Analysis of the effects of overexpression of metallothionein-I in transgenic mice on the reproductive toxicology of cadmium

Environmental Health Perspectives

Volumn 104, Issue 1, 1996, Pages 68-76

  Dalton, Tim ^a   Fu, Kai ^a   Enders, George C ^a   Palmiter, Richard D ^b   Andrews, Glen K ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cadmium; Metallothionein; Peri implantation; Reproductive; Testes; Toxicology; Transgenic mice

Indexed keywords

CADMIUM; MESSENGER RNA; METALLOTHIONEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLASTOCYST; CONTROLLED STUDY; FEMALE; FEMALE GENITAL SYSTEM; FERTILITY; HISTOLOGY; MALE; NECROSIS; NIDATION; NONHUMAN; PREGNANCY; PREGNANCY RATE; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; RAT; REPRODUCTIVE TOXICITY; SPERMATOGENESIS; TESTIS; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0030041435     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.9610468     Document Type: Article

References (65)

1. Emmerson BT. "Ouch-ouch" disease: the osteomalacia of cadmium nephropathy. Ann Intern Med 73:854-855 (1970).
2. Friberg L, Elinder C-G, Kjellstrom T, Nordberg GF. Cadmium and health: a toxicological and epidemiological appraisal. Boca Raton, FL:CRC Press, 1986.
3. Sunderman FW. Carcinogenicity and mutagenicity of some metals and their compounds. In: Environmental carcinogens: selected methods of analysis (O'Neill IK, Schuller P, Fishbein L, eds). Lyon:International Agency for Research on Cancer, 1986;17-43.
4. Poirier LA, Kasprzak KS, Hoover KL, Wenk ML. Effects of calcium and magnesium acetates on the carcinogenicity of cadmium chloride in Wistar rats. Cancer Res 43:4575-4581 (1983).
5. Waalkes MP, Rehm S, Riggs CW, Bare RM, Devor DE, Poirier LA, Wenk ML, Henneman JR. Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: dose-response analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site. Cancer Res 49:4282-4288 (1989).
6. Barlow SM, Sullivan FM. Cadmium and its compounds. In: Reproductive hazards of industrial chemicals (Barlow SM, Sullivan FM, eds). London:Academic Press, 1982;136-155.
7. Dencker L, Danielsson B, Khayat A, Lindgren A. Disposition of metals in the embryo and fetus. In: Reproductive and developmental toxicity of metals (Clarkson TW, Nordberg GF, Sager PR, eds). New York:Plenum Publishers, 1983;607-632.
8. Vallee BL, Ulmer DD. Biochemical effects of mercury, cadmium, and lead. Annu Rev Biochem 41:91-128 (1972).
9. Parizek J. The destructive effect of cadmium ion on testicular tissue and its prevention by zinc. J Endocrinol 15:56-63 (1957).
10. Gunn SA, Clark-Gould T, Anderson WA. Zinc protection against cadmium injury to rat testis. Arch Pathol 71:274-281 (1961).
11. De SK, Paria BC, Dey SK, Andrews GK. Stage-specific effects of cadmium on preimplantation embryo development and implantation in the mouse. Toxicology 80:13-25 (1993).
12. Schmid BP, Hall JL, Goulding E, Fabro S, Dixon R. In vitro exposure of male and female mice gametes to cadmium chloride during the fertilization process, and its effects on pregnancy outcome. Toxicol Appl Pharmacol 69:326-332 (1983).
13. Yu HS, Tam PP, Chan ST. Effects of cadmium on preimplantation mouse embryos in vitro with special reference to their implantation capacity and subsequent development. Teratology 32:347-353 (1985).
14. Andrews GK, Huet-Hudson YM, Paria BC, McMaster MT, De SK, Dey SK. Metallothionein gene expression and metal regulation during preimplantation mouse embryo development (MT mRNA during early development). Dev Biol 145:13-27 (1991).
15. Vallee BL. Metallobiochemistry: Part B. Metallothionein and related molecules. Introduction to metallothionein. Methods Enzymol 205:3-7 (1991).
16. Palmiter RD. Molecular biology of metallothionein gene expression. Exper Suppl 52:63-80 (1987).
17. Beach LR, Palmiter RD. Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc Natl Acad Sci USA 78:2110-2114 (1981).
