Metallothionein and its role in toxic metal regulation

Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology

Volumn 113, Issue 2, 1996, Pages 117-123

  Roesijadi, G ^a  

^a UNIVERSITY OF MARYLAND CENTER FOR ENVIRONMENTAL SCIENCE   (United States)

Author keywords

cadmium; metal detoxification metal toxicity; metallothionein; metals; mollusc; oyster

Indexed keywords

CADMIUM; HEAVY METAL; MESSENGER RNA; METALLOTHIONEIN; TOXIC SUBSTANCE; ZINC;

COMPLEX FORMATION; CONFERENCE PAPER; DETOXIFICATION; GENE CONTROL; GENE EXPRESSION; MODEL; MOLLUSC; NONHUMAN; OYSTER; PRIORITY JOURNAL; PROTEIN INDUCTION; REGULATORY MECHANISM;

EID: 0029879520     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/0742-8413(95)02077-2     Document Type: Conference Paper

References (49)

1. Anderson, R.D.; Taplitz, S.J.; Oberbauer, A.M.; Calame, K.L.; Herschman, H.R. Metal-dependent binding of a nuclear factor to the rat metallothionein-I promoter. Nucleic Acids Res. 18: 6049-6055;1990.
2. Bayne, B.L. Physiological measurements of stress. Rapports et Procés-verbaux des Réunions 179:56-61;1979.
3. Bayne, B.L.; Brown, D.A.; Harrison, F.L.; Yevich, P.D. Mussel health. In: The international mussel watch. Pp. 248. Washington, DC: National Academy Sciences; 1980.
4. Beach, L.R.; Palmiter, R.D. Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc. Natl. Acad. Sci. USA 78:2110-2114;1981.
5. Brouwer, M.; Brouwer-Hoexum, T. Glutathione-mediated transfer of copper (I) into American lobster apohemocyanin. Biochemistry 31:4096-4102;1992.
6. Brown, D.A.; Bawden, C.A.; Chatel, K.W.; Parsons, T.R. The wildlife community of Iona Island Jetty, Vancouver, B.C., and heavy-metal pollution effects. Environ. Conserv. 4:213-216; 1977.
7. Brown, D.A.; Parsons, T.R. Relationship between cytoplasmic distribution of mercury and toxic effects to zooplankton and chum salmon (Oncorhynchus keta) exposed to mercury in a controlled ecosystem. J. Fish. Res. Board Can. 35:880-884;1978.
8. Brugnera, E.; Georgiev, O.; Radtke, F.; Heuchel, R.; Baker, E.; Sutherland, G. R.; Schaffner, W. Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. Nucleic Acids Res. 22:3167-3173; 1994.
9. Cherian, M.G.; Chan, H.M. Biological functions of metallothionein - a review. In: Suzuki, K.T.; Imura, N.; Kimura, M., eds. Metallothionein III: Biological roles and medical implications. Basel: Birkhäuser Verlag; 1993: 87-109.
10. Churchich, J.E.; Scholz, G.; Kwok, F. Activation of pyridoxal kinase by metallothionein. Bioch. Biophys. Acta 996:181-186; 1989.
11. Datta, P.K.; Jacob, S.T. Identification of a sequence within the mouse metallothionein-I gene promoter mediating its basal transcription and of a protein interacting with this element. Cell. Mol. Biol. Res. 39:439-449;1993.
12. Din, W.S.; Frazier, J.M. Protective effect of metallothionein on cadmium toxicity in isolated rat hepatocytes. Biochem. J. 230: 395-402;1985.
13. Fuentes, M.E.; Unger, M.E.; Roesijadi, G. Individual variability in the 3'-untranslated region of metallothionein mRNAs in a natural population of the mollusc Crassostrea virginica. Molec. Mar. Biol. Biotech. 3:141-148;1994.
14. Fürst, P.; Hu, S.; Hackett, R.; Hamer, D. Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein. Cell 55:705-717;1988.
15. Goering, P.L.; Klaassen, C.D. Tolerance to cadmium-induced toxicity depends on presynthesized metallothionein in liver. J. Toxicol. Environ. Health 14:803-812;1984.
16. Hamer, D.H. Metallothioneins. Ann. Rev. Biochem. 55:913-951;1986.
17. Hamer, D.H.; Thiele, D.J.; Lemontt, J.E. Function and auto-regulation of yeast copperthionein. Science 228:685-690;1985.
18. Heuchel, R.; Radtke, F.; Georgiev, O.; Stark, G.; Aguet, M.; Schaffner, W. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 13:2870-2875;1994.
19. Huang, P.C. Metallothionein structure/function interface. In: Metallothionein III: Biological Roles and Medical Implications (edited by Suzuki, K.T.; Imura, N.; Kimura M.), pp. 407-426. Birkhäuser Verlag, Basel; 1993.
20. Kägi, J.H.R. Evolution, structure, and chemical activity of class I metallothioneins: an overview. In: Metallothionein III: Biological Roles and Medical Implications (edited by Suzuki, K.T.; Imura, N.; Kimura, M.), pp. 29-55. Birkhäuser Verlag, Basel; 1993.
21. Kägi, J.H.R.; Kojima, Y. Chemistry and biochemistry of metallothioneins. In: Metallothionein II (edited by Kägi, J.H.R.; Kojima, Y.), pp. 25-61. Birkhauser-Verlag, Basel; 1987.
22. Kägi, J.H.R.; Vallee, B.L. Metallothionein: a cadmium- and zinc-containing protein from equine renal cortex. J. Biol. Chem. 235:3460-3465;1960.
23. Karin, M. Metallothioneins: proteins in search of function. Cell 41:9-10;1985.
