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Volumn 47, Issue 6, 2000, Pages 694-706

The role of B cells and autoantibodies in multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

EID: 0034120945     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(200006)47:6<694::AID-ANA2>3.0.CO;2-W     Document Type: Article
Times cited : (228)

References (114)
  • 1
    • 0001494206 scopus 로고
    • The application of tissue culture to the study of experimental "allergic" encephalomyelitis. I. Patterns of demyelination
    • Bornstein MB, Appel SH. The application of tissue culture to the study of experimental "allergic" encephalomyelitis. I. Patterns of demyelination. J Neuropathol Exp Neurol 1961;20: 141-147
    • (1961) J Neuropathol Exp Neurol , vol.20 , pp. 141-147
    • Bornstein, M.B.1    Appel, S.H.2
  • 2
    • 0001398471 scopus 로고
    • Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods
    • Kabat EA, Glusman M, Knaub V. Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods. Am J Med 1948;4:653-662
    • (1948) Am J Med , vol.4 , pp. 653-662
    • Kabat, E.A.1    Glusman, M.2    Knaub, V.3
  • 3
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • 1996
    • Rajewski K. 1996. Clonal selection and learning in the antibody system. Nature 1996;381:751-758
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewski, K.1
  • 4
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-252
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 5
    • 0031032213 scopus 로고    scopus 로고
    • B-cell development and differentiation
    • Duchosal MA. B-cell development and differentiation. Semin Hematol 1997;34:2-12
    • (1997) Semin Hematol , vol.34 , pp. 2-12
    • Duchosal, M.A.1
  • 6
    • 0032476611 scopus 로고    scopus 로고
    • + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
    • + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998;188:1679-1689
    • (1998) J Exp Med , vol.188 , pp. 1679-1689
    • Klein, U.1    Rajewski, K.2    Küppers, R.3
  • 7
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-793
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 8
    • 0031927364 scopus 로고    scopus 로고
    • Crossregulation between Th1 and Th2 cells
    • Morel PA, Oriss TB. Crossregulation between Th1 and Th2 cells. Grit Rev Immunol 1998;18:275-303
    • (1998) Grit Rev Immunol , vol.18 , pp. 275-303
    • Morel, P.A.1    Oriss, T.B.2
  • 10
    • 0032033419 scopus 로고    scopus 로고
    • Cytokines induce the development of functionally heterogenous T helper cell subsets
    • O'Garra A. Cytokines induce the development of functionally heterogenous T helper cell subsets. Immunity 1998;8:275-283
    • (1998) Immunity , vol.8 , pp. 275-283
    • O'Garra, A.1
  • 11
    • 0031172781 scopus 로고    scopus 로고
    • The Th1/Th2 paradigm
    • Romagnani S. The Th1/Th2 paradigm. Immunol Today 1997;18:263-266
    • (1997) Immunol Today , vol.18 , pp. 263-266
    • Romagnani, S.1
  • 12
    • 0028941871 scopus 로고
    • The adhesion molecule and cytokine profile of multiple sclerosis lesions
    • Cannella B, Raine CS. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 1995;37:424-435
    • (1995) Ann Neurol , vol.37 , pp. 424-435
    • Cannella, B.1    Raine, C.S.2
  • 13
    • 0029762023 scopus 로고    scopus 로고
    • Cytokines and the pathogenesis of multiple sclerosis
    • Navikas V, Link H. Cytokines and the pathogenesis of multiple sclerosis. J Neurosci Res 1996;45:322-333
    • (1996) J Neurosci Res , vol.45 , pp. 322-333
    • Navikas, V.1    Link, H.2
  • 14
    • 0032706818 scopus 로고    scopus 로고
    • The B7-CD28/ CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system
    • Anderson DE, Sharpe AH, Haller DA. The B7-CD28/ CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Curr Opin Immunol 1999;11:677-683
    • (1999) Curr Opin Immunol , vol.11 , pp. 677-683
    • Anderson, D.E.1    Sharpe, A.H.2    Haller, D.A.3
  • 15
    • 0033118746 scopus 로고    scopus 로고
    • B cell development: Signal transduction by antigen receptors and their surrogates
    • Benschop RJ, Cambier JC. B cell development: signal transduction by antigen receptors and their surrogates. Curr Opin Immunol 1999;11:143-151
    • (1999) Curr Opin Immunol , vol.11 , pp. 143-151
    • Benschop, R.J.1    Cambier, J.C.2
  • 16
    • 0030913776 scopus 로고    scopus 로고
    • B-cell activation versus tolerance: The central role of immunoglobulin receptor engagement and T-cell help
    • Fulcher DA, Basten A. B-cell activation versus tolerance: the central role of immunoglobulin receptor engagement and T-cell help. Intern Rev Immunol 1997;15:33-52
    • (1997) Intern Rev Immunol , vol.15 , pp. 33-52
    • Fulcher, D.A.1    Basten, A.2
  • 17
    • 0002929410 scopus 로고
    • The cerebrospinal fluid in multiple sclerosis
    • Koetsier JC, ed. Amsterdam: Elsevier