18. Morton KA, Jones BJ, Sohn MH, Schaefer AE, Phelps RC, Datz FL, Lynch RE. Uptake of cadmium is diminished in transfected mouse NIH/3T3 cells enriched for metallothionein. J Biol Chem 267:2880-2883 (1992).
19. Liu Y, Liu J, Iszard MB, Andrews GK, Palmiter RD, Klaassen CD. Transgenic mice that over-express metallothionein-I are protected from cadmium lethality and hepatotoxicity. Toxicol Appl Pharmacol (in press).
20. Michalska AE, Choo KHA. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc Natl Acad Sci USA 90:8088-8092 (1993).
21. Masters BA, Kelly EJ, Quaife CJ, Brinster RL, Palmiter RD. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc Natl Acad Sci USA 91:584-588 (1994).
22. Palmiter RD, Sandgren EP, Koeller DM, Brinster RL. Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol Cell Biol 13:5266-5275 (1993).
23. Iszard MB, Liu JL, Liu Y, Dalton TD, Andrews GK, Palmiter RD, Klaassen CD. Characterization of metallothionein-I transgenic mice. Toxicol Appl Pharmacol 13:305-312 (1995).
24. Eaton DL, Cherian MG. Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay. Methods Enzymol 205:83-88 (1991).
25. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159 (1987).
26. Andrews GK, Huet YM, Lehman LD, Dey SK. Metallothionein gene regulation in the preimplantation rabbit blastocyst. Development 100:463-469 (1987).
27. Dalton TD, Kover K, Dey SK, Andrews GK. Analysis of the expression of growth factor, interleukin-1 and lactoferrin genes and the distribution of inflammatory leukocytes in the preimplantation mouse oviduct. Biol Reprod 51:597-606 (1994).
28. Aviv H, Leder P. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci USA 69:1408-1412 (1972).
29. Dalton TD, Palmiter RD, Andrews GK. Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements. Nucleic Acids Res 22:5016-5023 (1994).
30. De SK, McMaster MT, Andrews GK. Endotoxin induction of marine metallothionein gene expression. J Biol Chem 265:15267-15274 (1990).
31. Paria BC, Das SK, Andrews GK, Dey SK. Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation. Proc Natl Acad Sci USA 90:55-59 (1993).
32. Durnam DM, Perrin F, Gannon F, Palmiter RD. Isolation and characterization of the mouse metallothionein-I gene. Proc Natl Acad Sci USA 77:6511-6515 (1980).
33. Liang L, Lee DK, Sobieski RJ, Dalton T, Andrews GK. Activation of the complete metallothionein gene locus in the maternal deciduum. Mol Reprod Dev (in press).
34. Glanville N, Durnam DM, Palmiter RD. Structure of mouse metallothionein-I gene and its mRNA. Nature 292:267-269 (1981).
35. Kikuchi Y, Irie M, Ikebuchi H, Sawada J, Terao T, Nakayama S, Iguchi S, Okada Y. Antigenic determinants on rat metallothionein: fine epitope mapping for a murine monoclonal antibody and rabbit polyclonal antisera. J Biochem (Tokyo) 107:650-654 (1990).
36. Hsu SM, Raine L, Fanger H. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol 75:816-821 (1981).
37. Kapur S, Tamada H, Dey SK, Andrews GK. Expression of insulin-like growth factor-I (IGF-I) and its receptor in the peri-implantation mouse uterus, and cell-specific regulation of IGF-I gene expression by estradiol and progesterone. Biol Reprod 46:208-219 (1992).
38. Tamada H, McMaster MT, Flanders KC, Andrews GK, Dey SK. Cell type-specific expression of transforming growth factor-β1 in the mouse uterus during the periimplantation period. Mol Endocrinol 4:965-972 (1990).
39. Kelly J, Whelan CA, Weir DG, Feighery C. Removal of endogenous peroxidase activity from cryostat sections for immunoperoxidase visualisation of monoclonal antibodies. J Immunol Methods 96:127-132 (1987).
40. De SK, McMaster MT, Dey SK, Andrews GK. Cell-specific metallothionein gene expression in mouse decidua and placentae. Development 107:611-621 (1989).
