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Volumn 159, Issue 2, 1999, Pages 98-108

Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure

Author keywords

Anemia; Apoptosis; Cadmium; Metallothionein; Metallothionein null mice; Neutrophils; Splenomegaly; Thymic atrophy

Indexed keywords

CADMIUM CHLORIDE; HEMOGLOBIN; INTERLEUKIN 1BETA; METALLOTHIONEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033200343     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8718     Document Type: Article
Times cited : (73)

References (43)
  • 1
    • 0030201019 scopus 로고    scopus 로고
    • Nonprotective effects of extracellular metallothionein
    • Borghesi L. A., Lynes M. A. Nonprotective effects of extracellular metallothionein. Toxicol. Appl. Pharmacol. 139:1996;6-14.
    • (1996) Toxicol. Appl. Pharmacol. , vol.139 , pp. 6-14
    • Borghesi, L.A.1    Lynes, M.A.2
  • 2
    • 0029879261 scopus 로고    scopus 로고
    • Interactions of metallothionein with murine lymphocytes: Plasma membrane binding and proliferation
    • Borghesi L. A., Youn J., Olson E. A., Lynes M. A. Interactions of metallothionein with murine lymphocytes: Plasma membrane binding and proliferation. Toxicology. 108:1996;129-140.
    • (1996) Toxicology , vol.108 , pp. 129-140
    • Borghesi, L.A.1    Youn, J.2    Olson, E.A.3    Lynes, M.A.4
  • 3
    • 0022471992 scopus 로고
    • Immunopathology of chronic cadmium administration in mice
    • Borgman R. F., Au B., Chandra R. K. Immunopathology of chronic cadmium administration in mice. Int. J. Immunopharmacol. 8:1986;813-817.
    • (1986) Int. J. Immunopharmacol. , vol.8 , pp. 813-817
    • Borgman, R.F.1    Au, B.2    Chandra, R.K.3
  • 4
    • 0020472154 scopus 로고
    • Inhibition of mixed leukocyte culture responses in cadmium-treated mice
    • Bozelka B., Burkholder P. M. Inhibition of mixed leukocyte culture responses in cadmium-treated mice. Environ. Res. 27:1982;421-432.
    • (1982) Environ. Res. , vol.27 , pp. 421-432
    • Bozelka, B.1    Burkholder, P.M.2
  • 7
    • 0027151829 scopus 로고
    • Immunotoxicology of cadmium and mercury on B-lymphocytes. Effects in lymphocyte function
    • Daum J. R., Shepherd D. M., Noelle R. J. Immunotoxicology of cadmium and mercury on B-lymphocytes. Effects in lymphocyte function. Int. J. Immunopharmacol. 15:1993;383-394.
    • (1993) Int. J. Immunopharmacol. , vol.15 , pp. 383-394
    • Daum, J.R.1    Shepherd, D.M.2    Noelle, R.J.3
  • 8
    • 0344756682 scopus 로고
    • Immunotoxicity of cadmium
    • Descotes J. Immunotoxicity of cadmium. IARC Sci. Publ. 118:1992;386-390.
    • (1992) IARC Sci. Publ. , vol.118 , pp. 386-390
    • Descotes, J.1
  • 11
    • 0020078490 scopus 로고
    • In vitro evaluation of cadmium-induced augmentation of the antibody response
    • Fujimaki H., Murakami M., Kubota K. In vitro evaluation of cadmium-induced augmentation of the antibody response. Toxicol. Appl. Pharmacol. 62:1981;288-293.
    • (1981) Toxicol. Appl. Pharmacol. , vol.62 , pp. 288-293
    • Fujimaki, H.1    Murakami, M.2    Kubota, K.3
  • 15
    • 0027943676 scopus 로고
    • Hypoproduction of erythropoietin contributes to anemia in chronic cadmium intoxication: Clinical study on Itai-itai disease in Japan