    • Tourtelotte WW. The cerebrospinal fluid in multiple sclerosis. In: Koetsier JC, ed. Handbook of clinical neurology: demyelinating diseases, vol 47. Amsterdam: Elsevier, 1985:79-130
    • (1985) Handbook of Clinical Neurology: Demyelinating Diseases , vol.47 , pp. 79-130
    • Tourtelotte, W.W.1
  • 18
    • 0032167731 scopus 로고    scopus 로고
    • Clonal expansion and somatic hypermutation of VH genes of B cells from cerebrospinal fluid in multiple sclerosis
    • Qin Y, Duquette P, Zhang Y, et al. Clonal expansion and somatic hypermutation of VH genes of B cells from cerebrospinal fluid in multiple sclerosis. J Clin Invest 1998;102: 1045-1050
    • (1998) J Clin Invest , vol.102 , pp. 1045-1050
    • Qin, Y.1    Duquette, P.2    Zhang, Y.3
  • 19
    • 0031594141 scopus 로고    scopus 로고
    • H4 germline segments in an acute multiple sclerosis brain
    • H4 germline segments in an acute multiple sclerosis brain. Ann Neurol 1998;43:236-243
    • (1998) Ann Neurol , vol.43 , pp. 236-243
    • Owens, G.P.1    Kraus, H.2    Burgoon, M.P.3
  • 20
    • 0032758913 scopus 로고    scopus 로고
    • B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions
    • Baranzini SE, Jeong MC, Butunoi C, et al. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol 1999;163:5133-5144
    • (1999) J Immunol , vol.163 , pp. 5133-5144
    • Baranzini, S.E.1    Jeong, M.C.2    Butunoi, C.3
  • 21
    • 0242393167 scopus 로고    scopus 로고
    • Autoantibodies in demyelinating disease
    • Cook SD, ed. New York: Marcel-Dekker
    • Trotter JL, Cross AH. Autoantibodies in demyelinating disease. In: Cook SD, ed. Handbook of multiple sclerosis, 2nd ed. New York: Marcel-Dekker, 1996:187-199
    • (1996) Handbook of Multiple Sclerosis, 2nd Ed. , pp. 187-199
    • Trotter, J.L.1    Cross, A.H.2
  • 22
    • 0032080456 scopus 로고    scopus 로고
    • Dual implication of 2́,3́-cyclic nucleotide 3́ phosphodiesterase as a major autoantigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis
    • Walsh MJ, Murray JM. Dual implication of 2́,3́-cyclic nucleotide 3́ phosphodiesterase as a major autoantigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis, J Clin Invest 1998;101:1923-1931
    • (1998) J Clin Invest , vol.101 , pp. 1923-1931
    • Walsh, M.J.1    Murray, J.M.2
  • 23
    • 0028303658 scopus 로고
    • Presence of anti-CSL antibodies in the cerebrospinal fluid of patients: A sensitive and specific test in the diagnosis of multiple sclerosis
    • Zanetta JP, Tranchant C, Kuchler-Bopp S, et al. Presence of anti-CSL antibodies in the cerebrospinal fluid of patients: a sensitive and specific test in the diagnosis of multiple sclerosis. J Neuroimmunol 1994;52:175-182
    • (1994) J Neuroimmunol , vol.52 , pp. 175-182
    • Zanetta, J.P.1    Tranchant, C.2    Kuchler-Bopp, S.3
  • 24
    • 0031890230 scopus 로고    scopus 로고
    • Isolation and characterization of an oligodendrocyte-precursor-derived B cell epitope in multiple sclerosis
    • Archelos JJ, Trotter J, Previtali S, et al. Isolation and characterization of an oligodendrocyte-precursor-derived B cell epitope in multiple sclerosis. Ann Neurol 1998;43:15-24
    • (1998) Ann Neurol , vol.43 , pp. 15-24
    • Archelos, J.J.1    Trotter, J.2    Previtali, S.3
  • 25
    • 23444446413 scopus 로고
    • Humoral response to hsp 65 in multiple sclerosis and other neurologic conditions
    • Gao YL, Raine CS, Brosnan CF. Humoral response to hsp 65 in multiple sclerosis and other neurologic conditions. Neurology 1994;44:941-946
    • (1994) Neurology , vol.44 , pp. 941-946
    • Gao, Y.L.1    Raine, C.S.2    Brosnan, C.F.3
  • 26
    • 0028030870 scopus 로고
    • Heat shock protein immunoreactivity in CSF: Correlation with oligoclonal banding and demyelinating disease
    • Prabhakar S, Kurien E, Gupta RS, et al. Heat shock protein immunoreactivity in CSF: correlation with oligoclonal banding and demyelinating disease. Neurology 1994;44:1644-1648
    • (1994) Neurology , vol.44 , pp. 1644-1648
    • Prabhakar, S.1    Kurien, E.2    Gupta, R.S.3
  • 27
    • 0026011051 scopus 로고
    • Multiple sclerosis: Cells secreting antibodies against myelin-associated glycoprotein are present in CSF
    • Baig S, Olsson T, Jiang YP, et al. Multiple sclerosis: cells secreting antibodies against myelin-associated glycoprotein are present in CSF. Scand J Immunol 1991;33:73-79
    • (1991) Scand J Immunol , vol.33 , pp. 73-79
    • Baig, S.1    Olsson, T.2    Jiang, Y.P.3
  • 28
    • 0024502365 scopus 로고
    • Antibodies to myelin-associated glycoprotein (MAG) in the cerebrospinal fluid of multiple sclerosis patients
    • Möller JR, Johnson D, Brady RO, et al. Antibodies to myelin-associated glycoprotein (MAG) in the cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 1989;22:55-61
    • (1989) J Neuroimmunol , vol.22 , pp. 55-61
    • Möller, J.R.1    Johnson, D.2    Brady, R.O.3
  • 29
    • 0021048616 scopus 로고
