New Approaches to Construction of Transgenic Animals with a High-Level Tissue-Specific Expression of Foreign Genes: Construction and Reconstruction of Genomic Domains

Genetika

Volumn 36, Issue 11, 2000, Pages 1443-1453

  Razin, S V ^a   Verbovaia, L V ^a   Goldman, I L ^a  

^a INSTITUTE OF GENE BIOLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ENHANCER REGION; EUKARYOTIC CELL; GENE EXPRESSION; GENE TRANSFER; GENETICS; GENOME; HUMAN; INTRON; METABOLISM; PROMOTER REGION; REGULATOR GENE; REVIEW; TRANSGENE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ENHANCER ELEMENTS (GENETICS); EUKARYOTIC CELLS; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENOME; HUMANS; INTRONS; LOCUS CONTROL REGION; PROMOTER REGIONS (GENETICS); TRANSGENES;

EID: 0034320725     PISSN: 00166758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (94)

1. Weintraub H., Groudine M. Chromosomal subunits in active genes have an altered conformation // Science. 1976. V. 73. P. 848-856.
2. Lawson G.M., Knoll BJ., March CJ. et al. Definition of 5' and 3' structural boundaries of the chromatin domain containing the ovalbumin multigene family // J. Biol. Chem. 1982. V. 257. P. 1501-1507.
3. ForresterW.C.,TakegawaS.,Papayannopoulou T. étal. Evidence for a locus activating region: the formation of developmentally stable hypersensitive sites in globin expressing hybrids // Nucl. Acids Res. 1987. V. 15. P. 10159-10175.
4. Forrester W.C., Epner E., Driscoll M.C.etal.A. deletion of the human -globin locus activation region causes a major alteration in chromatin structure and replication across the entire -globin locus // Genes Dev. 1990. V. 4. P. 1637-1649.
5. Grosveld F., van Assandelt G.B., Greaves D.R., KolliasB. Position-independent, high-level expression of the human p-globin gene in transgenic mice // Cell. 1987. V. 51. P. 975-985.
6. Fraser P., Hurst J., Collis P., Grosveld F. DNase I hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression//Nucl. Acids Res. 1990. V. 18. P. 3503-3508.
7. Philipsen S., Talbot D., Fraser P., Grosveld F. The betaglobin dominant control region: hypersensitive site 2 // EMBO J. 1990. V. 9. P. 2159-2167.
8. Talbot D., Philipsen S., Fraser P., Grosveld F. Detailed analysis of the 3 region of the human beta-globin dominant control region // EMBO J. 1990. V. 9. P. 21692178.
9. Talbot D., Grosveld F, The 5'HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites // EMBO J. 1991. V. 10. P. 1391-1398.
10. Pruzina S., Hanscombe 0., Whyatt D. et al. Hypersensitive site 4 of the human -globin locus control region // Nucl. Acids Res. 1991. V. 19. P. 1413-1419.
11. Philipsen S., Pruzina S., Grosveld F. The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region // EMBO J. 1993. V. 12. P. 1077-1085.
12. Li Q., Stamatoyannopoulos G. Hypersensitive site 5 of the human locus control region functions as a chromatin insulator // Blood. 1994. V. 84. P. 1399-1401.
13. Li Q., Zhou B., Powers P. et al. -globin locus activations regions: conservation of organization, structure and function // Proc. Natl Acad. Sei. USA. 1990. V. 87. P. 8207-8211.
14. Moon A.M., Ley TJ. Conservation of the primary structure, organization, and fucntion of the human and mouse -globin locus-activating regions // Proc. Natl Acad. Sei. USA. 1990. V. 87. P. 7693-7697.
15. Felsenfeld G. Chromatin structure and the expression of globin-encoding genes // Gene. 1993. V. 135. P. 119124.
16. Hug B.A., Moon A.M., Ley TJ. Structure and function of the murine beta-globin locus control region 5'HS3 // Nucl. Acids Res. 1992. V. 20. P. 5771-5778.