    • Horiguchi H., Teranish H., Niiya K., Aoshima K., Katoh T., Sakuragawa N., Kasuya M. Hypoproduction of erythropoietin contributes to anemia in chronic cadmium intoxication: Clinical study on Itai-itai disease in Japan. Arch. Toxicol. 68:1994;632-636.
    • (1994) Arch. Toxicol. , vol.68 , pp. 632-636
    • Horiguchi, H.1    Teranish, H.2    Niiya, K.3    Aoshima, K.4    Katoh, T.5    Sakuragawa, N.6    Kasuya, M.7
  • 16
    • 0002106617 scopus 로고
    • Evolution, structure and chemical activity of class I metallothioneins: An overview
    • K. T. Suzuki, N. Imura, & M. Kimura. Berlin: Birkhauser Verlag
    • Kägi J. H. R. Evolution, structure and chemical activity of class I metallothioneins: An overview. Suzuki K. T., Imura N., Kimura M. Metallothionein III: Biological Roles and Medical Implications. 1993;29-56 Birkhauser Verlag, Berlin.
    • (1993) Metallothionein III: Biological Roles and Medical Implications , pp. 29-56
    • Kägi, J.H.R.1
  • 17
    • 0028047647 scopus 로고
    • An immunological study on workers occupationally exposed to cadmium
    • Karakaya A., Yucesoy B., Sardas O. S. An immunological study on workers occupationally exposed to cadmium. Hum. Exp. Toxicol. 13:1994;73-75.
    • (1994) Hum. Exp. Toxicol. , vol.13 , pp. 73-75
    • Karakaya, A.1    Yucesoy, B.2    Sardas, O.S.3
  • 18
    • 0019380195 scopus 로고
    • Inhibition of mitogen and specific antigen-induced human lymphocyte proliferation by cadmium
    • Kastelan M., Geremver M., Kastelan A., Gamulin S. Inhibition of mitogen and specific antigen-induced human lymphocyte proliferation by cadmium. Exp. Cell Biol. 49:1981;15-19.
    • (1981) Exp. Cell Biol. , vol.49 , pp. 15-19
    • Kastelan, M.1    Geremver, M.2    Kastelan, A.3    Gamulin, S.4
  • 19
  • 20
    • 0029122626 scopus 로고
    • Cadmium-induced renal damage and proinflammatory cytokines: Possible role of IL-6 in tubular epithelial cell regeneration
    • Kayama F., Yoshida T., Elwell M. R., Luster M. I. Cadmium-induced renal damage and proinflammatory cytokines: Possible role of IL-6 in tubular epithelial cell regeneration. Toxicol. Appl. Pharmacol. 134:1995b;26-34.
    • (1995) Toxicol. Appl. Pharmacol. , vol.134 , pp. 26-34
    • Kayama, F.1    Yoshida, T.2    Elwell, M.R.3    Luster, M.I.4
  • 21
    • 0026323591 scopus 로고
    • Metallothioneins of monocytes and lymphocytes
    • Kimura M. Metallothioneins of monocytes and lymphocytes. Methods Enzymol. 205:1991;291-302.
    • (1991) Methods Enzymol. , vol.205 , pp. 291-302
    • Kimura, M.1
  • 22
    • 0019288419 scopus 로고
    • Immunotoxicology of heavy metals
    • Koller L. D. Immunotoxicology of heavy metals. Int. J. Immunopharmacol. 2:1980;269-279.
    • (1980) Int. J. Immunopharmacol. , vol.2 , pp. 269-279
    • Koller, L.D.1
  • 24
    • 0022654686 scopus 로고
    • Density increment and decreased survival of rat red blood cells induced by cadmium
    • Kunimoto M., Miura T. Density increment and decreased survival of rat red blood cells induced by cadmium. Environ. Res. 39:1986;86-95.
    • (1986) Environ. Res. , vol.39 , pp. 86-95
    • Kunimoto, M.1    Miura, T.2
  • 25
    • 0019499247 scopus 로고
    • Heavy metal modulation of lymphocyte activities. I. In vitro effects of heavy metal on primary humoral immune responses
