACEA- 1011, prevent the development of tonic pain following subcutaneous formalin, Brain Res., 615 (1993) 331-334.
44. Yamamoto, T. and Yaksh, T.L., Comparison of the antinociceptive effects of pre- and post-treatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat, Anesthesiology, 77 (1992) 757-763.