Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis

Brain Pathology

Volumn 6, Issue 3, 1996, Pages 259-274

  Lucchinetti, Claudia F ^a   Brück, Wolfgang ^b   Rodriguez, Moses ^a   Lassmann, Hans ^c  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CONFERENCE PAPER; DEMYELINATING DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; MULTIPLE SCLEROSIS; OLIGODENDROGLIA;

EID: 0030056764     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.1996.tb00854.x     Document Type: Conference Paper

References (94)

1. Adams CW (1977) Pathology of multiple sclerosis: progression of the lesion. Brit Med Bull 33:15-20
2. Allen I (1990) Pathology of multiple sclerosis In McAlpine's Multiple Sclerosis, W.B Matthews (ed), pp 341-378, Churchill Livingstone Edinburgh
3. Allen I, Brankin B (1993) Pathogenesis of multiple sclerosis the immune diathesis and the role of virus. J Neuropathol Exp Neurol 52:95-105
4. Babinski J (1885) Recherches sur l'anatomie pathologique de la slerose en plaque et etude comparative des diverses varietes de la scleroses de la moelle. Arch Physiol (Paris) 5-6:186-207
5. Bo L, Mork S, Kong PA, Nyland H, Pardo CA, Trapp BO (1994) Detection of MHC class II on macrophages and microglia but not astrocytes and endothelia in active multiple sclerosis lesions J Neuroimmunol 51 135-146
6. Breitschopf H, Suchanek G, Gould RM, Coleman DR, Lassmann H (1992) In situ hybridization with digoxigenin-labelled probes sensitive and reliable detection method applied to myelinating rat brain Acta Neuropathol (Berl) 84 581-587
7. Broman Y (1964) Blood brain barrier damage in multiple sclerosis plaques Am J Pathol 137 575-584
8. Brosnan CF, Cannella B, Battistini L, Raine CS (1995) Cytokine localization in multiple sclerosis lesions. correlation with adhesion molecule expression and reactive nitrogen species. Neurology 45:S16-S21
9. Brück W, Porada P, Poser S, Rieckmann, Hanefeld F, Kretzschmar H, Lassmann H (1995) Monocyte / macrophage differentiation in early multiple sclerosis lesions. Ann Neurol 38:788-796
10. Brück W, Schmied M, Suchanek G, Bruck Y, Breitschopf H, Poser S, Piddlesden S, Lassmann W (1994) Oligodendrocytes in the early course of multiple sclerosis. Ann Neurol 35:65-73
11. Brunner C, Lassmann H, Waehnelt ThV, Matthieu JM, Linington C (1989) Differential ultrastructural localization of myelin basic protein, myelin/oligodendrocyte glycoprotein and 2′3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats. J Neurochem 52.296-304
12. Canella B, Raine CS (1995) The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 37:424-435
13. Challoner PB, Smith KT, Parker JD, Macleod DL, Coulter SN, Rose TM, Schultz ER, Bennett JL, Garber RL, Chang M, Schad PA, Stewart PA, Nowinski RC, Brown JP, Burmer GC (1995) Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci USA 92:7440-7444
14. Charcot JM (1868) Histologie de la sclerose en plaque. Gaz Hopital (Paris) 41:554-56
15. Coleman, Kreibich G, Frey AB, Sabatini DD (1982) Synthesis and incorporation of myelin polypeptides into CNS myelin. J Cell Biol 95:598-608
16. Compston DA, Keller WH, Robertson H, Saucer S, Wood NW (1995) Genes and susceptibility to multiple sclerosis. Acta Neurol Scand 161:43-51
17. Dal Canto MC, Rabinowitz SG (1982) Experimental models of virus-induced demyelination of the central nervous system. Ann Neurol 11:109-127
18. Davie CA, Hawkins CP, Barker GJ, Brennan A, Tofts PS, Miller DH, McDoanld WI (1994) Serial proton magnetic resonance spectroscopy in acute multiple sclerosis. Brain 117:49-58
19. Dawson JW (1916) The histology of disseminated sclerosis. Trans Roy Soc Edinburgh 5:517-740
20. Freedman MS, Ruijs TC, Selin LK, Antel JP (1991) Peripheral blood gamma/delta T cells lyse fresh human brain derived oligodendrocytes. Ann Neurol 30:794-800
21. Gay D, Esiri M (1991) Blood-brain barrier damage in acute multiple sclerosis plaques An immunocytochemical study. Brain 114.557-572