17. Huber M.C., Bosch F.X., Sippel A.E., Bonifer C. Chromosomal position effects in chicken lysozyme gene transgenic mice are correlated with suppresiion of DNase I hypersensitive site formation // Nucl. Acids Res. 1994. V. 22. P. 4195-201.
18. Bonifer C., Yannoutsos N., Kniger G. et al. Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice // Nucl. Acids Res. 1994. V. 20. P. 4202-4210.
19. BonifrC., Huber M.C., FaustN., Sippel A.E. Regulation of the chicken lysozyme locus in transgenic mice // Crit. rew. Eukaryot. Gene Exp. 1996. V. 6. P. 285-297.
20. Bonifer C., Huber M.C., Jagle U. et al. Prerequisites for tissue specific and position independent expression of a gene locus in transgenic mice // J. Mol. Med. 1996. V.74. P. 663-671.
21. Pasceri P., Pannell D.,WuX., Ellis J. Full activity from human beta-globin locus control region transgenes requires 5'HSI, distal beta-globin promoter, and 3'betaglobin sequences // Blood. 1998. V. 92. P. 653-663.
22. Stamatoyannopoulos G. Human hemoglobin switching // Science. 1991. V. 252. P. 383.
23. Threadgill D.W., Womack J.E. Genomic analysis of the major bovine milk protein genes // Nucl. Acids Res. 1990. V. 18. P. 6935-6942.
24. Vilotte J.L., Soulier S., Stinnakre M.G. et al. Efficient tissue specific expression of bovine alpha-lactalbumin in transgenic mice // Eur. J. Biochem. 1989. V. 186. P. 4348.
25. Soulier S., Vilotte J.L., Stinnakre M,G., Mercier J.C. Expression analysis of ruminant cc-lactalbumin in transgenic mice: development regulation and general location of important n's-regulatory elements // FEBS Lett. 1992. V. 297. P. 13-18.
26. Ninomiya T., Hirabayashi M., Sagara J., Yuki A. Functions of milk protein gene 5' flanking regions on human growth hormone gene // Mol. Rep. Dev. 1994. V. 37. P. 276-283.
27. Ahn J.Y., Aoki N., Adachi T. et al. Isolation and culture of bovine mammary epithelial cells and establishment of gene transfection conditions in the cells // Biosci. Biothechnol. Biochem. 1995. V. 59. P. 59-64.
28. AdashiT.,AhnJ.Y., YamamotoK. etal. Characterization of the bovine kappa-casein gene promoter // Biosci. Biotechnol. Biochem. 1996. V. 60. P. 1937-1940.
29. Bleck G.T., Bremel R.D. Variations in expression of bovine alpha-lactalbumin transgene in milk of transgenic mice//J. Dairy Sei. 1994. V. 77. P. 1897-1904.
30. Bleck G.T., White B.R., Miller D.J., Wheeler M.B. Production of bovine alpha-lactalbumin in the milk of transgenic pigs I/]. Anim. Sei. 1998. V. 76. P. 3072-3078.
31. Hyttinen J.M., Korhonen V.P., Hiltunen M.O. et al. High-level expression of bovine beta-lactoglobulin gene in transgenic mice //J. Biotechnol. 1998. V. 61. P. 191198.
32. Bijovet A.C., Kroos M.A., Pieper F.R. et al. Recombinant human acid alpha-glucosidase: high level production in mouse milk, biochemical characteristics, correction of enzyme deficiency in GSDII mice // Hum. Med. Genet. 1998. V. 7. P. 1815-1824.
33. Meade /J., Gates L., Lacy E., Lonberg N. Bovine alpha SI -casein gene sequences direct high level expression of active human urokinase in mouse milk // Biotechnology. 1990. V. 8. P. 443-446.
34. Brem G., Harti P., Besenfelder U. et al. Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-I) in the mammary gland of transgenic rabbits //Gene. 1994. V. 149. P. 351-355.
35. Rijnkels M., Kooiman P.M., Platenburg G.J. et al. Highlevel expression of bovine alpha SI-casein in milk of transgenic mice //Transgenic Res. 1998. V. 7. P. 5-14.
