메뉴 건너뛰기




Volumn 35, Issue 1, 2000, Pages 35-70

Induction, regulation, degradation, and biological significance of mammalian metallothioneins

Author keywords

[No Author keywords available]

Indexed keywords

HEAVY METAL; METALLOTHIONEIN; SCAVENGER;

EID: 0034053364     PISSN: 10409238     EISSN: None     Source Type: Journal    
DOI: 10.1080/10409230091169168     Document Type: Review
Times cited : (417)

References (328)
  • 1
    • 33947463103 scopus 로고
    • A cadmium protein from equine kidney cotex
    • Margoshes, M. and Vallee, B.L., A cadmium protein from equine kidney cotex, J. Am. Chem. Soc., 79, 4813-4814, 1957.
    • (1957) J. Am. Chem. Soc. , vol.79 , pp. 4813-4814
    • Margoshes, M.1    Vallee, B.L.2
  • 2
    • 0001593597 scopus 로고
    • A cadmium and zinc-containing protein from equine renal cortex
    • Kägi, J.H.R. and Vallee, B.L., A cadmium and zinc-containing protein from equine renal cortex, J. Biol. Chem., 235, 3460-3465, 1960.
    • (1960) J. Biol. Chem. , vol.235 , pp. 3460-3465
    • Kägi, J.H.R.1    Vallee, B.L.2
  • 3
    • 0001593597 scopus 로고
    • Metallothionein: A cadmium- and zinc-containing protein from equine renal and cortex
    • Kägi, J.H.R. and Vallee, B.L., Metallothionein: a cadmium-and zinc-containing protein from equine renal and cortex, J. Biol. Chem., 235, 3460-3465, 1960.
    • (1960) J. Biol. Chem. , vol.235 , pp. 3460-3465
    • Kägi, J.H.R.1    Vallee, B.L.2
  • 4
    • 0016211318 scopus 로고
    • Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content
    • Kägi, J.H., Himmelhoch, S.R., Whanger, P.D., Bethune, J.L. and Vallee, B.L., Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content, J. Biol. Chem., 249, 3537-3542, 1974.
    • (1974) J. Biol. Chem. , vol.249 , pp. 3537-3542
    • Kägi, J.H.1    Himmelhoch, S.R.2    Whanger, P.D.3    Bethune, J.L.4    Vallee, B.L.5
  • 5
    • 0023072509 scopus 로고
    • Nutritional and physiological significance of metallothionein
    • Bremner, I., Nutritional and physiological significance of metallothionein, Experientia, 52, 81-107, 1987.
    • (1987) Experientia , vol.52 , pp. 81-107
    • Bremner, I.1
  • 6
    • 0023728860 scopus 로고
    • Molecular aspects, physiological function, and clinical significance of metallothioneins
    • Nath, R., Kambadur, R., Gulati, S., Paliwal, V.K. and Sharma, M., Molecular aspects, physiological function, and clinical significance of metallothioneins, Crit. Rev. Food Sci. Nutr., 27, 41-85, 1988.
    • (1988) Crit. Rev. Food Sci. Nutr. , vol.27 , pp. 41-85
    • Nath, R.1    Kambadur, R.2    Gulati, S.3    Paliwal, V.K.4    Sharma, M.5
  • 7
    • 0029060897 scopus 로고
    • The function of metallothionein
    • Vallee, B.L., The function of metallothionein, Neurochem. Int., 27, 23-33, 1995.
    • (1995) Neurochem. Int. , vol.27 , pp. 23-33
    • Vallee, B.L.1
  • 9
    • 0029845691 scopus 로고    scopus 로고
    • The functional significance of brain metallothioneins
    • Aschner, M., The functional significance of brain metallothioneins, FASEB J., 10, 1129-1136, 1996.
    • (1996) FASEB J. , vol.10 , pp. 1129-1136
    • Aschner, M.1
  • 10
    • 0028106137 scopus 로고
    • The importance of zinc and metallothionein in brain
    • Ebadi, M., Elsayed, M.A. and Aly, M.H., The importance of zinc and metallothionein in brain, Biol. Signals, 3, 123-126, 1994.
    • (1994) Biol. Signals , vol.3 , pp. 123-126
    • Ebadi, M.1    Elsayed, M.A.2    Aly, M.H.3
  • 11
    • 0024693857 scopus 로고
    • Modulation of metal toxicity by metallothionein
    • Nordberg, G.F., Modulation of metal toxicity by metallothionein, Biol. Trace Elem. Res., 21, 131-135, 1989.
    • (1989) Biol. Trace Elem. Res. , vol.21 , pp. 131-135
    • Nordberg, G.F.1
  • 12
    • 0020504638 scopus 로고
    • Cellular adaptation in metal toxicology and metallothionein
    • Cherian, M.G. and Nordberg, M., Cellular adaptation in metal toxicology and metallothionein, Toxicol., 28, 1-15, 1983.
    • (1983) Toxicol. , vol.28 , pp. 1-15
    • Cherian, M.G.1    Nordberg, M.2
  • 13
    • 0018199778 scopus 로고
    • Methallothioneins and their role in the metabolism and toxicity of metals
    • Cherian, M.G. and Goyer, R.A., Methallothioneins and their role in the metabolism and toxicity of metals, Life Sci., 23, 1-9, 1978.
    • (1978) Life Sci. , vol.23 , pp. 1-9
    • Cherian, M.G.1    Goyer, R.A.2
  • 14
    • 0026346240 scopus 로고
    • Toxicological significance of metallothionein
    • Templeton, D.M. and Cherian, M.G., Toxicological significance of metallothionein, Meth. Enzymol., 205, 11-24, 1991.
    • (1991) Meth. Enzymol. , vol.205 , pp. 11-24
    • Templeton, D.M.1    Cherian, M.G.2
  • 15
    • 0020062847 scopus 로고
    • Functions of metallothionein
    • Webb, M. and Cain, K., Functions of metallothionein, Biochem. Pharmacol., 31, 137-142, 1982.
    • (1982) Biochem. Pharmacol. , vol.31 , pp. 137-142
    • Webb, M.1    Cain, K.2
  • 16
    • 0023064383 scopus 로고
    • Toxicological significance of metallothionein
    • Webb, M., Toxicological significance of metallothionein, Experientia, 52, 109-134, 1987.
    • (1987) Experientia , vol.52 , pp. 109-134
    • Webb, M.1
  • 17
    • 78651156297 scopus 로고
    • On cadmium in normal human kidneys together with a report on the isolation of metallothionein from livers of cadmium exposed rabbits
    • Piscator, M., on cadmium in normal human kidneys together with a report on the isolation of metallothionein from livers of cadmium exposed rabbits. Nord. Hyg. Tidskr., 45, 76-82, 1964.
    • (1964) Nord. Hyg. Tidskr. , vol.45 , pp. 76-82
    • Piscator, M.1
  • 18
    • 0031926361 scopus 로고    scopus 로고
    • Metallothioneins: Historical review and state of knowledge
    • Nordberg, M., Metallothioneins: historical review and state of knowledge, Talanta, 46, 243-254, 1998.
    • (1998) Talanta , vol.46 , pp. 243-254
    • Nordberg, M.1
  • 19
    • 0027533507 scopus 로고
    • Oxygen free radicals and metallothionein
    • Sato, M. and Bremner, I., Oxygen free radicals and metallothionein, Free Radical Biol. Med., 14, 325-337, 1993.
    • (1993) Free Radical Biol. Med. , vol.14 , pp. 325-337
    • Sato, M.1    Bremner, I.2
  • 20
    • 0030222319 scopus 로고    scopus 로고
    • Role of metallothionein and other antioxidants in scavenging superoxide radicals and their possible role in neuroprotection
    • 199
    • Hussain, S., Slikker, W., Jr. and Ali, S.F., Role of metallothionein and other antioxidants in scavenging superoxide radicals and their possible role in neuroprotection, Neurochem. Int., 29, 145-152, 199.
    • Neurochem. Int. , vol.29 , pp. 145-152
    • Hussain, S.1    Slikker Jr., W.2    Ali, S.F.3
  • 23
    • 0018551793 scopus 로고
    • Nomenclature of metallothionein: A proposal
    • Kägi, J.H. and Kojima, Y., Nomenclature of metallothionein: a proposal, Experientia, 34, 141-142, 1979.
    • (1979) Experientia , vol.34 , pp. 141-142
    • Kägi, J.H.1    Kojima, Y.2
  • 24
    • 0002599375 scopus 로고    scopus 로고
    • Metallothionein: Molecular evolution and classification
    • Klaassen, C.D., Ed., Basel, Birkhäuser Verlag
    • Binz, P.A. and Kägi, J.H.R., Metallothionein: molecular evolution and classification, in Metallothionein IV, Klaassen, C.D., Ed., Basel, Birkhäuser Verlag, 7-13, 1999.
    • (1999) Metallothionein IV , pp. 7-13
    • Binz, P.A.1    Kägi, J.H.R.2
  • 25
    • 0026353521 scopus 로고
    • Overview of metallothionein
    • Kägi, J.H., Overview of metallothionein, Meth. Enzymol., 205, 613-626, 1991.
    • (1991) Meth. Enzymol. , vol.205 , pp. 613-626
    • Kägi, J.H.1
  • 27
    • 0027225407 scopus 로고
    • Metallothionein detoxification function is impaired by replacement of both conserved lysines with glutamines in the hinge between the two domains
    • Cody, C.W. and Huang, P.C., Metallothionein detoxification function is impaired by replacement of both conserved lysines with glutamines in the hinge between the two domains, Biochemistry, 32, 5127-5131, 1993.
    • (1993) Biochemistry , vol.32 , pp. 5127-5131
    • Cody, C.W.1    Huang, P.C.2
  • 28
    • 0028170096 scopus 로고
    • Replacement of all alpha-domain lysines with glutamates reduces metallothionein detoxification function
    • Cody, C.W. and Huang, P.C., Replacement of all alpha-domain lysines with glutamates reduces metallothionein detoxification function, Biochem. Biophys. Res. Commun., 202, 954-959, 1994.
    • (1994) Biochem. Biophys. Res. Commun. , vol.202 , pp. 954-959
    • Cody, C.W.1    Huang, P.C.2
  • 29
    • 0022397919 scopus 로고
    • Interaction of lysine residues with the metal thiolate clusters in metallothionein
    • Pande, J., Vasak, M. and Kägi. J.H., Interaction of lysine residues with the metal thiolate clusters in metallothionein, Biochemistry, 24, 6717-6722, 1985.
    • (1985) Biochemistry , vol.24 , pp. 6717-6722
    • Pande, J.1    Vasak, M.2    Kägi, J.H.3
  • 32
    • 0023087396 scopus 로고
    • Chemistry and biochemistry of metallothionein
    • Kägi, J.H. and Kojima, Y., Chemistry and biochemistry of metallothionein, Experientia, 52, 25-61, 1987.
    • (1987) Experientia , vol.52 , pp. 25-61
    • Kägi, J.H.1    Kojima, Y.2
  • 33
    • 0020478923 scopus 로고
    • Domain nature of metallothionein
    • Winge, D.R. and Miklossy, K.A., Domain nature of metallothionein, J. Biol. Chem., 257, 3471-3476, 1982.
    • (1982) J. Biol. Chem. , vol.257 , pp. 3471-3476
    • Winge, D.R.1    Miklossy, K.A.2
  • 34
    • 0022397076 scopus 로고
    • Products of metal exchange reactions of metallothionein
    • Nettesheim, D.G., Engeseth, H.R. and Otvos, J.D., Products of metal exchange reactions of metallothionein, Biochemistry, 24, 6744-6751, 1985.
    • (1985) Biochemistry , vol.24 , pp. 6744-6751
    • Nettesheim, D.G.1    Engeseth, H.R.2    Otvos, J.D.3
  • 35
    • 0023071213 scopus 로고
    • Interprotein metal exchange reactions of metallothionein
    • Otvos, J.D., Engeseth, H.R., Netteshem, D.G. and Hilt, C.R., Interprotein metal exchange reactions of metallothionein, Experientia, 52, 171-178, 1987.
    • (1987) Experientia , vol.52 , pp. 171-178
    • Otvos, J.D.1    Engeseth, H.R.2    Netteshem, D.G.3    Hilt, C.R.4
  • 36
    • 0028840006 scopus 로고
    • Primary structures of seven metallothioneins from rabbit tissue
    • Hunziker, P.E., Kaur, P., Wan, M. and Kanzig, A., Primary structures of seven metallothioneins from rabbit tissue, Biochem. J., 306, 265-270, 1995.
    • (1995) Biochem. J. , vol.306 , pp. 265-270
    • Hunziker, P.E.1    Kaur, P.2    Wan, M.3    Kanzig, A.4
  • 38
    • 0031954442 scopus 로고    scopus 로고
    • Strategies for the qualitative and quantitative analysis of metallothionein isoforms by capillary electrophoresis
    • Beattie, J.H., Strategies for the qualitative and quantitative analysis of metallothionein isoforms by capillary electrophoresis, Talanta, 46, 255-270, 1998.
    • (1998) Talanta , vol.46 , pp. 255-270
    • Beattie, J.H.1
  • 39
    • 0023082725 scopus 로고
    • Human hepatic metallothioneins: Resolution of six isoforms
    • Hunziker, P.E. and Kagi, J.H., Human hepatic metallothioneins: resolution of six isoforms, Experientia, 52, 257-264, 1987.
    • (1987) Experientia , vol.52 , pp. 257-264
    • Hunziker, P.E.1    Kagi, J.H.2
  • 40
    • 0027546644 scopus 로고
    • Resolution and quantification of four metallothionein isoforms from rabbit kidney cells
    • Wan, M., Kagi, J.H. and Hunziker, P.E., Resolution and quantification of four metallothionein isoforms from rabbit kidney cells, Prot. Express. Purif., 4, 38-44, 1993.
    • (1993) Prot. Express. Purif. , vol.4 , pp. 38-44
    • Wan, M.1    Kagi, J.H.2    Hunziker, P.E.3
  • 41
    • 0030025255 scopus 로고    scopus 로고
    • Separation of three mouse metallothionein isoforms by free-solution capillary electrophoresis
    • Richards, M.P., Andrews, G.K., Winge, D.R. and Beattie, J.H., Separation of three mouse metallothionein isoforms by free-solution capillary electrophoresis, J. Chromatogr. B, 675, 327-331, 1996.
    • (1996) J. Chromatogr. B , vol.675 , pp. 327-331
    • Richards, M.P.1    Andrews, G.K.2    Winge, D.R.3    Beattie, J.H.4
  • 42
    • 0027362890 scopus 로고
    • Characterization of metallothionein isoforms. Comparison of capillary zone electrophoresis with reversed-phase high- performance liquid chromatography
    • Richards, M.P. and Beattie, J.H., Characterization of metallothionein isoforms. Comparison of capillary zone electrophoresis with reversed-phase high-performance liquid chromatography, J. Chromatogr., 648, 459-468, 1993.
    • (1993) J. Chromatogr. , vol.648 , pp. 459-468
    • Richards, M.P.1    Beattie, J.H.2
  • 46
    • 0021173920 scopus 로고
    • Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids
    • Richards, R.I., Heguy, A. and Karin, M., Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids, Cell, 37, 263-272, 1984.
    • (1984) Cell , vol.37 , pp. 263-272
    • Richards, R.I.1    Heguy, A.2    Karin, M.3
  • 47
    • 0022729556 scopus 로고
    • Structure and tissue-specific expression of the human metallothionein IB gene
    • Heguy, A., West, A., Richards, R.I. and Karin, M., Structure and tissue-specific expression of the human metallothionein IB gene, Mol. Cell. Biol., 6, 2149-2157, 1986.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 2149-2157
    • Heguy, A.1    West, A.2    Richards, R.I.3    Karin, M.4
  • 48
    • 0021885286 scopus 로고
    • Structure and expression of two human metallothionein-I isoform genes and a related pseudogene
    • Schmidt, C.J., Jubier, M.F. and Hamer, D.H., Structure and expression of two human metallothionein-I isoform genes and a related pseudogene, J. Biol. Chem., 260, 7731-7737, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 7731-7737
    • Schmidt, C.J.1    Jubier, M.F.2    Hamer, D.H.3
  • 49
    • 0022648524 scopus 로고
    • Structure, organization, and regulation of human metallothionein if gene: Differential and cell-type-specific expression in response to heavy metals and glucocorticoids
    • Varshney, U., Jahroudi, N., Foster, R. and Gedamu, L., Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids, Mol. Cell. Biol., 6, 26-37, 1986.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 26-37
    • Varshney, U.1    Jahroudi, N.2    Foster, R.3    Gedamu, L.4
  • 50
    • 0019932125 scopus 로고
    • Human metallothionein genes - Primary structure of the metallothionein-II gene and a related processed gene
    • Karin, M. and Richards, R.I., Human metallothionein genes - primary structure of the metallothionein-II gene and a related processed gene, Nature, 299, 797-802, 1982.
