Exposure of human proximal tubule cells to Cd2+, Zn2+, and Cu2+ induces metallothionein protein accumulation but not metallothionein isoform 2 mRNA

Environmental Health Perspectives

Volumn 106, Issue 9, 1998, Pages 587-595

  Garrett, Scott H ^a   Somji, Seema ^a   Todd, John H ^a   Sens, Donald A ^a,b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Cadmium; Copper; Gene regulation; Lead; Mercury; Metallothionein; mRNA expression; Nephrotoxicity; Proximal tubule; Silver; Zinc

Indexed keywords

CADMIUM; COPPER ION; ISOPROTEIN; LEAD; MERCURY; MESSENGER RNA; METALLOTHIONEIN; SILVER; ZINC ION;

ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE CONTROL; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECIES DIFFERENCE;

ANIMALIA; RODENTIA;

EID: 0031731185     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106587     Document Type: Article

References (49)

1. Hamer DH, Metallothionein. Annu Rev Biochem 55:913-951 (1986).
2. Kägi JHR. Evolution, structure and chemical activity of class I metallothioneins: an overview. In: Metallothionein III. Biological Roles and Medical Implications (Suzuki KT, Imura N, Kimura M, eds). Berlin:Birkhauser Verlag, 1993;29-56.
3. Cherian MG, Howell SB, Imura N, Klaassen CD, Koropatnick J, Lazo JS, Waalkes MP. Role of metallothionain in carcinogenesis. Toxicol Appl Pharmacol 126:1-5 (1994).
4. Misra RR, Crance KA, Bare RM, Waalkes MP. Lack of correlation between the inducibility of metallothionein mRIMA and metaliothionein protein in cadmium-exposed rodents. Toxicology 117:99-109 (1997).
5. Oberdorster G, Cherian MG, Baggs RB, Correlation between cadmium-induced pulmonary carcinogenicity, metaliothionein expression, and inflammatory processes: a species comparison. Environ Health Perspect 102(suppl 3):257-263 (1994).
6. Melo IM, Bare RM, Waalkes MP. Metallothionein gene expression in testicular interstitial cells and liver of rats treated with cadmium. Toxicology 107:121-130 (1996).
7. Shiralshi N, Hochadel JF, Coogan TP, Koropatnick J, Waalkes MP. Sensitivity to cadmium-induced genotoxicity in rat testicular cells is associated with minimal expression of the metallothionein gene. Toxicol Appl Pharmacol 130:229-236 (1995).
8. Waalkes MP, Perantoni A, Bhave MR, Rehm S. Strain dependence in mice of resistance and susceptibility to the testicular effects of cadmium: assessment of the role of testicular cadmium binding proteins. Toxicol Appl Pharmacol 93:47-61 (1988).
9. Coogan IP, Shiraishi N, Waalkes MP. Minimal basal activity and lack of metal-induced activation of the metallothionein gene correlates with lobe-specific sensitivity to the cercinogenic effects of cadmium in the rat prostate. Toxicol Appl Pharmacol 132:164-173 (1995).
10. Coogan TP, Shiraishi N, Waalkes MP. Apparent quiescence of the metallothionein gene in the rat ventral prostate: association with cadmium-induced prostate tumors in rats. Environ Health Perspect 102(suppl 3):137-139 (1995).
11. Searle PF, Davison BL, Stuart GW, Wilkie TM, Norstedt G, Palmiter RD. Regulation linkage and sequence of mouse metallothionein I and II genes. Mol Cell Biol 4:1221-1230 (1984).
12. Kägi JHR, Kojima Y. Chemistry and biochemistry of metallothionein. Experimenta Suppl 52:25-80 (1987).
13. Quaife CJ, Findley SD, Erickson JC, Froelick GJ, Kelly EJ, Zambrowicz BP, Palmiter RD. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry 33:7250-7259 (1994).
14. Palmiter RD, Findley SD, Whitmore TE, Durnam DM. MT-III, a brain-specific member of the metallothionein gene family, Proc Natl Acad Sci USA 89:6333-6337 (1992).
15. West AK, Stallings R, Mildebrand CE, Chiu R, Karin M, Richards R. Human metallothionein genes: structure of the functional locus at 16q13. Genomics 8:513-518 (1990).
16. Stennard FA, Holloway AF, Hamilton J, West AK. Characterization of six additional human mstallothionein genes. Biochim Biophys Acta 1218:357-365 (1994).
17. Bernard A, Roels H, Hubermont G, Buchet JP, Masson PL, Lauwerys R. Characterization of the proteinuria in Cd exposed workers. Int Arch Occup Environ Health 38:19-30 (1976).
18. Lauwerys R, Buchet JP, Roels H, Brouwers J, Stanescu D. Epidemiologicai survey of workers exposed to cadmium: effect of lung, kidney and several biological indices. Arch Environ Health 28:145-148 (1974).
19. Kido T, Honda R, Tsuritani I, Yamada H, Ishizaki M, Yamada Y, Nogawa K. Progress of renal dysfunction in inhabitants environmentally exposed to cadmium. Arch Environ Health 43:213-217 (1988).
20. Gonich HC, Indraprasit S, Rosen VJ, Neustein H, Van de Velde R, Raghavan SRV. Effect of cadmium on renal tubular function, the ATP-Na-ATPasa transport system and renal tubular ultrastructure. Miner Electrolyte Metab 3:21-35 (1980).
21. Bosco E, Porta N, Diezi J. Renal handling of cadmium: a study by tubular microinjections. Arch Toxicol 7:371-373 (1986).
