Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis

Journal of Clinical Investigation

Volumn 99, Issue 6, 1997, Pages 1238-1250

  Colombo, Emanuela ^a   Banki, Katalin ^a   Tatum, Arthur H ^a   Daucher, John ^a   Ferrante, Pasquale ^b   Murray, Ronald S ^c   Phillips, Paul E ^a   Perl, Andras ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b Multiple Sclerosis Center   (Italy)

^c Colorado Multiple Sclerosis Center ^*  (United States)

Author keywords

multiple sclerosis; myelin basic protein; transaldolase

Indexed keywords

AUTOANTIBODY; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSALDOLASE;

ADULT; AGED; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; CONTROLLED STUDY; DEMYELINATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; OLIGODENDROGLIA; PRIORITY JOURNAL;

EID: 0030901670     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119281     Document Type: Article

References (50)

1. Martin, R., H.F. McFarland, and D.E. McFarlin. 1992. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10:153-187. (Review).
2. Traugott, I., E.L. Reinherz, and C.S. Raine. 1983. Multiple sclerosis: distribution of T-cell subsets within active chronic lesions. Science (Wash. DC). 219:308-310.
3. Booss, J., M.M. Esiri, and W.W. Tourtellotte. 1983. Immunohistochemical analysis of T-lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J. Neurol. Sci. 62:19-32.
4. Hauser, S.L., A.K. Bhan, and F. Gilles. 1986. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann. Neurol. 19:578-587.
5. Traugott, U., L.C. Scheinberg, and C.S. Raine. 1985. On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation. J. Neuroimmunol. 8:1-14.
6. Fujinami, R.S., and M.B. Oldstone. 1985. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science (Wash. DC). 230:1043-1045.
7. Shaw, S.Y., R.A. Laursen, and M.B. Lees. 1986. Analogous amino acid sequences in myelin proteolipid and viral proteins. FEBS (Fed. Eur. Biol. Soc.) Lett. 207:266-270.
8. gag antigen. Cell. 51:211-220.
9. Antel, J.P., and N.R. Cashman. 1991. Human retrovirus and multiple sclerosis. Mayo Clin. Proc. 66:752-755.
10. Perl, A., and K. Banki. 1993. Human endogenous retroviral elements and autoimmunity: data and concepts. Trends Microbiol. 1:153-156.
11. Murphy, P.M. 1993. Molecular mimicry and the generation of host defense protein diversity. Cell. 72:823-826.
12. Steinman, L. 1996. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell. 85:299-302.
13. McCarron, R.M., R.J. Fallis, and D.E. McFarlin. 1990. Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis. J. Neuroimmunol. 29:73-79.
14. Whitham, R.H., R.E. Jones, G.A. Hashim, C.M. Hoy, R.Y. Wang, and A.A. Vandenbark. 1991. Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL X PL)F1 mice. J. Immunol. 147: 3803-3808.
15. Lees, M.B., and S.W. Brostoff. 1984. Proteins of myelin. In Myelin. P. Morrell, editor. Plenum Publishing Corp., New York. 197-224.
16. Banki, K., E. Colombo, F. Sia, D. Halladay, D. Mattson, A. Tatum, P. Massa, P.E. Phillips, and A. Perl. 1994. Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. J. Exp. Med. 180: 1649-1663.
17. Banki, K., D. Halladay, and A. Perl. 1994. Cloning and expression of the human gene for transaldolase: a novel highly repetitive element constitutes an integral part of the coding sequence. J. Biol. Chem. 269:2847-2851.
18. Mayes, P. 1993. The pentose phosphate pathway and other pathways of hexose metabolism. In Harper's Biochemistry. R. Murray, D. Granner, P. Mayes, and V. Rodwell, editors. Appleton & Lange, Norwalk, CT. 201-211.
19. Jacobson, S. 1963. Sequence of myelination in the brain of the albino rat. J. Comp. Neurol. 121:5-29.
20. McDougal, D.B., Jr., D.W. Schulz, J.V. Passonneau, J.R. Clark, M.A. Reynolds, and O.H. Lowry. 1961. Quantitative studies of white matter. I. Enzymes involved in glucose 6-phosphate metabolism. J. Gen. Physiol. 44:487-498.
21. Baquer, N.Z., J.S. Hothersall, P. McLean, and A.L. Greenbaum. 1977. Aspects of carbohydrate metabolism in developing brain. Developmental Medicine & Child Neurology. 19:81-104.
22. Balazs, R. 1970. Carbohydrate metabolism. In Handbook of Neurochemistry. A. Lajtha, editor. Plenum Press, New York. 1-36.
23. Hotta, S.S. 1962. Glucose metabolism in brain tissue: the hexose-monophosphate shunt and its role in glulathione reduction. J. Neurochem. 9:43-51.
24. Tan, E.M., A.S. Cohen, J.F. Fries, A.T. Masi, D.J. McShane, N.F. Rothfield, J.G. Schaller, N. Talal, and R.J. Winchester. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthr. Rheum. 25: 1271-1277.
