A 5′ β-globin matrix-attachment region and the polyoma enhancer together confer position-independent transcription

Gene

Volumn 139, Issue 2, 1994, Pages 139-145

  Yu, Jinghua ^a   Bock, Jeffrey H ^b   Slightom, Jerry L ^b   Villeponteau, Bryant ^a  

^a GERON CORPORATION   (United States)

^b PFIZER INC   (United States)

Author keywords

chromatin position effects; Gene regulation; locus control region

Indexed keywords

BETA GLOBIN;

ARTICLE; CHROMATIN; ENHANCER REGION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; POLYOMA VIRUS; POSITION EFFECT; PRIORITY JOURNAL; REPORTER GENE;

BASE SEQUENCE; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, REPORTER; GLOBINS; HELA CELLS; HUMAN; MOLECULAR SEQUENCE DATA; POLYOMAVIRUS; RNA, MESSENGER; SUPPORT, U.S. GOV'T, NON-P.H.S.; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0028180340     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1119(94)90747-1     Document Type: Article

References (39)

1. Absolute mRNA quantification using the polymerase chain reaction (PCR). A novel approach by a PCR aided transcript titration assay (PATTY)
2. Biological significance of unwinding capability of nuclear matrix-associating DNAs
3. Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice
4. DNA fragments associated with chromosome scaffolds
5. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
6. Characterization of nuclear structures containing superhelical DNA
7. 2,3,7,8-Tetrachlorodibenzo-p-dioxininducible aryl hydrocarbon receptor-mediated change in CYP1A1 chromatin structure occurs independently of transcription
8. Chromatin as an essential part of the transcriptional mechanism
9. Serum stimulation of the c-fos enhancer induces reversible changes in c-fos chromatin structure
10. High-resolution analysis of c-fos chromatin accessibility using a novel DNase I-PCR assay
11. Molecular analysis of the human β-globin locus activation region
12. A glimpse at chromosomal order
13. Position-independent high-level expression of the human β-globin gene in transgenic mice
14. An altered repertoire of fos/jun (AP-1) at the onset of replicative senescence
15. Nuclear scaffold attachment sites in the human globin gene complexes
16. A position-effect assay for boundaries of higher order chromosomal domains
17. A group of scs elements function as domain boundaries in a enhancer-blocking assay
18. Scaffold-attached regions from the human interferon β domain can be used to enhance the stable expression of genes under the control of various promoters
19. Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer
20. Supercoiling of the DNA template during transcription
21. Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold
22. Globin gene regulation and switching: circa 1990
23. Germline tranformation of mice
24. The structure of histone-depleted metaphase chromosomes
25. The chicken lysozyme 5′ matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes
26. The polyoma enhancer activates chromatin accessibility on integration into the HPRT gene
27. Hormonal induction of transfected genes depends on DNA topology
28. A-globin gene in transgenic mice
29. Ubiquitous MyoD transcription at the midblastula transition precedes induction-dependent MyoD expression in presumptive mesoderm of X. luevis
30. Chromatin assembly in Xenopus oocytes: in vivo studies
31. DNA sequencing with chainterminating inhibitors
32. Strategy and methods for directly sequencing cosmid clones
33. Orangutan fetal globin genes: nucleotide sequences reveals multiple gene conversions during hominid phylogeny
34. A nuclear DNA attachment element mediates elevated and position-independent gene activity
35. A dominant control region from the human β-globin locus conferring integration site-independent gene expression
36. The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner
37. Quantitation of mRNA by the polymerase chain reaction
38. Expression of transfected DNA depends on DNA topology
39. Position effects on eukaryotic gene expression