36. Rijnkels M., Kooiman P.M., Krimpenfort P.J.A. et al. Expression of the individual bovine , ocS2 and K-casein genes in transgenic mice // Biochem. J. 1995. V. 311. P. 929-937.
37. Cedran M.G., Young J.I., Zino E. et al. Accurate spatial and temporal transgene expression driven by a 3.8 kilobase promoter of the bovine beta-casein gene in the lactating mouse mammary gland // Mol. Reprod. Dev. 1998. V. 49. P. 236-245.
38. Kirn SJ., Sohn B.H., Jeong S. et al. High-level expression of human lactoferrin in milk of transgenic mice using genomic lactoferrin sequence // J. Biochem. 1999. V. 126. P. 320-325.
39. Oh K.B., Choi Y.H., Kang Y.K. étal. A hybrid bovine beta-casein/bGH directs transgene expression to the lung and mammary gland of transgenic mice // Transgenic Res. 1999. V. 8. P. 307-311.
40. Grosveld F. Activation by locus control regions? // Curr. Opin. Genet. Dev. 1999. V. 9. P. 152-157.
41. Ronai D., Berru M., Shulman MJ. Variegated expression of the endogenous immmunoglobulin heavy-chain gene in the absence of the intronic locus control region // Mol. Cell. Biol. 1999. V. 19. P. 7031-7040.
42. Craddock C.F., Vyas P., Sharpe JA. et al. Contrasting effects of alpha and beta-globin regulatory elements on chromatin sturcture may be related to their different chromosomal environments // EMBO J. 1995. V. 14. P. 1718-1726.
43. HiggsD.R., WoodW.G.,JarmanA.P. étal. A major positive regulatory region located far upstream of the human a-globin gene locus // Genes Dev. 1990. V. 4. P. 15881601.
44. Sutherland H.G., Martin D.I., Whitelaw E. A globin enhancer acts by increasing the proportion oferythrocytes expressing a linked transgene // Mol. Cell. Biol. 1997. V. 17. P. 1607-1614.
45. Kioussis D., Festenstein R. Locus control regions: overcoming heterochromatin induced gene inactivation in mammals // Curr. Opin. Genet. Dev. 1997. V. 7. P. 614619.
46. Taboit-Dimeron F., Malassagne B., Viglietta C. et al. Association of the 5'HS4 sequence of the chicken betaglobin locus control region with human EFI alpha gene promoter induces ubiquitous and high expression of human CD55 and CD59 cDNAs in transgenic rabbits // Transgenic Res. 1999. V. 8. P. 223-235.
47. Ortiz B.D., Cado D., Winoto A. A new element within T-cell receptor alpha locus required for tissue-specific locus control region activity // Mol. Cell. Biol. 1999. V. 19. P. 1901-1909.
48. Li G., Lim K.S., Engel J.D. Bungert J. Individual LCR hypersensitive sites cooperate to generate an open chromatin domain spanning the -globin locus // Genes Cells. 1998. V. 3. P. 415-29.
49. Needham M., Goading C., Hudson K. et al. LCR/MEL: a versatile system for high-level expression of heterologous proteins in erythroid cells // Nucl. Acids Res. 1992. V. 20. P. 997-1003.
50. Fujivara Y., Takahashi R.I., Miwa M. et al. Analysis of control elements for position-independent expression of human alpha-lactalbumin YAK // Mol. Reprod. Dev. 1999. V. 54. P. 17-23.
51. Talbot D., Descombes P., Schibler U. The 5' flanking region of the rat LAP (CIEBP beta) gene can direct highlevel, position independent, copy number-dependent expression in multiple tissues of transgenic mice // Nucl. Acids Res. 1994. V. 22. P. 756-766.
52. Dillon N., Grosveld F. Transcription regulation of multigene loci: multilevel control //Trends Genet. 1993. V. 9. P. 134-137.
53. Kellum R., Schedl P. A position-effect assay for boundares of higher order chromosomal domains // Cell. 1991. V. 64. P. 941-950.
