High-level expression of bovine β-lactoglobulin gene in transgenic mice

Journal of Biotechnology

Volumn 61, Issue 3, 1998, Pages 191-198

  Hyttinen, Juha Matti ^a   Korhonen, Veli Pekka ^a   Hiltunen, Mikko O ^a   Myöhänen, Sanna ^a   Jänne, Juhani ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Lactoglobulin; DNA methylation; Mice; Milk; Transgene

Indexed keywords

DNA; LIVING SYSTEMS STUDIES; TISSUE;

GENOMIC SEQUENCING; LACTOGLOBULIN; METHYLATION;

GENETIC ENGINEERING;

BETA LACTOGLOBULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DNA METHYLATION; EXPRESSION VECTOR; GENE EXPRESSION; GENE SEQUENCE; MILK; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BREAST; CATTLE; CLONING, MOLECULAR; DNA METHYLATION; FEMALE; GENE DOSAGE; GENE EXPRESSION; LACTOGLOBULINS; MICE; MICE, TRANSGENIC; MILK PROTEINS; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE ANALYSIS;

BOS TAURUS; BOVINAE; MURINAE; MUS MUSCULUS;

EID: 0032513718     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(98)00032-7     Document Type: Article

References (20)

1. Alexander L.J., Hayes G., Pearse M.J., Beattie C.W., Stewart A.F., Willis I.M., Mackinlay A.G. Complete sequence of the bovine β-lactoglobulin cDNA. Nucleic Acids Res. 17:1989;6739.
2. Allen N.D., Norris M.L., Surani M.A. Epigenetic control of transgene expression and imprinting by genotype-specific modifiers. Cell. 61:1990;853-861.
3. Carver A.S., Dalrymple M.A., Wright G., Cottom D.S., Reeves D.B., Gibson Y.H., Keenan J.L., Barrass J.D., Scott A.R., Colman A., Garner I. Transgenic livestock as bioreactors: stable expression of human alpha-1-antitrypsin by a flock of sheep. Biotechnology. 11:1993;1263-1270.
4. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
5. Dobie K.W., Lee M., Fantes J.A., Graham E., Clark A.J., Springbett A., Lathe R., McClenaghan M. Variegated transgene expression in mouse mammary gland is determined by the transgene integration locus. Proc. Natl. Acad. Sci. USA. 93:1996;6659-6664.
6. Ebert K.M., Selgrath J.P., DiTullio P., Denman J., Smith T.E., Memon M.A., Schindler J.E., Monastersky G.M., Vitale J.A., Gordon K. Transgenic production of a variant of human tissue-type plasminogen activator in goat milk: generation of transgenic goats and analysis of expression. Bio/Technology. 9:1991;835-838.
7. Engler P., Haasch D., Pinkert C.A., Doglio L., Glymour M., Brinster R., Storb U. A strain specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci. Cell. 65:1991;939-947.
8. Houdebine L.-M. Production of pharmaceutical proteins from transgenic animals. J. Biotechnol. 34:1994;269-287.
9. Hyttinen J.-M., Peura T., Tolvanen M., Aalto J., Alhonen L., Sinervirta R., Halmekytö M., Myöhänen S., Jänne J. Generation of transgenic dairy cattle from transgene-analyzed and sexed embryos produced in vitro. Bio/Technology. 12:1994;606-608.
10. Korhonen V.-P., Tolvanen M., Hyttinen J.-M., Uusi-Oukari M., Sinervirta R., Alhonen L., Jauhiainen M., Jänne O.A., Jänne J. Expression of bovine β-lactoglobulin/human erythropoietin fusion protein in the milk of transgenic mice and rabbits. Eur. J. Biochem. 245:1997;482-489.
11. Krimpenfort P., Rademakers A., Eyestone W., van der Schans A., van den Broek S., Kooiman P., Kootwijk E., Platenburg G., Pieper F., Strijker R., de Boer H. Generation of transgenic dairy cattle using 'in vitro' embryo production. Bio/Technology. 9:1991;844-847.
12. Maga E.A., Murray J.D. Mammary gland expression of transgenes and the potential of altering the properties of milk. Bio/Technology. 13:1995;1452-1457.
13. Mercier J.-C., Vilotte J.-L. Structure and function of milk protein genes. J. Dairy Sci. 76:1993;3079-3098.
14. Myöhänen S., Wahlfors J., Jänne J. Automated fluorescent genomic sequencing as applied to the methylation analysis of the human ornithine decarboxylase gene. DNA Seq. 5:1994;1-8.
15. Peura T., Tolvanen M., Hyttinen J.-M., Jänne J. Effects of membrane piercing and the type of pronuclear injection fluid on development of in vitro-produced bovine embryos. Theriogenology. 43:1995;1087-1096.
16. Shani M., Barash B., Nathan M., Ricca G., Searfoss G.H., Dekel I., Faerman A., Givol D., Hurwitz D.R. Expression of human serum albumin in the milk of transgenic mice. Transgenic Res. 1:1992;195-208.
17. Simons J.P., McClenaghan M., Clark A.J. Alteration of the quality of milk by expression of sheep β-lactoglobulin in transgenic mice. Nature. 328:1987;530-532.
18. Uusi-Oukari M., Hyttinen J.-M., Korhonen V.-P., Västi A., Alhonen L., Jänne O., Jänne J. Bovine αS1-casein gene sequences direct high level expression of human granulocyte-macrophage colony-stimulating factor in the milk of transgenic mice. Transgenic Res. 6:1996;75-84.
19. Velander W.H., Johnson J.L., Page R.L., Russell C.G., Subramanian A., Wilkins T.D., Gwazdauskas F.C., Pittius C., Drohan W.N. High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C. Proc. Natl. Acad. Sci. USA. 89:1992;12003-12007.
20. Wright G., Carver A., Cottom D., Reeves D., Scott A., Simons P., Wilmut I., Garner I., Colman A. High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep. Bio/Technology. 9:1991;830-834.