Pathobiology of copper-induced injury in Bedlington terriers: Ultrastructural and microanalytical studies

Analytical Cellular Pathology

Volumn 10, Issue 3, 1996, Pages 229-241

  Haywood, Susan ^a   Fuentealba, Isolina Carmen ^a,c   Foster, John ^b   Ross, Gordon ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ICI   (United Kingdom)

^c UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

Author keywords

Apoptosis; Canine; Copper; Liver; Microanalytical; Ultrastructure

Indexed keywords

COPPER; PROTEIN P53;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOG; FAMILIAL DISEASE; HUMAN; INTOXICATION; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; STORAGE DISEASE; ULTRASTRUCTURE; X RAY MICROANALYSIS;

ANIMALS; COPPER; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LIVER DISEASES; ORGAN SIZE;

EID: 0029978576     PISSN: 09218912     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Bryan SE, Frieden E. Interaction of copper II with desoxyribonucleic acid below 30°C. Biochemistry 1967;6:2728-2734.
2. Carson DA, Riberio JM. Apoptosis and disease. Lancet 1993;341:1251-1254.
3. Cheville NF. Ultrastructural Pathology. An Introduction to Interpretation. Ames: Iowa State University Press, 1994;791.
4. Douglas K. Making friends with death wish genes. N Sci 1994;1936:31-34.
5. Elmes ME, Haywood S, Jasani B. A histochemical and immunocytochemical study of hepatic copper and metallothionein in the pre- and post-natal rat. J Pathol 1991;164:83-87.
6. Eriksoon J. Verifying copper toxicosis in Bedlington terriers by analytical microscopy of needle biopsies of liver. J Comp Pathol 1983;100:443-448.
7. Fuentealba IC, Haywood S. Cellular mechanisms of toxicity and tolerance in the copper loaded rat. I. Ultrastructural changes in the liver. Liver 1988;8:372-380.
8. Fuentealba IC, Haywood S, Trafford J. Evaluation of histochemical methods for the detection of copper overload in rat liver. Liver 1987;7:277-282.
9. Fuentealba IC, Haywood S, Foster J. Cellular mechanisms of toxicity and tolerance in the copper loaded rat. III. Ultrastructural changes and copper localization in the kidney. Br J Exp Pathol 1989;70:543-556.
10. Fuentealba IC, Haywood S, Foster J. Cellular mechanisms of toxicity and tolerance in the copper loaded rat. II. Pathogenesis of copper toxicity in the liver. Exp Mol Pathol 1989;50:26-37.
11. Fuentealba IC, Haywood S, Trafford J. Variations in the intralobular distribution of copper in the livers of copper loaded rats in relation to the pathogenesis of copper storage disease. J Comp Pathol 1988;100:1-11.
12. Goldfischer S, Popper H, Sternlieb I. The significance of variations in the distribution of copper in liver disease. Am J Pathol 1980;99:715-730.
13. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. New York: Oxford Science Publication, 1985.
14. Hardy RM, Stevens JB, Stowe CM. Chronic progressive hepatitis in Bedlington terriers associated with elevated liver copper concentrations. Minn Vet J 1975;15:13-24.
15. Hardy RM, Stevens JB. Chronic progressive hepatitis in Bedlington terriers. Proc AAHA's 45th Annual Meeting 1978;187-190.
16. Haywood S, Fuentealba IC. Variations in the zonal distribution of accumulated copper in the livers of rats and Bedlington terriers in relation to disease. Proc 154th Meeting Pathol Soc Great Britain and Ireland. J Pathol 1987;151:82A.
17. Johnson GI, Gilbertson SR, Goldfischer S, Grushoff PS, Sternlieb I. Cytochemical detection of inherited copper toxicosis of Bedlington terriers. Vet Pathol 1984;21:57-60.
18. Johnson GF, Sternlieb I, Twedt DC, Grushoff PS, Scheinberg IH. Inheritance of copper toxicosis in Bedlington terriers. Am J Vet Res 1980;41:1865-1866.
19. Johnson GF, Zawie DA, Gilbertson SR, Sternlieb I. Chronic active hepatitis in Doberman pinschers. J Am Vet Med Assoc 1982;180:1438-1442.
20. Karnovsky, MS. A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy. J Cell Biol 1965;27:137A.
21. Kastan MB, Zhan Q, Wofik S, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelsten B, Fornace AJ Jr. A mammalian cell cycle check point pathway utilising p53 and GADD4S is defective in ataxia-telangjectasia. Cell 1992;71:587-597.
22. Kelly DF, Haywood S, Bennet AM. Copper toxicosis in Bedlington terriers in the United Kingdom. J Small Anim Pract 1984;25:293-298.
23. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257.
24. King TP, Bremner I. Autophagy and apoptosis in liver during the prehaemolytic phase of chronic copper poisoning in sheep. J Comp Pathol 1979;89:515-530.
25. Lane P. A death in the life of p53. Nature 1993;362:786-787.
26. Li Y, Trush MA. DNA damage resulting from the oxidation of hydroquinone by copper: role for a Cu(II)/Cu(I) redox cycle and reactive oxygen generation. Carcinogenesis 1993;14:1303-1311.
27. Li Y, Trush MA. Oxidation of hydroquinone by copper, chemical mechanisms and biological effects. Arch Biochem Biophys 1993;300:340-355.
28. Lindquist RR. Studies on the pathogenesis of hepatolenticular degeneration III. The effect of copper on rat liver lysosomes. Am J Pathol 1968;53:903-927.
29. Ludwig J, Owen CA, Barham SS, McCall JT, Hardy RM. The liver in the inherited copper disease of Bedlington terriers. Lab Invest 1980;43:82-87.
30. Phillips MJ, Poucell S, Patterson J, Valencia P. The Liver. An Atlas and Text of Ultrastructural Pathology. New York: Raven Press, 1987;165, 255-256, 328-337.
31. Robertson HM, Studdert VP, Reuter RE. Inherited copper toxicosis in Bedlington terriers. Aust Vet J 1983;60:235-238.
32. Su LC, Owen CA, Zollman PE, Hardy RM. A defect of biliary excretion of copper in copper laden Bedlington terrier. Am J Physiol 1982;243:G231-G236.
33. Su LC, Ravanshad S, Owen C, McCall JT, Zollman PE, Hardy RM. A comparison of copper-loading disease in Bedlington terriers and Wilson's disease in humans. Am J Physiol 1982;243:G226-G230.
34. Twedt DC, Sternlieb I, Gilbertson SR. Clinical, morphologic and chemical studies on copper toxicosis of Bedlington terriers. J Am Vet Med Assoc 1979;175:269-275.
35. Wyllie AH. Apoptosis: cell death in tissue regulation. J Pathol 1987;153:313-310.