Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats

Pain

Volumn 75, Issue 2-3, 1998, Pages 261-272

  Chapman, Victoria ^a   Suzuki, Rie ^a   Chamarette, Holly L C ^a   Rygh, Lars J ^a   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Carbamazepine; Electrophysiological study; Gabapentin; Inhibitory effects; Neuronal responses

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; GABAPENTIN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; EVOKED RESPONSE; MALE; NERVE CELL PLASTICITY; NERVE CONDUCTION; NERVE INJURY; NERVE LIGATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SOMATOSENSORY SYSTEM; SPINAL NERVE; SUBCUTANEOUS DRUG ADMINISTRATION;

ACETIC ACIDS; AMINES; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CARBAMAZEPINE; CYCLOHEXANECARBOXYLIC ACIDS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; EVOKED POTENTIALS; GAMMA-AMINOBUTYRIC ACID; HUMANS; LIGATION; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVES;

EID: 0031921954     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(98)00004-9     Document Type: Article

References (45)

1. Benson, R.F., Parris, W.C.V., Cooper, J., Galiwango, C., Pervez, K. and Johnson, B., Efficacy of gabapentin for neuropathic pain. In: Abstracts, 8th World Congress on Pain, IASP Press, Seattle, WA, 1996, p. 373.
2. Berde, C.B., New and old anticonvulsants for management of pain, IASP Newsletter, IASP Press, Seattle, WA, 1997.
3. Bowersox S.S., Gadbois T., Singh T., Pettus M., Wang Y-X, Luther R.R. Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal anti-nociception in rat models of acute, persistent and neuropathic pain. J. Pharmacol. Exp. Ther. 279:1996;1243-1249.
4. Burchiel K.J. Carbamazepine inhibits spontaneous activity in experimental neuromas. Exp. Neurol. 102:1988;249-253.
5. Chabal C., Russell L.C., Burchiel K.J. The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas. Pain. 38:1989;333-338.
6. Chapman, V., Suzuki, R. and Dickenson, A.H., Electrophysiological characterization of spinal neuronal response properties in anaesthetised rats after ligation of spinal nerves L5-L6, J. Physiol., (1998) in press.
7. Chaplan S.R., Malmberg A.B., Yaksh T.L. Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked alloynia in the rat. J. Pharmacol. Exp. Ther. 280:1997;829-838.
8. Chapman, V., Suzuki, R. and Dickenson, A.H., Carbamazepine and gabapentin modulate abberant spinal neuronal responses after chung neuropathy, American Society of Neuroscience, New Orleans, MS, 1997.
9. Chapman V., Dickenson A.H. Inflammation reveals inhibition of noxious responses of rat spinal neurones by carbamezapine. NeuroReport. 8:1997;1399-1404.
10. Dickenson, A.H., Where and how do opioids act? In: G.F. Gebhart, D.L. Hammond and T.S. Jensen (Eds.), Progress in Pain Research and Management, Vol. 2, Proceedings of the 7th World Congress on Pain, IASP Press, Seattle, WA, 1994, pp. 525-552.
11. Dickenson A.H., Sullivan A.F. Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat. Brain Res. 506:1990;31-39.
12. DiPiero V., Jones A.K.P., Iannotti F., Powell M., Perani D., Lenzi G.L., Frackowiak R.S.J. Chronic pain: a PET study of the central effects of percutaneous high cervical cordotomy. Pain. 46:1991;9-12.
13. Fields, H.L. and Rowbotham, M.C., Multiple mechanisms of neuropathic pain: A clinical perspective. In: G.F. Gebhart, D.L. Hammond and T.S. Jensen (Eds.), Progress in Pain Research and Management, Vol. 2, Proc. VIIth World Congress on Pain, IASP Press, Seattle, WA, 1994, pp. 437-454.
14. Fields, H.L., Rowbotham, M.C. and Devor, M., Excitability blockers: anti-convulsants and low concentration local anesthetics in the treatment of chronic pain. In: A.H. Dickenson and J.M. Besson (Eds.), The Pharmacology of Pain, Vol. 130, Handbook of Experimental Pharmacology, Springer, Heidelberger, 1997, pp. 93-111.
15. + current in nociceptors. Proc. Natl. Acad. Sci. USA. 93:1996;1108-1112.
16. Gracely R.H., Lynch S.A., Bennett G.J. Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain. 51:1992;175-195.
17. Hunter J.C., Gogas K.R., Hedley L.R., Jacobson L.O., Kassotakis L., Thompson J., Fontana D.J. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. Eur. J. Pharmacol. 324:1997;153-160.
18. Iadarola M.J., Max M.B., Berman K.F., Byas-Smith M.G., Coghill R.C., Gracely R.H., Bennett G.J. Unilateral decrease in thalamic activity observed with positron emission tomography in patients with chronic neuropathic pain. Pain. 68:1995;55-64.