    • (1982) Nature , vol.299 , pp. 797-802
    • Karin, M.1    Richards, R.I.2
  • 52
    • 0028289610 scopus 로고
    • Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia
    • Quaife, C.J., Findley, S.D., Erickson, J.C., Froelick, G.J., Kelly, E.J., Zambrowicz, B.P. and Palmiter, R.D., Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia, Biochemistry, 33, 7250-7259, 1994.
    • (1994) Biochemistry , vol.33 , pp. 7250-7259
    • Quaife, C.J.1    Findley, S.D.2    Erickson, J.C.3    Froelick, G.J.4    Kelly, E.J.5    Zambrowicz, B.P.6    Palmiter, R.D.7
  • 53
    • 0021807207 scopus 로고
    • Metallothioneins: Proteins in search of function
    • Karin, M., Metallothioneins: proteins in search of function, Cell, 41, 9-10, 1985.
    • (1985) Cell , vol.41 , pp. 9-10
    • Karin, M.1
  • 54
    • 0026492595 scopus 로고
    • Cloning and specific polymerised-chain reaction amplification of a third charge-separable human metallothionein isoform
    • Soumillion, A., Van Damme, J. and De Ley, M., Cloning and specific polymerised-chain reaction amplification of a third charge-separable human metallothionein isoform, Eur. J. Biochem., 209, 999-1004, 1992.
    • (1992) Eur. J. Biochem. , vol.209 , pp. 999-1004
    • Soumillion, A.1    Van Damme, J.2    De Ley, M.3
  • 56
    • 0009756109 scopus 로고    scopus 로고
    • Metallothionein expression in the mammalian brain
    • Klaassen, C.D., Ed., Basel, Birkhäuser Verlag
    • West, A.K., Holloway, A.F., Stennard, F.A. and Miller, J.M., Metallothionein expression in the mammalian brain, in Metallothionein IV, Klaassen, C.D., Ed., Basel, Birkhäuser Verlag, 377-382, 1999.
    • (1999) Metallothionein IV , pp. 377-382
    • West, A.K.1    Holloway, A.F.2    Stennard, F.A.3    Miller, J.M.4
  • 57
    • 0031818254 scopus 로고    scopus 로고
    • Expression of the gene encoding metallothionein-3 in organs of the reproductive system
    • Moffatt, P. and Seguin, C., Expression of the gene encoding metallothionein-3 in organs of the reproductive system, DNA Cell Biol., 17, 501-510, 1998.
    • (1998) DNA Cell Biol. , vol.17 , pp. 501-510
    • Moffatt, P.1    Seguin, C.2
  • 58
    • 0030052798 scopus 로고    scopus 로고
    • Activation of the complete mouse metallothionein gene locus in the maternal deciduum
    • Liang, L., Fu, K., Lee, D.K., Sobieski, R.J., Dalton, T. and Andrews, G.K., Activation of the complete mouse metallothionein gene locus in the maternal deciduum, Mol. Reprod. Develop., 43, 25-37, 1996.
    • (1996) Mol. Reprod. Develop. , vol.43 , pp. 25-37
    • Liang, L.1    Fu, K.2    Lee, D.K.3    Sobieski, R.J.4    Dalton, T.5    Andrews, G.K.6
  • 60
    • 0030802387 scopus 로고    scopus 로고
    • Expression of MT-3 mRNA in human kidney, proximal tubule cell cultures, and renal cell carcinoma
    • Hoey, J.G., Garrett, S.H., Sens, M.A., Todd, J.H. and Sens, D.A., Expression of MT-3 mRNA in human kidney, proximal tubule cell cultures, and renal cell carcinoma, Toxicol. Lett., 92, 149-160, 1997.
    • (1997) Toxicol. Lett. , vol.92 , pp. 149-160
    • Hoey, J.G.1    Garrett, S.H.2    Sens, M.A.3    Todd, J.H.4    Sens, D.A.5
  • 61
    • 0032574672 scopus 로고    scopus 로고
    • Multiple isoforms of metallothionein are expressed in the porcine liver
    • Huang, M.C., Pan, P.K., Zheng, Z.F., Chen, N.C., Peng, J.Y. and Huang, P.C., Multiple isoforms of metallothionein are expressed in the porcine liver, Gene, 211, 49-55, 1998.
    • (1998) Gene , vol.211 , pp. 49-55
    • Huang, M.C.1    Pan, P.K.2    Zheng, Z.F.3    Chen, N.C.4    Peng, J.Y.5    Huang, P.C.6
  • 62
    • 0030784961 scopus 로고    scopus 로고
    • Cloning of porcine neuron growth inhibitory factor (metallothionnein III) cDNA and expression of the gene in Saccharomyces cerevisiae
    • Wang, S.H., Chang, C.Y., Chen, C.F., Tam, M.F., Shih, Y.H. and Lin, L.Y., Cloning of porcine neuron growth inhibitory factor (metallothionnein III) cDNA and expression of the gene in Saccharomyces cerevisiae, Gene, 203, 189-197, 1997.
    • (1997) Gene , vol.203 , pp. 189-197
    • Wang, S.H.1    Chang, C.Y.2    Chen, C.F.3    Tam, M.F.4    Shih, Y.H.5    Lin, L.Y.6
  • 63
    • 0023877744 scopus 로고
    • Differential expression of four linked sheep metallothionein genes
    • Peterson, M.G. and Mercer, J.F., Differential expression of four linked sheep metallothionein genes, Eur. J. Biochem., 174, 425-429, 1988.
    • (1988) Eur. J. Biochem. , vol.174 , pp. 425-429
    • Peterson, M.G.1    Mercer, J.F.2
  • 64
    • 0033054780 scopus 로고    scopus 로고
    • Rat metallothionein-2 contains N(a)-acetylated and unacetylated isoforms
    • Beattie, J.H., Wood, A.M. and Duncan, G.J., Rat metallothionein-2 contains N(a)-acetylated and unacetylated isoforms, Electrophoresis, 20, 1613-1618, 1999.
    • (1999) Electrophoresis , vol.20 , pp. 1613-1618
    • Beattie, J.H.1    Wood, A.M.2    Duncan, G.J.3
  • 65
    • 0033492374 scopus 로고    scopus 로고
    • Biological significance of non-acetylated metallothionein
    • Ogra, Y. and Suzuki, K.T., Biological significance of non-acetylated metallothionein, J. Chromatogr., 735, 17-24, 1999.
    • (1999) J. Chromatogr. , vol.735 , pp. 17-24
    • Ogra, Y.1    Suzuki, K.T.2
  • 66
    • 0023071221 scopus 로고
    • Molecular biology of metallothionein gene expression
    • Palmiter, R.D., Molecular biology of metallothionein gene expression, Experientia, 52, 63-80, 1987.
    • (1987) Experientia , vol.52 , pp. 63-80
    • Palmiter, R.D.1
  • 67
    • 0025240099 scopus 로고
    • Cell-type specific and differential regulation of the human metallothionein genes. Correlation with DNA methylation and chromatin structure
    • Jahroudi, N., Foster, R., Price-Haughey, J., Beitel, G. and Gedamu, L., Cell-type specific and differential regulation of the human metallothionein genes. Correlation with DNA methylation and chromatin structure, J. Biol. Chem., 265, 6506-6511, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 6506-6511
    • Jahroudi, N.1    Foster, R.2    Price-Haughey, J.3    Beitel, G.4    Gedamu, L.5
  • 70
    • 0021929190 scopus 로고
    • Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids
    • Yagle, M.K. and Palmiter, R.D., Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids, Mol. Cell. Biol., 5, 291-294, 1985.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 291-294
    • Yagle, M.K.1    Palmiter, R.D.2
  • 71
    • 0023862975 scopus 로고
    • Regulation of human metallothionein (MT) genes. Differential expression of MTI-F, MTI-G, and MTII-A genes in the hepatoblastoma cell line (HepG2)
    • Sadhu, C. and Gedamu, L., Regulation of human metallothionein (MT) genes. Differential expression of MTI-F, MTI-G, and MTII-A genes in the hepatoblastoma cell line (HepG2), J. Biol. Chem., 263, 2679-2684, 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 2679-2684
    • Sadhu, C.1    Gedamu, L.2
  • 72
    • 0031606565 scopus 로고    scopus 로고
    • Molecular analyses of metallothionein gene regulation
    • Samson, S.L. and Gedamu, L., Molecular analyses of metallothionein gene regulation, Prog. Nucleic Acid Res. Mol. Biol., 59, 257-288, 1998.
    • (1998) Prog. Nucleic Acid Res. Mol. Biol. , vol.59 , pp. 257-288
    • Samson, S.L.1    Gedamu, L.2
  • 73
    • 0025154985 scopus 로고
    • Regulation of metallothionein gene expression
    • Andrews, G.K., Regulation of metallothionein gene expression, Progr. Food Nutr. Sci., 14, 193-258, 1990.
    • (1990) Progr. Food Nutr. Sci. , vol.14 , pp. 193-258
    • Andrews, G.K.1
  • 75
    • 84940122268 scopus 로고
    • Brain metallothionein gene expression and regulation
    • Saijoh, K., Katsuyama, H. and Sumino, K., Brain metallothionein gene expression and regulation, Biol. Signals, 3, 150-156, 1994.
    • (1994) Biol. Signals , vol.3 , pp. 150-156
    • Saijoh, K.1    Katsuyama, H.2    Sumino, K.3
  • 76
    • 0029685732 scopus 로고    scopus 로고
    • Metal-responsive gene regulation and the zinc metalloregulatory model
    • Suhy, D.A. and O'Halloran, T.V., Metal-responsive gene regulation and the zinc metalloregulatory model, Metal Ions Biol. Systems, 32, 557-578, 1996.
    • (1996) Metal Ions Biol. Systems , vol.32 , pp. 557-578
    • Suhy, D.A.1    O'Halloran, T.V.2
  • 77
    • 0022555879 scopus 로고
    • Metallothionein
    • Hamer, D.H., Metallothionein, Annu. Rev. Biochem., 55, 913-951, 1986.
    • (1986) Annu. Rev. Biochem. , vol.55 , pp. 913-951
    • Hamer, D.H.1
  • 78
    • 0030845535 scopus 로고    scopus 로고
    • Metallothionein in physiological and physiopathological processes
    • Moffatt, P. and Denizeau, F., Metallothionein in physiological and physiopathological processes, Drug Metab. Rev., 29, 261-307, 1997.
    • (1997) Drug Metab. Rev. , vol.29 , pp. 261-307
    • Moffatt, P.1    Denizeau, F.2
  • 79
    • 0023391421 scopus 로고
    • Metallothionein gene regulation
    • Searle, P.F., Metallothionein gene regulation, Biochem. Soc. Trans., 15, 584-586, 1987.
    • (1987) Biochem. Soc. Trans. , vol.15 , pp. 584-586
    • Searle, P.F.1
  • 81
    • 0023072502 scopus 로고
    • Transcriptional control mechanisms which regulate the expression of human metallothionein genes
    • Karin, M., Haslinger, A., Heguy, A., Dietlin, T. and Imbra, R., Transcriptional control mechanisms which regulate the expression of human metallothionein genes, Experientia, 52, 401-405, 1987.
    • (1987) Experientia , vol.52 , pp. 401-405
    • Karin, M.1    Haslinger, A.2    Heguy, A.3    Dietlin, T.4    Imbra, R.5
  • 82
    • 0021399238 scopus 로고
    • The human metallothionein gene family: Structure and expression
    • Karin, M. and Richards, R.I., The human metallothionein gene family: structure and expression, Environ. Health Persp., 54, 111-115, 1984.
    • (1984) Environ. Health Persp. , vol.54 , pp. 111-115
    • Karin, M.1    Richards, R.I.2
  • 83
    • 0033990794 scopus 로고    scopus 로고
    • Regulation of metallothionein gene expression by oxidative stress and metal ions
    • Andrews, G.K., Regulation of metallothionein gene expression by oxidative stress and metal ions, Biochem. Pharmacol., 59, 95-104, 2000.
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 95-104
    • Andrews, G.K.1
  • 84
    • 0021242444 scopus 로고
    • Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene
    • Karin, M., Haslinger, A., Holtgreve, H., Richards, R.I., Krauter, P., Westphal, H.M. and Beato, M., Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene, Nature, 308, 513-519, 1984.
    • (1984) Nature , vol.308 , pp. 513-519
    • Karin, M.1    Haslinger, A.2    Holtgreve, H.3    Richards, R.I.4    Krauter, P.5    Westphal, H.M.6    Beato, M.7
  • 86
    • 0033083839 scopus 로고    scopus 로고
    • Transcriptional activity and regulatory protein binding of metal- Responsive elements of the human metallothionein-IIA gene
    • Koizumi, S., Suzuki, K., Ogra, Y., Yamada, H. and Otsuka, F., Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene, Eur. J. Biochem., 259, 635-642, 1999.
    • (1999) Eur. J. Biochem. , vol.259 , pp. 635-642
    • Koizumi, S.1    Suzuki, K.2    Ogra, Y.3    Yamada, H.4    Otsuka, F.5
  • 87
    • 0022410464 scopus 로고
    • Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences
    • Stuart, G.W., Searle, P.F. and Palmiter, R.D., Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences, Nature, 317, 828-831, 1985.
    • (1985) Nature , vol.317 , pp. 828-831
    • Stuart, G.W.1    Searle, P.F.2    Palmiter, R.D.3
  • 88
    • 0023551951 scopus 로고
    • Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter
    • Andersen, R.D., Taplitz, S.J., Wong, S., Bristol, G., Larkin, B. and Herschman, H.R., Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter, Mol. Cell. Biol., 7, 3574-3581, 1987.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 3574-3581
    • Andersen, R.D.1    Taplitz, S.J.2    Wong, S.3    Bristol, G.4    Larkin, B.5    Herschman, H.R.6
  • 89
    • 0027978163 scopus 로고
    • The immediate vicinity of mouse metallothionein-I gene contains two sites conferring glucocorticoid inducibility to the heterologous promoter
    • Plisov, S.Y., Nichiporenko, M.G., Shkapenko, A.L., Kumarev, V.P., Baranova, L.V. and Merkulova, T.I., The immediate vicinity of mouse metallothionein-I gene contains two sites conferring glucocorticoid inducibility to the heterologous promoter, FEBS Lett., 352, 339-341, 1994.
    • (1994) FEBS Lett. , vol.352 , pp. 339-341
    • Plisov, S.Y.1    Nichiporenko, M.G.2    Shkapenko, A.L.3    Kumarev, V.P.4    Baranova, L.V.5    Merkulova, T.I.6
  • 91
    • 0028593507 scopus 로고
    • Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements
    • Dalton, T., Palmiter, R.D. and Andrews, G.K., Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements, Nucleic Acids Res., 22, 5016-5023, 1994.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5016-5023
    • Dalton, T.1    Palmiter, R.D.2    Andrews, G.K.3
  • 92
    • 0024330614 scopus 로고
    • Transcription factor MBF-I interacts with metal regulatory elements of higher eucaryotic metallothionein genes
    • Imbert, J., Zafarullah, M., Culotta, V.C., Gedamu, L. and Hamer, D., Transcription factor MBF-I interacts with metal regulatory elements of higher eucaryotic metallothionein genes, Mol. Cell. Biol., 9, 5315-5323, 1989.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5315-5323
    • Imbert, J.1    Zafarullah, M.2    Culotta, V.C.3    Gedamu, L.4    Hamer, D.5
  • 93
    • 0023779378 scopus 로고
    • Detection of a nuclear protein that interacts with a metal regulatory element of the mouse metallothionein 1 gene
    • Seguin, C. and Prevost, J., Detection of a nuclear protein that interacts with a metal regulatory element of the mouse metallothionein 1 gene, Nucleic Acids Res., 16, 10547-10560, 1988.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 10547-10560
    • Seguin, C.1    Prevost, J.2
  • 94
    • 0025025391 scopus 로고
    • Zinc dependent binding of a liver nuclear factor to metal response element MRE-a of the mouse metallothionein-I gene and variant sequences
    • Searle, P.F., Zinc dependent binding of a liver nuclear factor to metal response element MRE-a of the mouse metallothionein-I gene and variant sequences, Nucleic Acids Res., 18, 4683-4690, 1990.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 4683-4690
    • Searle, P.F.1
  • 95
    • 0030695298 scopus 로고    scopus 로고
    • Regulation of ZiRF1 and basal SP1 transcription factor MRE- Binding activity by transition metals
    • Remondelli, P., Moltedo, O. and Leone, A., Regulation of ZiRF1 and basal SP1 transcription factor MRE-binding activity by transition metals, FEBS Lett., 416, 254-258, 1997.
