CpG islands from the α-globin gene cluster increase gene expression in an integration-dependent manner

Molecular and Cellular Biology

Volumn 17, Issue 10, 1997, Pages 5856-5866

  Shewchuk, Brian M ^a   Hardison, Ross C ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN;

ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; CPG ISLAND; GENE CLUSTER; GENE EXPRESSION REGULATION; GLOBIN GENE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION;

ORYCTOLAGUS CUNICULUS;

EID: 0030864008     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.10.5856     Document Type: Article

References (52)

1. Atchison, M. L., O. Meyuhas, and R. P. Perry. 1989. Localization of transcriptional regulatory elements and nuclear factor binding sites in mouse ribosomal protein gene rpL32. Mol. Cell. Biol. 9:2067-2074.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1993. Current protocols in molecular biology. Greene Publishing Associates, Inc., and John Wiley and Sons, Inc., New York, N.Y.
3. Banerji, J., L. Olson, and W. Schaffner. 1983. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell 33:729-740.
4. Bernardi, G., B. Olofsson, J. Filipski, M. Zerial, J. Salivas, G. Cuny, M. Meunier-Rotival, and F. Rodier. 1985. The mosaic genome of warm-blooded vertebrates. Science 228:953-958.
5. Bird, A., M. Taggart, R. Nicholls, and D. Higgs. 1987. Non-methylated CpG-rich islands at the human α-globin locus: implications for evolution of the α-globin pseudogene. EMBO J. 6:999-1004.
6. Breuning, M. H., K. Madan, M. Verjaal, J. T. Wijnen, P. Meera Khan, and P. L. Pearson. 1987. Human α-globin maps to pter-p13.3 in chromosome 16 distal to PGP. Hum. Genet. 76:287-289.
7. Brickner, H. E., X.-X. Zhu, and G. F. Atweh. 1991. A novel regulatory element of the human α-globin gene responsible for its constitutive expression. J. Biol. Chem. 266:15363-15368.
8. Buckle, V. J., D. R. Higgs, A. O. M. Wilkie, M. Super, and D. J. Weatherall. 1988. Localization of human alpha-globin to 16p13.3-pter. J. Med. Genet. 25:847-859.
9. Cereghini, S., and M. Yaniv. 1984. Assembly of transfected DNA into chromatin: structural changes in the origin-promoter-enhancer region upon replication. EMBO J. 3:1243-1253.
10. Charnay, P., R. Treisman, P. Mellon, M. Chao, R. Axel, and T. Maniatis. 1984. Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell 38:251-263.
11. Cheng, J. F., L. Raid, and R. C. Hardison. 1986. Isolation and nucleotide sequence of the rabbit gene cluster ψζ-α1-ψα. J. Biol. Chem. 261:839-848.
12. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
13. Chung, S., and R. P. Perry. 1989. Importance of introns for expression of mouse ribosomal protein gene rpL32. Mol. Cell. Biol. 9:2075-2082.
14. Craddock, C. F., P. Vyas, J. A. Sharpe, H. Ayyub, W. G. Wood, and D. R. Higgs. 1995. Contrasting effects of α and β globin regulatory elements on chromatin structure may be related to their different chromosomal environments. EMBO J. 14:1718-1726.
15. Deisseroth, A., and D. Hendrick. 1978. Human α-globin gene expression following chromosomal dependent gene transfer into mouse erythroleukemia cells. Cell 15:55-63.
16. Fischel-Ghodsian, N., R. D. Nichols, and D. R. Higgs. 1987. Unusual features of CpG-rich (HTF) islands in the human α-globin complex: association with nonfunctional pseudogenes and presence within the 3′ portion of the ζ genes. Nucleic Acids Res. 15:9215-9225.
17. Gardiner-Garden, M., and M. Frommer. 1987. CpG islands in vertebrate genomes. J. Mol. Biol. 196:261-282.
18. Hanscombe, O., M. Vidal, J. Kaeda, L. Luzzatto, D. R. Greaves, and F. Grosveld. 1989. High-level, erythroid-specific expression of the human α-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes. Genes Dev. 3:1572-1581.
19. Hardison, R. C., D. Krane, D. Vandenbergh, J.-F. Cheng, J. Mansberger, J. Taddie, S. Schwartz, X. Huang, and W. Miller. 1991. Sequence and comparative analysis of the rabbit α-like globin gene cluster reveals a rapid mode of evolution in a G+C-rich region of mammalian genomes. J. Mol. Biol. 222:233-249.
20. Higgs, D. R., W. G. Wood, A. P. Jarman, J. Lida, I.-M. Pretorius, and H. Ayyub. 1990. A major positive regulatory region located far upstream of the human alpha-globin gene locus. Genes Dev. 4:1588-1601.
21. Humphries, R. K., T. Ley, P. Turner, A. D. Moulton, and A. W. Nienhuis. 1982. Differences in human α-, β- and δ-globin gene expression in monkey kidney cells. Cell 30:173-183.
22. James-Pederson, M., S. Yost, B. Shewchuk, T. Zeigler, R. Miller, and R. Hardison. 1995. Flanking and intragenic sequences regulating the expression of the rabbit α-globin gene. J. Biol. Chem. 270:3965-3973.
23. Kim, C. G., S. L. Swendeman, K. M. Barnhart, and M. Sheffery. 1990. Promoter elements and erythroid cell nuclear factors that regulate α-globin gene transcription in vitro. Mol. Cell. Biol. 10:5958-5966.