41. De SK, Enders GC, Andrews GK. High levels of metallothionein messenger RNAs in male germ cells of the adult mouse. Mol Endocrinol 5:628-636 (1991).
42. Gunn SA, Gould TC, Anderson WA. Selectivity of organ response to cadmium injury and various protective measures. J Pathol Bacteriol 96:89-96 (1968).
43. Lee DK, Fu K, Liang L, Dalton T, Palmitet RD, Andrews GK. Transgenic mouse blastocysts that over-express metallothionein-I resist cadmium toxicity in vitro. Mol Reprod Dev (in press).
44. Palmiter RD. Constitutive expression of metallothionein-III (MT-III), but not MT-I, inhibits growth when cells become zinc deficient. Toxicol Appl Pharmacol (in press).
45. Lazo JS, Kondo Y, Dellapiazza D, Michalska AE, Choo KHA, Pitt BR. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J Biol Chem 270:5506-5510 (1995).
46. Cain K, Skilleter DN. Selective uptake of cadmium by the parenchyumal cells of liver. Biochem J 188:285-288 (1980).
47. Frazier JM, Puglese J. Dose dependence of cadmium kinetics in the rat liver following intravenous injection. Toxicol Appl Pharmacol 43:461-474 (1978).
48. Meek ES. Cellular changes induced by cadmium in the mouse testis and liver. Br J Exp Pathol 40:503-506 (1959).
49. Dudley RE, Svoboda DJ, Klaassen C. Acute exposure to cadmium causes severe liver injury in rats. Toxicol Appl Pharmacol 65:302-313 (1982).
50. Nolan CV, Shaikh ZA. An evaluation of tissue metallothionein and genetic resistance to cadmium toxicity in mice. Toxicol Appl Pharmacol 85:135-144 (1986).
51. Danielson KG, Ohi S, Huang PC. Immunochemical detection of metallothionein in specific epithelial cells of rat organs. Proc Natl Acad Sci USA 79:2301-2304 (1982).
52. Nishimura H, Nishimura N, Tohyama C. Localization of metallothionein in the genital organs of the male rat. J Histochem Cytochem 38:927-933 (1990).
53. Gunn SA, Gould TC, Anderson WA. Strain differences in susceptibility of mice and rats to cadmium-induced testicular damage. J Reprod Fertil 10:273-275 (1965).
54. Chiquoine AD, Suntzeff V. Sensitivity of mammals to cadmium necrosis of the testis. J Reprod Fertil 10:455-457 (1965).
55. Taylor BA, Heiniger HJ, Meier H. Genetic analysis of resistance to cadmium-induced testicular damage in mice. Proc Soc Exp Biol Med 143:629-633 (1973).
56. Deagen JT, Whanger PD. Properties of cadmium-binding proteins in rat testes. Characteristics unlike metallothionein. Biochem J 231:279-283 (1985).
57. Waalkes MP, Perantoni A, Bhave MR, Rehm S Strain dependence in mice of resistance and susceptibility to the testicular effects of cadmium: assessment of the role of testicular cadmium-binding proteins. Toxicol Appl Pharmacol 93:47-61 (1988).
58. Bergh ARJ. The acute vascular effects of cadmium in the testis do not require the presence of Leydig cells. Toxicology 63:183-186 (1990).
59. Johnson AD, Sigman MB. Early actions of cadmium in the rat and domestic fowl testis. IV. Autoradiographic location of 115m cadmium. J Reprod Fertil 24:115-117 (1971).
60. Berlin M, Ullberg S. The fate of 109Cd in the mouse. An autoradiographic study after a single intravenous injection of 109CdC12. Arch Environ Health 7:686-693 (1963).
61. De SK, Dey SK, Andrews GK. Cadmium teratogenicity and its relationship with metallothionein gene expression in midgestation mouse embryos. Toxicology 64:89-104 (1990).
62. Liu J, Kershaw WC, Liu YP, Klaassen CD. Cadmium-induced hepatic endothelial cell injury in inbred strains of mice. Toxicology 75:51-62 (1992)
63. Gunn SA, Clark-Gould T, Anderson WAD. The selective injurious response to testicular and epididymal blood vessels to cadmium and its prevention by zinc. Am J Pathol 42:685-702 (1963).
64. Chiquoine AD. Observations on the early events of cadmium necrosis of the testis. Anat Rec 149:23-35 (1964).
65. Nolan CV, Shaikh ZA. The vascular endothelium as a target tissue in acute cadmium toxicity. Life Sci 39:1403-1409 (1986).