24. A Gene. Eur. J. Biochem. 210:555-560;1992.
25. Labbe, S.; Larouche, L.; Mailhot, D.; Seguin, C. Purification of Mouse MEP-1, a Nuclear Protein Which Binds to the Metal Regulatory Elements of Genes Encoding Metallothionein. 21: 1549-1554;1993.
26. Laurent, T.; Ho, A.-S.; Maroni, G. Recent evolutionary history of the metallothionein gene Mtn in Drosophila. Genet. Res., Camb. 58:203-210;1991.
27. Margoshes, M.; Vallee, B.L. A cadmium protein from equine kidney cortex. J. Am. Chem. Soc. 79:4813-4814;1957.
28. Masters, B.A.; Kelly, E.J.; Quaife, C.J.; Brinster, R.L.; Palmiter, R.D. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. USA 91:584-588;1994.
29. Michalska, A.E.; Choo, K.H.A. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mice. Proc. Natl. Acad. Sci. USA 90:8088-8092;1993.
30. Minichiello, L.; Remondelli, P.; Cigliano, S.; Bonatti, S.; Leone, A. Interactions of nuclear proteins from uninduced, induced and superinduced HeLa cells with metal regulatory elements MRE3 and 4 of the human metallothionein IIa-encoding gene. Gene 143:289-294;1994.
31. Olafson, R.W.; Thompson, J.A.J. Isolation of heavy metal binding proteins from marine vertebrates. Mar. Biol., 28:83-86; 1974.
32. Otsuka, F.; Iwamatsu, A.; Suzuki, K.; Ohsawa, M.; Hamer, D.H.; Koizumi, S. Purification and characterization of a protein that binds to metal responsive elements of the human metallothionein IIA gene. J. Biol. Chem., 269:23700-23707;1995.
33. Otsuka, F.; Ohsawa, M.; Koizumi, S. A human metal responsive element-binding protein interacts with a homologue element of the mouse metallothionein-I gene. Industrial Hlth. 31:133-142; 1993.
34. Otvos, J.D.; Liu, X.; Li, H.; Shen, G.; Basti, M. Dynamic aspects of metallothionein structure. In: Metallothionein III: Biological Roles and Medical Implications (edited by Suzuki, K.T.; Imura, N.; Kimura, M.), pp. 57-74. Birkhäuser Verlag, Basel; 1993.
35. Palmiter, R.D. Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1. Proc. Natl. Acad. Sci. USA, 91:1219-1223;1994.
36. Radtke, F.; Heuchel, R.; Georgiev, O.; Hergersberg, M.; Gariglio, M.; Dembic, Z.; Schaffner, W. Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. EMBO Journal, 12:1355-1362;1993.
37. Roesijadi, G. Metallothioneins in metal regulation and toxicity in aquatic animals. Aquat. Toxicol. 22:81-114;1992.
38. Roesijadi, G. Behavior of metallothionein-bound metals in a natural population of an estuarine mollusc. Mar. Environ. Res., 38:147-168;1994.
39. Roesijadi, G.; Klerks, P. A kinetic analysis of Cd-binding to metallothionein and other intracellular ligands in oyster gills. J. Exp. Zool. 251:1-12;1989.
40. Roesijadi, G.; Vestling, M.M.; Murphy, C.M.; Klerks, P.L.; Fenselau, C. Structure and time-dependent behavior of acetylated and nonacetylated forms of a molluscan metallothionein. Biochim. Biophys. Acta 1074:230-236;1991.
41. Sato, M.; Bremner, I. Oxygen free radicals and metallothionein. Free Radical Biol. Med. 14:325-337;1993.
42. 2+ to bind a regulatory MRE element of the mouse gene encoding metallothionein-1. Gene 97:295-300;1991.
43. Stegeman, J.J.; Brouwer, M.; Di Giulio, R.T.; Förlin, L.; Fowler, B.A.; Sanders, B.M.; Van Veld, P.A. Molecular responses to environmental contamination: enzyme and protein systems as indicators of chemical exposure and effect. In: Biomarkers: Biochemical, Physiological, and Histological Markers of Anthropogenic Stress (edited by Huggett, R.J.; Kimerle, R.A.; Mehrle P.M.; Bergman, H.L.), pp. 235-335. Lewis Publishers, Chelsea, MI; 1992.
44. Thiele, D.J. Metal-regulated transcription in eukaryotes. Nucleic Acids Res. 20:1183-1191;1992.
45. Udom, U.O.; Brady, F.O. Reactivation in vitro of zinc-requiring apo-enzymes by rat liver zinc-thionein. Biochem. J., 187:329-335;1980.
46. Unger, M.E.; Chen, T.T.; Murphy, C.M.; Vestling, M.M.; Fenselau, C.C.; Roesijadi, G. Primary structure of molluscan metallothionein deduced from PCR-amplified cDNA and mass spectrometry of purified proteins. Biochim. Biophys. Acta 1074: 371-377;1991.
47. Vallee, B.L.; Maret, W. The functional potential and potential functions of metallothioneins: a personal perspective. In: Metallothionein III: Biological Roles and Medical Implications (edited by Suzuki, K.T.; Imura, N.; Kimura, M.), pp. 1-27. Birkhäuser Verlag, Basel; 1993.
48. Webb, M. 1972. Protection by zinc against cadmium toxicity. Biochem. Pharmacol. 21:2767-2771;1972.
49. Winge, D.; Krasno, J.; Colucci, A.V. Cadmium accumulation in rat liver: correlation between metal and pathology. In: Trace Element Metabolism in Animals - 2 (edited by Hoekstra, W.G.; Suttie, J.W.; Ganther, J.W.; Mertz, W.), pp. 500-502. University Park Press, Baltimore; 1973.