Enhanced apoptosis in metallothionein null cells

Molecular Pharmacology

Volumn 52, Issue 2, 1997, Pages 195-201

  Kondo, Yukihiro ^a,b   Rusnak, James M ^a   Hoyt, Dale G ^a   Settineri, Catherine E ^a   Pitt, Bruce R ^a   Lazo, John S ^a,c  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CISPLATIN; CYTARABINE; DNA; MELPHALAN; METALLOTHIONEIN; OXIDIZING AGENT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TERT BUTYL HYDROPEROXIDE; ZINC;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CATTLE; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; EMBRYO CELL; ETIOLOGY; IMMUNOBLOTTING; LUNG FIBROBLAST; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RABBIT;

EID: 0030799592     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.2.195     Document Type: Article

References (40)

1. Steller, H. Mechanisms and genes of cellular suicide. Science (Washington D. C.) 267:1445-1449 (1995).
2. Hockenbery, D. M. Bcl-2, a novel regulator of cell death. Bioassays 17:631-638 (1995).
3. Yonish-Rouach, E. Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6. Nature (Lond.) 352:345-347 (1991).
4. Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington D. C.) 267:1456-1462 (1995).
5. Earnshaw, W. C. Nuclear changes in apoptosis. Cur. Opin. Cell Biol. 7:337-343 (1995).
6. Buttke, T. M., and P. A. Sandstrom. Oxidative stress as a mediator of apoptosis. Immunol. Today 15:7-10 (1994).
7. Greenlund, L. J., T. L. Deckwerth, and E. M. Johnson, Jr. Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14:303-315 (1995).
8. Lotem, J., M. Peled-Kamar, Y. Groner, and L. Sachs. Cellular oxidative stress and the control of apoptosis by wild-type p53 cytotoxic compounds and cytokines. Proc. Natl. Acad. Sci. USA 93:9166-9171 (1996).
9. Johnson, T. M., Z.-X. Yu, V. J. Ferrans, R. A. Lowenstein, and T. Finkel. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc. Natl. Acad. Sci. USA 93:11848-11852 (1996).
10. Shimizu, S., Y. Eguchi, H. Kosaka, W. Kamiike, H. Matsuda, and Y. Tsujimoto. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature (Lond.) 374:811-816 (1995).
11. Jacobson, M. D., and M. C. Raff. Programmed cell death and Bcl-2 protection in very low oxygen. Nature (Lond.) 374:814-816 (1995).
12. Shimizu, T., M. Kubatoa, A. Tanizawa, H. Sano, Y. Kasai, H. Hashimoto, Y. Akiyama, and H. Mikawa. Inhibition of both etoposide-induced DNA fragmentation and activation of poly-ADP-ribose synthesis by zinc ion. Biochem. Biophys. Res. 169:1172-1177 (1990).
13. Lazo, J. S., and B. R. Pitt. Metallothioneins and cell death by anticancer drugs. Annu. Rev. Pharmacol. Toxicol. 35:635-653 (1995).
14. Kelley, S. L., A. Basu, B. A. Teicher, M. P. Hacker, D. H. Hamer, and J. S. Lazo Overexpression of metallothionein confers resistance to anticancer drugs. Science (Washington D. C.) 241:1813-1815 (1988).
15. Kaina, B., H. Lohrer, M. Karin, and P. Herrlich. Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents. Proc. Natl. Acad. Sci. USA 87:2710-3714 (1990).
16. Schwarz, M. A., J. S. Lazo, J. C. Yalowich, I. Reynolds, V. E. Kagan, V. Tyurin, T.-M. Kim, S. C. Watkins, and B. R. Pitt. Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity. J. Biol. Chem. 269:15238-15243 (1994).
17. Schwarz, M. A., J. S. Lazo, J. C. Yalowich, W. P. Allen, M. Whitmore, H. A. Bergonia, E. Tzeng, T. R. Billiar, P. D. Robbins, J. R. Lancaster, Jr., and B. R. Pitt. Metallothionein protects against the cytotoxic and DNA damaging effects of nitric oxide. Proc. Natl. Acad. Sci. USA 92:4452-4456 (1995).