    • CSF antibodies to myelin basic protein and to myelin-associated glycoprotein in multiple sclerosis: Evidence of the intrathecal production of antibodies
    • Wajgt A, Corny M. CSF antibodies to myelin basic protein and to myelin-associated glycoprotein in multiple sclerosis: evidence of the intrathecal production of antibodies. Acta Neurol Scand 1983;68:337-343
    • (1983) Acta Neurol Scand , vol.68 , pp. 337-343
    • Wajgt, A.1    Corny, M.2
  • 30
    • 0023223026 scopus 로고
    • Immunoblot detection of oligoclonal anti-myelin basic protein IgG antibodies in cerebrospinal fluid in multiple sclerosis
    • Cruz M, Olsson T, Ernerudt J, et al. Immunoblot detection of oligoclonal anti-myelin basic protein IgG antibodies in cerebrospinal fluid in multiple sclerosis. Neurology 1987;37: 1515-1519
    • (1987) Neurology , vol.37 , pp. 1515-1519
    • Cruz, M.1    Olsson, T.2    Ernerudt, J.3
  • 31
    • 0028348545 scopus 로고
    • Anti-myelin basic protein and anti-proteolipid protein specific forms of multiple sclerosis
    • Warren KG, Catz I, Johnson E, Mielke B. Anti-myelin basic protein and anti-proteolipid protein specific forms of multiple sclerosis. Ann Neurol 1994;35:280-289
    • (1994) Ann Neurol , vol.35 , pp. 280-289
    • Warren, K.G.1    Catz, I.2    Johnson, E.3    Mielke, B.4
  • 32
    • 0022504515 scopus 로고
    • Serum and cerebrospinal fluid antibodies against myelin basic protein and their IgG subclass distribution in multiple sclerosis
    • García-Merino A, Persson MAA, Ernerudh J, et al. Serum and cerebrospinal fluid antibodies against myelin basic protein and their IgG subclass distribution in multiple sclerosis. J Neurol Neurosurg Psych 1986;49:1066-1070
    • (1986) J Neurol Neurosurg Psych , vol.49 , pp. 1066-1070
    • García-Merino, A.1    Persson, M.A.A.2    Ernerudh, J.3
  • 33
    • 0026088037 scopus 로고
    • Antibodies to myelinoligodendrocyte glycoprotein in cerebrospinal fluid from patients wirh multiple sclerosis and controls
    • Xiao BG, Linington C, Link H. Antibodies to myelinoligodendrocyte glycoprotein in cerebrospinal fluid from patients wirh multiple sclerosis and controls. J Neuroimmunol 1991;31:91-96
    • (1991) J Neuroimmunol , vol.31 , pp. 91-96
    • Xiao, B.G.1    Linington, C.2    Link, H.3
  • 34
    • 0025979945 scopus 로고
    • T and B cell responses to myelin oligodendrocyte glycoprotein in multiple sclerosis
    • Sun J, Link H, Olsson T, et al. T and B cell responses to myelin oligodendrocyte glycoprotein in multiple sclerosis. J Immunol 1991;146:1490-1495
    • (1991) J Immunol , vol.146 , pp. 1490-1495
    • Sun, J.1    Link, H.2    Olsson, T.3
  • 35
    • 0033059092 scopus 로고    scopus 로고
    • Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis
    • Karni A, Bakimer-Kleiner R, Abramsky O, Ben-Nun A. Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis. Arch Neurol 1999;56:311-315
    • (1999) Arch Neurol , vol.56 , pp. 311-315
    • Karni, A.1    Bakimer-Kleiner, R.2    Abramsky, O.3    Ben-Nun, A.4
  • 36
    • 0032723691 scopus 로고    scopus 로고
    • Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: A comparative study
    • Reindl M, Linington C, Brehm U, et al. Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study. Brain 1999;122:2047-2056
    • (1999) Brain , vol.122 , pp. 2047-2056
    • Reindl, M.1    Linington, C.2    Brehm, U.3
  • 37
    • 0032753320 scopus 로고    scopus 로고
    • Multiple sclerosis: B-and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein
    • Lindert RB, Haase CG, Brehm U, et al. Multiple sclerosis: B-and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain 1999;122:2089-2099
    • (1999) Brain , vol.122 , pp. 2089-2099
    • Lindert, R.B.1    Haase, C.G.2    Brehm, U.3
  • 38
    • 0025909739 scopus 로고
    • Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls
    • Sun J, Olsson T, Wang WZ, et al. Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur J Immunol 1991;21:1461-1468
    • (1991) Eur J Immunol , vol.21 , pp. 1461-1468
    • Sun, J.1    Olsson, T.2    Wang, W.Z.3
  • 39
    • 0030901670 scopus 로고    scopus 로고
    • Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis
    • Colombo K, Banki K, Tatum AH, et al. Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis. J Clin Invest 1997;99:1238-1250
    • (1997) J Clin Invest , vol.99 , pp. 1238-1250
    • Colombo, K.1    Banki, K.2    Tatum, A.H.3
  • 40
    • 0033551485 scopus 로고    scopus 로고
    • A humoral response to oligodendrocyte-specitic protein in MS
    • Bronstein JM, Lallone RL, Seitz RS, et al. A humoral response to oligodendrocyte-specitic protein in MS. Neurology 1999; 53:154-161
    • (1999) Neurology , vol.53 , pp. 154-161
    • Bronstein, J.M.1    Lallone, R.L.2    Seitz, R.S.3
  • 42
    • 0030784484 scopus 로고    scopus 로고
    • CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes
