Bivalence of EGF-like ligands drives the ErbB signaling network

EMBO Journal

Volumn 16, Issue 16, 1997, Pages 4938-4950

  Tzahar, Eldad ^a   Pinkas Kramarski, Ronit ^a   Moyer, James D ^b   Klapper, Leah N ^a   Alroy, Iris ^a   Levkowitz, Gil ^a   Shelly, Maya ^a   Henis, Sivan ^a   Eisenstein, Miriam ^a   Ratzkin, Barry J ^c   Sela, Michael ^a   Andrews, Glenn C ^b   Yarden, Yosef ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c AMGEN INC   (United States)

Author keywords

Growth factor; Neuregulin; Oncogene; Signal transduction; Tyrosine kinase

Indexed keywords

CHIMERIC PROTEIN; EPIDERMAL GROWTH FACTOR; LIGAND; MEMBRANE RECEPTOR; NEU DIFFERENTIATION FACTOR; ONCOPROTEIN; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; LIGAND BINDING; MODEL; NONHUMAN; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; DIMERIZATION; EPIDERMAL GROWTH FACTOR; GLYCOPROTEINS; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS; NEUREGULINS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 20244367576     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.16.4938     Document Type: Article

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