19. Jensen, T.S., Mechanisms of neuropathic pain. In: J.N. Campbell (Ed.), Pain 1996 - An Updated Review Refresher Course Syllabus, International Association for the Study of Pain, IASP Press, Seattle, WA, 1996, pp. 77-88.
20. Jett M-F., McCuirk J., Waligora D., Hunter J.C. The effects of mexiletine, desipramine and fluoxetine in rat models inolving central sensitization. Pain. 69:1997;161-169.
21. Kajander K.C., Wakisaka S., Bennett G.J. Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat. Neurosci. Lett. 138:1992;225-228.
22. Kajander K.C., Bennett G.J. Onset of a painful peripheral neuropathy in rat: A partial and differential deafferentation and spontaneous discharge in Aβ and Aδ primary afferent neurons. J. Neurophysiol. 68:1992;734-744.
23. Kim S.H., Chung J.M. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 50:1992;355-363.
24. Kim K.J., Yoon Y.W., Chung J.M. Comparison of three rodent neuropathic pain models. Exp. Brain Res. 113:1997;200-206.
25. Laird J.M.A., Bennett G.J. An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy. J. Neurophysiol. 69:1993;1-14.
26. Lee Y-W., Yaksh T.L. Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. J. Pharmacol. Exp. Ther. 277:1996;1642-1648.
27. Lekan H.A., Carlton S.M., Coggeshall R.E. Sprouting of Aβ fibers into lamina II of the rat dorsal horn in peripheral neuropathy. Neurosci. Lett. 208:1996;147-150.
28. McQuay H., Carroll D., Jasdad A.R., Wiffen P., Moore A. Anticonvulsant drugs for management of pain: a systematic review. Br. Med. J. 311:1995;1047-1052.
29. McQuay H.J., Tramer M., Nye B.A., Carroll D., Wiffen P.J., Moore R.A. A systematic review of antidepressants in neuropathic pain. Pain. 68:1996;217-227.
30. Mendell L.M. Physiological properties of unmyelinated fiber projection to the spinal cord. Exp. Neurol. 16:1966;316-332.
31. Na H.S., Leem J.W., Chung J.M. Abnormalities of mechanoreceptors in a rat model of neuropathic pain: possible involvement in mediating mechanical allodynia. J. Neurophysiol. 70:1993;522-528.
32. Palecek J., Dougherty P.M., Kim S.H., Paleckova V., Lekan H., Chung J.M., Carlton S.M., Willis W.D. Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy in primates. J. Neurophysiol. 67:1992;1562-1573.
33. Rosner H., Rubin L., Kestenbaum A. Gabapentin adjunctive therapy in neuropathic pain states. Clin. J. Pain. 12:1996;56-58.
34. Shimoyama N., Shimoyama M., Davis A.M., Inturrisi C.E., Elliott K.J. Spinal gabapentin is antinociceptive in the rat formalin test. Neurosci. Lett. 222:1997;65-67.
35. Singh L., Field M.J., Ferris P., Hunter J.C., Oles R.J., Williams R.G., Woodruff G.N. The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology. 127:1996;1-9.
36. Stanfa L.C., Singh L., Williams R.G., Dickenson A.H. Gabapentin, ineffective in normal rats, markedly reduces C-fiber evoked responses after inflammation. NeuroReport. 8:1997;587-590.
37. Tal M., Eliav E. Abnormal discharge originates at the site of nerve injury in experimental constriction neuropathy (CCI) in the rat. Pain. 64:1996;511-518.
38. Tanelian D.L., Brose W.G. Neuropathic pain can be relieved by drugs that are use-dependent sodium channel blockers: lidocaine, carbamazepine, and mexiletine. Anesthesiology. 74:1991;949-951.
39. Wall P.D., Devor M. Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats. Pain. 17:1983;321-339.
40. Wegert S., Ossipov M.H., Nichols M.L., Bian D., Vanderah T.W., Malan T.P. Jr., Porreca F. Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechancal stimuli in normal or nerve-injured rats. Pain. 71:1997;57-64.
41. Woolf C.J., Wiesenfeld-Hallin Z. The systemic administration of local anaesthetics produces a selective depression of C-afferent fibre evoked activity in the spinal cord. Pain. 23:1985;361-374.
42. Xiao, W.-H. and Bennett, G.J., Gabapentin relieves abnormal pains in a rat model of painful peripheral neuropathy. In: Pain Modulation: Anatomy and Physiology Neuropathic Pain, Vol. 21, Society for Neuroscience, San Diego, CA, 1995.
43. Yoon Y.W., Heung S.N., Chung J.M. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Pain. 64:1996;27-36.
44. Zeltser, R. and Seltzer, Z., A practical guide for the use of animal models in the study of neuropathic pain. In: J. Bovie, P. Hansson and U. Lindblom (Eds.), Progress in Pain Research and Management, Vol. 3, Touch, Temperature and Pain in Health and Disease Mechanisms and Assessments, IASP Press, Seattle, WA, 1994, 295-298.
45. Zimmerman M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.