    • Inaoki M, Sato S, Weintraub BC, et al. CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. J Exp Med 1997;186: 1923-1931
    • (1997) J Exp Med , vol.186 , pp. 1923-1931
    • Inaoki, M.1    Sato, S.2    Weintraub, B.C.3
  • 43
    • 0033583479 scopus 로고    scopus 로고
    • Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies
    • O'Keefe TL, Williams GT, Batista FD, Neuberger MS. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med 1999;189:1307-1313
    • (1999) J Exp Med , vol.189 , pp. 1307-1313
    • O'Keefe, T.L.1    Williams, G.T.2    Batista, F.D.3    Neuberger, M.S.4
  • 44
    • 0031942986 scopus 로고    scopus 로고
    • Transcriptional regulation during B cell development
    • Henderson A, Calame K. Transcriptional regulation during B cell development. Annu Rev Immunol 1998;16:163-200
    • (1998) Annu Rev Immunol , vol.16 , pp. 163-200
    • Henderson, A.1    Calame, K.2
  • 45
    • 0030459465 scopus 로고    scopus 로고
    • B cells in systemic autoimmune disease: Recent insights from Fas-deficient mice and men
    • Elkon KB, Marshak-Rothstein. B cells in systemic autoimmune disease: recent insights from Fas-deficient mice and men. Curr Opin Immunol 1996;8:852-859
    • (1996) Curr Opin Immunol , vol.8 , pp. 852-859
    • Elkon, K.B.1    Marshak-Rothstein2
  • 46
    • 0030740708 scopus 로고    scopus 로고
    • B-cell superantigens
    • Silvermans GJ. B-cell superantigens. Immunol Today 1997; 18:379-386
    • (1997) Immunol Today , vol.18 , pp. 379-386
    • Silvermans, G.J.1
  • 47
    • 0033619915 scopus 로고    scopus 로고
    • Molecular mimicry and autoimmunity
    • Albert LJ, Inman RD. Molecular mimicry and autoimmunity. N Engl J Med 1999;341:2068-2074
    • (1999) N Engl J Med , vol.341 , pp. 2068-2074
    • Albert, L.J.1    Inman, R.D.2
  • 48
    • 0032915806 scopus 로고    scopus 로고
    • Molecular mimicry and multiple sclerosis: Degenerate T cell recognition and the induction of autoimmunity
    • Gran B, Hemmer B, Vergelli M, et al Molecular mimicry and multiple sclerosis: degenerate T cell recognition and the induction of autoimmunity. Ann Neurol 1999;45:559-567
    • (1999) Ann Neurol , vol.45 , pp. 559-567
    • Gran, B.1    Hemmer, B.2    Vergelli, M.3
  • 49
    • 0027503708 scopus 로고
    • Correlation between magnetic resonance imaging and lesion development in chronic active multiple sclerosis
    • Katz D, Taubenberger JK, Cannella B, et al. Correlation between magnetic resonance imaging and lesion development in chronic active multiple sclerosis. Ann Neurol 1993;34:661-669
    • (1993) Ann Neurol , vol.34 , pp. 661-669
    • Katz, D.1    Taubenberger, J.K.2    Cannella, B.3
  • 50
    • 0030797232 scopus 로고    scopus 로고
    • Pathology and pathogenesis of demyelinating diseases
    • Storch MK, Lassmann H. Pathology and pathogenesis of demyelinating diseases. Curr Opin Neurol 1997;10:186-192
    • (1997) Curr Opin Neurol , vol.10 , pp. 186-192
    • Storch, M.K.1    Lassmann, H.2
  • 51
    • 0031921084 scopus 로고    scopus 로고
    • The role of complement and complement receptors in induction and regulation of immunity
    • Carroll MC. The role of complement and complement receptors in induction and regulation of immunity. Annu Rev Immunol 1998;16:545-568
    • (1998) Annu Rev Immunol , vol.16 , pp. 545-568
    • Carroll, M.C.1
  • 52
    • 0025639032 scopus 로고
    • Immunological and neuropathological significance of the Virchow-Robin space
    • Esiri MM, Gay D. Immunological and neuropathological significance of the Virchow-Robin space. J Neurol Sci 1990;100: 3-8
    • (1990) J Neurol Sci , vol.100 , pp. 3-8
    • Esiri, M.M.1    Gay, D.2
  • 53
    • 0018760184 scopus 로고
    • Multiple sclerosis: Presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord
    • Prineas JW. Multiple sclerosis: presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord. Science 1979;203:1123-1125
    • (1979) Science , vol.203 , pp. 1123-1125
    • Prineas, J.W.1
  • 54
    • 0032727128 scopus 로고    scopus 로고
    • The role of anti-myelin (auto)-antibodies in the phagocytosis of myelin by macrophages
    • Van der Goes A, Kortekaas M, Hoekstra K, et al. The role of anti-myelin (auto)-antibodies in the phagocytosis of myelin by macrophages. J Neuroimmunol 1999;101:61-67
    • (1999) J Neuroimmunol , vol.101 , pp. 61-67
    • Van Der Goes, A.1    Kortekaas, M.2    Hoekstra, K.3
  • 55
    • 0029314742 scopus 로고
    • Circulating adhesion molecules and inflammatory mediators in demyelination. A review
    • Hartung HP, Archelos JJ, Zielasek J, et al. Circulating adhesion molecules and inflammatory mediators in demyelination. a review. Neurology 1995;45(Suppl 6):S22-S32
    • (1995) Neurology , vol.45 , Issue.SUPPL. 6
    • Hartung, H.P.1    Archelos, J.J.2    Zielasek, J.3
  • 56
    • 0028869485 scopus 로고
    • The structural requirements for complement activation by IgG: Does it hinge on the hinge?