54. Kellum R., Schedl P. A group of ses elements function as domain boundaries in an enhancer-blocking assay // Mol. Cell. Biol. 1992. V. 12. P. 2424-2431.
55. Anal J., Cajero-Juarez M., Petitderc D. et al. The effecl of matrix-attached regions (MAR) and specialized chromatin structure (SCS) on the expression of gene constructs in cultured cells and in transgenic mice // Mol. Biol. Rep. 1995-1996. V. 22. P. 37-46.
56. Chung J.H., Whiteley M., Felsenfeld G. A 5' element of the chicken -glocin domain serves as an insulator in human erythroid cells and protects against position effects in Drosophila II Cell. 1993. V. 74. P. 505-514.
57. Kalos M., Fournier R.E. Position independent transgene expression mediated by boundary elements from the apolipoprotein B chromatin domain // Mol. Cell. Biol. 1995. V. 15. P. 198-207.
58. StiefA., Winter D.M., Sträfling W.H., Sippel A.E. A nuclear DNA attachment element mediates elevated and position-independent gene activity // Nature. 1989. V. 341. P. 343-345.
59. Phi-Van L., Von Kries J.P., Ostertag W., Sträfling W.H. The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects of the expression of transfected genes // Mol. Cell. Biol. 1990. V. 10. P. 2302-2307.
60. Klehr D., Maass K., Bode J. Scaffold-attached regions from the human Interferon B domain can be used to enhance the stable expression of genes under the control of various promoters // Biochemistry. 1991. V. 30. P. 1264-1270.
61. YuJ.,BockJ.H.,SlightomJ.L., VilleponteauB. A 5' matrix-attachment region and the polyoma enhancer together confer position-independent transcription // Gene. 1994. V. 139. P. 139-145.
62. McKnight RA., Spencer M., Wall RJ., HenninghausenL. Severe position effects imposed on I kb mouse whey acidic protein gene promoter are overcome by heterologous matrix attachment regions // Mol. Reprod. Dev. 1996. V. 44. P. 179-184.
63. Phi-Van L., Sträfling W.H. Dissection of the ability of the chicken lysozyme gene 5' matrix attachment region to stimulate transgene expression and to dampen position effects // Biochemistry. 1996. V. 35. P. 1073510742.
64. Poljak L., Seum C., Mattioni T., Laemmii U.K. SARs stimulate but do not confer position independent gene expression // Nucl. Acids Res. 1994. V. 22. P. 43864394.
65. Schoffi F., Schröder G., Kleim M., Rieping M. An SAR sequence containing 395 bp DNA fragment mediates enhanced, gene-dosage-correlated expression of a chimaeric heat shock gene in transgenic tobacco plants // Transgenic Res. 1993. V. 2. P. 93-100.
66. Wang D.M., Taylor S., Levi-Wilson B. Evaluation of the function of the human apollipoprotein B gene nuclear matrix association regions in transgenic mice // J. Lipid Res. 1996. V. 37. P. 2117-2124.
67. Liu J.W., Tabe L.M. The influence of two plant nuclear matrix attachment regions (MARs) on gene expression in transgenic plants // Plant Cell Physiol. 1998. V. 39. P. 115-123.
68. Gardiner-Garden M., Frommer M. CpG islands in vertebrate genomes // J. Mol. Biol. 1987. V. 196. P. 261-282.
69. Razin A. CpG methylation, chromatin structure and gene silencing-a three-way connection // EMBO J. 1998. V. 17. P. 4905-4908.
70. Larsen F., Gundersen G., Lopez R., Prydz H. CpG islands as gene markers in the human genome // Genomics. 1992. V. 13. P. 1095-1107.
71. Cross S.H., Bird A.P. CpG islands and genes // Curr. Opin. Genet. Dev. 1995. V. 5. P. 309-314.
72. Kundu T.K., Rao M.R. CpG islands in chromatin organization and gene expression // J. Biochem. 1999. V. 125. P. 217-222.