24. Laker, C., C. Stocking, U. Bergholz, N. Hess, J. F. DeLamarter, and W. Ostertag. 1987. Autocrine stimulation after transfer of the granulocyte/macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathway. Proc. Natl. Acad. Sci. USA 84:8458-8462.
25. Mellon, P., V. Parker, Y. Gluzman, and T. Maniatis. 1981. Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system. Cell 27:279-288.
26. Melton, D. A., P. A. Krieg, M. R. Rebagliati, T. Maniatis, K. Zinn, and M. Green. 1984. Efficient in vitro synthesis of biologically active RNA and RNA probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12:7035-7056.
27. Neumann, E., M. Schaefer-Ridder, Y. Wang, and P. Hofschneider. 1982. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J. 1:841-845.
28. Noti, J. D., B. C. Reinemann, and M. Petrus. 1996. Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with API to activate transcription. Mol. Cell. Biol. 16:2940-2950.
29. Palmiter, R. D., and R. L. Brinster. 1986. Germline transformation of mice. Annu. Rev. Genet. 20:465-499.
30. Pascal, E., and R. Tjian. 1991. Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism. Genes Dev. 5:1646-1656.
31. Pondel, M. D., M. George, and N. J. Proudfoot. 1992. The LCR-like α-globin positive regulatory element functions as an enhancer in transiently transfected cells during erythroid differentiation. Nucleic Acids Res. 20:237-243.
32. Pondel, M. D., S. Murphy, L. Pearson, C. Craddock, and N. J. Proudfoot. 1995. Sp1 functions in a chromatin-dependent manner to augment human α-globin promoter activity. Proc. Natl. Acad. Sci. USA 92:7237-7241.
33. Potter, H., L. Weir, and P. Leder. 1984. Enhancer-dependent expression of human K immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc. Natl. Acad. Sci. USA 81:7161-7165.
34. Price, D. K., J. A. Ayres, D. Pasqualone, C. H. Cabell, W. Miller, and R. C. Hardison. 1991. The 5′ end of LINE1 repeats in rabbit DNA define subfamilies and reveal a short sequence conserved between rabbits and humans. Genomics 14:320-331.
35. Reeves, R., C. M. Gorman, and B. Howard. 1985. Minichromosome assembly of non-integrated plasmid DNA transfected into mammalian cells. Nucleic Acids Res. 13:3599-3615.
36. Ren S., X. Luo, and G. F. Atweh. 1993. The major regulatory element upstream of the α-globin gene has classical and inducible enhancer activity. Blood 81:1058-1066.
37. Rombel, I., K.-Y. Hu, Q. Zhang, T. Papayannopoulou, G. Stamatoyannopoulos, and C.-K. J. Shen. 1995. Transcriptional activation of human adult α-globin genes by hypersensitive site -40 enhancer: function of nuclear factor-binding motifs occupied in erythroid cells. Proc. Natl. Acad. Sci. USA 92:6454-6458.
38. Ryan, T. M., R. R. Behringer, T. M. Townes, R. D. Palmiter, and R. L. Brinster. 1989. High-level erythroid expression of human α-globin genes in transgenic mice. Proc. Natl. Acad. Sci. USA 86:37-41.
39. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
40. Shen, C.-K. J., and T. Maniatis. 1980. Tissue-specific DNA methylation in a cluster of rabbit β-like globin genes. Proc. Natl. Acad. Sci. USA 77:6634-6638.
41. Shewchuk, B. M. 1997. Effect of CpG islands from the α-globin gene cluster on gene expression: evidence for a chromatic-dependent activity. Ph.D. thesis. Pennsylvania State University, University Park, Pa.
42. Tazi, J., and A. Bird. 1990. Alternative chromatin structure at CpG islands. Cell 60:909-920.
43. Thompson, J. P., C. P. Simkevich, M. A. Holness, A. H. Kang, and R. Raghow. 1991. In vitro methylation of the promoter and enhancer of Proζ1(I) collagen gene leads to its transcriptional inactivation. J. Biol. Chem. 266:2549-2556.
44. Vandenbergh, D. J., M. James-Pederson, and R. C. Hardison. 1991. An apparent pause site in the transcription unit of the rabbit α-globin gene. J. Mol. Biol. 220:255-270.
45. van der Ploeg, L. H., and R. A. Flavell. 1980. DNA mcthylation in the human γ-δ-β-globin locus in erythroid and nonerythroid tissues. Cell 19:947-958.
46. Vihinen, T., A. Maatta, P. Jaakkola, P. Auvinen, and M. Jalkanen. 1996. Functional characterization of mouse syndecan-1 promoter. J. Biol. Chem. 271:12532-12541.
47. Whitelaw, E., P. Hobgen, O. Hanscombe, and N. J. Proudfoot. 1989. Transcriptional promiscuity of the human α-globin gene. Mol. Cell. Biol. 9:241-251.
48. Xu, J., and R. C. Hardison. 1991. Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization. Genomics 9:362-365.
49. Yang, J.-Q., E. F. Remmers, and K. B. Marcu. 1986. The first exon of the c-myc proto-oncogene contains a novel positive control clement. EMBO J. 5:3553-3562.
50. Yost, S. E. 1991. Ph.D. thesis. The Pennsylvania State University, University Park.
51. Yost, S. E., B. Shewchuk, and R. Hardison. 1993. Nuclear protein binding sites in a transcriptional control region of the rabbit α-globin gene. Mol. Cell. Biol. 13:5439-5449.
52. Yu, C.-Y., K. Motamed, J. Chen, A. D. Bailey, and C.-K. Shen. 1991. The CACC box upstream of human embryonic epsilon globin gene binds Sp1 and is a functional promoter element in vitro and in vivo. J. Biol. Chem. 266: 8907-8915.