    • (1997) FEBS Lett. , vol.416 , pp. 254-258
    • Remondelli, P.1    Moltedo, O.2    Leone, A.3
  • 97
    • 0026448118 scopus 로고
    • Zinc rapidly induces a metal response element-binding factor
    • Czupryn, M., Brown, W.E. and Vallee, B.L., Zinc rapidly induces a metal response element-binding factor, Proc. Natl. Acad. Sci. U.S.A., 89, 10395-10399, 1992.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 10395-10399
    • Czupryn, M.1    Brown, W.E.2    Vallee, B.L.3
  • 98
    • 0026764942 scopus 로고
    • A nuclear factor that recognizes the metal-responsive elements of human metallothionein IIA gene
    • Koizumi, S., Suzuki, K. and Otsuka, F., A nuclear factor that recognizes the metal-responsive elements of human metallothionein IIA gene, J. Biol. Chem., 267, 18659-18664, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18659-18664
    • Koizumi, S.1    Suzuki, K.2    Otsuka, F.3
  • 99
    • 0024222446 scopus 로고
    • A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene
    • Westin, G. and Schaffner, W., A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene, EMBO J., 7, 3763-3770, 1988.
    • (1988) EMBO J. , vol.7 , pp. 3763-3770
    • Westin, G.1    Schaffner, W.2
  • 100
    • 0027938768 scopus 로고
    • Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1
    • Brugnera, E., Georgiev, O., Radtke, F., Heuchel, R., Baker, E., Sutherland, G.R. and Schaffner, W., Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1, Nucleic Acids Res., 22, 3167-3173, 1994.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 3167-3173
    • Brugnera, E.1    Georgiev, O.2    Radtke, F.3    Heuchel, R.4    Baker, E.5    Sutherland, G.R.6    Schaffner, W.7
  • 101
    • 0029009956 scopus 로고
    • Functional domains of the heavy metal-responsive transcription regulator MTF-1
    • Radtke, F., Georgiev, O., Muller, H.P., Brugnera, E. and Schaffner, W., Functional domains of the heavy metal-responsive transcription regulator MTF-1, Nucleic Acids Res., 23, 2277-2286, 1995.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 2277-2286
    • Radtke, F.1    Georgiev, O.2    Muller, H.P.3    Brugnera, E.4    Schaffner, W.5
  • 102
    • 0032549517 scopus 로고    scopus 로고
    • The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals
    • Bittel, D., Dalton, T., Samson, S.L., Gedamu, L. and Andrews, G.K., The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals, J. Biol. Chem., 273, 7127-7133, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 7127-7133
    • Bittel, D.1    Dalton, T.2    Samson, S.L.3    Gedamu, L.4    Andrews, G.K.5
  • 103
    • 0028358324 scopus 로고
    • The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression
    • Heuchel, R., Radtke, F., Georgiev, O., Stark, G., Aguet, M. and Schaffner, W., The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression, EMBO J., 13, 2870-2875, 1994.
    • (1994) EMBO J. , vol.13 , pp. 2870-2875
    • Heuchel, R.1    Radtke, F.2    Georgiev, O.3    Stark, G.4    Aguet, M.5    Schaffner, W.6
  • 104
    • 0029910072 scopus 로고    scopus 로고
    • Oxidative stress activates metal-responsive transcription factor- 1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-I gene promoter
    • Dalton, T.P., Li, Q., Bittel, D., Liang, L. and Andrews, G.K., Oxidative stress activates metal-responsive transcription factor-1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-I gene promoter, J. Biol. Chem., 271, 26233-26241, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 26233-26241
    • Dalton, T.P.1    Li, Q.2    Bittel, D.3    Liang, L.4    Andrews, G.K.5
  • 106
    • 0028125990 scopus 로고
    • Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1
    • Palmiter, R.D., Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1, Proc. Natl. Acad. Sci. U.S.A., 91, 1219-1223, 1994.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 1219-1223
    • Palmiter, R.D.1
  • 107
    • 0032940101 scopus 로고    scopus 로고
    • Trans repression of the human metallothionein IIa gene promoter by PZ120, a novel 120-kilodalton zinc finger protein
    • Tang, C.M., Westling, J. and Seto, E., trans repression of the human metallothionein IIA gene promoter by PZ120, a novel 120-kilodalton zinc finger protein, Mol. Cell. Biol., 19, 680-689, 1999.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 680-689
    • Tang, C.M.1    Westling, J.2    Seto, E.3
  • 108
    • 0033605358 scopus 로고    scopus 로고
    • Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1
    • Chu, W.A., Moehlenkamp, J.D., Bittel, D., Andrews, G.K. and Johnson, J., Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1, J. Biol. Chem., 274, 5279-5284, 1999.
    • (1999) J. Biol. Chem. , vol.274 , pp. 5279-5284
    • Chu, W.A.1    Moehlenkamp, J.D.2    Bittel, D.3    Andrews, G.K.4    Johnson, J.5
  • 109
    • 0019483405 scopus 로고
    • Transcriptional regulation of the mouse metallothionein-I gene by heavy metals
    • Durnam, D.M. and Palmiter, R.D., Transcriptional regulation of the mouse metallothionein-I gene by heavy metals, J. Biol. Chem., 256, 5712-5716, 1981.
    • (1981) J. Biol. Chem. , vol.256 , pp. 5712-5716
    • Durnam, D.M.1    Palmiter, R.D.2
  • 110
    • 0024331811 scopus 로고
    • Metal-specific posttranscriptional control of human metallothionein genes
    • Sadhu, C. and Gedamu, L., Metal-specific posttranscriptional control of human metallothionein genes, Mol. Cell. Biol., 9, 5738-5741, 1989.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5738-5741
    • Sadhu, C.1    Gedamu, L.2
  • 111
    • 0029872621 scopus 로고    scopus 로고
    • Evidence for differences in the post-transcriptional regulation of rat metallothionein isoforms
    • Vasconcelos, M.H., Tam, S.C., Beattie, J.H. and Hesketh, J.E., Evidence for differences in the post-transcriptional regulation of rat metallothionein isoforms, Biochem. J., 315, 665-671, 1996.
    • (1996) Biochem. J. , vol.315 , pp. 665-671
    • Vasconcelos, M.H.1    Tam, S.C.2    Beattie, J.H.3    Hesketh, J.E.4
  • 112
    • 0021168535 scopus 로고
    • DNA methylation patterns. Formation and function
    • Razin, A. and Szyf, M., DNA methylation patterns. Formation and function, Biochim. Biophys. Acta, 782, 331-342, 1984.
    • (1984) Biochim. Biophys. Acta , vol.782 , pp. 331-342
    • Razin, A.1    Szyf, M.2
  • 113
    • 0021344845 scopus 로고
    • Methylation, expression and chromosomal position of genes in mammals
    • Jaenisch, R. and Jahner, D., Methylation, expression and chromosomal position of genes in mammals, Biochim. Biophys. Acta, 782, 1-9, 1984.
    • (1984) Biochim. Biophys. Acta , vol.782 , pp. 1-9
    • Jaenisch, R.1    Jahner, D.2
  • 114
    • 0026537820 scopus 로고
    • Metallothionein biodegradation in rat hepatoma cells: A compartmental analysis aided 35S-radiotracer study
    • Steinebach, O.M. and Wolterbeek, B.T., Metallothionein biodegradation in rat hepatoma cells: a compartmental analysis aided 35S-radiotracer study, Biochim. Biophys. Acta, 1116, 155-165, 1992.
    • (1992) Biochim. Biophys. Acta , vol.1116 , pp. 155-165
    • Steinebach, O.M.1    Wolterbeek, B.T.2
  • 116
    • 0017190705 scopus 로고
    • Degradation of hepatic zinc-thionein after parenteral zinc administration
    • Feldman, S.L. and Cousins, R.J., Degradation of hepatic zinc-thionein after parenteral zinc administration, Biochem. J., 160, 583-588, 1976.
    • (1976) Biochem. J. , vol.160 , pp. 583-588
    • Feldman, S.L.1    Cousins, R.J.2
  • 117
    • 0024341498 scopus 로고
    • Degradation of zinc-metallothionein in monolayer cultures of rat hepatocytes
    • Chen, M.L. and Failla, M.L., Degradation of zinc-metallothionein in monolayer cultures of rat hepatocytes, Proc. Soc. Exp. Biol. Med., 191, 130-138, 1989.
    • (1989) Proc. Soc. Exp. Biol. Med. , vol.191 , pp. 130-138
    • Chen, M.L.1    Failla, M.L.2
  • 118
  • 121
    • 0026672416 scopus 로고
    • In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D
    • McKim, J.M., Jr., Choudhuri, S. and Klaassen, C.D., In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D, Toxicol. App. Pharmacol., 116, 117-124, 1992.
    • (1992) Toxicol. App. Pharmacol. , vol.116 , pp. 117-124
    • McKim Jr., J.M.1    Choudhuri, S.2    Klaassen, C.D.3
  • 123
    • 0018549233 scopus 로고
    • Synthesis and degradation of liver metallothionein
    • Cousins, R.J., Synthesis and degradation of liver metallothionein, Experientia, 34, 293-301, 1979.
    • (1979) Experientia , vol.34 , pp. 293-301
    • Cousins, R.J.1
  • 124
    • 0018332793 scopus 로고
    • Metallothionein synthesis and degradation: Relationship to cadmium metabolism
    • Cousins, R.J., Metallothionein synthesis and degradation: relationship to cadmium metabolism, Environ. Health Persp., 28, 131-136, 1979.
    • (1979) Environ. Health Persp. , vol.28 , pp. 131-136
    • Cousins, R.J.1
  • 125
    • 0018161007 scopus 로고
    • Effect of zinc status of rats on the synthesis and degradation of copper-induced metallothioneins
    • Bremner, I., Hoekstra, G., Davies, N.T. and Young, B.W., Effect of zinc status of rats on the synthesis and degradation of copper-induced metallothioneins, Biochem. J., 174, 883-892, 1978.
    • (1978) Biochem. J. , vol.174 , pp. 883-892
    • Bremner, I.1    Hoekstra, G.2    Davies, N.T.3    Young, B.W.4
  • 127
    • 0018668023 scopus 로고
    • Metallothionein degradation: Metal composition as a controlling factor
    • Cain, K. and Holt, D.E., Metallothionein degradation: metal composition as a controlling factor, Chem. Biol. Interact., 28, 91-106, 1979.
    • (1979) Chem. Biol. Interact. , vol.28 , pp. 91-106
    • Cain, K.1    Holt, D.E.2
  • 128
    • 0019842752 scopus 로고
    • Regulation of metallothionein syn-thesis in HeLa cells by heavy metals and glucocorticoids
    • Karin, M., Slater, E.P. and Herschman, H.R., Regulation of metallothionein syn-thesis in HeLa cells by heavy metals and glucocorticoids, J. Cell. Physiol., 106, 63-74, 1981.
    • (1981) J. Cell. Physiol. , vol.106 , pp. 63-74
    • Karin, M.1    Slater, E.P.2    Herschman, H.R.3
  • 130
    • 0021334856 scopus 로고
    • A comparison of isometallothionein synthesis in rat liver after partial hepatectomy and parenteral zinc injection
    • Cain, K. and Griffiths, B.L., A comparison of isometallothionein synthesis in rat liver after partial hepatectomy and parenteral zinc injection, Biochem. J., 217, 85-92, 1984.
    • (1984) Biochem. J. , vol.217 , pp. 85-92
    • Cain, K.1    Griffiths, B.L.2
  • 131
    • 0026586139 scopus 로고
    • Degradation and metal composition of hepatic isometallothioneins in rats
    • Kershaw, W.C. and Klaassen, C.D., Degradation and metal composition of hepatic isometallothioneins in rats, Toxicol. App. Pharmacol., 112, 24-31, 1992.
    • (1992) Toxicol. App. Pharmacol. , vol.112 , pp. 24-31
    • Kershaw, W.C.1    Klaassen, C.D.2
  • 132
    • 0023841810 scopus 로고
    • Mechanisms of regulation of rat hepatic metallothionein-I and metallothionein-II levels following administration of zinc
    • Lehman-McKeeman, L.D., Andrews, G.K. and Klaassen, C.D., Mechanisms of regulation of rat hepatic metallothionein-I and metallothionein-II levels following administration of zinc, Toxicol. App. Pharmacol., 92, 1-9, 1988.
    • (1988) Toxicol. App. Pharmacol. , vol.92 , pp. 1-9
    • Lehman-McKeeman, L.D.1    Andrews, G.K.2    Klaassen, C.D.3
  • 134
    • 0021911968 scopus 로고
    • Induction and degradation of Zn-, Cu-and Cd-thionein in Chang liver cells
    • Kobayashi, S., Imano, M. and Kimura, M., Induction and degradation of Zn-, Cu-and Cd-thionein in Chang liver cells, Chem. Biol. Interact., 52, 319-334, 1985.
    • (1985) Chem. Biol. Interact. , vol.52 , pp. 319-334
    • Kobayashi, S.1    Imano, M.2    Kimura, M.3
  • 135
    • 0029932310 scopus 로고    scopus 로고
    • Differential sensitivity of metallothionein-1 and -2 in liver of zinc-injected rat toward proteolysis
    • Saito, S. and Hunziker, P.E., Differential sensitivity of metallothionein-1 and -2 in liver of zinc-injected rat toward proteolysis, Biochim. Biophys. Acta, 1289, 65-70, 1996.
    • (1996) Biochim. Biophys. Acta , vol.1289 , pp. 65-70
    • Saito, S.1    Hunziker, P.E.2
  • 137
    • 0031958413 scopus 로고    scopus 로고
    • Copper metabolism in the kidney of rats administered copper and copper-metallothionein
    • Kurasaki, M., Okabe, M., Saito, S. and Suzuki-Kurasaki, M., Copper metabolism in the kidney of rats administered copper and copper-metallothionein, Am. J. Physiol., 274, F783-790, 1998.
    • (1998) Am. J. Physiol. , vol.274
    • Kurasaki, M.1    Okabe, M.2    Saito, S.3    Suzuki-Kurasaki, M.4
  • 138
    • 0020659546 scopus 로고
    • Studies of cadmium-thionein induced nephropathy: Time course of cadmium-thionein uptake and degradation
    • Cain, K. and Holt, D.E., Studies of cadmium-thionein induced nephropathy: time course of cadmium-thionein uptake and degradation, Chem. Biol. Interact., 43, 223-237, 1983.
    • (1983) Chem. Biol. Interact. , vol.43 , pp. 223-237
    • Cain, K.1    Holt, D.E.2
  • 139
    • 0020628386 scopus 로고
    • Levels of metallothionein messenger RNA in foetal, neonatal and maternal rat liver
    • Andersen, R.D., Piletz, J.E., Birren, B.W. and Herschman, H.R., Levels of metallothionein messenger RNA in foetal, neonatal and maternal rat liver, Eur. J. Biochem., 131, 497-500, 1983.