    • Lawrence D. Heavy metal modulation of lymphocyte activities. I. In vitro effects of heavy metal on primary humoral immune responses. Toxicol. Appl. Pharmacol. 57:1981;439-451.
    • (1981) Toxicol. Appl. Pharmacol. , vol.57 , pp. 439-451
    • Lawrence, D.1
  • 26
    • 0032425077 scopus 로고    scopus 로고
    • 2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex
    • 2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex. Toxicol. Sci. 46:1998;197-203.
    • (1998) Toxicol. Sci. , vol.46 , pp. 197-203
    • Liu, J.1    Liu, Y.P.2    Habeebu, S.M.3    Klaassen, C.D.4
  • 28
    • 0029595386 scopus 로고
    • Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity
    • Liu Y. P., Liu J., Iszard M. B., Andrews G. K., Palmiter R. D., Klaassen C. D. Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity. Toxicol. Appl. Pharmacol. 135:1995;222-228.
    • (1995) Toxicol. Appl. Pharmacol. , vol.135 , pp. 222-228
    • Liu, Y.P.1    Liu, J.2    Iszard, M.B.3    Andrews, G.K.4    Palmiter, R.D.5    Klaassen, C.D.6
  • 29
    • 0018070182 scopus 로고
    • Influence of cadmium on the phagocytic and microbicidal activity of murine peritoneal macrophages, pulmonary alveolar macrophages and polymorphonuclear neutrophils
    • Loose L. D., Silkworth J. B., Simpson D. W. Influence of cadmium on the phagocytic and microbicidal activity of murine peritoneal macrophages, pulmonary alveolar macrophages and polymorphonuclear neutrophils. Infect. Immun. 22:1978;378-385.
    • (1978) Infect. Immun. , vol.22 , pp. 378-385
    • Loose, L.D.1    Silkworth, J.B.2    Simpson, D.W.3
  • 30
    • 0345186969 scopus 로고
    • The toxic effects of heavy metals on rat bone marrow in vitro erythropoiesis: Protective role of hemin and zinc
    • Lutton J. D., Ibraham N. G., Friedland M., Levere R. D. The toxic effects of heavy metals on rat bone marrow in vitro erythropoiesis: Protective role of hemin and zinc. Environ. Res. 39:1984;86-95.
    • (1984) Environ. Res. , vol.39 , pp. 86-95
    • Lutton, J.D.1    Ibraham, N.G.2    Friedland, M.3    Levere, R.D.4
  • 31
    • 0027769328 scopus 로고
    • Immunomodulatory activities of extracellular metallothionein. I. Metallothionein effects on antibody production
    • Lynes M. A., Borghesi L. A., Youn J., Olson E. A. Immunomodulatory activities of extracellular metallothionein. I. Metallothionein effects on antibody production. Toxicology. 85:1993;161-177.
    • (1993) Toxicology , vol.85 , pp. 161-177
    • Lynes, M.A.1    Borghesi, L.A.2    Youn, J.3    Olson, E.A.4
  • 33
    • 0028912584 scopus 로고
    • Accumulation of metallothionein and its multiple forms by zinc, cadmium and dexamethasone in human peripheral T and B lymphocytes and monocytes
    • Mesna O. J., Steffensen I. L., Hjertholm H., Andersen R. A. Accumulation of metallothionein and its multiple forms by zinc, cadmium and dexamethasone in human peripheral T and B lymphocytes and monocytes. Chem. Biol-Interact. 94:1995;225-242.
    • (1995) Chem. Biol-Interact. , vol.94 , pp. 225-242
    • Mesna, O.J.1    Steffensen, I.L.2    Hjertholm, H.3    Andersen, R.A.4
  • 34
    • 0027204069 scopus 로고
    • Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse
    • Michalska A.E., Choo K. H. A. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. USA. 90:1993;8088-8092.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8088-8092
    • Michalska, A.E.1    Choo, K.H.A.2
  • 36
    • 0020319574 scopus 로고
    • Effects of cadmium, lead, and zinc on macrophage-mediated cytotoxicity towards tumor cells
    • Nelson D. J., Kiremidjian-Achumacher L., Stotzky G. Effects of cadmium, lead, and zinc on macrophage-mediated cytotoxicity towards tumor cells. Environ. Res. 28:1982;154-163.
    • (1982) Environ. Res. , vol.28 , pp. 154-163
    • Nelson, D.J.1    Kiremidjian-Achumacher, L.2    Stotzky, G.3
  • 37
    • 0025973535 scopus 로고
    • Iron as a possible aggravating factor for osteopathy in Itai-itai disease, a disease associated with chronic cadmium intoxication
    • Noda M., Yasuda M., Kitagawa M. Iron as a possible aggravating factor for osteopathy in Itai-itai disease, a disease associated with chronic cadmium intoxication. J. Bone Miner. Res. 6:1991;245-255.
    • (1991) J. Bone Miner. Res. , vol.6 , pp. 245-255
    • Noda, M.1    Yasuda, M.2    Kitagawa, M.3
  • 38
    • 0019427290 scopus 로고
    • Cytological shift in lymphocytes induced by cadmium in mice and rats
    • Ohsawa M., Kawai K. Cytological shift in lymphocytes induced by cadmium in mice and rats. Environ. Res. 24:1981;192-200.
    • (1981) Environ. Res. , vol.24 , pp. 192-200
    • Ohsawa, M.1    Kawai, K.2
  • 39
    • 0021025438 scopus 로고
    • Modified distribution of lymphocyte subpopulation in blood and spleen from mice exposed to cadmium
    • Ohsawa M., Sato K., Takahashi K., Ochi T. Modified distribution of lymphocyte subpopulation in blood and spleen from mice exposed to cadmium. Toxicol. Lett. 19:1983;29-35.
    • (1983) Toxicol. Lett. , vol.19 , pp. 29-35
    • Ohsawa, M.1    Sato, K.2    Takahashi, K.3    Ochi, T.4
  • 40
    • 0023783679 scopus 로고
    • Effects of cadmium on in vitro and in vivo erythropoiesis: Erythroid progenitor cells (CFU-E), iron, and erythropoietin in cadmium-induced iron deficiency anemia
    • Sakata S., Iwami K., Enoki Y., Kohzuki H., Shimizu S. Effects of cadmium on in vitro and in vivo erythropoiesis: Erythroid progenitor cells (CFU-E), iron, and erythropoietin in cadmium-induced iron deficiency anemia. Exp. Hematol. 16:1988;581-587.
    • (1988) Exp. Hematol. , vol.16 , pp. 581-587
    • Sakata, S.1    Iwami, K.2    Enoki, Y.3    Kohzuki, H.4    Shimizu, S.5
  • 41
    • 0021946918 scopus 로고
    • Iron retention and distribution in the cadmium-induced iron deficiency
    • Schaefer S. G., Elsenhans B. Iron retention and distribution in the cadmium-induced iron deficiency. Ecotoxicol. Environ. Safety. 10:1985;128-141.
    • (1985) Ecotoxicol. Environ. Safety , vol.10 , pp. 128-141
    • Schaefer, S.G.1    Elsenhans, B.2
  • 43
    • 0023066496 scopus 로고
    • Synthesis and degradation of erythrocyte metallothionein in cadmium-administered mice
    • Tanaka K., Min K., Onosaka S., Fukuhara C. Synthesis and degradation of erythrocyte metallothionein in cadmium-administered mice. Experientia. 52:1987;525-532.
    • (1987) Experientia , vol.52 , pp. 525-532
    • Tanaka, K.1    Min, K.2    Onosaka, S.3    Fukuhara, C.4


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