Notch signaling: A dance of proteins changing partners

Experimental Cell Research

Volumn 260, Issue 1, 2000, Pages 1-8

  Kadesch, Tom ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; CELL SURFACE PROTEIN; NOTCH RECEPTOR; RECEPTOR PROTEIN;

ANIMAL CELL; CELL FUNCTION; DNA BINDING; GENE FUNCTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REVIEW; TRANSCRIPTION REGULATION;

EID: 0034633964     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4921     Document Type: Review

References (86)

1. Notch and the immune system
2. Regulation of T cell fate by Notch
3. Notch signaling: Cell fate control and signal integration in development
4. Notch as a mediator of cell fate determination in hematopoiesis: Evidence and speculation
5. Modulators of Notch signaling
6. Notch signaling and the control of cell fate choices in vertebrates
7. Notch and neurogenesis
8. Notch/LIN-12 signaling: Transduction by regulated protein slicing
9. Notch signaling: Direct or what?
10. Roles for proteolysis and trafficking in notch maturation and signal transduction
11. Human ligands of the Notch receptor
12. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
13. The Notch1 receptor is cleaved constitutively by a furin-like convertase
14. Calcium depletion dissociates and activates heterodimeric Notch receptors
15. Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain
16. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
17. A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
18. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
19. Nuclear access and action of notch in vivo
20. Requirement for dynamin during Notch signaling in Drosophila neurogenesis
21. Control of EGF receptor signaling by clathrin-mediated endocytosis
22. Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: Members of the Notch signalling pathway in Drosophila
23. Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development
24. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
25. Processing of the notch ligand delta by the metalloprotease Kuzbanian
26. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
27. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
28. Presenilin is required for activity and nuclear access of Notch in Drosophila
29. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
30. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
31. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling
32. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
33. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
34. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor
35. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
36. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
37. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
38. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription
39. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
40. The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis
41. The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development
42. Recognition sequence of a highly conserved DNA binding protein RBP-J kappa
43. Lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)
44. The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor
45. The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein
46. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa
47. Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2
48. Signalling downstream of activated mammalian Notch
49. Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region
50. Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor
51. Histone deacetylases: Transcriptional repression with SINers and NuRDs
52. Sin meets NuRD and other tails of repression
53. The coregulator exchange in transcriptional functions of nuclear receptors
54. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
55. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
56. A role for SKIP in EBNA2 activation of CBF1-repressed promoters
57. The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription
58. The notch 3 intracellular domain represses notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters
59. Notch signalling controls pancreatic cell differentiation
60. The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development
61. Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless
62. LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein
63. Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication
64. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
65. Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch
66. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
67. NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1
68. Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity
69. Deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster
70. Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway
71. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
72. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling
73. Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
74. Human deltex is a conserved regulator of Notch signalling Nat
75. Notch inhibition of E47 supports the existence of a novel signaling pathway
76. Correlating notch signaling with thymocyte maturation
77. A novel cDNA transcript expressed in fractionated X-irradiation-induced murine thymomas
78. Protective effects of notch-1 on TCR-induced apoptosis
79. Activated notch inhibits myogenic activity of the MADS-box transcription factor myocyte enhancer factor 2C
80. T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells
81. NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
82. Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors
83. Delta-1 activation of notch-1 signaling results in HES-1 trans-activation
84. Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split
85. NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
86. Interaction of the nuclear protein CBF1 with the kappaB site of the IL-6 gene promoter