25. Poser, C.M., D.W. Paty, L. Scheinberg, W.I. McDonald, F.A. Davis, G.C. Ebers, K.P. Johnson, W.A. Sibley, W.H. Silberberg, and W.W. Tourtellotte. 1983. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13:227-231.
26. Smith, D.B., and K.S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (Amst.). 67:31-10.
27. Pontremoli, S., D.B. Prandini, A. Bonsignore, and B.L. Horecker. 1961. The preparation of crystalline transaldolase from Candida utilis. Proc. Natl. Acad. Sci. USA. 47:1942-1955.
28. Deibler, G.E. , R.E. Martenson, and M.W. Kies. 1972. Large scale preparation of myelin basic protein of several mammalian species. Prep. Biochem. 2: 139-165.
29. Towbin, H.H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:4350-4354.
30. + T-cell subsets in lectin-dependent cell-mediated cytotoxicity against adherent HEp-2 cells. Cell. Immunol. 84:185-193.
31. Dawson-Saunders, B., and R.G. Trapp. 1994. Basic and Clinical Biostatistics. Appleton & Lange, Norwalk, CT. 344 pp.
32. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guadinium-isothiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
33. Genevee, C., A. Diu, J. Nierat, A. Caignard, P. Dietrich, L. Ferradini, S. Roman-Roman, F. Triebel, and T. Hercend. 1992. An experimentally validated panel of subfamily-specific oligonucleotide primers (Vαl-w29/Vβ1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur. J. Immunol. 22:1261-1269.
34. Gulwani-Akolkar, B., P.N. Akolkar, A. Minassian, R. Pergolizzi, M. McKinley, G. Mullin, S. Fisher, and J. Silver. 1996. Selective expansion of specific T cell receptors in the inflamed colon of Crohn's disease. J. Clin. Invest. 98: 1344-1354.
35. Vandenbark, A.A., G. Hashim, and H. Offner. 1993. TCR peptide therapy in autoimmune diseases. Int. Rev. Immunol. 9:251-276. (Review.)
36. Zhang, J., S. Markovic-Plese, B. Lacet, J. Raus, H.L. Weiner, and D.A. Hafler. 1994. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179:973-984.
37. Perl, A., R. Gonzalez-Cabello, K. Onody, I. Bodo, and P. Gergely. 1986. Independence of depressed lectin-dependent cell-mediated cytotoxicity from interleukin 2 production in patients with systemic lupus erythematosus. Clin. Exp. Immunol. 65:286-292.
38. Banki, K., and A. Perl. 1996. Inhibition of the catalytic activity of human transaldolase by antibodies and site-directed mutagenesis. FEBS (Fed. Eur. Biol. Soc.) Lett. 378:161-165.
39. James, J.A., T. Gross, R.H. Scofield, and J.B. Harley. 1995. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. J. Exp. Med. 181:453-461.
40. Seboun, E., M.A. Robinson, T.H. Doolittle, T.A. Ciulla, T.J. Kindt, and S.L. Hauser. 1989. A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex. Cell. 57:1095-1100.
41. Oksenberg, J.R., M. Sherritt, A.B. Begovich, H.A. Erlich, C.C. Bernard, L.L. Cavalli-Sforza, and L. Steinman. 1989. T-cell receptor Vα and Cα alleles associated with multiple sclerosis and myasthenia gravis. Proc. Natl. Acad. Sci. USA. 86:988-992.
42. Utz, U., W.E. Biddison, H.F. McFarland, D.E. McFarlin, M. Flerlage, and R. Martin. 1993. Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis. Nature (Lond.). 364:243-247.
43. Utz, U., R. Martin, J.A. Brooks, W.E. Biddison, and H.F. McFarland. 1995. T-cell receptor use in multiple sclerosis. Ann. NY Acad. Sci. 756:259-264.
44. Kotzin, B.L., S. Karutiri, Y.K. Chou, J. Lafferty, J.M. Forrester, M. Better, G.E. Nedwin, H. Offner, and A.A. Vandenbark. 1991. Preferential T cell receptor β-chain variable gene use in myelin basic protein reactive T cell clones from patients with multiple sclerosis. Proc. Natl. Acad. Sci. USA. 88:9161-9165.
45. Oksenberg, J.R., M.A. Panzara, A.B. Begovich, D. Mitchell, H.A. Erlich, R.S. Murray, R. Shimonkevitz, M. Sherritt, J. Rothbard, C.C.A. Bernard, and L. Steinman. 1993. Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature (Lond.). 362:68-70.
46. Shimonkevitz, R., R. Murray, and B. Kotzin. 1995. Characterization of T-cell receptor Vβ usage in the brain of a subject with multiple sclerosis. Ann. NY Acad. Sci. 756:305-306.
47. Richert, J.R., E.D. Robinson, A.H. Johnson, C.A. Bergman, L.J. Dragovic, and C.K. Hurley. 1991. Heterogeneity of the T-cell receptor beta gene rearrangements generated in myelin basic protein-specific T-cell clones isolated from a patient with multiple sclerosis. Ann. Neurol. 29:299-306.
48. Wucherpfennig, K.K., J. Newcombe, H. Li, C. Keddy, M.L. Cuzner, and D.A. Hafler. 1992. T cell receptor Vα-Vβ-repertoire and cytokine gene expression in active multiple sclerosis lesions. J. Exp. Med. 175:993-1002.
49. + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J. Immunol. 148:1359-1366.
50. Linington, C., and B. Waksman. 1995. The T-cell receptor in multiple sclerosis. Ann. NY Acad. Sci. 756:294-304.