22. Gold R, Schmied M, Rothe G, Zischler H, Breitschopf H, Wekerle H, Lassmann H (1993) Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections. J Histochem Cytochem 41:1023-30
23. Griot C, Vandevelde M, Richard A, Peterhans E, Stocker R (1990) Selective degeneration of oligodendrocytes mediated by reactive oxygen species. Free Republic Res Commun 11:181-193
24. Grossmann RI, Braffman BH, Brorson JR, Goldberg HI, Silberberg DH Gonzales-Scarano F (1988) Multiple sclerosis serial study of gadolinium-enhanced MR imaging. Radiology 169 117-122
25. Guo YP, Gao SF (1983) Concentric sclerosis. In Clinical and Experimental Neurology, JH Tyrer, MJ Eadie (eds), Proc Australian Association of Neurologists Vol 19; pp 67-76, Adis Health Science Press, Sydney
26. Guseo A, Jellinger K (1975) The significance of perivascular infiltrations in multiple sclerosis. J Neurol 211:51-60
27. Hallpike JF, Adams CW, Bayliss OB (1970) Histochemistry of myelin. Loss of basic protein in early multiple sclerosis plaques. Histochem J 2:323-328
28. Hauser SL, Bhan AK, Gilles F, Kemp M, Kerr C, Weiner HL (1986) An imunocytochemical analysis of the cellular infiltrates in multiple sclerosis lesions. Ann Neurol 19(6):578-587
29. Hofman FM, Hinton DR, Johnson K, Merrill JE (1989) Tumor-necrosis factor identified in multiple sclerosis brain J Exp Med 170.607-612
30. Itoyama Y, Sternberger NH, Webster HdeF, Quarles RH, Cohen SR, Richardson EP Jr (1980) Immunocytochemical observation on the distribution of myelin-associated glycoprotein and myelin basic protein in multiple sclerosis lesions Ann Neurol 14:339-346
31. Jordan C, Friedrich V Jr, Dubois Dalcq ME (1989) In situ hybridization analysis of myelin gene transcripts in developing mouse spinal cord J Neurosci 9:248-257
32. Jordan CA, Friedrich VL Jr, Godfraind C, Cardellechio CB, Holmes KV, Dubois-Dalcqu M (1989) Expression of viral and myelin gene transcripts in a murine CNS demyelinating disease caused by a coronavirus. Glia 2:318-329
33. Kermode AG, Thompson AJ, Tofts B, MacManus DG, Kendall BE, Kingsley DP, Moseley IF, Rudge P, McDonald WI (1990) Breakdown of the blood brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications. Brain 113.1477-1489
34. Kirk J (1979) The fine structure of the CNS in multiple sclerosis. Vesicular demyelination in an acute case. Neuropathol Appl Neurobiol 5:289-294
35. Lampert PW, Carpenter S (1965) Electron microscope studies on the vascular permeability and the mechanisms of demyelination in experimental allergic encephalomyelitis. J Neuropath Exp Neurol 29:11-24
36. Lassmann H (1983) Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Schriftenr Neurol 25:1-135
37. Lassmann H, Brunner C, Bradl M, Linington C (1988) Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determine size and structure of demyelinated lesions. Acta Neuropathol (Berl) 75:566-576
38. Lassmann H, Wisniewski HM (1979) Chronic relapsing experimental allergic encephalomyelitis: Morphological sequence of myelin degradation. Brain Res 169:357-368
39. Lee SC, Moore GR, Golensky G, Raine CS (1990) Multiple sclerosis: a role for astroglia in active demyelination suggested by class II MHC expression and ultrastructural study J Neuopathol Exp Neurol 49.122-136
40. Li H, Newcombe J, Groome NP, Cuzner ML (1993) Characterization and distribution of phagocytic macrophages in multiple sclerosis plaques Neuropathol Appl Neurobiol 19:214-223
41. Linington C, Bradl M, Lassmann H, Brunner C, Vass K (1988): Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against myelin/oligodendrocyte glycoprotein (MOG). J Neuroimmunol 17 61-69
42. Linington C, Engelhardt B, Kapocs G, Lassmann H (1992) Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T-cells and demyelinating antibodies. J Neuroimmunol 40:219-224
43. Ludwin SK (1980) Chronic demyeliantion inhibits remyelination in the central nervous system. An analysis of contributing factors. Lab Invest 43:382-387
