Hypersensitive site 5 of the human β locus control region functions as a chromatin insulator

Blood

Volumn 84, Issue 5, 1994, Pages 1399-1401

  Li, Qiliang ^a   Stamatoyannopoulos, George ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; DEOXYRIBONUCLEASE I; DNA; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CHROMATIN; GENE; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SOUTHERN BLOTTING;

EID: 0027998844     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v84.5.1399.1399     Document Type: Article

References (23)

1. Tuan D, Solomon W, Li Q, London I: The "β-like-globin" gene domain in human erythroid cells. Proc Natl Acad Sci USA 82:6384, 1985
2. Forrester WC, Takegawa S, Papayannopoulou T, Stamatoyannopoulos G, Groudine M: Evidence for a locus activation region: The formation of developmentally stable hypersensitive sites in globin-expressing hybrid. Nucleic Acids Res 15:10159, 1987
3. Grosveld F, van Assendelft GB, Greaves DR, Kollias G: Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51:975, 1987
4. Talbot D, Colliis P, Antoniou M, Vidai M, Grosveld F, Greaves DR: A dominant control region from the human β-globin locus conferring integration site-independent gene expression. Nature 338:352, 1989
5. van Assendelft GB, Hanscombe O, Grosveld F, Greaves R: The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner. Cell 56:969, 1989
6. Reitman M, Felsenfeld G: Developmental regulation of topoisomerase II sites and Dnase I-hypersensitive sites in the chicken β-globin locus. Mol Cell Biol 10:2774, 1990
7. Chung JH, Whiteley M, Felsenfeld G: A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74:505, 1993
8. Stamatoyannopoulos G, Josephson B, Zhang JW, Li Q: Developmental regulation of human y-globin genes in transgenic mice. Mol Cell Biol 13:7636, 1993
9. Collis P, Antoniou M, Grosveld F: Definition of the minimal requirements within the human β-globin gene and the dominant control region for high level expression. EMBO J 9:233, 1990
10. Philipsen S, Talbot D, Fraser P, Grosveld F: The β-globin dominant control region: Hypersensitive site 2. EMBO J 9:2159, 1990
11. Fraser P, Hurst J, Collis P, Grosveld F: DNaseI hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression. Nucleic Acids Res 18:3503, 1990
12. Li Q, Slamatoyannopoulos J: Position-independence and proper developmental control of γ-globin expression require both a 5′LCR and a downstream sequence element. Mol Cell Biol (in press)
13. Strauss EC, Orkin SH: In vivo protein-DNA interactions at hypersensitive site 3 of the human β-globin locus control region. Proc Natl Acad Sci USA 89:5809, 1992
14. Ikuta T, Kan YW: In vivo protein-DNA interaction at the β-globin gene locus. Proc Natl Acad Sci USA 88:10188, 1991
15. Reid LH, Shesely EG, Kim H-S, Smithies O: Cotransformation and gene targeting in mouse embryonic stem cells. Mol Cell Biol 11:2769, 1991
16. Forrester WC, Novak U, Gelinas R, Groudine M: Molecular analysis of the human β-globin locus activation region. Proc Natl Acad Sci USA 86:5439, 1989
17. Talbot D, Philipsen S, Fraser P, Grosveld F: Detailed analysis of the site 3 region of the human β-globin dominant control region. EMBO J 9:2169, 1990
18. Kellum R, Schedl P: A position-effect assay for boundaries of higher order chromosomal domains. Cell 64:941, 1991
19. Stief A, Winter DM, Stratling WH, Sippel AE: A nuclear DNA attachment element mediates elevated and position-independent gene activity. Nature 341:343, 1989
20. Jarman AP, Higgs DR: Nuclear scaffold attachment sites in the human globin gene complexes. EMBO J 7:337, 1988
21. Kellum R, Schedl P: A group of ses elements function as domain boundaries in an enhancer-blocking assay. Mol Cell Biol 12:2424, 1992
22. Novak U, Harris EAS, Forrester W, Groudine M, Gelinas R. High-level β-globin expression after retroviral transfer of locus activation region-containing human β-globin gene derivatives into murine erythroleukemia cells. Proc Natl Acad Sci USA 87:3386, 1990
23. Plavec I, Papayannopoulou Th, Maury C, Meyer F: A human β-globin gene fused to the human β-globin locus control region is expressed at high levels in erythroid cells of mice engrafted with retrovirus-transduced hematopoietic stem cells. Blood 81:1384, 1993