    • Brekke OH, Michaelsen TE, Sandlie I. The structural requirements for complement activation by IgG: does it hinge on the hinge? Immunol Today 1995;16:85-90
    • (1995) Immunol Today , vol.16 , pp. 85-90
    • Brekke, O.H.1    Michaelsen, T.E.2    Sandlie, I.3
  • 57
    • 0030174530 scopus 로고    scopus 로고
    • Effect of immunoglobulin variable region structure on C3b and C4b deposition
    • White KD, Frank MB, Foundling S, Waxman FJ. Effect of immunoglobulin variable region structure on C3b and C4b deposition. Mol Immunol 1996;33:759-768
    • (1996) Mol Immunol , vol.33 , pp. 759-768
    • White, K.D.1    Frank, M.B.2    Foundling, S.3    Waxman, F.J.4
  • 58
    • 0033168629 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: Disease susceptibility is determined by MHC and MHC-linked effects on the B-cell response
    • Stefferl A, Brehm U, Storch M, et al. Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B-cell response. J Immunol 1999;163:40-49
    • (1999) J Immunol , vol.163 , pp. 40-49
    • Stefferl, A.1    Brehm, U.2    Storch, M.3
  • 59
    • 0032964881 scopus 로고    scopus 로고
    • Autoimmunity and neurological disease: Antibody modulation of synaptic transmission
    • Whitney KD, McNamara JO. Autoimmunity and neurological disease: antibody modulation of synaptic transmission. Annu Rev Neurosci 1999;22:175-195
    • (1999) Annu Rev Neurosci , vol.22 , pp. 175-195
    • Whitney, K.D.1    McNamara, J.O.2
  • 60
    • 0000603927 scopus 로고    scopus 로고
    • Experimental models of multiple sclerosis
    • Compston A, Ebers G, Lassmann H, et al, eds. London: Churchill Livingstone
    • Lassmann H, Wekerle H. Experimental models of multiple sclerosis. In: Compston A, Ebers G, Lassmann H, et al, eds. McAlpine's multiple sclerosis. 3rd ed. London: Churchill Livingstone, 1998:409-433
    • (1998) McAlpine's Multiple Sclerosis. 3rd Ed. , pp. 409-433
    • Lassmann, H.1    Wekerle, H.2
  • 61
    • 0030056639 scopus 로고    scopus 로고
    • Mechanisms of immune injury in multiple sclerosis
    • Brosnan CF, Raine CR. Mechanisms of immune injury in multiple sclerosis. Brain Pathol 1996;6:243-257
    • (1996) Brain Pathol , vol.6 , pp. 243-257
    • Brosnan, C.F.1    Raine, C.R.2
  • 62
    • 0345633543 scopus 로고    scopus 로고
    • A quantitative analysis of oligodendrocytes in multiple sclerosis lesions: A study of 113 cases
    • Lucchinetti C, Brück W, Parisi J, et al. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions: a study of 113 cases. Brain 1999;122:2279-2295
    • (1999) Brain , vol.122 , pp. 2279-2295
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3
  • 63
    • 0016684155 scopus 로고
    • The significance of perivascular infiltrations in multiple sclerosis
    • Guseo A, Jellinger K. The significance of perivascular infiltrations in multiple sclerosis. J Neurol 1975;211:51-60
    • (1975) J Neurol , vol.211 , pp. 51-60
    • Guseo, A.1    Jellinger, K.2
  • 64
    • 0017645154 scopus 로고
    • Immunoglobulin-containing cells in multiple sclerosis plaques
    • Esiri MM. Immunoglobulin-containing cells in multiple sclerosis plaques. Lancet 1977;2:478-480
    • (1977) Lancet , vol.2 , pp. 478-480
    • Esiri, M.M.1
  • 65
    • 0018098512 scopus 로고
    • Macrophages, lymphocytes and plasma cells in the perivascular compartment in chronic multiple sclerosis
    • Prineas JW, Wright RG. Macrophages, lymphocytes and plasma cells in the perivascular compartment in chronic multiple sclerosis. Lab Invest 1978;38:409-421
    • (1978) Lab Invest , vol.38 , pp. 409-421
    • Prineas, J.W.1    Wright, R.G.2
  • 66
    • 0028578038 scopus 로고
    • Patterns of oligodendroglia pathology in multiple sclerosis
    • Ozawa K, Suchanek G, Breitschopf H, et al. Patterns of oligodendroglia pathology in multiple sclerosis. Brain 1994;117: 1311-1322
    • (1994) Brain , vol.117 , pp. 1311-1322
    • Ozawa, K.1    Suchanek, G.2    Breitschopf, H.3
  • 67
    • 0018959296 scopus 로고
    • Multiple sclerosis: Serum gamma globulin and demyelination in culture
    • Grundke-Iqbal I, Bornstein MB. Multiple sclerosis: serum gamma globulin and demyelination in culture. Neurology 1980;30:749-754
    • (1980) Neurology , vol.30 , pp. 749-754
    • Grundke-Iqbal, I.1    Bornstein, M.B.2
  • 68
    • 0030961031 scopus 로고    scopus 로고
    • Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes
    • Wucherpfennig K, Catz I, Hausmann S, et al. Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes. J Clin Invest 1997;100:1114-1122
    • (1997) J Clin Invest , vol.100 , pp. 1114-1122
    • Wucherpfennig, K.1    Catz, I.2    Hausmann, S.3
  • 69
    • 0032950794 scopus 로고    scopus 로고
    • Identification of autoantibodies associated with myelin damage in multiple sclerosis
    • Genain CP, Cannella B, Hauser SL, Raine CS. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 1999;5:170-175
    • (1999) Nat Med , vol.5 , pp. 170-175
    • Genain, C.P.1    Cannella, B.2    Hauser, S.L.3    Raine, C.S.4
  • 70
    • 0032839687 scopus 로고    scopus 로고
    • Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: A case for antigen-specific antibody mediation