    • (1983) Eur. J. Biochem. , vol.131 , pp. 497-500
    • Andersen, R.D.1    Piletz, J.E.2    Birren, B.W.3    Herschman, H.R.4
  • 140
    • 0023081308 scopus 로고
    • Biosynthesis and metabolism of metallothionein in rat during perinatal development
    • Cherian, M.G., Templeton, D.M., Gallant, K.R. and Banerjee, D., Biosynthesis and metabolism of metallothionein in rat during perinatal development, Experientia, 52, 499-505, 1987.
    • (1987) Experientia , vol.52 , pp. 499-505
    • Cherian, M.G.1    Templeton, D.M.2    Gallant, K.R.3    Banerjee, D.4
  • 142
    • 0021447006 scopus 로고
    • The ontogeny of expression of murine metallothionein: Comparison with the alpha-fetoprotein gene
    • Andrews, G.K., Adamson, E.D. and Gedamu, L., The ontogeny of expression of murine metallothionein: comparison with the alpha-fetoprotein gene, Develop. Biol., 103, 294-303, 1984.
    • (1984) Develop. Biol. , vol.103 , pp. 294-303
    • Andrews, G.K.1    Adamson, E.D.2    Gedamu, L.3
  • 143
    • 0020561489 scopus 로고
    • Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development
    • Panemangalore, M., Banerjee, D., Onosaka, S. and Cherian, M.G., Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development, Develop. Biol., 97, 95-102, 1983.
    • (1983) Develop. Biol. , vol.97 , pp. 95-102
    • Panemangalore, M.1    Banerjee, D.2    Onosaka, S.3    Cherian, M.G.4
  • 144
    • 0028910004 scopus 로고
    • Enhanced transcription of metallothionein genes in rat kidney: Effect of uninephrectomy and compensatory renal growth
    • Zalups, R.K., Fraser, J. and Koropatnick, J., Enhanced transcription of metallothionein genes in rat kidney: effect of uninephrectomy and compensatory renal growth, Am. J. Physiol., 268, F643-650, 1995.
    • (1995) Am. J. Physiol. , vol.268
    • Zalups, R.K.1    Fraser, J.2    Koropatnick, J.3
  • 145
    • 0028836796 scopus 로고
    • Cell cycle regulation of metallothionein in human colonic cancer cells
    • Nagel, W.W. and Vallee, B.L., Cell cycle regulation of metallothionein in human colonic cancer cells, Proc. Natl. Acad. Sci. U.S.A., 92, 579-583, 1995.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 579-583
    • Nagel, W.W.1    Vallee, B.L.2
  • 147
    • 0030711622 scopus 로고    scopus 로고
    • Metallothionein accretion in human hepatic cells is linked to cellular proliferation
    • Studer, R., Vogt, C.P., Cavigelli, M., Hunziker, P.E. and Kägi. J.H., Metallothionein accretion in human hepatic cells is linked to cellular proliferation, Biochem. J., 328, 63-67, 1997.
    • (1997) Biochem. J. , vol.328 , pp. 63-67
    • Studer, R.1    Vogt, C.P.2    Cavigelli, M.3    Hunziker, P.E.4    Kägi, J.H.5
  • 148
    • 0027438814 scopus 로고
    • Induction of metallothionein and its localization in the nucleus of rat hepatocytes after partial hepatectomy
    • Tohyama, C., Suzuki, J.S., Hemelraad, J., Nishimura, N. and Nishimura, H., Induction of metallothionein and its localization in the nucleus of rat hepatocytes after partial hepatectomy, Hepatol., 18, 1193-1201, 1993.
    • (1993) Hepatol. , vol.18 , pp. 1193-1201
    • Tohyama, C.1    Suzuki, J.S.2    Hemelraad, J.3    Nishimura, N.4    Nishimura, H.5
  • 149
    • 0024604011 scopus 로고
    • Immunohistochemical localization of metallothionein in developing rat tissues
    • Nishimura, H., Nishimura, N. and Tohyama, C., Immunohistochemical localization of metallothionein in developing rat tissues, J. Histochem. Cytochem., 37, 715-722, 1989.
    • (1989) J. Histochem. Cytochem. , vol.37 , pp. 715-722
    • Nishimura, H.1    Nishimura, N.2    Tohyama, C.3
  • 150
    • 0023258490 scopus 로고
    • Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development
    • Nartey, N.O., Banerjee, D. and Cherian, M.G., Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development, Pathol., 19, 233-238, 1987.
    • (1987) Pathol. , vol.19 , pp. 233-238
    • Nartey, N.O.1    Banerjee, D.2    Cherian, M.G.3
  • 151
    • 0029996408 scopus 로고    scopus 로고
    • Nucleophilic distribution of metallothionein in human tumor cells
    • Woo, E.S., Kondo, Y., Watkins, S.C., Hoyt, D.G. and Lazo, J.S., Nucleophilic distribution of metallothionein in human tumor cells, Exp. Cell Res., 224, 365-371, 1996.
    • (1996) Exp. Cell Res. , vol.224 , pp. 365-371
    • Woo, E.S.1    Kondo, Y.2    Watkins, S.C.3    Hoyt, D.G.4    Lazo, J.S.5
  • 153
    • 0029877578 scopus 로고    scopus 로고
    • Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney
    • Mididoddi, S., McGuirt, J.P., Sens, M.A., Todd, J.H. and Sens, D.A., Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney, Toxicol. Lett., 85, 17-27, 1996.
    • (1996) Toxicol. Lett. , vol.85 , pp. 17-27
    • Mididoddi, S.1    McGuirt, J.P.2    Sens, M.A.3    Todd, J.H.4    Sens, D.A.5
  • 154
    • 0030768617 scopus 로고    scopus 로고
    • Nucleocytoplasmic functionality of metallothionein
    • Woo, E.S. and Lazo, J.S., Nucleocytoplasmic functionality of metallothionein, Cancer Res., 57, 4236-4241, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 4236-4241
    • Woo, E.S.1    Lazo, J.S.2
  • 156
    • 0025976912 scopus 로고
    • Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp1
    • Zeng, J., Heuchel, R., Schaffner, W. and Kagi, J.H., Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp1, FEBS Lett., 279, 310-312, 1991.
    • (1991) FEBS Lett. , vol.279 , pp. 310-312
    • Zeng, J.1    Heuchel, R.2    Schaffner, W.3    Kagi, J.H.4
  • 157
    • 0027620493 scopus 로고
    • Involvement of metallothionein and copper in cell proliferation
    • Wlostowski, T., Involvement of metallothionein and copper in cell proliferation, Biometals, 6, 71-76, 1993.
    • (1993) Biometals , vol.6 , pp. 71-76
    • Wlostowski, T.1
  • 158
    • 0019445956 scopus 로고
    • Metabolism of zinc and copper in the neonate. (Zinc, copper)- Thionein in the developing rat kidney and testis
    • Brady, F.O. and Webb, M., Metabolism of zinc and copper in the neonate. (Zinc, copper)-thionein in the developing rat kidney and testis, J. Biol. Chem., 256, 3931-3935, 1981.
    • (1981) J. Biol. Chem. , vol.256 , pp. 3931-3935
    • Brady, F.O.1    Webb, M.2
  • 159
    • 0019506471 scopus 로고
    • Metabolism of zinc and copper in the neonate: Changes in the concentrations and contents of thionein-bound Zn and Cu with age in the livers of the newborn of various mammalian species
    • Bakka, A. and Webb, M., Metabolism of zinc and copper in the neonate: changes in the concentrations and contents of thionein-bound Zn and Cu with age in the livers of the newborn of various mammalian species, Biochem. Pharmacol., 30, 721-725, 1981.
    • (1981) Biochem. Pharmacol. , vol.30 , pp. 721-725
    • Bakka, A.1    Webb, M.2
  • 160
    • 0345466127 scopus 로고
    • Metallothionein and cell death
    • Collery, P.H., Poirier, L.A., Littlefield, N.A. and Etienne, J.C., Eds., Paris, John Libbey Eurotext
    • Lazo, J.S., Schwarz, M.A. and Pitt, B.R., Metallothionein and cell death, in Metal ions in Biology and Medicine, Collery, P.H., Poirier, L.A., Littlefield, N.A. and Etienne, J.C., Eds., Paris, John Libbey Eurotext, 15-16b, 1994.
    • (1994) Metal Ions in Biology and Medicine
    • Lazo, J.S.1    Schwarz, M.A.2    Pitt, B.R.3
  • 162
    • 0031133179 scopus 로고    scopus 로고
    • Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells
    • Abdel-Mageed, A. and Agrawal, K.C., Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells, Cancer Gene Ther., 4, 199-207, 1997.
    • (1997) Cancer Gene Ther. , vol.4 , pp. 199-207
    • Abdel-Mageed, A.1    Agrawal, K.C.2
  • 163
    • 0031906024 scopus 로고    scopus 로고
    • Metallothionein (MT)-null mice are sensitive to cisplatin- Induced hepatotoxicity
    • Liu, J., Liu, Y., Habeebu, S.S. and Klaassen, C.D., Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity, Toxicol. App. Pharmacol., 149, 24-31, 1998.
    • (1998) Toxicol. App. Pharmacol. , vol.149 , pp. 24-31
    • Liu, J.1    Liu, Y.2    Habeebu, S.S.3    Klaassen, C.D.4
  • 164
    • 0031951735 scopus 로고    scopus 로고
    • Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes
    • Baba, T., Nakano, H., Tamai, K., Sawamura, D., Hanada, K., Hashimoto, I. and Arima, Y., Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes, J. Invest. Dermatol., 110, 24-28, 1998.
    • (1998) J. Invest. Dermatol. , vol.110 , pp. 24-28
    • Baba, T.1    Nakano, H.2    Tamai, K.3    Sawamura, D.4    Hanada, K.5    Hashimoto, I.6    Arima, Y.7
  • 165
    • 0031954785 scopus 로고    scopus 로고
    • Metallothionein and apoptosis in primary human hepatocellular carcinoma and metastatic adenocarcinoma
    • Deng, D.X., Chakrabarti, S., Waalkes, M.P. and Cherian, M.G., Metallothionein and apoptosis in primary human hepatocellular carcinoma and metastatic adenocarcinoma, Histopathol., 32, 340-347, 1998.
    • (1998) Histopathol. , vol.32 , pp. 340-347
    • Deng, D.X.1    Chakrabarti, S.2    Waalkes, M.P.3    Cherian, M.G.4
  • 166
    • 0030611126 scopus 로고    scopus 로고
    • Apoptosis in epithelial hyperplastic laryngeal lesions
    • Hellquist, H.B., Apoptosis in epithelial hyperplastic laryngeal lesions, Acta Oto-Laryngologica, 527, 25-29, 1997.
    • (1997) Acta Oto-Laryngologica , vol.527 , pp. 25-29
    • Hellquist, H.B.1
  • 167
    • 0031424547 scopus 로고    scopus 로고
    • Metallothionein and Fas (CD95) are expressed in squamous cell carcinoma of the tongue
    • Sundelin, K., Jadner, M., Norberg-Spaak, L., Davidsson, A. and Hellquist, H.B., Metallothionein and Fas (CD95) are expressed in squamous cell carcinoma of the tongue, Eur. J. Cancer, 33, 1860-1864, 1997.
    • (1997) Eur. J. Cancer , vol.33 , pp. 1860-1864
    • Sundelin, K.1    Jadner, M.2    Norberg-Spaak, L.3    Davidsson, A.4    Hellquist, H.B.5
  • 169
    • 0029978576 scopus 로고    scopus 로고
    • Pathobiology of copper-induced injury in Bedlington terriers: Ultrastructural and microanalytical studies
    • Haywood, S., Fuentealba, I.C., Foster, J. and Ross, G., Pathobiology of copper-induced injury in Bedlington terriers: ultrastructural and microanalytical studies, Anal. Cell. Pathol., 10, 229-241, 1996.
    • (1996) Anal. Cell. Pathol. , vol.10 , pp. 229-241
    • Haywood, S.1    Fuentealba, I.C.2    Foster, J.3    Ross, G.4
  • 170
    • 0031939026 scopus 로고    scopus 로고
    • Metallothionein and apoptosis in the toxic milk mutant mouse
    • Deng, D.X., Ono, S., Koropatnick, J. and Cherian, M.G., Metallothionein and apoptosis in the toxic milk mutant mouse, Lab. Invest., 78, 175-183, 1998.
    • (1998) Lab. Invest. , vol.78 , pp. 175-183
    • Deng, D.X.1    Ono, S.2    Koropatnick, J.3    Cherian, M.G.4
  • 171
    • 0030983989 scopus 로고    scopus 로고
    • Significance of metallothionein overexpression in human tumours
    • Jasani, B. and Schmid, K.W., Significance of metallothionein overexpression in human tumours, Histopathology, 31, 211-214, 1997.
    • (1997) Histopathology , vol.31 , pp. 211-214
    • Jasani, B.1    Schmid, K.W.2
  • 174
    • 0030917266 scopus 로고    scopus 로고
    • Overexpression of metallothionein correlates with chemoresistance to cisplatin and prognosis in esophageal cancer
    • Hishikawa, Y., Abe, S., Kinugasa, S., Yoshimura, H., Monden, N., Igarashi, M., Tachibana, M. and Nagasue, N., Overexpression of metallothionein correlates with chemoresistance to cisplatin and prognosis in esophageal cancer, Oncology, 54, 342-347, 1997.
    • (1997) Oncology , vol.54 , pp. 342-347
    • Hishikawa, Y.1    Abe, S.2    Kinugasa, S.3    Yoshimura, H.4    Monden, N.5    Igarashi, M.6    Tachibana, M.7    Nagasue, N.8
  • 175
    • 0031033203 scopus 로고    scopus 로고
    • Metallothionein expression in basaloid proliferations overlying dermatofibromas and in basal cell carcinomas
    • Rossen, K., Haerslev, T., Hou-Jensen, K. and Jacobsen, G.K., Metallothionein expression in basaloid proliferations overlying dermatofibromas and in basal cell carcinomas, Br. J. Dermatol., 136, 30-34, 1997.
    • (1997) Br. J. Dermatol. , vol.136 , pp. 30-34
    • Rossen, K.1    Haerslev, T.2    Hou-Jensen, K.3    Jacobsen, G.K.4
  • 176
    • 0026353891 scopus 로고
    • Immunohistochemical localization of metallothionein in transitional cell carcinoma of the bladder
    • Bahnson, R.R., Banner, B.F., Ernstoff, M.S., Lazo, J.S., Cherian, M.G., Banerjee, D. and Chin, J.L., Immunohistochemical localization of metallothionein in transitional cell carcinoma of the bladder, J. Urol., 146, 1518-1520, 1991.
    • (1991) J. Urol. , vol.146 , pp. 1518-1520
    • Bahnson, R.R.1    Banner, B.F.2    Ernstoff, M.S.3    Lazo, J.S.4    Cherian, M.G.5    Banerjee, D.6    Chin, J.L.7
  • 177
    • 0027496641 scopus 로고
    • Metallothionein in testicular germ cell tumors and drug resistance. Clinical correlation
    • Chin, J.L., Banerjee, D., Kadhim, S.A., Kontozoglou, T.E., Chauvin, P.J. and Cherian, M.G., Metallothionein in testicular germ cell tumors and drug resistance. Clinical correlation, Cancer, 72, 3029-3035, 1993.
    • (1993) Cancer , vol.72 , pp. 3029-3035
    • Chin, J.L.1    Banerjee, D.2    Kadhim, S.A.3    Kontozoglou, T.E.4    Chauvin, P.J.5    Cherian, M.G.6
  • 178
    • 0027381677 scopus 로고
    • Localization of metallothionein in breast carcinomas. An immunohistochemical study
    • Fresno, M., Wu, W., Rodriguez, J.M. and Nadji, M., Localization of metallothionein in breast carcinomas. An immunohistochemical study, Virchows Arch., 423, 215-219, 1993.
    • (1993) Virchows Arch. , vol.423 , pp. 215-219
    • Fresno, M.1    Wu, W.2    Rodriguez, J.M.3    Nadji, M.4
  • 179
    • 0024422993 scopus 로고
    • Immunohistochemical localization of metallothionein in human testicular embryonal carcinoma cells
    • Kontozoglou, T.E., Banerjee, D. and Cherian, M.G., Immunohistochemical localization of metallothionein in human testicular embryonal carcinoma cells, Virchows Arch., 415, 545-549, 1989.
