Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

Molecular Cell

Volumn 6, Issue 3, 2000, Pages 743-750

  Schlessinger, Joseph ^a   Plotnikov, Alexander N ^a   Ibrahimi, Omar A ^a   Eliseenkova, Anna V ^a   Yeh, Brian K ^a   Yayon, Avner ^b   Linhardt, Robert J ^c   Mohammadi, Moosa ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c University of Iowa   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; HEPARIN DERIVATIVE;

ANGIOGENESIS; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DIMERIZATION; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG STRUCTURE; MOLECULAR MODEL; SIGNAL TRANSDUCTION; STOICHIOMETRY; STRUCTURE ANALYSIS;

EID: 0033635299     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00073-3     Document Type: Article

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