The functional significance of epitope spreading and its regulation by co-stimulatory molecules

Immunological Reviews

Volumn 164, Issue , 1998, Pages 63-72

  Vanderlugt, Carol L ^a   Begolka, Wendy Smith ^a   Neville, Katherine L ^a   Katz Levy, Yael ^a   Howard, Laurence M ^a   Eagar, Todd N ^a   Bluestone, Jeffrey A ^b   Miller, Stephen D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; EPITOPE; MYELIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CROSS REACTION; DEMYELINATING DISEASE; IMMUNE RESPONSE; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; RELAPSE; T LYMPHOCYTE; VIRUS INFECTION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; CARDIOVIRUS INFECTIONS; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNODOMINANT EPITOPES; MICE; MODELS, IMMUNOLOGICAL; THEILOVIRUS;

EID: 17344363488     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1998.tb01208.x     Document Type: Article

References (58)

1. Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1993;366:72-75.
2. Kaufman DL, et al. Spontaneous loss of T cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 1993;366:69-72.
3. McRae BL, Vanderlugt CL, Dal Canto MC, Miller SD. Functional evidence for epitope spreading in the relapsing pathology of EAE in the SJL/J mouse. J Exp Med 1995;182:75-85.
4. Yu M, Johnson JM, Tuohy VK. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J Exp Med 1996;183:1777-1788.
5. Sercarz EE, Lehmann PV, Ametani A. Benichou G, Miller A, Moudgil K. Dominance and crypticity of T cell antigenic determinants. Annu Rev Immunol 1993;11:729-766.
6. Lehmann PV, Sercarz EE, Forsthuber T, Dayan CM, Gammon G. Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol Today 1993;14:203-208.
7. Elson CJ, Barker RN, Thompson SJ, Williams NA. Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol Today 1995;16:71-76.
8. Tian J, Lehmann PV, Kaufman DL. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J Exp Med 1997;186:2039-2043.
9. Mamula MJ, Janeway CA Jr. Do B cells drive the diversification of immune responses? Immunol Today 1993;14:151-154.
10. Amigorena S, Lankar D, Briken V, Gapin L, Viguier M, Bonnerot C. Type II and III receptors for immunoglobulin G (IgG) control the presentation of different T cell epitopes from single IgG-complexed antigens. J Exp Med 1998;187:505-515.
11. Miller SD, et al. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat Med 1997;3:1133-1136.
12. Steinman L, Conlon P. Viral damage and the breakdown of self-tolerance. Nat Med 1997;3:1085-1087.
13. Clark L, Fareed M, Miller SD, Merryman C, Heber-Katz E. Corneal infection with herpes simplex virus type I leads to autoimmune responses in rats. J Neurosci Res 1996;45:770-775.
14. Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990;346:183-187.
15. Bernard CC, de Rosbo NK. Immunopathological recognition of autoantigens in multiple sclerosis. Acta Neurol (Napoli) 1991;13:171-178.
16. Kurtzke JF. Epidemiologic evidence for multiple sclerosis as an infection. Clin Microbiol Rev 1993;6:382-427.
17. Fujinami RS, Oldstone MB. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 1985;230:1043-1045.
18. Zhao Z-S, Granucci F, Yeh L, Schaffer PA, Cantor H. Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science 1998;279:1344-1347.
19. Scherer MT, Ignatowicz L, Winslow GM, Kappler JW, Marrack P. Superantigens: bacterial and viral proteins that manipulate the immune system. Annu Rev Cell Biol 1993;9:101-128.
20. Tian J, et al. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 1996;183:1561-1567.
21. James JA, Gross T, Scofield RH, Harley JB. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. J Exp Med 1995;181:453-461.
22. Topfer F, Gordon T, McCluskey J. Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Proc Natl Acad Sci USA 1995;92:875-879.
23. Chan LS, et al. Epitope spreading: lessons from autoimmune skin diseases. J Lab Clin Med 1998;110:103-109.
24. Tuohy VK, Yu M, Weinstock-Guttman B, Kinkel RP. Diversity and plasticity of self recognition during the development of multiple sclerosis. Clin Invest 1997;99:1682-1690.
25. Miller SD, et al. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 1995;3:739-745.