    • (1989) Virchows Arch. , vol.415 , pp. 545-549
    • Kontozoglou, T.E.1    Banerjee, D.2    Cherian, M.G.3
  • 180
    • 0342884840 scopus 로고    scopus 로고
    • High metallothionein expression is associated with features predictive of aggressive behaviour in endometrial carcinoma
    • McCluggage, W.G., Maxwell, P., Hamilton, P.W. and Jasani, B., High metallothionein expression is associated with features predictive of aggressive behaviour in endometrial carcinoma, Histopathol., 34, 51-55, 1999.
    • (1999) Histopathol. , vol.34 , pp. 51-55
    • McCluggage, W.G.1    Maxwell, P.2    Hamilton, P.W.3    Jasani, B.4
  • 181
    • 0023618716 scopus 로고
    • Immunohistochemical localization of metallothionein in human thyroid tumors
    • Nartey, N., Cherian, M.G. and Banerjee, D., Immunohistochemical localization of metallothionein in human thyroid tumors, Am. J. Pathol., 129, 177-182, 1987.
    • (1987) Am. J. Pathol. , vol.129 , pp. 177-182
    • Nartey, N.1    Cherian, M.G.2    Banerjee, D.3
  • 182
    • 0030747594 scopus 로고    scopus 로고
    • Metallothionein: A potential marker for differentiating benign and neoplastic gastrointestinal lymphoid infiltrates
    • Rizkalla, K.S. and Cherian, M.G., Metallothionein: a potential marker for differentiating benign and neoplastic gastrointestinal lymphoid infiltrates, Pathol., 29, 141-146, 1997.
    • (1997) Pathol. , vol.29 , pp. 141-146
    • Rizkalla, K.S.1    Cherian, M.G.2
  • 183
    • 0032919927 scopus 로고    scopus 로고
    • Immunohistochemical expression of metallothionein in resected hepatic primary tumors and colorectal carcinoma metastases
    • Stenram, U., Ohlsson, B. and Tranberg, K.G., Immunohistochemical expression of metallothionein in resected hepatic primary tumors and colorectal carcinoma metastases, APMIS, 107, 420-424, 1999.
    • (1999) APMIS , vol.107 , pp. 420-424
    • Stenram, U.1    Ohlsson, B.2    Tranberg, K.G.3
  • 184
    • 0027689314 scopus 로고
    • Metallothionein as an epithelial proliferative compartment marker for DNA flow cytometry
    • Haile Meskel, H., Cherian, M.G., Martinez, V.J., Veinot, L.A. and Frei, J.V., Metallothionein as an epithelial proliferative compartment marker for DNA flow cytometry, Modern Pathol., 6, 755-760, 1993.
    • (1993) Modern Pathol. , vol.6 , pp. 755-760
    • Haile Meskel, H.1    Cherian, M.G.2    Martinez, V.J.3    Veinot, L.A.4    Frei, J.V.5
  • 185
    • 0028036588 scopus 로고
    • The significance of the nuclear and cytoplasmic localization of metallothionein in human liver and tumor cells
    • Cherian, M.G., The significance of the nuclear and cytoplasmic localization of metallothionein in human liver and tumor cells, Environ. Health Persp., 102, 131-135, 1994.
    • (1994) Environ. Health Persp. , vol.102 , pp. 131-135
    • Cherian, M.G.1
  • 186
    • 0029055516 scopus 로고
    • The prognostic significance of immunohistochemically detectable metallothionein in primary breast carcinomas
    • Haerslev, T., Jacobsen, G.K. and Zedeler, K., The prognostic significance of immunohistochemically detectable metallothionein in primary breast carcinomas, APMIS, 103, 279-285, 1995.
    • (1995) APMIS , vol.103 , pp. 279-285
    • Haerslev, T.1    Jacobsen, G.K.2    Zedeler, K.3
  • 187
    • 0033045565 scopus 로고    scopus 로고
    • Immunohistochemical demonstration of metallothionein in benign and malignant canine mammary tumours
    • Fuentealba, I.C. and Mullins, J.E., Immunohistochemical demonstration of metallothionein in benign and malignant canine mammary tumours, Histol. Histopathol., 14, 51-61, 1999.
    • (1999) Histol. Histopathol. , vol.14 , pp. 51-61
    • Fuentealba, I.C.1    Mullins, J.E.2
  • 188
    • 0033611580 scopus 로고    scopus 로고
    • Downregulation of metallothionein-IIA expression occurs at immortalization
    • Duncan, E.L. and Reddel, R.R., Downregulation of metallothionein-IIA expression occurs at immortalization, Oncogene, 18, 897-903, 1999.
    • (1999) Oncogene , vol.18 , pp. 897-903
    • Duncan, E.L.1    Reddel, R.R.2
  • 189
    • 0027514254 scopus 로고
    • Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast
    • Schmid, K.W., Ellis, I.O., Gee, J.M., Darke, B.M., Lees, W.E., Kay, J., Cryer, A., Stark, J.M., Hittmair, A., Ofner, D. and al, e., Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast, Virchows Arch., 422, 153-159, 1993.
    • (1993) Virchows Arch. , vol.422 , pp. 153-159
    • Schmid, K.W.1    Ellis, I.O.2    Gee, J.M.3    Darke, B.M.4    Lees, W.E.5    Kay, J.6    Cryer, A.7    Stark, J.M.8    Hittmair, A.9    Ofner, D.10
  • 190
    • 0031924088 scopus 로고    scopus 로고
    • The prognostic role of p53, metallothionein, P-glycoprotein, and MIB-1 in muscle-invasive urothelial transitional cell carcinoma
    • Siu, L.L., Banerjee, D., Khurana, R.J., Pan, X., Pflueger, R., Tannock, I.F. and Moore, M.J., The prognostic role of p53, metallothionein, P-glycoprotein, and MIB-1 in muscle-invasive urothelial transitional cell carcinoma, Clin. Cancer Res., 4, 559-565, 1998.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 559-565
    • Siu, L.L.1    Banerjee, D.2    Khurana, R.J.3    Pan, X.4    Pflueger, R.5    Tannock, I.F.6    Moore, M.J.7
  • 191
    • 0031964417 scopus 로고    scopus 로고
    • Immunohistochemical detection of metallothionein and MIB1 in uterine cervical squamous lesions
    • McCluggage, W.G., Maxwell, P. and Bharucha, H., Immunohistochemical detection of metallothionein and MIB1 in uterine cervical squamous lesions, Int. J. Gynecol. Pathol., 17, 29-35, 1998.
    • (1998) Int. J. Gynecol. Pathol. , vol.17 , pp. 29-35
    • McCluggage, W.G.1    Maxwell, P.2    Bharucha, H.3
  • 192
  • 193
    • 0026310632 scopus 로고
    • The role of metallothioneins in anticancer drug resistance
    • Bahnson, R.R., Basu, A. and Lazo, J.S., The role of metallothioneins in anticancer drug resistance, Cancer Treat. Res., 57, 251-260, 1991.
    • (1991) Cancer Treat. Res. , vol.57 , pp. 251-260
    • Bahnson, R.R.1    Basu, A.2    Lazo, J.S.3
  • 194
    • 0019811657 scopus 로고
    • Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein
    • Bakka, A., Endresen, L., Johnsen, A.B., Edminson, P.D. and Rugstad, H.E., Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein, Toxicol. App. Pharmacol., 61, 215-226, 1981.
    • (1981) Toxicol. App. Pharmacol. , vol.61 , pp. 215-226
    • Bakka, A.1    Endresen, L.2    Johnsen, A.B.3    Edminson, P.D.4    Rugstad, H.E.5
  • 195
    • 0025021751 scopus 로고
    • A hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs
    • Basu, A. and Lazo, J.S., A hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs, Toxicol. Lett., 50, 123-135, 1990.
    • (1990) Toxicol. Lett. , vol.50 , pp. 123-135
    • Basu, A.1    Lazo, J.S.2
  • 196
    • 0027772721 scopus 로고
    • Metallothionein and anticancer agents: The role of metallothionein in cancer chemotherapy
    • Doz, F., Roosen, N. and Rosenblum, M.L., Metallothionein and anticancer agents: the role of metallothionein in cancer chemotherapy, Journal of NeuroOncol., 17, 123-129, 1993.
    • (1993) Journal of NeuroOncol. , vol.17 , pp. 123-129
    • Doz, F.1    Roosen, N.2    Rosenblum, M.L.3
  • 197
    • 0028143697 scopus 로고
    • Metallothionein in carcinogenesis and cancer chemotherapy
    • Ebadi, M. and Iversen, P.L., Metallothionein in carcinogenesis and cancer chemotherapy, Gen. Pharmacol., 25, 1297-1310, 1994.
    • (1994) Gen. Pharmacol. , vol.25 , pp. 1297-1310
    • Ebadi, M.1    Iversen, P.L.2
  • 198
    • 0023696141 scopus 로고
    • Overexpression of metallothionein confers resistance to anticancer drugs
    • Kelley, S.L., Basu, A., Teicher, B.A., Hacker, M.P., Hamer, D.H. and Lazo, J.S., Overexpression of metallothionein confers resistance to anticancer drugs, Science, 241, 1813-1815, 1988.
    • (1988) Science , vol.241 , pp. 1813-1815
    • Kelley, S.L.1    Basu, A.2    Teicher, B.A.3    Hacker, M.P.4    Hamer, D.H.5    Lazo, J.S.6
  • 199
    • 0029022588 scopus 로고
    • Metallothionein null cells have increased sensitivity to anticancer drugs
    • Kondo, Y., Woo, E.S., Michalska, A.E., Choo, K.H. and Lazo, J.S., Metallothionein null cells have increased sensitivity to anticancer drugs, Cancer Res., 55, 2021-2023, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 2021-2023
    • Kondo, Y.1    Woo, E.S.2    Michalska, A.E.3    Choo, K.H.4    Lazo, J.S.5
  • 200
    • 0028987879 scopus 로고
    • Metallothioneins and cell death by anticancer drugs
    • Lazo, J.S. and Pitt, B.R., Metallothioneins and cell death by anticancer drugs, Annu. Rev. Pharmacol. Toxicol., 35, 635-653, 1995.
    • (1995) Annu. Rev. Pharmacol. Toxicol. , vol.35 , pp. 635-653
    • Lazo, J.S.1    Pitt, B.R.2
  • 201
    • 17744409665 scopus 로고    scopus 로고
    • The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs
    • Lazo, J.S., Kuo, S.M., Woo, E.S. and Pitt, B.R., The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs, Chem. Biol. Interact., 111-112, 255-262, 1998.
    • (1998) Chem. Biol. Interact. , vol.111-112 , pp. 255-262
    • Lazo, J.S.1    Kuo, S.M.2    Woo, E.S.3    Pitt, B.R.4
  • 203
    • 0028898536 scopus 로고
    • Metallothionein localization and cisplatin resistance in human hormone-independent prostatic tumor cell lines
    • Kondo, Y., Kuo, S.M., Watkins, S.C. and Lazo, J.S., Metallothionein localization and cisplatin resistance in human hormone-independent prostatic tumor cell lines, Cancer Res., 55, 474-477, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 474-477
    • Kondo, Y.1    Kuo, S.M.2    Watkins, S.C.3    Lazo, J.S.4
  • 204
    • 0026209548 scopus 로고
    • Metallothionein expression and transient resistance to electrophilic antineoplastic drugs
    • Lazo, J.S. and Basu, A., Metallothionein expression and transient resistance to electrophilic antineoplastic drugs, Semin. Cancer Biol., 2, 261-271, 1991.
    • (1991) Semin. Cancer Biol. , vol.2 , pp. 261-271
    • Lazo, J.S.1    Basu, A.2
  • 205
    • 0027437854 scopus 로고
    • Prevention of carcinogenicity of anticancer drugs by metallothionein induction
    • Satoh, M., Kondo, Y., Mita, M., Nakagawa, I., Naganuma, A. and Imura, N., Prevention of carcinogenicity of anticancer drugs by metallothionein induction, Cancer Res., 53, 4767-4768, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 4767-4768
    • Satoh, M.1    Kondo, Y.2    Mita, M.3    Nakagawa, I.4    Naganuma, A.5    Imura, N.6
  • 206
    • 0032953164 scopus 로고    scopus 로고
    • Metallothionein: An intracellular protein to protect against cadmium toxicity
    • Klaassen, C.D., Liu, J. and Choudhuri, S., Metallothionein: an intracellular protein to protect against cadmium toxicity, Annu. Rev. Pharmacol. Toxicol., 39, 267-294, 1999.
    • (1999) Annu. Rev. Pharmacol. Toxicol. , vol.39 , pp. 267-294
    • Klaassen, C.D.1    Liu, J.2    Choudhuri, S.3
  • 208
    • 0026335645 scopus 로고
    • Nutritional and physiologic significance of metallothionein
    • Bremner, I., Nutritional and physiologic significance of metallothionein, Meth. Enzymol., 205, 25-35, 1991.
    • (1991) Meth. Enzymol. , vol.205 , pp. 25-35
    • Bremner, I.1
  • 210
    • 0016711005 scopus 로고
    • Mammalian zinc homeostasis: Requirement for RNA and metallothionein synthesis
    • Richards, M.P. and Cousins, R.J., Mammalian zinc homeostasis: requirement for RNA and metallothionein synthesis, Biochem. Biophys. Res. Commun., 64, 1215-1223, 1975.
    • (1975) Biochem. Biophys. Res. Commun. , vol.64 , pp. 1215-1223
    • Richards, M.P.1    Cousins, R.J.2
  • 211
    • 0029985755 scopus 로고    scopus 로고
    • Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency
    • Dalton, T., Fu, K., Palmiter, R.D. and Andrews, G.K., Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency, J. Nutr., 126, 825-833, 1996.
    • (1996) J. Nutr. , vol.126 , pp. 825-833
    • Dalton, T.1    Fu, K.2    Palmiter, R.D.3    Andrews, G.K.4
  • 212
    • 0029987684 scopus 로고    scopus 로고
    • Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice
    • Kelly, E.J., Quaife, C.J., Froelick, G.J. and Palmiter, R.D., Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice, J. Nutr., 126, 1782-1790, 1996.
    • (1996) J. Nutr. , vol.126 , pp. 1782-1790
    • Kelly, E.J.1    Quaife, C.J.2    Froelick, G.J.3    Palmiter, R.D.4
  • 214
    • 0032555204 scopus 로고    scopus 로고
    • The elusive function of metallothioneins
    • Palmiter, R.D., The elusive function of metallothioneins, Proc. Natl. Acad. Sci. U.S.A., 95, 8428-8430, 1998.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 8428-8430
    • Palmiter, R.D.1
  • 215
    • 0019085620 scopus 로고
    • Ligand substitution reactions of metallothioneins with EDTA and apo-carbonic anhydrase
    • Li, T.Y., Kraker, A.J., Shaw, C.F., 3d and Petering, D.H., Ligand substitution reactions of metallothioneins with EDTA and apo-carbonic anhydrase, Proc. Natl. Acad. Sci. U.S.A., 77, 6334-6338, 1980.
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 6334-6338
    • Li, T.Y.1    Kraker, A.J.2    Shaw III, C.F.3    Petering, D.H.4
  • 216
    • 0019013769 scopus 로고
    • Reactivation in vitro of zinc-requiring apo-enzymes by rat liver zinc-thionein
    • Udom, A.O. and Brady, F.O., Reactivation in vitro of zinc-requiring apo-enzymes by rat liver zinc-thionein, Biochem. J., 187, 329-335, 1980.
    • (1980) Biochem. J. , vol.187 , pp. 329-335
    • Udom, A.O.1    Brady, F.O.2
  • 217
    • 0030006123 scopus 로고    scopus 로고
    • Re-versible zinc exchange between metallothionein and the estrogen receptor zinc finger
    • Cano-Gauci, D.F. and Sarkar, B., Re-versible zinc exchange between metallothionein and the estrogen receptor zinc finger, FEBS Lett., 386, 1-4, 1996.
