Synergistic effect between intrathecal non-NMDA antagonist and gabapentin on allodynia induced by spinal nerve ligation in rats

Anesthesiology

Volumn 92, Issue 2, 2000, Pages 500-506

  Chen, Shao Rui ^b   Eisenach, James C ^b   McCaslin, Patrick P ^b   Pan, Hui Lin ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

AMPA; Glutamate; Kainate; Neuropathic pain; NMDA receptors; Spinal cord

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GABAPENTIN; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; MALE; NERVE CELL PLASTICITY; NERVE LIGATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL NERVE; WITHDRAWAL REFLEX;

EID: 0033964361     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200002000-00033     Document Type: Article

References (35)

1. MacFarlane BV, Wright A, O'Callaghan J, Benson HA: Chronic neuropathic pain and its control by drugs. Pharmacol Ther 1997; 75:1-19
2. Arner S, Meyerson BA: Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 1988; 33:11-23
3. Leem JW, Choi EJ, Park ES, Paik KS: N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptor antagonists differentially suppress dorsal horn neuron responses to mechanical stimuli in rats with peripheral nerve injury. Neurosci Lett 1996; 211:37-40
4. Tolle TR, Berthele A, Schadrack J, Zieglgansberger W: Involvement of glutamatergic neurotransmission and protein kinase C in spinal plasticity and the development of chronic pain Prog Brain Res 1996; 110:193-206
5. Dougherty PM, Palecek J, Paleckova V, Sorkin LS, Willis WD: The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli. J Neurosci 1992; 12:3025-41
6. Dougherty PM, Willis WD: Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of N-methyl-D-aspartic acid and substance P. Pain 1991; 47:85-93
7. Ren K, Williams GM, Hylden JL, Ruda MA, Dubner R: The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats. Eur J Pharmacol 1992; 219:235-43
8. Max MB, Byas-Smith MG, Gracely RH, Bennett GJ: Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: A double-blind comparison to alfentanil and placebo. Clin Neuropharmacol 1995; 18:360-8
9. McQuay HJ, Carroll D, Jadad AR, Glynn CJ, Jack T, Moore RA, Wiffeh PJ: Dextromethorphan for the treatment of neuropathic pain: A double-blind randomised controlled crossover trial with integral n-of-1 design. Pain 1994; 59:127-33
10. Chaplan SR, Malmberg AB, Yaksh TL: Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J Pharmacol Exp Ther 1997; 280:829-38
11. Wei HB, Jakeman LB, Hunter JC, Bonhaus DW: Pharmacological characterization of N-methyl-D-aspartate receptors in spinal cord of rats with a chronic peripheral mononeuropathy. Neuropharmacology 1997; 36:1561-9
12. Mao J, Price DD, Haves RL, Lu J, Mayer DJ: Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Res 1992; 598:271-8
13. Mellick GA, Mellicy LB, Mellick LB: Gabapentin in the management of reflex sympathetic dystrophy. J Pain Symptom Manage 1995; 10:265-6
14. Rosenberg JM, Harrell C, Ristic H, Werner RA, de Rosayro AM: The effect of gabapentin on neuropathic pain. Clin J Pain 1997; 13:251-5
15. Rock DM, Kelly KM, Macdonald RL: Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons. Epilepsy Res 1993; 16:89-98
16. Taylor CP, Gee NS, Su TZ, Kocsis JD, Welty DF, Brown JP, Dooley DJ, Boden P, Singh L: A summary of mechanistic hypotheses of gahapentin pharmacology Epilepsy Res 1998; 29:233-49
17. Hwang JH, Yaksh TL: Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat. Reg Anesth 1997; 22:249-56
18. Chapman V, Suzuki R, Chamarette HL, Rygh LJ, Dickenson AH: Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats. Pain 1998; 75:261-72
19. Kim SH, Chung JM: An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1993; 50:355-63
20. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL: Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53:55-63
21. Yaksh TL, Rudy TA: Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976; 7:1032-6
22. Pan H-L, Chen SR, Eisenach JC: Role of spinal nitric oxide in antiallodynic effect of intrathecal clonidine in neuropathic rats. ANESTHESIOLOGY 1998; 89:1518-23
23. Tallarida RJ, Porreca F, Cowan A: Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sci 1989; 45:947-61
24. Harris JA, Corsi M, Quartaroli M, Arban R, Bentivoglio M: Up-regulation of spinal glutamate receptors in chronic pain. Neuroscience 1996; 74:7-12
25. Neugebauer V, Lucke T, Schaible HG: N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint. J Neurophysiol 1993; 70:1365-77
26. Furuyama T, Kiyama H, Sato K, Park HT, Maeno H, Takagi H, Tohyama M: Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception. Brain Res Mol Brain Res 1993; 18:141-51
27. Popratiloff A, Kharazia VN, Weinberg RJ, Laonipon B, Rustioni A: Glutamate receptors in spinal motoneurons after sciatic nerve transection. Neuroscience 1996; 74:953-8
28. Coderre TJ, Van Empel I: The utility of excitatory amino acid (EAA) antagonists as analgesic agents: I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests. Pain 1994; 59:345-52
29. Sang CN, Hostetter MP, Gracely RH, Chappell AS, Schoepp DD, Lee G, Whitcup S, Caruso R, Max MB: AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans. ANESTHESIOLOGY 1998; 89:1060-7
30. Loscher W, Honack D, Taylor CP: Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. Neurosci Lett 1991; 128:150-4
31. Goldlust A, Su TZ, Welty DF, Taylor CP, Oxender DL: Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA. Epilepsy Res 1995; 22:1-11
32. 3H]leucine. Anal Biochem 1998; 255:236-43
33. Chaplan SR, Pogrel JW, Yaksh TL: Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. J Pharmacol Exp Ther 1994; 269:1117-23
34. Hunter JC, Singh L: Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat. Neurosci Lett 1994; 174:217-21
35. Simmons RM, Li DL, Hoo KH, Deverill M, Ornstein PL, Iyengar S: Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat. Neuropharmacology 1998; 37:25-36