18. Lazo, J. S., Y. Kondo, D. Dellapiazza, A. E. Michalska, K. H. A. Choo, and B. R. Pitt. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem. 270:5506-5510 (1995).
19. Kondo, Y., E. Woo, A. E. Michalska, A. C. Choo, and J. S. Lazo. Metallothionein null cells have increased sensitivity to anticancer drugs. Cancer Res. 55:2021-2023 (1995).
20. Zheng, H., J. Liu, K. H. A. Choo, A. E. Michalska, and C. D. Klaassen. Metallothionein-I, and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53. Toxicol. Appl. Pharmacol. 136:229-235 (1996).
21. Zaia, J., L. Jiang, M. S. Han, J. R. Tabb, Z. Wu, D. Fabris, and C. Fenselau. A binding site for chlorambucil on metallothionein. Biochemistry 35:2830-2835 (1996).
22. Leyshon-Sorland, K., L. Morkrid, and H. E. Rugstrad. Metallothionein: a protein conferring resistance in vitro to tumor necrosis factor. Cancer Res. 53:4874-4880 (1993).
23. Michalska, A. E., and K. H. A. Choo. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. USA 90:8088-8092 (1993).
24. Lazo, J. S., C. J. Boland, and P. E. Schwartz. Bleomycin hydrolase activity and cytotoxicity in human tumors. Cancer Res. 42:4026-4031 (1982).
25. Rusnak, J. M., T. P. G. Calmels, D. G. Hoyt, Y. Kondo, J. C. Yalowich, and J. S. Lazo. Genesis of discrete higher order DNA fragments in apoptotic human prostate carcinoma cells. Mol. Pharmacol. 49:244-252 (1996).
26. Lowe, S. W., H. E. Ruley, T. Jacks, and D. E. Housman. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967 (1993).
27. Mayer, M., and M. Noble. N-Acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc. Natl. Acad. Sci. USA 91:7496-7500 (1994).
28. 2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response. Cell 79:583-593 (1994).
29. Troy, C. M., and M. L. Shelanski. Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proc. Natl. Acad. Sci. USA 91:6384-6387 (1994).
30. Kane, D. J., T. A. Sarafian, R. Anton, H. Hahn, E. B. Gralla, J. S. Valentine, T. Ord, and D. E. Bredesen. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science (Washington D. C.) 262:1274-1277 (1993).
31. Lin, K. I., S. H. Lee, R. Narayanan, J. M. Baraban, J. M. Hardwick, and R. R. Ratan. Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B. J. Cell Biol. 131:1149-1161 (1995).
32. Wang, C. Y., M. W. Mayo, and A. S. Baldwin. TNF- and cancer therapy-induced apoptosis - potentiation by inhibition of NF-kappa B. Science (Washington D. C.) 274:784-787 (1996).
33. Abdel-Mageed, A. B., and K. C. Agrawal. Antisense down-regulation of metallothoinein induces growth arrest and apoptosis in human breast carcinoma cells. Cancer Gene Ther 4:199-207 (1997).
34. Kang, Y. J. Suppression of doxorubicin-induced apoptosis in the metallothionein overexpressing heart of transgenic mice. Proc. Am. Assoc. Cancer Res. 38:192 (1997).
35. Tamai, K. T., E. B. Gralla, L. M. Ellerby, V. J. S., and D. J. Thiele. Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase. Proc. Natl. Acad. Sci. USA 90:8013-8017 (1993).
36. Fliss, H., and M. Menard. Oxidant-induced mobilization of zinc from metallothionein. Archiv. Biochem. Biophys. 293:195-199 (1992).
37. Sato, M., and I. Bremner. Oxygen free radicals and metallothionein. Free Radical Biol. Med. 14:325-337 (1993).
38. Coyle, P., J. C. Philcox, and A. M. Rofe. Hepatic zinc in metallothionein-null mice following zinc challenge: in vivo and in vitro studies. Biochem. J. 309:25-31 (1995).
39. Miyashita, T., and J. C. Reed. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299 (1995).
40. Abdel-Mageed, A. B., and K. C. Agrawal. Activation of NF-k β: A potential mechanism for metallothionein-induced cellular proliferation. Proc. Am. Assoc. Cancer Res. 38:447 (1997).