44. Ludwin SK, Johnson ES (1981) Evidence of a "dyingback" gliopathy in demyelinating disease. Ann Neurol 9:301-305
45. Lumsden CE (1970) The neuropathology of multiple sclerosis. In Handbook of Clinical Neurology, Vinken PI, Bruyn GW (eds), vol 9, pp.217-309, Elsevier: New York
46. Marburg O (1906) Die sogenannte "akute Multiple Sklerose". Jahrb Psychiatrie 27 211-312
47. Matthieu J-M, Amiguet P (1990) Myelin/oligodendrocyte glycoprotein expression during development in normal and myelin-deficient mice. Dev Neurosci 12:293-302
48. McGeer RL, Itagaki S, Tago H, McGeer EG (1987) Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci Lett 79:195-200
49. McLean BN, Zeman AZ, Barnes D, Thompson EJ (1993) Patterns of blood brain barrier impairment and clinical features in multiple sclerosis. J Neurol Neurosurg Psychiat 56:356-360
50. Miller DH, Rudge P, Johnson G, Kendall BE, MacManus DG, Moseley IF, Barnes D, McDonald WI (1988) Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis. Brain 111:927-939
51. Mitrovic B, Martin FC, Charles AC, Ignarro LJ, Anton PA, Shanahan F, Merrill JE (1994) Neurtotransmitters and cytokines in CNS pathology. Prog Brain Res 103:319-330
52. Moore GR, Raine CS (1988) Immunogold localization and analysis of IgG during immune-mediated demyelination. Lab Invest 59:641-648
53. Nesbit GM, Forbes GS, Scheithauer BW, Okazaki H, Rodriguez M (1991) Histopathologic and MR and/or CT correlation in 37 cases at biopsy and 3 cases at autopsy Radiology 180:467-474
54. Newcombe J, Cuzner ML (1993) Organization and reserach applications of the U.K. Multiple Sclerosis Soiciety tissue bank. J Neurol Transm (Suppl) 39:155-163
55. Newcombe J, Li H, Cuzner ML (1994) Low density lipoprotein uptake by macrophages in multiple sclerosis plaques:implications for pathogenesis. Neuropathol Apl Neurobiol 20:152-162
56. Ozawa K, Suchanek G, Breitschopf H, Bruck W, Budka H, Jellinger K, Lassmann H (1994) Patterns of oligodendroglia pathology in multiple sclerosis. Brain 117:1311-1322
57. Prineas J (1975) Pathology of the early lesion in multiple sclerosis. Hum Pathol 6.531-554
58. Prineas JW (1985) The neuropathology of multiple sclerosis. In Handbook of Clinical Neurology, JC Koetsier (ed), Vol 47, pp 337-395, Elsevier Science
59. Prineas JW, Barnard RO, Kwon EE, Sharer LR, Cho ES (1993) Multiple sclerosis. remyelination of nascent lesions Ann Neurol 33 137-151
60. Prineas JW, Barnard RO, Revesz T, Kwon EE, Sharer L, Cho ES (1993) Multiple sclerosis. Pathology of recurrent lesions. Brain 116:681-693
61. Prineas JW, Graham JS (1981) Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown. Ann Neurol 10:149-158
62. Prineas JW, Kwon EE, Cho ES, Sharer LR (1984) Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques. Ann NY Acad Sci 436:11-332
63. Prineas JW, Kwon EE, Goldenberg PZ, Ilyas AA, Quarles RH, Benjamin JA, Sprinkle TJ (1989) Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions. Lab Invest 61:489-503
64. Prineas JW, Raine CS (1976) Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions. Neurology 26:29-32
65. Raine CS (1994) Multiple sclerosis: Immune system molecule expression in the central nervous system. J Neuropath Exp Neurol 53:328-337
66. Raine CS (1994) The Dale E McFarlin memorial lecture. The immunology of the multiple sclerosis lesion. Ann Neurol 36:S61-S72
67. Raine CS, Scheinberg L, Waltz JM (1981) Multiple Sclerosis: Oligodendrocyte survival and proliferation in an active established lesion. Lab Invest 45:534-546
68. Rodriguez M (1992) Central nervous system demyelination and remyelination in multiple sclerosis and viral models of disease. J Neuroimmunol 40:255-263
69. Rodriguez M, Lennon VA (1990) Immunoglobulins promote remyelination in the central nervous system. Ann Neurol 27:12-17
70. Rodriguez M, Miller DJ (1994) Immune promotion of central nervous system remyelination. Prog in Brain Res 103:343-355
