Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals

Environmental Health Perspectives

Volumn 106, Issue 12, 1998, Pages 825-831

  Garrett, Scott H ^a   Somji, Seema ^a   Todd, John H ^a   Sens, Mary Ann ^a   Sens, Donald A ^a,b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Cadmium; Copper; Gene expression; Heavy metals; Lead; Mercury; Metallothionein; mRNA; Proximal tubule; Reverse transcriptase polymerase chain reaction; RT PCR; Silver; Zinc

Indexed keywords

CADMIUM; COPPER ION; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ISOPROTEIN; LEAD; MERCURY; MESSENGER RNA; METAL; METALLOTHIONEIN; SILVER; ZINC ION;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOGENE;

EUKARYOTA;

EID: 0032459134     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.2307/3434126     Document Type: Article

References (30)

1. Hamer DH. Metallothionein. Annu Rev Biochem 55:913-951 (1986).
2. Kägi JHR. Evolution, structure and chemical activity of class I metallothioneins: an overview. In: Metallothionein III. Biological Roles and Medical Implications (Suzuki KT, Imura N, Kimura M, eds). Berlin:Birkhauser Verlag, 1993;29-56.
3. Kägi JHR, Kojima Y. Chemistry and biochemistry of metallothionein. Exper Suppl 52:25-80 (1987).
4. Palmiter RD, Findley SD, Whitmore TE, Durnam DM. MT-III, a brain-specific member of the metallothionein gene family. Proc Natl Acad Sci 89:6333-6337 (1992).
5. Quaife CJ, Findley SD, Erickson JC, Froelick GJ, Kelly EJ, Zambrowicz BP, Palmiter RD. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry 33:7250-7259 (1994).
6. Searle PF, Davison BL, Stuart GW, Wilkie TM, Norstedt G, Palmiter RD. Regulation linkage and sequence of mouse metallothionein I and II genes. Mol Cell Biol 4:1221-1230 (1984).
7. West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards R. Human metallothionein genes: structure of the functional locus at 16q13. Genomics 8:513-518 (1990).
8. Stennard FA, Holloway AF, Hamilton J, West AK. Characterization of six additional human metallothionein genes. Biochim Biophys Acta 1218:357-365 (1994).
9. A gene: differential induction by metal ions and glucocorticoids. Cell 37:263-272 (1984).
10. B gene. Mol Cell Biol 6:2149-2157 (1986).
11. F gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids. Mol Cell Biol 6:26-37 (1986).
12. Schmidt CJ, Jubier MF, Hamer DH. Structure and expression of two human metallothionein-I isoform genes and a related pseudogene. J Biol Chem 260:7731-7737 (1985).
13. Jahroudi N, Foster R, Price-Haughey J, Beitel G, Gedamu L. Cell-type specific and differential regulation of the human metallothionein genes. J Biol Chem 265:6506-6511 (1990).
14. Cavigelli M, Kagi JHR, Hunziker PE. Cell and inducer-specific accretion of human isometallothioneins. Biochem J 292:551-554 (1993).
15. Pauwels M, Van Weyenbergh J, Soumillion A, Proost P, DeLey M. Induction by zinc of specific metallothionein isoforms in human monocytes. Eur J Biochem 220:105-110 (1994).
16. Soumillion A, Van Damme J, DeLey M. Cloning and specific polymerized-chain-reaction amplification of a third charge-separable human metallothionein isoform. Eur J Biochem 209:999-1004 (1992).
17. Schmidt CJ, Hamer DH. Cell specificity and an effect of ras on human metallothionein gene expression. Proc Natl Acad Sci USA 83:3346-3350 (1986).
18. Cousins RJ. Metallothionein - aspects related to copper and zinc metabolism. J Inherit Metab Dis 6(suppl 1):15-21 (1983).
19. Kagi JHR, Hunziker P. Mammalian metallothionein. Biol Trace Element Res 21:111-118 (1989).
20. Goering PL, Klaassen CD. Altered subcellular distribution of cadmium following cadmium pretreatment: possible mechanism of tolerance to cadmium-induced lethality. Toxicol Appl Pharmacol 70:195-203 (1983).
21. Bernard A, Roels H, Hubermont G, Buchet JP, Massen PL, Lauwerys R. Characterization of the proteinuria in Cd exposed workers. Int Arch Occup Environ Hearth 38:19-30 (1976).
22. Gonich HC, Indraprasit S, Rosen VJ, Neustein H, Van de Velde R, Raghavan SRV. Effect of cadmium on renal tubular function, the ATP-Na-ATPase transport system and renal tubular ultrastructure. Miner Electrolyte Metab 3:21-35 (1980).
23. Bosco E, Porta N, Diezi J. Renal handling of cadmium: a study by tubular microinjections. Arch Toxicol 7:371-373 (1986).
24. 2+ induces metallothionein protein accumulation but not metallothionein isoform 2 mRNA. Environ Health Perspect 106:587-595 (1998).
25. Todd JH, McMartin K, Sens DA. Enzymatic isolation and serum-free culture of human renal cells retaining properties of proximal tubule cells. In: Methods in Molecular Medicine. Human Cell Culture Protocols (Jones GE, ed). Totawa, NJ:Humana Press Inc., 1996;431-436.
26. Sens DA, Detrisac CJ, Sens MA, Rossi MR, Wenger SL, Todd JH. Tissue culture of human renal epithelial cells using a defined serum-free growth formulation. Exper Nephrol (in press).
27. Mididoddi S, McGuirt JP, Sens MA, Todd JH, Sens DA. Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. Toxicol Lett 685:17-27 (1996).
28. Nartey NO, Banerjee D, Cherian MG. Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development. Pathology 19:233-238 (1987).
29. Kojima Y, Hamashima Y. Immunohistochemical studies of metallothionein. II. Its detection in the human fetal kidney. Acta Histochem Cytochem 13:277-286 (1980).
30. Hoey JG, Garrett SH, Sens MA, Todd JH, Sens DA. Expression of MT-3 mRNA in human kidney, proximal tubule cell cultures, and renal cell carcinoma. Toxicol Lett 92:149-160 (1997).