    • Raine CS, Cannella B, Hauser SL, Genain CP. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation. Ann Neurol 1999;46:144-160
    • (1999) Ann Neurol , vol.46 , pp. 144-160
    • Raine, C.S.1    Cannella, B.2    Hauser, S.L.3    Genain, C.P.4
  • 71
    • 0019469331 scopus 로고
    • Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown
    • Prineas JW, Graham JS. Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown. Ann Neurol 1981;10:149-158
    • (1981) Ann Neurol , vol.10 , pp. 149-158
    • Prineas, J.W.1    Graham, J.S.2
  • 72
    • 0017653791 scopus 로고
    • Immunofluorescence study of brain plaques front two patients with multiple sclerosis
    • Woyciechowska JL, Brzosko WJ. Immunofluorescence study of brain plaques front two patients with multiple sclerosis. Neurology 1977;27:620-622
    • (1977) Neurology , vol.27 , pp. 620-622
    • Woyciechowska, J.L.1    Brzosko, W.J.2
  • 73
    • 0015235073 scopus 로고
    • The immunogenesis of the multiple sclerosis plaque
    • Lumsden CE. The immunogenesis of the multiple sclerosis plaque. Brain Res 1971;28:365-390
    • (1971) Brain Res , vol.28 , pp. 365-390
    • Lumsden, C.E.1
  • 74
    • 0026013693 scopus 로고
    • Blood-brain harrier damage in acute multiple sclerosis plaques: An immunocytochemical study
    • Gay D, Esiri M. Blood-brain harrier damage in acute multiple sclerosis plaques: an immunocytochemical study. Brain 1991; 114:557-572
    • (1991) Brain , vol.114 , pp. 557-572
    • Gay, D.1    Esiri, M.2
  • 75
    • 1842367972 scopus 로고    scopus 로고
    • The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis: Identification and characterization of the primary demyelinating lesion
    • Gay FW, Drye TJ, Dick GWA, Esiri MM. The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis: identification and characterization of the primary demyelinating lesion. Brain 1997;120:1461-1483
    • (1997) Brain , vol.120 , pp. 1461-1483
    • Gay, F.W.1    Drye, T.J.2    Dick, G.W.A.3    Esiri, M.M.4
  • 76
    • 0024976416 scopus 로고
    • Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement
    • Scolding NJ, Morgan BP, Houston WA, et al. Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement. Nature 1989;339:620-622
    • (1989) Nature , vol.339 , pp. 620-622
    • Scolding, N.J.1    Morgan, B.P.2    Houston, W.A.3
  • 77
    • 0031748566 scopus 로고    scopus 로고
    • Multiple sclerosis: In situ evidence for antibody and complement mediated demyelination
    • Storch MK, Piddlesden S, Haltia M, et al. Multiple sclerosis: in situ evidence for antibody and complement mediated demyelination. Ann Neurol 1998;43:465-471
    • (1998) Ann Neurol , vol.43 , pp. 465-471
    • Storch, M.K.1    Piddlesden, S.2    Haltia, M.3
  • 78
    • 0030748022 scopus 로고    scopus 로고
    • The controversy surrounding the pathogenesis of the multiple sclerosis lesion
    • Lucchinetti CF, Rodriguez M. The controversy surrounding the pathogenesis of the multiple sclerosis lesion. Mayo Clin Proc 1997;72:665-678
    • (1997) Mayo Clin Proc , vol.72 , pp. 665-678
    • Lucchinetti, C.F.1    Rodriguez, M.2
  • 79
    • 0031688565 scopus 로고    scopus 로고
    • Autoimmunity to myelin oligodendrocyte glycoprotein (MOG) in rats mimics the spectrum of multiple sclerosis pathology
    • Storch MK, Stefferl A, Brehm U, et al. Autoimmunity to myelin oligodendrocyte glycoprotein (MOG) in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol 1998; 8:681-694
    • (1998) Brain Pathol , vol.8 , pp. 681-694
    • Storch, M.K.1    Stefferl, A.2    Brehm, U.3
  • 80
    • 0023893911 scopus 로고
    • Experimental allergic encephalomyelitis: The balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions
    • Lassmann H, Brunner C, Bradl M, Linington C. Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions. Acta Neuropathol 1988;75:566-576
    • (1988) Acta Neuropathol , vol.75 , pp. 566-576
    • Lassmann, H.1    Brunner, C.2    Bradl, M.3    Linington, C.4
  • 81
    • 0023931606 scopus 로고
    • Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/ oligodendrocyte glycoprotein
    • Linington C, Bradl M, Lassmann H, et al. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/ oligodendrocyte glycoprotein. Am J Pathol 1988;130:443-454
    • (1988) Am J Pathol , vol.130 , pp. 443-454
    • Linington, C.1    Bradl, M.2    Lassmann, H.3
  • 82
    • 0027733797 scopus 로고
    • The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement
    • Piddlesden SJ, Lassmann H, Zimprich F, et al. The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. Am J Pathol 1993;143:555-564
    • (1993) Am J Pathol , vol.143 , pp. 555-564
    • Piddlesden, S.J.1    Lassmann, H.2    Zimprich, F.3
  • 83
    • 0030937677 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein: A novel candidate autoantigen in multiple sclerosis
    • Bernard CCA, Johns TG, Slavin SAJ, et al. Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis. J Mol Med 1997;75:77-88
    • (1997) J Mol Med , vol.75 , pp. 77-88
    • Bernard, C.C.A.1    Johns, T.G.2    Slavin, S.A.J.3
  • 84
    • 0024535322 scopus 로고
    • Differential ultrastructural localization of myelin basic protein, myelin/ oligodendroglia glycoprotein and 2́, 3́-cyclic nucleotide 3́-phosphodiesterase in the CNS of adult rats