22. Schmidt CJ, Hamer DH, Cell specificity and an effect of ras on human metallothionein gene expression. Proc Natl Acad Sci USA 83:3346-3350 (1986).
23. Todd JH, McMertin K, Sens DA. Enzymatic isolation and serum-free culture of human renal cells retaining properties of proximal tubule cells. In: Methods in Molecular Medicine: Human Cell Culture Protocols (Jones GE, ed). Totawa, NJ:Humana Press, 1996;431-436.
24. Tarnowski BL, Sens DA, Nicholson JH, Hazen-Martin DJ, Garvin AJ, Sens MA. Automatic quantitation of cell growth and determination of mitotic index using DAPI nuclear staining. Pediatr Pathol 13:249-265 (1993).
25. Mididoddi S, McGuirt JP, Sens MA, Todd JH, Sens DA. Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. Toxicol Lett 685:17-27 (1996).
26. Mizzen CA, Cartel NJ, Yu WH, Fraser PE, McLachlan DR. Sensitive detection of metallothioneins-1, -2 and -3 in tissue homogenstes by immunoblottlng: a method for enhanced membrane transfer and retention. J Biochem Biophys Methods 32:77-83 (1996).
27. Hoey JG, Garrett SH, Sens MA, Todd JH, Sens DA. Expression of MT-3 mRNA in human kidney, proximal tubule cell cultures, and renal cell carcinoma. Toxicol Lett 92:149-160 (1997).
28. Kägi JHR, Schäffer A. Biochemistry of the metallothioneins. Biochemistry 27:8509-8515 (1988).
29. Koropatnick J, Leibbrandt MEI. Effects of metals on gene expression. In: Toxicology of Metals (Goyer RA, Cherian MG, eds). Berlin:Springer, 1995;93-120.
30. Beyersmann D, Hechtenberg S. Cadmium, gene regulation, and cellular signaling in mammalian cells. Toxicol Appl Pharmacol 144:247-261 (1997).
31. Bremmer I. Nutritional and physiologic significance of metallothionein. Methods Enzymol 205:25-35 (1991).
32. Dalton T, Fu K, Palmiter RD, Andrews GK. Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency. J Nutr 126:825-833 (1996).
33. Kelly EJ, Quaife CJ, Froelick J, Palmiter RD. Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J Nutr 126:1782-1790 (1996).
34. Waalkes MP, Klaassen CD. Concentration of metallothionein in major organs of rats after administration of various metals. Fundam Appl Toxicol 5:473-477 (1985).
35. Irato P, Sturniolo GC, Giacon G, Magro A, D'lnca R, Mestriner C, Albergon V. Effect of zinc supplementation on metallothionein, copper, and zinc concentration in various tissues of copper-loaded rats. Biol Trace Elem Res 51:87-96 (1996).
36. Piotrowski JK, Trojanowska B, Wisniewska-Knypl JM, Bolanowska W. Mercury binding in the kidney and liver or rats repeatedly exposed to mercuric chloride. Toxicol Appl Pharmacol 27:11-19 (1974).
37. Zalups RK, Cherian MG. Renal metallothionein metabolism after a reduction of renal mass. I. Effect of unilateral nephrectomy and compensatory renal growth on basal and metal-induced renal metallothionein metabolism. Toxicology 71:83-102 (1992).
38. Morcillo MA, Santamaria J. Mercury distribution and renal metallothionein induction after subchronic oral exposure in rats. Biometals 9:213-220 (1996).
39. Zalups RK, Lash LH. Advances in understanding the renal transport and toxicity of mercury. J Toxicol Environ Health 42:1-44 (1994).
40. Hollinger MA. Toxicological aspects of topical slver pharmaceuticals. Crit Rev Toxicol 26:255-260 (1996).
41. Shinogi M, Maeizumi S. Effect of preinduction of metallothionein on tissue distribution of silver and hepatic lipid peroxidation. Biol Pharm Bull 16:372-377 (1993).
42. Liu J, Kershaw WC, Klaassen CD. The protective effect of metallothionein on the toxicity of various matais in rat primary hepatocyte culture. Toxicol Appl Pharmacol 107:27-34 (1991).
43. Durnam DM, Palmiter RD. Induction of metallothionein-1 mRNA in cultured cells by heavy metals and iodoacetate: evidence for gratuitous inducers. Mol Cell Biol 4:484-491 (1984).
44. Goering PI, Fowler BA. Metal constitution of metallothionein influences inhibition of delta aminolaevulinic acid dehydratase porphobilinogen synthetase by lead. Biochem J 245:339-345 (1987).
45. Maitani T, Watahiki A, Suzuki KT. Induction of metallothionein after lead administration by three injection routes in mice. Toxicol Appl Pharmacol 83:211-217 (1986).
46. Ikebuchi H, Teshlma R, Suzuki K, Sawada JI, Terao T, Yamane Y. An immunological study of a leadthionein-like protein in rat liver. Biochem Biophys Res Comm 136:535-541 (1986).
47. Ikebuchi H, Teshima R, Suzuki K, Terao T, Yamane Y. Simultaneous induction of lead-metallothionein-like protein and zinc-thionein in the liver of rats given lead acetate. Biochem J 233:541-546 (1986).
48. 2+ in human T cell line. Eur J Pharmacol 270:221-228 (1994).
49. Yang Y-Y, Woo ES, Reese CE, Bahnson RR, Saijo N, Lazo JS. Human metallothionein isoform gene expression in cisplatin-sensitive and resistant cells. Mol Pharmacol 45:453-460 (1994).