Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis

Journal of Clinical Investigation

Volumn 102, Issue 5, 1998, Pages 1045-1050

  Qin, Yufen ^a   Duquette, Pierre ^b   Zhang, Yiping ^c   Talbot, Pierre ^d   Poole, Robin ^c   Antel, Jack ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NOTRE DAME HOSPITAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

Autoimmunity; Complementarity determining region; Immunoglobulin heavy chain variable gene; Intrathecal antibody forming B cells; Oligoclonal bands

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; ARTICLE; B LYMPHOCYTE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; HUMAN; MALE; MULTIPLE SCLEROSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0032167731     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3568     Document Type: Article

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