    • Brunner C, Lassmann H, Waehnelt TV, et al. Differential ultrastructural localization of myelin basic protein, myelin/ oligodendroglia glycoprotein and 2́, 3́-cyclic nucleotide 3́-phosphodiesterase in the CNS of adult rats. J Neurochem 1989;52:296-304
    • (1989) J Neurochem , vol.52 , pp. 296-304
    • Brunner, C.1    Lassmann, H.2    Waehnelt, T.V.3
  • 85
    • 0032531157 scopus 로고    scopus 로고
    • MHC haplotypedependent regulation of MOG-induced EAE in rats
    • Weissert R, Wallstrom E, Storch MK, et al. MHC haplotypedependent regulation of MOG-induced EAE in rats. J Clin Invest 1998;102:1265-1273
    • (1998) J Clin Invest , vol.102 , pp. 1265-1273
    • Weissert, R.1    Wallstrom, E.2    Storch, M.K.3
  • 86
    • 0032729174 scopus 로고    scopus 로고
    • B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide
    • Lyons JA, San M, Happ MP, Cross AH. B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide. Eur J Immunol 1999;29:3432-3439
    • (1999) Eur J Immunol , vol.29 , pp. 3432-3439
    • Lyons, J.A.1    San, M.2    Happ, M.P.3    Cross, A.H.4
  • 87
    • 2642638773 scopus 로고    scopus 로고
    • B lymphocytes producing demyelinating autoantibodies: Development and function in gene-targeted transgenic mice
    • Litzenburger T, Fässler R, Bauer J, et al. B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice. J Exp Med 1998;188: 169-180
    • (1998) J Exp Med , vol.188 , pp. 169-180
    • Litzenburger, T.1    Fässler, R.2    Bauer, J.3
  • 88
    • 0032758846 scopus 로고    scopus 로고
    • A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease
    • Weinshenker BG, O'Brien PC, Petterson TM, et al. A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease. Ann Neurol 1999; 46:878-886
    • (1999) Ann Neurol , vol.46 , pp. 878-886
    • Weinshenker, B.G.1    O'Brien, P.C.2    Petterson, T.M.3
  • 89
    • 0032173451 scopus 로고    scopus 로고
    • Targeting of IgMkappa antibodies to oligodendrocytes promotes CNS remyelination
    • Asakura K, Miller DJ, Pease LR, Rodriguez M. Targeting of IgMkappa antibodies to oligodendrocytes promotes CNS remyelination. J Neurosci 1998;18:7700-7708
    • (1998) J Neurosci , vol.18 , pp. 7700-7708
    • Asakura, K.1    Miller, D.J.2    Pease, L.R.3    Rodriguez, M.4
  • 91
    • 0025060269 scopus 로고
    • B cells expressing CD5 are increased in cerebrospinal fluid of patients with multiples sclerosis
    • Mix E, Olsson T, Correale J, et al. B cells expressing CD5 are increased in cerebrospinal fluid of patients with multiples sclerosis. Clin Exp Immunol 1990;79:21-27
    • (1990) Clin Exp Immunol , vol.79 , pp. 21-27
    • Mix, E.1    Olsson, T.2    Correale, J.3
  • 92
    • 0028951867 scopus 로고
    • B cell activation, tolerance and antigen-presenting function
    • Hodgkin PD, Basten A. B cell activation, tolerance and antigen-presenting function. Curr Opin Immunol 1995;7: 121-129
    • (1995) Curr Opin Immunol , vol.7 , pp. 121-129
    • Hodgkin, P.D.1    Basten, A.2
  • 93
    • 0029978178 scopus 로고    scopus 로고
    • CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis
    • Gerritse K, Laman JD, Noelle RJ, et al. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci USA 1996;93:2409-2504
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2409-2504
    • Gerritse, K.1    Laman, J.D.2    Noelle, R.J.3
  • 94
    • 17344363488 scopus 로고    scopus 로고
    • The functional significance of epitope spreading and its regulation by co-stimulatory molecules
    • Vanderlugt CT, Begolka WS, Neville KL, et al. The functional significance of epitope spreading and its regulation by co-stimulatory molecules. Immunol Rev 1998;164:63-72
    • (1998) Immunol Rev , vol.164 , pp. 63-72
    • Vanderlugt, C.T.1    Begolka, W.S.2    Neville, K.L.3
  • 95
    • 0030899404 scopus 로고    scopus 로고
    • Diversity and plasticity of self recognition during the development of multiple sclerosis
    • Tuohy VK, Yu M, Weinstock-Guttman B, Kinkel RP. Diversity and plasticity of self recognition during the development of multiple sclerosis. J Clin Invest 1997;99:1682-1690
    • (1997) J Clin Invest , vol.99 , pp. 1682-1690
    • Tuohy, V.K.1    Yu, M.2    Weinstock-Guttman, B.3    Kinkel, R.P.4
  • 96
    • 0032943375 scopus 로고    scopus 로고
    • Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNβ-1a) for relapsing multiple sclerosis
    • Rudick RA, Cookfair DL, Simonian NA, et al. Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNβ-1a) for relapsing multiple sclerosis. J Neuroimmunol 1999;93: 8-14
    • (1999) J Neuroimmunol , vol.93 , pp. 8-14
    • Rudick, R.A.1    Cookfair, D.L.2    Simonian, N.A.3
  • 97
  • 98
    • 0030741166 scopus 로고    scopus 로고
    • Production of cytokines by human B cells in health and disease
    • Pistoia V. Production of cytokines by human B cells in health and disease. Immunol Today 1997;18:343-350
    • (1997) Immunol Today , vol.18 , pp. 343-350
    • Pistoia, V.1
  • 99
    • 0031908501 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers in multiple sclerosis: An overview
    • Massaro AR, Tonali P. Cerebrospinal fluid markers in multiple sclerosis: an overview. Multiple Sclerosis 1998;4:1-4
