Transcriptional activity and regulatory protein binding of metal- responsive elements of the human metallothionein-IIA gene

European Journal of Biochemistry

Volumn 259, Issue 3, 1999, Pages 635-642

  Koizumi, Shinji ^a,b   Suzuki, Kaoru ^a   Ogra, Yasumitsu ^a   Yamada, Hirotomo ^b   Otsuka, Fuminori ^c  

^a Division of Hazard Assessment   (Japan)

^b NATL INSTITUTE OF INDUSTRIAL HEALTH   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

Metallothionein; Protein nucleic acid interaction; Transcription factor; Zinc

Indexed keywords

GENE PRODUCT; HEAVY METAL; METALLOTHIONEIN; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, REPORTER; HELA CELLS; HUMANS; METALLOTHIONEIN; METALS; MUTATION; OLIGODEOXYRIBONUCLEOTIDES; PROMOTER REGIONS (GENETICS); REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; ZINC;

MAMMALIA;

EID: 0033083839     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00069.x     Document Type: Article

References (29)

1. 1. Durnam, D.M. & Palmiter, R.D. (1981) Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J. Biol. Chem. 256, 5712-5716.
2. 2. Karin, M., Andersen, R.D., Slater, E., Smith, K. & Herschman, H.R. (1980) Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response. Nature 286, 295-297.
3. 2+-induced synthesis of metallothionein in HeLa cells. Biochem. J. 227, 879-886.
4. A gene. Nature 308, 513-519.
5. 5. Carter, A.D., Felber, B.K., Walling, M., Jubier, M.-F., Schmidt, C.J. & Hamer, D.H. (1984) Duplicated heavy metal control sequences of the mouse metallothionein-I gene. Proc: Natl Acad. Sci. USA 81, 7392-7396.
6. 6. Stuart, G.W., Searle, P.F., Chen, H.Y., Brinster, R.L. & Palmiter, R.D. (1984) A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc. Natl Acad. Sci. USA 81, 7318-7322.
7. 7. Culotta, V.C. & Hamer, D.H. (1989) Fine mapping of a mouse metallothionein gene metal response element. Mol. Cell. Biol. 9, 1376-1380.
8. 8. Stuart, G.W., Searle, P.F. & Palmiter, R.D. (1985) Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature 317, 828-831.
9. 9. Koizumi, S. & Otsuka, F. (1993) Factors involved in the transcriptional regulation of metallothionein genes. In Metallothionein III (Suzuki, K.T., Imura, N. & Kimura, M., eds.), pp. 457-474. Birkhäuser-Verlag, Basel.
10. 10. Radtke, F., Heuchel, R., Georgiev, O., Hergersberg, M., Gariglio, M., Dembic, Z. & Schaffner, W. (1993) Cloned transcription factor MTF-I activates the mouse metallothionein I promoter. EMBO J. 12, 1355-1362.
11. 11. Palmiter, R.D. (1994) Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-I. Proc. Natl Acad. Sci. USA 91, 1219-1223.
12. 12. Heuchel, R., Radtke, F., Georgiev, O., Stark, G., Aguet, M. & Schaffner, W. (1994) The transcription factor MTF-I is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 13, 2870-2875.
13. A gene. J. Biol. Chem. 269, 23700-23707.
14. 14. Brugnera, E., Georgiev, O., Radtke, F., Heuchel, R., Baker, E., Sutherland, G.R. & Schaffner, W. (1994) Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-I. Nucleic Acids Res. 22, 3167-3173.
15. 15. Koizumi, S. & Otsuka, F. (1995) Transcriptional regulation of the metallothionein gene: metal-responsive element and zinc regulatory factor. In Genetic Response to Metals (Sarkar, B., ed.), pp. 397-410. Marcel Dekker, Inc., New York NY.
16. A gene. Eur. J. Biochem. 210, 555-560.
17. 17. Sambrook, J., Fritsch, E.F. & Maniatís, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring, Harbor NY.
18. 18. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. & Struhl, K. (1995) Current Protocols in Molecular Biology, John Wiley & Sons, Inc., New York NY.
19. 19. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
20. 20. Karin, M., Haslinger, A., Holtgreve, H., Cathala, G., Slater, E. & Baxter, J.D. (1984) Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA. Cell 36, 371-379.
21. B gene. Mol. Cell Biol. 6, 2149-2157.
22. 22. Westin, G. & Schaffner, W. (1988) A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene. EMBO J. 7, 3763-3770.
23. 23. Searle, P.F., Stuart, G.W. & Palmiter, R.D. (1985) Building a metal-responsive promoter with synthetic regulatory elements. Mol. Cell. Biol. 5, 1480-1489.
24. 24. Thiesen, H.-J. & Bach, C. (1991) Transition metals modulate DNA-protein interactions of Sp1 zinc finger domains with its cognate target site. Biochem. Biophys. Res. Commun. 176, 551-557.
25. 25. Hanas, J.S. & Gunn, C.G. (1996) Inhibition of transcription factor IIIA-DNA interactions by xenobiotic metal ions. Nucleic Acids Res. 24, 924-930.
26. A enhancer activity. Mol. Cell. Biol. 7, 606-613.
27. 27. Koizumi, S., Otsuka, F. & Yamada, H. (1991) A nuclear factor that interacts with metal responsive elements of a human metallothionein gene. Chem.-Biol. Interact. 80, 145-157.
28. 28. Searle, P.F., Stuart, G.W. & Palmiter, R.D. (1987) Metal regulatory elements of the mouse metallothionein-I gene. Experientia (Suppl. 52), 407-414.
29. 29. Samson, S.L.-A. & Gedamu, L. (1995) Metal-responsive elements of the rainbow trout metallothionein-B gene function for basal and metal-induced activity. J. Biol. Chem. 270, 6864-6871.