    • (1996) FEBS Lett. , vol.386 , pp. 1-4
    • Cano-Gauci, D.F.1    Sarkar, B.2
  • 218
    • 0028082427 scopus 로고
    • Oxidative metal release from metallothionein via zinc- Thiol/disulfide interchange
    • Maret, W., Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange, Proc. Natl. Acad. Sci. U.S.A., 91, 237-241, 1994.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 237-241
    • Maret, W.1
  • 219
    • 0023916682 scopus 로고
    • Zinc metabolism in Ehrlich cells: Properties of a metallothionein-like zinc-binding protein
    • Kraker, A.J., Krakower, G., Shaw, C.F., 3d, Petering, D.H. and Garvey, J.S., Zinc metabolism in Ehrlich cells: properties of a metallothionein-like zinc-binding protein, Cancer Res., 48, 3381-3388, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 3381-3388
    • Kraker, A.J.1    Krakower, G.2    Shaw III, C.F.3    Petering, D.H.4    Garvey, J.S.5
  • 220
    • 0027204255 scopus 로고
    • A putative glutathione-binding site in CdZn-metallothionein identified by equilibrium binding and molecular-modelling studies
    • Brouwer, M., Hoexum-Brouwer, T. and Cashon, R.E., A putative glutathione-binding site in CdZn-metallothionein identified by equilibrium binding and molecular-modelling studies, Biochem. J., 294, 219-225, 1993.
    • (1993) Biochem. J. , vol.294 , pp. 219-225
    • Brouwer, M.1    Hoexum-Brouwer, T.2    Cashon, R.E.3
  • 221
    • 0032584078 scopus 로고    scopus 로고
    • The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase
    • Jiang, L.J., Maret, W. and Vallee, B.L., The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase, Proc. Natl. Acad. Sci. U.S.A., 95, 3483-3488, 1998.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 3483-3488
    • Jiang, L.J.1    Maret, W.2    Vallee, B.L.3
  • 222
    • 0032584186 scopus 로고    scopus 로고
    • Control of zinc transfer between thionein, metallothionein, and zinc proteins
    • Jacob, C., Maret, W. and Vallee, B.L., Control of zinc transfer between thionein, metallothionein, and zinc proteins, Proc. Natl. Acad. Sci. U.S.A., 95, 3489-3494, 1998.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 3489-3494
    • Jacob, C.1    Maret, W.2    Vallee, B.L.3
  • 223
    • 0032584166 scopus 로고    scopus 로고
    • Thiolate ligands in metallothionein confer redox activity on zinc clusters
    • Maret, W. and Vallee, B.L., Thiolate ligands in metallothionein confer redox activity on zinc clusters, Proc. Natl. Acad. Sci. U.S.A., 95, 3478-3482, 1998.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 3478-3482
    • Maret, W.1    Vallee, B.L.2
  • 224
    • 0024554012 scopus 로고
    • The role of glutathione in copper metabolism and toxicity
    • Freedman, J.H., Ciriolo, M.R. and Peisach, J., The role of glutathione in copper metabolism and toxicity, J. Biol. Chem., 264, 5598-5605, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 5598-5605
    • Freedman, J.H.1    Ciriolo, M.R.2    Peisach, J.3
  • 225
    • 0024419699 scopus 로고
    • Intracellular copper transport in cultured hepatoma cells
    • Freedman, J.H. and Peisach, J., Intracellular copper transport in cultured hepatoma cells, Biochem. Biophys. Res. Commun., 164, 134-140, 1989.
    • (1989) Biochem. Biophys. Res. Commun. , vol.164 , pp. 134-140
    • Freedman, J.H.1    Peisach, J.2
  • 227
    • 0032584091 scopus 로고    scopus 로고
    • Recent excitement regarding metallothionein
    • Fischer, E.H. and Davie, E.W., Recent excitement regarding metallothionein, Proc. Natl. Acad. Sci. U.S.A., 95, 3333-3334, 1998.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 3333-3334
    • Fischer, E.H.1    Davie, E.W.2
  • 228
    • 0028369066 scopus 로고
    • Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure
    • Piedboeuf, B., Johnston, C.J., Watkins, R.H., Hudak, B.B., Lazo, J.S., Cherian, M.G. and Horowitz, S., Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure. Am. J. Resp. Cell Mol. Biol., 10, 123-132, 1994.
    • (1994) Am. J. Resp. Cell Mol. Biol. , vol.10 , pp. 123-132
    • Piedboeuf, B.1    Johnston, C.J.2    Watkins, R.H.3    Hudak, B.B.4    Lazo, J.S.5    Cherian, M.G.6    Horowitz, S.7
  • 229
    • 0025944389 scopus 로고
    • Increase in metallothionein produced by chemicals that induce oxidative stress
    • Bauman, J.W., Liu, J., Liu, Y.P. and Klaassen, C.D., Increase in metallothionein produced by chemicals that induce oxidative stress, Toxicol. App. Pharmacol., 110, 347-354, 1991.
    • (1991) Toxicol. App. Pharmacol. , vol.110 , pp. 347-354
    • Bauman, J.W.1    Liu, J.2    Liu, Y.P.3    Klaassen, C.D.4
  • 230
    • 0032996361 scopus 로고    scopus 로고
    • Metallothionein in radiation exposure: Its induction and protective role
    • Cai, L., Satoh, M., Tohyama, C. and Cherian, M.G., Metallothionein in radiation exposure: its induction and protective role, Toxicol., 132, 85-98, 1999.
    • (1999) Toxicol. , vol.132 , pp. 85-98
    • Cai, L.1    Satoh, M.2    Tohyama, C.3    Cherian, M.G.4
  • 231
    • 0031830581 scopus 로고    scopus 로고
    • Effects of gamma radiation on levels of brain metallothionein and lipid peroxidation in transgenic mice
    • Ono, S., Cai, L. and Cherian, M.G., Effects of gamma radiation on levels of brain metallothionein and lipid peroxidation in transgenic mice, Radiat. Res., 150, 52-57, 1998.
    • (1998) Radiat. Res. , vol.150 , pp. 52-57
    • Ono, S.1    Cai, L.2    Cherian, M.G.3
  • 232
    • 0018223827 scopus 로고
    • Biological function of metallothionein. V. Its induction in rats by various stresses
    • Oh, S.H., Deagen, J.T., Whanger, P.D. and Weswig, P.H., Biological function of metallothionein. V. Its induction in rats by various stresses, Am. J. Physiol., 234, E282-285, 1978.
    • (1978) Am. J. Physiol. , vol.234
    • Oh, S.H.1    Deagen, J.T.2    Whanger, P.D.3    Weswig, P.H.4
  • 233
    • 0032962680 scopus 로고    scopus 로고
    • Metallothionein induction in rat liver by dietary restriction or exercise and reduction of exercise-induced hepatic lipid peroxidation
    • Shinogi, M., Sakaridani, M. and Yokoyama, I., Metallothionein induction in rat liver by dietary restriction or exercise and reduction of exercise-induced hepatic lipid peroxidation, Biol. Pharm. Bull., 22, 132-136, 1999.
    • (1999) Biol. Pharm. Bull. , vol.22 , pp. 132-136
    • Shinogi, M.1    Sakaridani, M.2    Yokoyama, I.3
  • 234
    • 0029948862 scopus 로고    scopus 로고
    • Cold-induced expression of the metallothionein-1 gene in brown adipose tissue of rats
    • Beattie, J.H., Black, D.J., Wood, A.M. and Trayhurn, P., Cold-induced expression of the metallothionein-1 gene in brown adipose tissue of rats, Am. J. Physiol., 270, R971-977, 1996.
    • (1996) Am. J. Physiol. , vol.270
    • Beattie, J.H.1    Black, D.J.2    Wood, A.M.3    Trayhurn, P.4
  • 235
    • 0023154466 scopus 로고
    • Induction of hepatic metallothionein by alcohols: Evidence for an indirect mechanism
    • Bracken, W.M. and Klaassen, C.D., Induction of hepatic metallothionein by alcohols: evidence for an indirect mechanism, Toxicol. App. Pharmacol., 87, 257-263, 1987.
    • (1987) Toxicol. App. Pharmacol. , vol.87 , pp. 257-263
    • Bracken, W.M.1    Klaassen, C.D.2
  • 236
    • 0025646457 scopus 로고
    • Ethanol decreases cadmium hepatotoxicity in rats: Possible role of hepatic metallothionein induction
    • Kershaw, W.C., Iga, T. and Klaassen, C.D., Ethanol decreases cadmium hepatotoxicity in rats: possible role of hepatic metallothionein induction, Toxicol. App. Pharmacol., 106, 448-455, 1990.
    • (1990) Toxicol. App. Pharmacol. , vol.106 , pp. 448-455
    • Kershaw, W.C.1    Iga, T.2    Klaassen, C.D.3
  • 239
    • 0031714274 scopus 로고    scopus 로고
    • Metallothionein (MT) isoforms in the central nervous system (CNS): Regional and cell-specific distribution and potential functions as an antioxidant
    • Aschner, M., Metallothionein (MT) isoforms in the central nervous system (CNS): regional and cell-specific distribution and potential functions as an antioxidant, Neuroroxicol., 19, 653-660, 1998.
    • (1998) Neuroroxicol. , vol.19 , pp. 653-660
    • Aschner, M.1
  • 241
    • 0023755124 scopus 로고
    • Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin 1
    • Cousins, R.J. and Leinart, A.S., Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin 1, FASEB J., 2, 2884-2890, 1988.
    • (1988) FASEB J. , vol.2 , pp. 2884-2890
    • Cousins, R.J.1    Leinart, A.S.2
  • 242
    • 17044453671 scopus 로고
    • Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice
    • Hernandez, J., Molinero, A., Campbell, I.L. and Hidalgo, J., Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice, Brain Res., 125-131, 1994.
    • (1994) Brain Res. , pp. 125-131
    • Hernandez, J.1    Molinero, A.2    Campbell, I.L.3    Hidalgo, J.4
  • 243
    • 0022362620 scopus 로고
    • Interleukin 1 regulates human metallothionein gene expression
    • Karin, M., Imbra, R.J., Heguy, A. and Wong, G., Interleukin 1 regulates human metallothionein gene expression, Mol. Cell. Biol., 5, 2866-2869, 1985.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 2866-2869
    • Karin, M.1    Imbra, R.J.2    Heguy, A.3    Wong, G.4
  • 245
    • 0025228503 scopus 로고
    • Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures
    • Schroeder, J.J. and Cousins, R.J., Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures, Proc. Natl. Acad. Sci. U.S.A., 87, 3137-3141, 1990.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 3137-3141
    • Schroeder, J.J.1    Cousins, R.J.2
  • 246
    • 0029026221 scopus 로고
    • Regulation of metallothionein gene expression by TNF-alpha and IFN-beta in human fibroblasts
    • Sciavolino, P.J. and Vilcek, J., Regulation of metallothionein gene expression by TNF-alpha and IFN-beta in human fibroblasts, Cytokine, 7, 242-250, 1995.
    • (1995) Cytokine , vol.7 , pp. 242-250
    • Sciavolino, P.J.1    Vilcek, J.2
  • 248
    • 0028944114 scopus 로고
    • Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes
    • Lazo, J.S., Kondo, Y., Dellapiazza, D., Michalska, A.E., Choo, K.H. and Pitt, B.R., Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes, J. Biol. Chem., 270, 5506-5510, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5506-5510
    • Lazo, J.S.1    Kondo, Y.2    Dellapiazza, D.3    Michalska, A.E.4    Choo, K.H.5    Pitt, B.R.6
  • 249
    • 0030272947 scopus 로고    scopus 로고
    • Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- And tert-butylhydroperoxide-induced cytotoxicity
    • Zheng, H., Liu, J., Liu, Y. and Klaassen, C.D., Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium-and tert-butylhydroperoxide-induced cytotoxicity, Toxicol. Lett., 87, 139-145, 1996.
    • (1996) Toxicol. Lett. , vol.87 , pp. 139-145
    • Zheng, H.1    Liu, J.2    Liu, Y.3    Klaassen, C.D.4
  • 250
    • 0029048855 scopus 로고
    • The oxidative stress response
    • Camhi, S.L., Lee, P. and Choi, A.M., The oxidative stress response, New Horizons, 3, 170-182, 1995.
    • (1995) New Horizons , vol.3 , pp. 170-182
    • Camhi, S.L.1    Lee, P.2    Choi, A.M.3
  • 251
    • 0021944046 scopus 로고
    • Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals
    • Thornalley, P.J. and Vasak, M., Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals, Biochim. Biophys. Acta, 827, 36-44, 1985.
    • (1985) Biochim. Biophys. Acta , vol.827 , pp. 36-44
    • Thornalley, P.J.1    Vasak, M.2
  • 252
    • 0022908892 scopus 로고
    • Inhibition of cell membrane lipid peroxidation by cadmium- And zinc-metallothioneins
    • Thomas, J.P., Bachowski, G.J. and Girotti, A.W., Inhibition of cell membrane lipid peroxidation by cadmium-and zinc-metallothioneins, Biochim. Biophys. Acta, 884, 448-461, 1986.
    • (1986) Biochim. Biophys. Acta , vol.884 , pp. 448-461
    • Thomas, J.P.1    Bachowski, G.J.2    Girotti, A.W.3
  • 253
    • 0030632095 scopus 로고    scopus 로고
    • Antioxidant activity of metallothionein compared with reduced glutathione
    • Miura, T., Muraoka, S. and Ogiso, T., Antioxidant activity of metallothionein compared with reduced glutathione, Life Sci., 60, PL:301-309, 1997.
    • (1997) Life Sci. , vol.60 , Issue.PL , pp. 301-309
    • Miura, T.1    Muraoka, S.2    Ogiso, T.3
  • 254
    • 0028293844 scopus 로고
    • Copper-metallothionein from the toxic milk mutant mouse enhances lipid peroxidation initiated by an organic hydroperoxide
    • Stephenson, G.F., Chan, H.M. and Cherian, M.G., Copper-metallothionein from the toxic milk mutant mouse enhances lipid peroxidation initiated by an organic hydroperoxide, Toxicol. App. Pharmacol., 125, 90-96, 1994.
    • (1994) Toxicol. App. Pharmacol. , vol.125 , pp. 90-96
    • Stephenson, G.F.1    Chan, H.M.2    Cherian, M.G.3
  • 255
    • 0018175707 scopus 로고
    • Cadmium toxicity. Nutritional influences and the role of metallothionein
    • Bremner, I., Cadmium toxicity. Nutritional influences and the role of metallothionein, World Rev. Nutr. Diet., 32, 165-197, 1978.
    • (1978) World Rev. Nutr. Diet. , vol.32 , pp. 165-197
    • Bremner, I.1
  • 256
    • 0030848109 scopus 로고    scopus 로고
    • Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity
    • Klaassen, C.D. and Liu, J., Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity, Drug Metab. Rev., 29, 79-102, 1997.
    • (1997) Drug Metab. Rev. , vol.29 , pp. 79-102
    • Klaassen, C.D.1    Liu, J.2
  • 257
    • 0031966275 scopus 로고    scopus 로고
    • Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury
    • Klaassen, C.D. and Liu, J., Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury, Environ. Health Persp., 106, 297-300, 1998.
    • (1998) Environ. Health Persp. , vol.106 , pp. 297-300
    • Klaassen, C.D.1    Liu, J.2
  • 258
    • 0026022671 scopus 로고
    • The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture
    • Liu, J., Kershaw, W.C. and Klaassen, C.D., The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture, Toxicol. App. Pharmacol., 107, 27-34, 1991.
    • (1991) Toxicol. App. Pharmacol. , vol.107 , pp. 27-34
    • Liu, J.1    Kershaw, W.C.2    Klaassen, C.D.3
  • 259
    • 0027034988 scopus 로고
    • Metallothionein: Analysis in tissues and toxicological significance
    • Suzuki, K.T., Metallothionein: analysis in tissues and toxicological significance, IARC Scientific Publications, 211-217, 1992.
    • (1992) IARC Scientific Publications , pp. 211-217
    • Suzuki, K.T.1
  • 260
    • 0018822418 scopus 로고
    • Different inducibility of metallothionein in various mammalian cells in vitro
    • Kobayashi, S. and Kimura, M., Different inducibility of metallothionein in various mammalian cells in vitro, Toxicol. Lett., 5, 357-362, 1980.