73. Brickner H.E., Zhu X.X., Atweh G.F. A novel regulatory element of the human oc-globin gene responcible for its constitutive expression // J. Biol. Chem. 1991. V. 266. P. 15363-15368.
74. Shewchuk B.M., Hardison R.C. CpG islands from the alpha-globin gene cluster increase gene expression in an integration-dependent manner // Mol. Cell. Biol. 1997. V. 17. P. 5856-5866.
75. Dorr er D.R., Henikoff S. Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila II Cell. 1994. V. 77. P. 993-1002.
76. Dorrer D.R., Henikoff S. Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and in trans // Genetics. 1997. V. 147. P. 1181-1190.
77. Dobie K., Mentali M., McClenaghan M., Lathe R. Variegated gene expression in mice // Trends in Genet. 1997. V. 13. P. 127-130.
78. Wolffe A. Repressed repeats express themselves // Curr. Biol. 1997. V. 7. P. R796-R798.
79. Carrick D., Fiering S., Martin D.I., Whitelaw E. Repeatinduced gene silencing in mammals // Nat. Genet. 1998. V. 18. P. 56-59.
80. Henikoff S. Conspiracy of silence among repeated transgenes // Bioessays. 1998. V. 20. P. 532-535.
81. Fanti L., Dorrer D.R., Berloco M. et al. Heterochromatin protein I binds transgene arrays // Chromosoma. 1998. V. 107. P. 286-292.
82. Festenstein R., Sharghi-Namini S., Fox M. et al. Heterochromatin protein I modifies mammalian PEV in a doseand chromosomal-context-dependent manner // Nat. Genet. 1999. V. 23. P. 457-461.
83. Francastel C., Walters M.C., Groudine M., Martin D.I.K. A functional enhancer suppresses silencing of a transgene and prevents its localization close to centromeric heterochromatin // Cell. 1999. V. 99. P. 259-269.
84. Bode J., Schlake T., Rios-Ramirez M. et al. Scaffold-matrix-attached regions: Structural properties creating transcriptionally active loci // Int. Rev. Cytol. 1995. V. 162A. P. 389-454.
85. Whitelaw C.B., Archibald A.L., Harris S. et al. Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice // Transgenic Res. 1991. V. 1. P. 3-13.
86. Hennighausen L. The prospects for domesticating milk protein genes // J. Cell. Biochem. 1992. V. 49. P. 325-332.
87. Clark A J., Harold G., Yull F.E. Mammalian cDNA and procaryotic reporter séquences silence adjacent transgenes in transgenic mice // Nucl. Acids Res. 1997. V. 25. P. 1009-1014.
88. Lang G., Wotton D., Owen MJ. et al. The structure of the human CD2 gene and its expression in transgenic mice // EMBO J. 1988. V. 7. P. 1675-1682.
89. Ess K.S., Whitaker T.L., Cost G.J. étal. A central role for a single c-Myb binding site in a thymic locus control region // Mol. Cell. Biol. 1995. V. 15. P. 5707-5715.
90. Diaz P., Cado D., Winoto A. A locus control region in the T cell receptor alpha/delta locus // Immunity. 1994. V. 1. P. 207-217.
91. Carson S., Wiles M.V. Far upstream regions of class II MHC Ea are necessary for position-independent, copy-dependent expression of Ea transgene // Nucl. Acids Res. 1993. V. 21. P. 2065-2072.
92. Palmiter R.D., Sandgren E.P., Koeller D.M., Brinster R.L. Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice // Mol. Cell. Biol. 1993. V. 13. P. 5266-5275.
93. Porter S.D., Meyer CJ. A distal tyrosinase upstream element stimulates gene expression in neutral-crest-derived melanocytes of transgenic mice: position-independent and mosaic expression // Development. 1994. V. 120. P. 2103-2111.
94. Aizawa A., Yoneyama T., Kalahari K., Ono M. DNase I - hypersensitive sites in the chromatin of rat growth hormone gene locus and enhancer activity of regions with these sites // Nucl. Acids Res. 1995. V. 23. P. 22362244.