Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity

Toxicology and Applied Pharmacology

Volumn 149, Issue 1, 1998, Pages 24-31

  Liu, Jie ^a   Liu, Yaping ^a   Habeebu, Sultan S M ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cisplatin; DNA fragmentation; Hepatotoxicity; Metallothionein deficient mice; Mouse hepatocyte primary cultures

Indexed keywords

ALANINE AMINOTRANSFERASE; CADMIUM; CISPLATIN; DNA FRAGMENT; METALLOTHIONEIN;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; DRUG SENSITIVITY; ENZYME BLOOD LEVEL; FEMALE; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; LETHALITY; LIVER CELL; LIVER INJURY; LIVER TOXICITY; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; STRAIN DIFFERENCE; UREA NITROGEN BLOOD LEVEL;

ANIMALIA;

EID: 0031906024     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8325     Document Type: Article

References (47)

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