71. Rodriguez M, Prayoonwiwat N, Howe C, Sanborn K (1994) Proteolipid protein gene expression in demyelination and remyelination of the central nervous system: a model for multiple sclerosis. J Neuropath Exp Neurol 53:136-1443
72. Rodriguez M, Scheithauer B (1994) Ultrastructure of multiple sclerosis. Ultrastructural Pathol 18:3-13
73. Rodriguez M, Scheithauer BW, Forbes G, Kelly PJ (1993) Oligodendrocyte injury is an early event in lesions of multiple sclerosis. Mayo Clin Proc 68:627-636
74. Sanders V, Conrad AJ, Tourtellotte WW (1993) On classification of post-mortem multiple sclerosis plaques for neuroscientists. J Neuroimmunol 46:207-216
75. Schmied M, Breitschopf H, Gold R, Zischler H, Rothe G, Wekerle H, Lassmann H (1993) Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am J Pathol 143:446-452
76. Scolding NJ, Jones J, Compston DAS, Morgan BP (1990) Oligodendrocyte susceptibility to injury by T-cell perforin. Immunology 1 70:6-10
77. Scolding NJ, Morgan BP, Houston A, Campbell AK, Linigton C, Compston DAS (1989) Normal rat serum cytotoxicity against syngeneic oligodendrocytes complement activation and attack in the absence of anti-myelin antibodies. J Neurol Sci 89:289-300
78. Seitelberger F (1960) Histochemistry of demyelinating diseases proper, including allergic encephalomyelitis and Pelizaeus Merzbacher's disease. In Modern Scientific Aspects of Neurology, Cumings JN (ed), Arnold: London, pp 146-187
79. Selmaj K, Brosnan CF, Raine CS (1992) Expression of heat shock protein-65 by oligodendrocytes in vivo and in vitro: implications for multiple sclerosis Neurology 42 795-800
80. Selmaj K, Raine CS, Cannella B, Brosnan CF (1991) Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions J Clin Invest 87:949-954
81. Selmaj KW, Brosnan CF, Raine CS (1991) Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis. Proc Natl Acad Sci (USA) 88:6452-6456
82. Selmaj KW, Raine CS (1988) Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 23:339-346
83. Sobel RA, Mitchell ME (1989) Fibronectin in multiple sclerosis lesions. Am J Pathol 135:161-168
84. Sobel RA, Mitchell ME, Fondren G (1990) Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol 136:1309-1316
85. Sun J, Link H, Olsson T, Xiao BG, Anderson G, Ekre HP, Linington C, Diener P (1991) T and B cell responses to myelin oligodendroglia glycoprotein in multiple sclerosis. J Immunol 146:1490-1495
86. Tavolato B (1975) Immunoglobulin G distribution in multiple sclerosis brain. An immunofluorescence study. J Neurol Sci 24:1-11
87. Traugott U (1987) Multiple sclerosis: relevance of class I and class II MHC-expressing cells to lesion development. J Neuroimmunol 16:283-302
88. Traugott U, Reinherz EL, Raine CS (1983) Distribution of T cell subsets and la-positive macrophages in lesions of different ages. J Neuroimmunol 4:201-221
89. Ulvestad E, Williams K, Vedeler C, Antel J, Nyland H, Mork S, Matre R (1994) Reactive microglia in multiple sclerosis lesions have increased expression of receptors for the Fc part of IgG. J Neurol Sci 121:125-131
90. Van Noort JM, van Sechel AC, Bajramovic J, El Ouagmiri M, Polman CH Lassmann H, Ravid R (1995) A novel candidate autoantigen in multiple sclerosis: αβ-crystallin, a smalll heat shock protein Nature in press
91. Washington R, Burton J, Todd RF 3rd, Newman W, Dragovic L, Dore-Duffy P (1994) Expression of immunologically relevant endothelial cell activation antigens on isolated central nervous system microvessels from patients with multiple sclerosis. Ann Neurol 35:89-97
92. Woodroofe MN, Cuzner ML (1993) Cytokine mRNA expression in inflammatory multiple sclerosis lesions:detection by nonradioactive in situ hybridization. Cytokine 5:583-588
93. Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA (1992) Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proc Natl Acan Sci USA 89.4588-4592
94. Yao DL, Webster HdeF, Hudson LD, Brenner M, Liu DS, Escobar AI, Komoly S (1991) Concentric scerosis (Balo); morphometric and in situ hybridization study of lesions in six patients, Ann Neurol 35:18-30