    • (1980) Toxicol. Lett. , vol.5 , pp. 357-362
    • Kobayashi, S.1    Kimura, M.2
  • 261
    • 0021398140 scopus 로고
    • Induction of metallothionein-I mRNA in cultured cells by heavy metals and iodoacetate: Evidence for gratuitous inducers
    • Durnam, D.M. and Palmiter, R.D., Induction of metallothionein-I mRNA in cultured cells by heavy metals and iodoacetate: evidence for gratuitous inducers, Mol. Cell. Biol., 4, 484-491, 1984.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 484-491
    • Durnam, D.M.1    Palmiter, R.D.2
  • 262
    • 0023674709 scopus 로고
    • Mechanisms of metal-induced renal cell injury: Roles of high-affinity metal-binding proteins
    • Fowler, B.A., Mechanisms of metal-induced renal cell injury: roles of high-affinity metal-binding proteins, Contr. Nephrol., 64, 83-92, 1988.
    • (1988) Contr. Nephrol. , vol.64 , pp. 83-92
    • Fowler, B.A.1
  • 263
    • 0026771952 scopus 로고
    • Relationship between stress protein induction in rat kidney by mercuric chloride and nephrotoxicity
    • Goering, P.L., Fisher, B.R., Chaudhary, P.P. and Dick, C.A., Relationship between stress protein induction in rat kidney by mercuric chloride and nephrotoxicity, Toxicol. App. Pharmacol., 113, 184-191, 1992.
    • (1992) Toxicol. App. Pharmacol. , vol.113 , pp. 184-191
    • Goering, P.L.1    Fisher, B.R.2    Chaudhary, P.P.3    Dick, C.A.4
  • 264
    • 0030297011 scopus 로고    scopus 로고
    • Expression of the 25-kDa heat-shock protein (HSP27) correlates with resistance to the toxicity of cadmium chloride, mercuric chloride, cis-platinum(II)-diammine dichloride, or sodium arsenite in mouse embryonic stem cells transfected with sense or antisense HSP27 cDNA
    • Wu, W. and Welsh, M.J., Expression of the 25-kDa heat-shock protein (HSP27) correlates with resistance to the toxicity of cadmium chloride, mercuric chloride, cis-platinum(II)-diammine dichloride, or sodium arsenite in mouse embryonic stem cells transfected with sense or antisense HSP27 cDNA, Toxicol. App. Pharmacol., 141, 330-339, 1996.
    • (1996) Toxicol. App. Pharmacol. , vol.141 , pp. 330-339
    • Wu, W.1    Welsh, M.J.2
  • 265
    • 0027376468 scopus 로고
    • Mercury-metallothionein and the renal accumulation and handling of mercury
    • Zalups, R.K., Cherian, M.G. and Barfuss, D.W., Mercury-metallothionein and the renal accumulation and handling of mercury, Toxicol., 83, 61-78, 1993.
    • (1993) Toxicol. , vol.83 , pp. 61-78
    • Zalups, R.K.1    Cherian, M.G.2    Barfuss, D.W.3
  • 267
    • 0023609534 scopus 로고
    • Glutathione, a first line of defense against cadmium toxicity
    • Singhal, R.K., Anderson, M.E. and Meister, A., Glutathione, a first line of defense against cadmium toxicity, FASEB J., 1, 220-223, 1987.
    • (1987) FASEB J. , vol.1 , pp. 220-223
    • Singhal, R.K.1    Anderson, M.E.2    Meister, A.3
  • 268
    • 0024604724 scopus 로고
    • Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats
    • Suzuki, C.A. and Cherian, M.G., Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats, Toxicol. App. Pharmacol., 98, 544-552, 1989.
    • (1989) Toxicol. App. Pharmacol. , vol.98 , pp. 544-552
    • Suzuki, C.A.1    Cherian, M.G.2
  • 269
    • 0021230379 scopus 로고
    • Tolerance to cadmium-induced hepatotoxicity following cadmium pretreatment
    • Goering, P.L. and Klaassen, C.D., Tolerance to cadmium-induced hepatotoxicity following cadmium pretreatment, Toxicol. App. Pharmacol., 74, 308-313, 1984.
    • (1984) Toxicol. App. Pharmacol. , vol.74 , pp. 308-313
    • Goering, P.L.1    Klaassen, C.D.2
  • 270
    • 0021215861 scopus 로고
    • Zinc-induced tolerance to cadmium hepatotoxicity
    • Goering, P.L. and Klaassen, C.D., Zinc-induced tolerance to cadmium hepatotoxicity, Toxicol. App. Pharmacol., 74, 299-307, 1984.
    • (1984) Toxicol. App. Pharmacol. , vol.74 , pp. 299-307
    • Goering, P.L.1    Klaassen, C.D.2
  • 271
    • 0031104855 scopus 로고    scopus 로고
    • Tolerance induced by all-trans-retinol to the hepatotoxic effects of cadmium in rats: Role of metallothionein expression
    • Sauer, J.M., Waalkes, M.P., Hooser, S.B., Baines, A.T., Kuester, R.K. and Sipes, I.G., Tolerance induced by all-trans-retinol to the hepatotoxic effects of cadmium in rats: role of metallothionein expression, Toxicol. App. Pharmacol., 143, 110-119, 1997.
    • (1997) Toxicol. App. Pharmacol. , vol.143 , pp. 110-119
    • Sauer, J.M.1    Waalkes, M.P.2    Hooser, S.B.3    Baines, A.T.4    Kuester, R.K.5    Sipes, I.G.6
  • 272
    • 0026757248 scopus 로고
    • Uptake of cadmium is diminished in transfected mouse NIH/3T3 cells enriched for metallothionein
    • Morton, K.A., Jones, B.J., Sohn, M.H., Schaefer, A.E., Phelps, R.C., Datz, F.L. and Lynch, R.E., Uptake of cadmium is diminished in transfected mouse NIH/3T3 cells enriched for metallothionein, J. Biol. Chem., 267, 2880-2883, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 2880-2883
    • Morton, K.A.1    Jones, B.J.2    Sohn, M.H.3    Schaefer, A.E.4    Phelps, R.C.5    Datz, F.L.6    Lynch, R.E.7
  • 273
    • 0027052664 scopus 로고
    • Possible mechanism for zinc protection against cadmium cytotoxicity in cultured vascular endothelial cells
    • Kaji, T., Mishima, A., Koyanagi, E., Yamamoto, C., Sakamoto, M. and Kozuka, H., Possible mechanism for zinc protection against cadmium cytotoxicity in cultured vascular endothelial cells, Toxicology, 76, 257-270, 1992.
    • (1992) Toxicology , vol.76 , pp. 257-270
    • Kaji, T.1    Mishima, A.2    Koyanagi, E.3    Yamamoto, C.4    Sakamoto, M.5    Kozuka, H.6
  • 274
    • 0026709219 scopus 로고
    • Protective effect of copper against cadmium cytotoxicity on cultured vascular endothelial cells
    • Kaji, T., Fujiwara, Y., Koyanagi, E., Yamamoto, C., Mishima, A., Sakamoto, M. and Kozuka, H., Protective effect of copper against cadmium cytotoxicity on cultured vascular endothelial cells, Toxicol. Lett., 63, 13-20, 1992.
    • (1992) Toxicol. Lett. , vol.63 , pp. 13-20
    • Kaji, T.1    Fujiwara, Y.2    Koyanagi, E.3    Yamamoto, C.4    Mishima, A.5    Sakamoto, M.6    Kozuka, H.7
  • 275
    • 0028871049 scopus 로고
    • Zinc-induced tolerance to cadmium cytotoxicity without metallothionein induction in cultured bovine aortic endothelial cells
    • Mishima, A., Kaji, T., Yamamoto, C., Sakamoto, M. and Kozuka, H., Zinc-induced tolerance to cadmium cytotoxicity without metallothionein induction in cultured bovine aortic endothelial cells, Toxicol. Lett., 75, 85-92, 1995.
    • (1995) Toxicol. Lett. , vol.75 , pp. 85-92
    • Mishima, A.1    Kaji, T.2    Yamamoto, C.3    Sakamoto, M.4    Kozuka, H.5
  • 276
    • 0031588936 scopus 로고    scopus 로고
    • Tolerance to cadmium cytotoxicity is induced by zinc through non- Metallothionein mechanisms as well as metallothionein induction in cultured cells
    • Mishima, A., Yamamoto, C., Fujiwara, Y. and Kaji, T., Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells, Toxicology, 118, 85-92, 1997.
    • (1997) Toxicology , vol.118 , pp. 85-92
    • Mishima, A.1    Yamamoto, C.2    Fujiwara, Y.3    Kaji, T.4
  • 277
    • 0030028239 scopus 로고    scopus 로고
    • Bismuth induces metallothionein but does not protect against cadmium cytotoxicity in cultured vascular endothelial cells
    • Kaji, T., Mishima, A., Yamamoto, C., Fujiwara, Y., Sakamoto, M., Kozuka, H. and Koizumi, F., Bismuth induces metallothionein but does not protect against cadmium cytotoxicity in cultured vascular endothelial cells, Bull. Environ. Contam. Toxicol., 56, 630-634, 1996.
    • (1996) Bull. Environ. Contam. Toxicol. , vol.56 , pp. 630-634
    • Kaji, T.1    Mishima, A.2    Yamamoto, C.3    Fujiwara, Y.4    Sakamoto, M.5    Kozuka, H.6    Koizumi, F.7
  • 278
    • 0031901890 scopus 로고    scopus 로고
    • Exposure of cultured human proximal tubular cells to cadmium, mercury, zinc and bismuth: Toxicity and metallothionein induction
    • Rodilla, V., Miles, A.T., Jenner, W. and Hawksworth, G.M., Exposure of cultured human proximal tubular cells to cadmium, mercury, zinc and bismuth: toxicity and metallothionein induction, Chem. Biol. Interact., 115, 71-83, 1998.
    • (1998) Chem. Biol. Interact. , vol.115 , pp. 71-83
    • Rodilla, V.1    Miles, A.T.2    Jenner, W.3    Hawksworth, G.M.4
  • 279
    • 85038045519 scopus 로고    scopus 로고
    • Metallothionein induction in human proximal tubular cell cultures - Lack of protection against heavy metal toxicity
    • Klaassen, C.D., Ed., Basel, Birkhäuser Verlag
    • Miles, A.T., Rodilla, V., Breen, A.G., Beattie, J., Jenner, W. and Hawksworth, G.M., Metallothionein induction in human proximal tubular cell cultures - lack of protection against heavy metal toxicity, in Metallothionein IV, Klaassen, C.D., Ed., Basel, Birkhäuser Verlag, 477-484, 1999.
    • (1999) Metallothionein IV , pp. 477-484
    • Miles, A.T.1    Rodilla, V.2    Breen, A.G.3    Beattie, J.4    Jenner, W.5    Hawksworth, G.M.6
  • 280
    • 0025940448 scopus 로고
    • Effect of bismuth nitrate given in combination with cis-diamminedichloroplatinum(II) on the antitumor activity and renal toxicity of the latter in nude mice inoculated with human bladder tumor
    • Kondo, Y., Satoh, M., Imura, N. and Akimoto, M., Effect of bismuth nitrate given in combination with cis-diamminedichloroplatinum(II) on the antitumor activity and renal toxicity of the latter in nude mice inoculated with human bladder tumor, Cancer Chemother.Pharmacol., 29, 19-23, 1991.
    • (1991) Cancer Chemother.Pharmacol. , vol.29 , pp. 19-23
    • Kondo, Y.1    Satoh, M.2    Imura, N.3    Akimoto, M.4
  • 281
    • 0026034109 scopus 로고
    • The role of metallothionein in the reduction of cisplatin- Induced nephrotoxicity by Bi3(+)-pretreatment in the rat in vivo and in vitro. Are antioxidant properties of metallothionein more relevant than platinum binding?
    • Boogaard, P.J., Slikkerveer, A., Nagelkerke, J.F. and Mulder, G.J., The role of metallothionein in the reduction of cisplatin-induced nephrotoxicity by Bi3(+)-pretreatment in the rat in vivo and in vitro. Are antioxidant properties of metallothionein more relevant than platinum binding?, Biochem. Pharmacol., 41, 369-375, 1991.
    • (1991) Biochem. Pharmacol. , vol.41 , pp. 369-375
    • Boogaard, P.J.1    Slikkerveer, A.2    Nagelkerke, J.F.3    Mulder, G.J.4
  • 282
    • 0027104446 scopus 로고
    • Tissue-specific induction of metallothionein by bismuth as a promising protocol for chemotherapy with repeated administration of cis-diamminedichloroplatinum (II) against bladder tumor
    • Kondo, Y., Satoh, M., Imura, N. and Akimoto, M., Tissue-specific induction of metallothionein by bismuth as a promising protocol for chemotherapy with repeated administration of cis-diamminedichloroplatinum (II) against bladder tumor, Anticancer Res., 12, 2303-2307, 1992.
    • (1992) Anticancer Res. , vol.12 , pp. 2303-2307
    • Kondo, Y.1    Satoh, M.2    Imura, N.3    Akimoto, M.4
  • 283
    • 0024236167 scopus 로고
    • Involvement of cardiac metallothionein in prevention of adriamycin induced lipid peroxidation in the heart
    • Satoh, M., Naganuma, A. and Imura, N., Involvement of cardiac metallothionein in prevention of adriamycin induced lipid peroxidation in the heart, Toxicology, 53, 231-237, 1988.
    • (1988) Toxicology , vol.53 , pp. 231-237
    • Satoh, M.1    Naganuma, A.2    Imura, N.3
  • 284
    • 0032425077 scopus 로고    scopus 로고
    • 2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex
    • 2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex, Toxicol. Sci., 197-203, 1998.
    • (1998) Toxicol. Sci. , pp. 197-203
    • Liu, J.1    Liu, Y.2    Habeebu, S.S.3    Klaassen, C.D.4
  • 286
    • 0029595386 scopus 로고
    • Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity
    • Liu, Y., Liu, J., Iszard, M.B., Andrews, G.K., Palmiter, R.D. and Klaassen, C.D., Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity, Toxicol. App. Pharmacol., 135, 222-228, 1995.
    • (1995) Toxicol. App. Pharmacol. , vol.135 , pp. 222-228
    • Liu, Y.1    Liu, J.2    Iszard, M.B.3    Andrews, G.K.4    Palmiter, R.D.5    Klaassen, C.D.6
  • 287
    • 0030041435 scopus 로고    scopus 로고
    • Analysis of the effects of overexpression of metallothionein-I in transgenic mice on the reproductive toxicology of cadmium
    • Dalton, T., Fu, K., Enders, G.C., Palmiter, R.D. and Andrews, G.K., Analysis of the effects of overexpression of metallothionein-I in transgenic mice on the reproductive toxicology of cadmium, Environ. Health Persp., 104, 68-76, 1996.
    • (1996) Environ. Health Persp. , vol.104 , pp. 68-76
    • Dalton, T.1    Fu, K.2    Enders, G.C.3    Palmiter, R.D.4    Andrews, G.K.5
  • 288
    • 0030030055 scopus 로고    scopus 로고
    • Transgenic mouse blastocysts that overexpress metallothionein-I resist cadmium toxicity in vitro
    • Lee, D.K., Fu, K., Liang, L., Dalton, T., Palmiter, R.D. and Andrews, G.K., Transgenic mouse blastocysts that overexpress metallothionein-I resist cadmium toxicity in vitro, Mol. Reprod. Develop., 43, 158-166, 1996.
    • (1996) Mol. Reprod. Develop. , vol.43 , pp. 158-166
    • Lee, D.K.1    Fu, K.2    Liang, L.3    Dalton, T.4    Palmiter, R.D.5    Andrews, G.K.6
  • 291
    • 0028969521 scopus 로고
    • Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA
    • Bylander, J.E., Li, S.L., Sens, M.A. and Sens, D.A., Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA, Toxicol. Lett., 76, 209-217, 1995.
    • (1995) Toxicol. Lett. , vol.76 , pp. 209-217
    • Bylander, J.E.1    Li, S.L.2    Sens, M.A.3    Sens, D.A.4
  • 292
    • 0013508331 scopus 로고
    • Metallothionein structure/ function interface
    • Suzuki, K.T., Imura, N. and Kimura, M., Eds., Basel, Berkhäuser Verlag
    • Huang, P.C., Metallothionein structure/ function interface, in Metallothionein III: Biological roles and medical implications, Suzuki, K.T., Imura, N. and Kimura, M., Eds., Basel, Berkhäuser Verlag, 407-426, 1993.