    • (1998) Multiple Sclerosis , vol.4 , pp. 1-4
    • Massaro, A.R.1    Tonali, P.2
  • 100
    • 0028082170 scopus 로고
    • Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG
    • Ulvestad E, Williams K, Vedeler C, et al. Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG. J Neurol Sci 1994;121:125-131
    • (1994) J Neurol Sci , vol.121 , pp. 125-131
    • Ulvestad, E.1    Williams, K.2    Vedeler, C.3
  • 101
    • 0030271257 scopus 로고    scopus 로고
    • Expression of complement in the brain: Role in health and disease
    • Morgan BP, Gasque P. Expression of complement in the brain: role in health and disease. Immunol Today 1996;17: 461-466
    • (1996) Immunol Today , vol.17 , pp. 461-466
    • Morgan, B.P.1    Gasque, P.2
  • 102
    • 0033559346 scopus 로고    scopus 로고
    • Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
    • Sørensen TL, Tani M, Jensen J, et al. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 1999;103: 807-815
    • (1999) J Clin Invest , vol.103 , pp. 807-815
    • Sørensen, T.L.1    Tani, M.2    Jensen, J.3
  • 103
    • 0032752574 scopus 로고    scopus 로고
    • Role of the cervical lymphatics in the Th2-type hierarchy of CNS immune regulation
    • Harling-Berg CJ, Park JT, Knopf PM. Role of the cervical lymphatics in the Th2-type hierarchy of CNS immune regulation. J Neuroimmunol 1999;101:111-127
    • (1999) J Neuroimmunol , vol.101 , pp. 111-127
    • Harling-Berg, C.J.1    Park, J.T.2    Knopf, P.M.3
  • 104
    • 0032169223 scopus 로고    scopus 로고
    • Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease
    • Stott DI, Hiepe F, Hummel M, et al. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. J Clin Invest 1998;102:938-946
    • (1998) J Clin Invest , vol.102 , pp. 938-946
    • Stott, D.I.1    Hiepe, F.2    Hummel, M.3
  • 105
    • 0029134035 scopus 로고
    • Affinity of antigen-specific IgG distinguishes multiple sclerosis from encephalitis
    • Luxton RW, Zeman A, Holzel H, et al. Affinity of antigen-specific IgG distinguishes multiple sclerosis from encephalitis. J Neurol Sci 1995;132:11-19
    • (1995) J Neurol Sci , vol.132 , pp. 11-19
    • Luxton, R.W.1    Zeman, A.2    Holzel, H.3
  • 106
    • 0022656998 scopus 로고
    • Temporal invariance and clonal uniformity of brain and CSF IgG, IgA, and IgM in multiple sclerosis
    • Walsh MJ, Tourtelotte WW. Temporal invariance and clonal uniformity of brain and CSF IgG, IgA, and IgM in multiple sclerosis. J Exp Med 1986;163:41-53
    • (1986) J Exp Med , vol.163 , pp. 41-53
    • Walsh, M.J.1    Tourtelotte, W.W.2
  • 107
    • 0033103608 scopus 로고    scopus 로고
    • Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation?
    • Kerschensteiner M, Gallmeier E, Behrens L, et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 1999;189: 865-870
    • (1999) J Exp Med , vol.189 , pp. 865-870
    • Kerschensteiner, M.1    Gallmeier, E.2    Behrens, L.3
  • 108
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson B, Matyszak MK, Esiri MM, Perry VH. Axonal damage in acute multiple sclerosis lesions. Brain 1997;120: 393-399
    • (1997) Brain , vol.120 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Perry, V.H.4
  • 109
    • 0032576752 scopus 로고    scopus 로고
    • Axonal transection in the lesions of multiple sclerosis
    • Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 338:278-285
    • (1998) N Engl J Med , vol.338 , pp. 278-285
    • Trapp, B.D.1    Peterson, J.2    Ransohoff, R.M.3
  • 110
    • 0030056764 scopus 로고    scopus 로고
    • Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis
    • Lucchinetti CF, Brück W, Rodriguez M, Lassmann H. Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis. Brain Pathol 1996;6:259-274
    • (1996) Brain Pathol , vol.6 , pp. 259-274
    • Lucchinetti, C.F.1    Brück, W.2    Rodriguez, M.3    Lassmann, H.4
  • 111
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C, Brück W, Parisi J, et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000;47:707-717
    • (2000) Ann Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3
  • 112
    • 0032953939 scopus 로고    scopus 로고
    • Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis
    • Howard-LM, Miga-AJ, Vanderlugt CE, et al. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis. J Clin Invest 1999;103:281-290
    • (1999) J Clin Invest , vol.103 , pp. 281-290
    • Howard, L.M.1    Miga, A.J.2    Vanderlugt, C.E.3
  • 113
    • 0030452309 scopus 로고    scopus 로고
    • Late complications of immune deviation therapy in a non-human primate
    • Genain CP, Abel K, Belmar N, et al. Late complications of immune deviation therapy in a non-human primate. Science 1996;274:2054-2057
    • (1996) Science , vol.274 , pp. 2054-2057
    • Genain, C.P.1    Abel, K.2    Belmar, N.3
  • 114
    • 0031916192 scopus 로고    scopus 로고
    • TNF is a potent antiinflammatory cytokine in autoimmune-mediated demyelination
    • Liu J, Manne MW, Won G, et al. TNF is a potent antiinflammatory cytokine in autoimmune-mediated demyelination. Nat Med 1998;4:78-83
    • (1998) Nat Med , vol.4 , pp. 78-83
    • Liu, J.1    Manne, M.W.2    Won, G.3


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