26. Tan LJ, Kennedy MK, Miller SD. Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition. J Immunol 1992;148:2748-2755.
27. + T cell line specific for an immunodominant VP2 epitope. J Immunol 1994;152:919-929.
28. Karpus WJ, Pope JG, Peterson JD, Dal Canto MC, Miller SD. Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction. J Immunol 1995;155:947-957.
29. + T cell-mediated pathology. J Immunol 1996;156:4050-4058.
30. Miller SD, et al. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. III. Failure of neuroantigen-specific immune tolerance to affect the clinical course of demyelination. J Neuroimmunol 1990;26:9-23.
31. Miller SD, Clatch RJ, Pevear DC, Trotter JL, Lipton HL. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins. J Immunol 1987;138:3776-3784.
32. Karandikar NJ, Vanderlugt CL, Walunas TL, Miller SD, Bluestone JA. CTLA-4: a negative regulator of autoimmune disease. J Exp Med 1996;184:783-788.
33. Karandikar NJ, Eagar TA, Vanderlugt CL, Bluestone JA, Miller SD. CTLA-4 downregulates epitope spreading in autoimmune disease. J Immunol 1998 (Submitted).
34. Vanderlugt CL, Karandikar NJ, Lenschow DJ, Dal Canto MC, Bluestone JA, Miller SD. Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE. J Neuroimmunol 1997;79:113-118.
35. Perry LL, Barzaga ME. Kinetics and specificity of T and B cell responses in relapsing experimental allergic encephalomyelitis. J Immunol 1987;138:1434-1441.
36. McCarron RM, Fallis RJ, McFarlin DE. Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis. J Neuroimmunol 1990;29:73-79.
37. Perry LL, Barzaga-Gilbert E, Trotter JL. T cell sensitization to proteolipid protein in myelin basic protein-induced experimental allergic encephalomyelitis. J Neuroimmunol 1991;33:7-16.
38. Cross AH, Tuohy VK, Raine CS. Development of reactivity to new myelin antigens during chronic relapsing autoimmune demyelination. Cell Immunol 1993;146:261-269.
39. Lehmann PV, Forsthuber T, Miller A, Sercarz EE. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992;358:155-157.
40. Offner H, et al. T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats. J Exp Med 1989;170:355-367.
41. Tan L-J, Kennedy MK, Dal Canto MC, Miller SD. Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance. J Immunol 1991;147:1797-1802.
42. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996;14:233-258.
43. Linsley PS, Clark EA, Ledbetter JA. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci USA 1990;87:5031-5035.
44. Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med 1991;173:721-730.
45. Lenschow DJ, et al. Expression and functional significance of an additional ligand for CTLA-4. Proc Natl Acad Sci USA 1993;90:11054-11058.
46. Hathcock KS, Laszlo G, Dickler HB, Bradshaw J, Linsley P, Hodes RJ. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 1993;262:905-907.
47. Karandikar NJ, Vanderlugt CL, Bluestone JA, Miller SD. Tissue-specific upregulation of B7-1 expression and function during an autoimmune disease. J Immunol 1998;161:192-199.
48. Jenkins MK, Schwartz RH. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 1987;165:302-319.
49. Clark LB, Foy TM, Noelle RJ. CD40 and its ligand. Adv Immunol 1996;63:43-78.
50. Grewal IS, et al. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science 1996;273:1864-1867.
51. Gerritse K, et al. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci USA 1996;93:2499-2504.
52. Caux C, et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med 1994;180:1263-1272.
53. Van Kooten C, Banchereau J. Functional role of CD40 and its ligand. Int Arch Allergy Immunol 1997;113: 393-399.
54. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260:547-549.
55. Miller SD, Gerety SJ. Immunologic aspects of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. Semin Virol 1990;1:263-272.
56. Clatch RJ, Miller SD, Metzner R, Dal Canto MC, Lipton HL. Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Virol 1990;176:244-254.
57. Clatch RJ, Lipton HL, Miller SD. Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs. J Immunol 1986;136:920-927.
58. Pope JG, Vanderlugt CL, Lipton HL, Rahbe SM, Miller SD. Characterization of and functional antigen presentation by CNS mononuclear cells from mice infected with Theiler's murine encephalomyelitis virus. J Virol 1998 (Submitted).