    • (1993) Metallothionein III: Biological Roles and Medical Implications , pp. 407-426
    • Huang, P.C.1
  • 293
    • 0029879520 scopus 로고    scopus 로고
    • Metallothionein and its role in toxic metal regulation
    • Roesijadi, G., Metallothionein and its role in toxic metal regulation, Comp. Biochem. Physiol. C, 113, 117-123, 1996.
    • (1996) Comp. Biochem. Physiol. C , vol.113 , pp. 117-123
    • Roesijadi, G.1
  • 294
    • 0025768860 scopus 로고
    • The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein
    • Uchida, Y., Takio, K., Titani, K., Ihara, Y. and Tomonaga, M., The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein, Neuron, 7, 337-347, 1991.
    • (1991) Neuron , vol.7 , pp. 337-347
    • Uchida, Y.1    Takio, K.2    Titani, K.3    Ihara, Y.4    Tomonaga, M.5
  • 295
    • 0028819715 scopus 로고
    • Constitutive expression of metallothionein-III (MT-III), but not MT-I, inhibits growth when cells become zinc deficient
    • Palmiter, R.D., Constitutive expression of metallothionein-III (MT-III), but not MT-I, inhibits growth when cells become zinc deficient, Toxicol. App. Pharmacol., 135, 139-146, 1995.
    • (1995) Toxicol. App. Pharmacol. , vol.135 , pp. 139-146
    • Palmiter, R.D.1
  • 296
  • 298
    • 0028263925 scopus 로고
    • Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF)
    • Erickson, J.C., Sewell, A.K., Jensen, L.T., Winge, D.R. and Palmiter, R.D., Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF), Brain Res., 649, 297-304, 1994.
    • (1994) Brain Res. , vol.649 , pp. 297-304
    • Erickson, J.C.1    Sewell, A.K.2    Jensen, L.T.3    Winge, D.R.4    Palmiter, R.D.5
  • 299
    • 0031016825 scopus 로고    scopus 로고
    • Disruption of the metallothionein-III gene in mice: Analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures
    • Erickson, J.C., Hollopeter, G., Thomas, S.A., Froelick, G.J. and Palmiter, R.D., Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures, J. Neurosci., 17, 1271-1281, 1997.
    • (1997) J. Neurosci. , vol.17 , pp. 1271-1281
    • Erickson, J.C.1    Hollopeter, G.2    Thomas, S.A.3    Froelick, G.J.4    Palmiter, R.D.5
  • 300
    • 0030725838 scopus 로고    scopus 로고
    • Zinc metabolism in the brain: Relevance to human neurodegenerative disorders
    • Cuajungco, M.P. and Lees, G.J., Zinc metabolism in the brain: relevance to human neurodegenerative disorders, Neurobiol. Dis., 4, 137-169, 1997.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 137-169
    • Cuajungco, M.P.1    Lees, G.J.2
  • 301
    • 0031846893 scopus 로고    scopus 로고
    • Metallothionein, neurotrophins and selegiline in providing neuroprotection in Parkinson's disease
    • Ebadi, M., Kumari, M.V.R., Hiramatsu, M., Hao, R., Pfeiffer, R.F. and Rojas, P., Metallothionein, neurotrophins and selegiline in providing neuroprotection in Parkinson's disease, Rest. Neurol. Neurosi., 12, 103-111, 1998.
    • (1998) Rest. Neurol. Neurosi. , vol.12 , pp. 103-111
    • Ebadi, M.1    Kumari, M.V.R.2    Hiramatsu, M.3    Hao, R.4    Pfeiffer, R.F.5    Rojas, P.6
  • 302
    • 0026597204 scopus 로고
    • Characterization of neutral proteinases from Alzheimer-affected and control brain specimens: Identification of calcium-dependent metalloproteinases from the hippocampus
    • Backstrom, J.R., Miller, C.A. and Tokes, Z.A., Characterization of neutral proteinases from Alzheimer-affected and control brain specimens: identification of calcium-dependent metalloproteinases from the hippocampus, J. Neurochem., 58, 983-992, 1992.
    • (1992) J. Neurochem. , vol.58 , pp. 983-992
    • Backstrom, J.R.1    Miller, C.A.2    Tokes, Z.A.3
  • 303
    • 0025315320 scopus 로고
    • Metals and the liver in Alzheimer's disease: An investigation of hepatic zinc, copper, cadmium and metallothionein
    • Lui, E., Fisman, M., Wong, C. and Diaz, F., Metals and the liver in Alzheimer's disease: an investigation of hepatic zinc, copper, cadmium and metallothionein, J. Am. Geriatr. Soc., 38, 633-639, 1990.
    • (1990) J. Am. Geriatr. Soc. , vol.38 , pp. 633-639
    • Lui, E.1    Fisman, M.2    Wong, C.3    Diaz, F.4
  • 304
    • 0030781471 scopus 로고    scopus 로고
    • Astrocyte metallothioneins (MTs) and their neuroprotective role
    • Aschner, M., Astrocyte metallothioneins (MTs) and their neuroprotective role, Ann. NY. Acad. Sci., 825, 334-347, 1997.
    • (1997) Ann. NY. Acad. Sci. , vol.825 , pp. 334-347
    • Aschner, M.1
  • 305
    • 84940139156 scopus 로고
    • Glial metallothionein
    • Young, J.K., Glial metallothionein, Biol. Signals, 3, 169-175, 1994.
    • (1994) Biol. Signals , vol.3 , pp. 169-175
    • Young, J.K.1
  • 307
    • 0031906795 scopus 로고    scopus 로고
    • Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice
    • Quaife, C.J., Kelly, E.J., Masters, B.A., Brinster, R.L. and Palmiter, R.D., Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice, Toxicol. App. Pharmacol., 148, 148-157, 1998.
    • (1998) Toxicol. App. Pharmacol. , vol.148 , pp. 148-157
    • Quaife, C.J.1    Kelly, E.J.2    Masters, B.A.3    Brinster, R.L.4    Palmiter, R.D.5
  • 308
    • 0027177058 scopus 로고
    • Cell- And inducer-specific accretion of human isometallothioneins
    • Cavigelli, M., Kagi, J.H. and Hunziker, P.E., Cell-and inducer-specific accretion of human isometallothioneins, Biochem. J., 292, 551-554, 1993.
    • (1993) Biochem. J. , vol.292 , pp. 551-554
    • Cavigelli, M.1    Kagi, J.H.2    Hunziker, P.E.3
  • 309
    • 0022447163 scopus 로고
    • Cell specificity and an effect of ras on human metallothionein gene expression
    • Schmidt, C.J. and Hamer, D.H., Cell specificity and an effect of ras on human metallothionein gene expression, Proc. Natl. Acad. Sci. U.S.A., 83, 3346-3350, 1986.
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 3346-3350
    • Schmidt, C.J.1    Hamer, D.H.2
  • 310
    • 0031038551 scopus 로고    scopus 로고
    • An immunohistochemical study on the tissue-specific localization of metallothionein in dogs
    • Shimada, A., Yanagida, M. and Umemura, T., An immunohistochemical study on the tissue-specific localization of metallothionein in dogs, J. Comp. Pathol., 116, 1-11, 1997.
    • (1997) J. Comp. Pathol. , vol.116 , pp. 1-11
    • Shimada, A.1    Yanagida, M.2    Umemura, T.3
  • 311
    • 0023870805 scopus 로고
    • Metallothionein gene expression in rats: Tissue-specific regulation by dietary copper and zinc
    • Blalock, T.L., Dunn, M.A. and Cousins, R.J., Metallothionein gene expression in rats: tissue-specific regulation by dietary copper and zinc, J. Nutr., 118, 222-228, 1988.
    • (1988) J. Nutr. , vol.118 , pp. 222-228
    • Blalock, T.L.1    Dunn, M.A.2    Cousins, R.J.3
  • 312
    • 0004469845 scopus 로고    scopus 로고
    • Metallothionein isoform gene expression in four human bladder cell lines
    • Klaassen, C.D., Ed., Basel, Birkhäuser Verlag
    • Garrett, S.H., Somji, S., Todd, J.H., Sens, D.A., Lamm, D.L. and Sens, M.A., Metallothionein isoform gene expression in four human bladder cell lines, in Metallothionein IV, Klaassen, C.D., Ed., Basel, Birkhäuser Verlag, 607-611, 1999.
    • (1999) Metallothionein IV , pp. 607-611
    • Garrett, S.H.1    Somji, S.2    Todd, J.H.3    Sens, D.A.4    Lamm, D.L.5    Sens, M.A.6
  • 313
    • 0033983806 scopus 로고    scopus 로고
    • Immunocytochemical localization of metallothionein in human pancreatic islets
    • Tomita, T. and Matsubara, O., Immunocytochemical localization of metallothionein in human pancreatic islets, Pancreas, 20, 21-24, 2000.
    • (2000) Pancreas , vol.20 , pp. 21-24
    • Tomita, T.1    Matsubara, O.2
  • 314
    • 0029942808 scopus 로고    scopus 로고
    • Cadmium accumulation and metallothionein expression in brain of mice at different stages of development
    • Choudhuri, S., Liu, W.L., Berman, N.E. and Klaassen, C.D., Cadmium accumulation and metallothionein expression in brain of mice at different stages of development, Toxicol. Lett., 84, 127-133, 1996.
    • (1996) Toxicol. Lett. , vol.84 , pp. 127-133
    • Choudhuri, S.1    Liu, W.L.2    Berman, N.E.3    Klaassen, C.D.4
  • 315
    • 0029857287 scopus 로고    scopus 로고
    • Evidence for developmentally regulated transcriptional, translational and posttranslational control of metallothionein gene expression in hair follicles
    • Nishimura, N., Cam, G.R., Nishimura, H., Tohyama, C., Saitoh, Y. and Adelson, D.L., Evidence for developmentally regulated transcriptional, translational and posttranslational control of metallothionein gene expression in hair follicles, Reprod. Fert. Develop., 8, 1089-1096, 1996.
    • (1996) Reprod. Fert. Develop. , vol.8 , pp. 1089-1096
    • Nishimura, N.1    Cam, G.R.2    Nishimura, H.3    Tohyama, C.4    Saitoh, Y.5    Adelson, D.L.6
  • 317
    • 0023022781 scopus 로고
    • Glucocorticoid regulation of metallothionein during murine development
    • Quaife, C., Hammer, R.E., Mottet, N.K. and Palmiter, R.D., Glucocorticoid regulation of metallothionein during murine development, Develop. Biol., 118, 549-555, 1986.
    • (1986) Develop. Biol. , vol.118 , pp. 549-555
    • Quaife, C.1    Hammer, R.E.2    Mottet, N.K.3    Palmiter, R.D.4
  • 318
    • 0031984712 scopus 로고    scopus 로고
    • Differential expression of the MT-1E gene in estrogen-receptor-positive and -negative human breast cancer cell lines
    • Friedline, J.A., Garrett, S.H., Somji, S., Todd, J.H. and Sens, D.A., Differential expression of the MT-1E gene in estrogen-receptor-positive and -negative human breast cancer cell lines, Am. J. Pathol., 152, 23-27, 1998.
    • (1998) Am. J. Pathol. , vol.152 , pp. 23-27
    • Friedline, J.A.1    Garrett, S.H.2    Somji, S.3    Todd, J.H.4    Sens, D.A.5
  • 319
    • 0025309819 scopus 로고
    • Hepatic isometallothioneins in mice: Induction in adults and postnatal ontogeny
    • Kershaw, W.C., Lehman-McKeeman, L.D. and Klaassen, C.D., Hepatic isometallothioneins in mice: induction in adults and postnatal ontogeny, Toxicol. App. Pharmacol., 104, 267-275, 1990.
    • (1990) Toxicol. App. Pharmacol. , vol.104 , pp. 267-275
    • Kershaw, W.C.1    Lehman-McKeeman, L.D.2    Klaassen, C.D.3
  • 320
    • 0028905411 scopus 로고
    • Induction of hepatic metallothionein I in tumour-bearing mice
    • Kloth, D.M., Chin, J.L. and Cherian, M.G., Induction of hepatic metallothionein I in tumour-bearing mice, Br. J. Cancer, 71, 712-716, 1995.
    • (1995) Br. J. Cancer , vol.71 , pp. 712-716
    • Kloth, D.M.1    Chin, J.L.2    Cherian, M.G.3
  • 321
    • 0023887156 scopus 로고
    • Isolation of mouse isometallothioneins. A comparison of isometallothioneins in growing cells and post-mitotic cells
    • Kobayashi, S. and Sayato-Suzuki, J., Isolation of mouse isometallothioneins. A comparison of isometallothioneins in growing cells and post-mitotic cells, Biochem. J., 251, 649-655, 1988.
    • (1988) Biochem. J. , vol.251 , pp. 649-655
    • Kobayashi, S.1    Sayato-Suzuki, J.2
  • 322
    • 0027435262 scopus 로고
    • Distinct TATA motifs regulate differential expression of human metallothionein I genes MT-IF and MT-IG
    • Shworak, N.W., O'Connor, T., Wong, N.C. and Gedamu, L., Distinct TATA motifs regulate differential expression of human metallothionein I genes MT-IF and MT-IG, J. Biol. Chem., 268, 24460-24466, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 24460-24466
    • Shworak, N.W.1    O'Connor, T.2    Wong, N.C.3    Gedamu, L.4
  • 323
    • 0028329653 scopus 로고
    • Human metallothionein isoform gene expression in cisplatin- Sensitive and resistant cells
    • Yang, Y.Y., Woo, E.S., Reese, C.E., Bahnson, R.R., Saijo, N. and Lazo, J.S., Human metallothionein isoform gene expression in cisplatin-sensitive and resistant cells, Mol. Pharmacol., 45, 453-460, 1994.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 453-460
    • Yang, Y.Y.1    Woo, E.S.2    Reese, C.E.3    Bahnson, R.R.4    Saijo, N.5    Lazo, J.S.6
  • 324
    • 0032459134 scopus 로고    scopus 로고
    • Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals
    • Garrett, S.H., Somji, S., Todd, J.H., Sens, M.A. and Sens, D.A., Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals, Environ. Health Persp., 106, 825-832, 1998.
    • (1998) Environ. Health Persp. , vol.106 , pp. 825-832
    • Garrett, S.H.1    Somji, S.2    Todd, J.H.3    Sens, M.A.4    Sens, D.A.5
  • 325
    • 0031731185 scopus 로고    scopus 로고
    • Exposure of human proximal tubule cells to cd2+, zn2+, and Cu2+ induces metallothionein protein accumulation but not metallothionein isoform 2 mRNA
    • Garrett, S.H., Somji, S., Todd, J.H. and Sens, D.A., Exposure of human proximal tubule cells to cd2+, zn2+, and Cu2+ induces metallothionein protein accumulation but not metallothionein isoform 2 mRNA, Environ. Health Persp., 106, 587-595, 1998.
    • (1998) Environ. Health Persp. , vol.106 , pp. 587-595
    • Garrett, S.H.1    Somji, S.2    Todd, J.H.3    Sens, D.A.4
  • 326
    • 0019475320 scopus 로고
    • Induction of metallothionein in HeLa cells by dexamethasone and zinc
    • Karin, M. and Herschman, H.R., Induction of metallothionein in HeLa cells by dexamethasone and zinc, Eur. J. Biochem., 113, 267-272, 1981.
    • (1981) Eur. J. Biochem. , vol.113 , pp. 267-272
    • Karin, M.1    Herschman, H.R.2
  • 327
    • 0019827677 scopus 로고
    • Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals
    • Karin, M., Andersen, R.D. and Herschman, H.R., Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals, Eur. J. Biochem., 118, 527-531, 1981.
    • (1981) Eur. J. Biochem. , vol.118 , pp. 527-531
    • Karin, M.1    Andersen, R.D.2    Herschman, H.R.3
  • 328
    • 0022356875 scopus 로고
    • Induction of metallothionein synthesis in cultured cells derived from rabbit kidney
    • Koizumi, S., Sone, T. and Kimura, M., Induction of metallothionein synthesis in cultured cells derived from rabbit kidney, J. Cell. Physiol., 125, 223-228, 1985.
    • (1985) J. Cell. Physiol. , vol.125 , pp. 223-228
    • Koizumi, S.1    Sone, T.2    Kimura, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.