Effects of gabapentin on the different components of peripheral and central neuropathic pain syndromes: A pilot study

European Neurology

Volumn 40, Issue 4, 1998, Pages 191-200

  Attal, Nadine ^a   Brasseur, Louis ^a   Parker, Fabrice ^a   Chauvin, Marcel ^a   Bouhassira, Didier ^a  

^a INSERM   (France)

Author keywords

Allodynia; GABA; Gabapentin; Hyperalgesia; Neuropathic pain

Indexed keywords

ANTICONVULSIVE AGENT; GABAPENTIN;

ADULT; AGED; ALLODYNIA; ANALGESIA; ARTICLE; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; HYPERALGESIA; MALE; PAIN THRESHOLD; PERIPHERAL NERVE INJURY; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; STEADY STATE;

EID: 0031787829     PISSN: 00143022     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007979     Document Type: Article

References (29)

1. Price DD, Mao J, Meyer D: Central mechanism of normal and abnormal pain states: in Fields HL, Liebeskind JC (eds): Progress in Pain Research and Management. Seattle, IASP Press, 1994, vol 1, pp 61-84.
2. Bennett GJ: Neuropathic pain; in Wall PD, Melzck R (eds): Textbook of Pain. Edinburgh, Churchill Livingstone, 1994, pp 201-224.
3. Ellenberg M: Treatment of diabetic neuropathy with diphenylhydantoin. N Y State J Med 1968;68:2653-2655.
4. McQuay H, Carroll D, Jadad AR, Wiffern P, Moore A: Anticonvulsant drugs for management of pain: A systematic review. Br Med J 1995;311:1047-1052.
5. Leijon G, Boivie J: Central post-stroke pain - a controlled trial of amitriptyline and carbamazepine. Pain 1989;36:27-36.
6. Killian JM, Fromm GH: Carbamazepine in the treatment of neuralgia. Arch Neurol 1968;19: 129-136.
7. Swerdlow M, Cundill JG: Anticonvulsivant drugs used in the treatment of lancinating pain. A comparison. Anaesthesia 1981;36:1129-1132.
8. Andrews CO, Fischer JH: Gabapentin: A new agent for the management of epilepsy. Ann Pharmacother 1994;28:1188-1196.
9. Dichter MA, Brodie MJ: New antiepileptic drugs. N Engl J Med 1996;334:1583-1590.
10. Sist T, Filadora V, Miner M, Lema M: Gabapentin for idiopathic trigeminal neuralgia: Report of two cases. Neurology 1997;48:1467-1471.
11. Rosner H, Rubin L, Kestenbaum A: Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain 1996;12:56-58.
12. Segal AZ, Rordorf G: Gabapentin as a novel treatment for postherpetic neuralgia. Neurology 1996;47:1175-1176.
13. Mellick GA, Mellick LB: Reflex sympathetic dystrophy treated with gahapentin. Arch Phys Med Rehabil 1997;78:98-104.
14. Backonja M, Hes MS, LaMoreaux LK, Garofalo EA, Koto EM: Gabapentin (GBP, Neurontin) reduces pain in diabetics with painful peripheral neuropathy: Results of a double-blind, placebo-controlled clinical trial (abstract No 654). 16th Annual Meeting, American Pain Society, New Orleans, October 23-26, 1997.
15. Fruhstorfer H, Lindblom U, Schmidt WG: Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiatry 1976;39:1071-1075.
16. Hansson P, Lindblom U: Hyperalgesia assessed with quantitative sensory testing in patients with neurogenic pain; in Willis WD (ed): Hyperalgesia and allodynia. New York, Raven Press, 1992, pp 335-343.
17. Hunter JC, Gogas KR, Hedley LR, Jacobson LO, Kassotakis L, Thompson J, Fontana DJ: The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. Eur J Pharmacol 1997;324:153-160.
18. Hwang JHH, Yaksh TL: Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat. Reg Anesth 1997;22:249-256.
19. Löscher W, Hönack D, Taylor CP: Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. Neurosci Lett 1991;156:150-154.
20. Petroff OAC, Rothman DL, Behar KL, Lamoureux D, Mattson RH: The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Ann Neurol 1996;39: 95-99.
21. Götz E, Feuerstein RJ, Lais A, Meyer DK: Effects of gabapentin on relaese of γ-aminobutyric acid from slices of rat neostriatum. Drug Res 1993;43:636-638.
22. Koksis JD, Honmou O: Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve. Neurosci Lett 1994;169:181-184.
23. Rock DM, Kelly KM MacDonald RL: Gabapentin actions on ligand and voltage-dated responses in cultured rodent neurons. Epilepsy Res 1993;16:89-98.
24. Goldlust A, Zhi Su T, Welty DF, Taylor CP, Oxender DL: Effects of anticonvulsant drug gabapentin on the enzymes on metabolic pathways of glutamate and GABA. Epilepsy Res 1995;22:1-11.
25. 3H gabapentin binding to a novel site in the rat brain: Homogenate binding studies. Eur J Pharmacol 1993;244:293-301.
26. Kondo T, Fromm GH, Schmidt B: Comparison of gabapentin with other antiepileptic and GABAergic drugs. Epilepsy Res 1991;8:226-231.
27. Gee NS, Brown JP, Dissanayake VUK, Offord J, Thurlow R, Woodruff GN: The novel anticonvulsant drug, gabapentin (Neurontin), binds to the a26 subunit of a calcium channel. J Biol Chem 1996;271:5768-5776.
28. Marson AG, Kadir ZA, Chadwick DW: New antiepileptic drugs: A systematic review of their efficacy and tolerability. Br Med J 1996; 313:1169-1174.
29. Buetefisch CM, Gutierrez A, Gutman L: Choreoathetotic movements: A possible side effect of gabapentin. Neurology 1996;46:851-852.