Acute CdMT injection is not a good model to study chronic Cd nephropathy: Comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats

Toxicology and Applied Pharmacology

Volumn 153, Issue 1, 1998, Pages 48-58

  Liu, Jie ^a   Habeebu, Sultan S ^a   Liu, Yaping ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Acute CdMT injection; Apoptosis; Cadmium exposure; Enzymuria; Glomerular damage; Glucosuria; Interstitial nephritis; Nephrotoxicity; Proteinuria; Regeneration; Tubular cell atrophy; Tubular cell necrosis

Indexed keywords

CADMIUM; CADMIUM CHLORIDE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; LACTATE DEHYDROGENASE; METALLOTHIONEIN; N ACETYL BETA GLUCOSAMINIDASE; NITROGEN; PROTEIN; UREA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; INJECTION; KIDNEY DISEASE; LONG TERM EXPOSURE; NEPHROTOXICITY; NONHUMAN; RAT; URINALYSIS; URINARY EXCRETION;

ANIMALIA;

EID: 0032210952     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8506     Document Type: Article

References (50)

1. Bernard, A., Lauwerys, R., and Amor, A. O. (1992). Loss of glomerular polyanion correlated with albuminuria in experimental cadmium nephropathy. Arch. Toxicol. 66, 272-278.
2. Bhattacharyya, M. H., Wilson, A. K., Silbergeld, E. K., Watson, L., and Jeffrey, E. (1995). Metal-induced osteotoxicities. In Metal Toxicology (R. A. Goyer, C. D. Klaassen, and M. P. Waalkes, Eds.), pp. 465-510. Academic Press, San Diego.
3. 2+ and Cd-metallothionein on cultured kidney tubule cells. Toxicol. Appl. Pharmacol. 136, 220-228.
4. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein binding. Anal. Biochem. 72, 248-254.
5. Cain, K., and Griffiths, B. (1980). Transfer of liver cadmium to the kidney after aflatoxin induced liver damage. Biochem. Pharmacol. 29, 1852-1855.
6. Cain, K., and Holt, E. (1983). Studies on cadmium-thionein (CdMT)-induced nephropathy: Time-course of CdMT uptake and degradation. Chem.-Biol. Interact. 43, 223-237.
7. Chan, H. M., Zhu, L. F., Zhong, R., Grant, D., Goyer, R. A., and Cherian, M. G. (1993). Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats. Toxicol. Appl. Pharmacol. 123, 89-96.
8. Cherian, M. G. (1985). Rat kidney epithelial cell culture for metal toxicity studies. In Vitro Cell. Dev. Biol. 21, 505-508.
9. Cherian, M. G., Goyer, R. A., and Delaquerriere-Richardson, L. (1976). Cadmium-metallothionein-induced nephropathy. Toxicol. Appl. Pharmacol. 38, 399-408.
10. 2 and Cd-metallothionein on cultured mesangial cells. Toxicol. Appl. Pharmacol. 116, 133-141.
11. 109CdMT. Toxicol. Appl. Pharmacol. 114, 173-181.
12. Dorian, C., Gattone, V. H. II, and Klaassen C. D. (1995a). Discrepancy between the nephrotoxic potencies of cadmium-metallothionein and cadmium chloride and the renal concentration of cadmium in proximal convoluted tubules. Toxicol. Appl. Pharmacol. 130, 161-168.
13. Dorian, C., and Klaassen C. D. (1995b). Protection by zinc-metallothionein (ZnMT) against cadmium-metallothionein-induced nephrotoxicity. Fundam. Appl. Toxicol. 26, 99-106.
14. Dudley, R. E., Gammal, L. M., and Klaassen, C. D. (1985). Cadmium-induced hepatic and renal injury in chronically exposed rats: Likely role of hepatic cadmium-metallothionein in nephrotoxicity. Toxicol. Appl. Pharmacol. 77, 414-426.
15. Dudley, R. E., Svoboda, D. J., and Klaassen, C. D. (1982). Acute exposure of cadmium causes severe liver injury in rats. Toxicol. Appl. Pharmacol. 65, 302-313.
16. Eaton, D. L., and Toal, B. F. (1982). Evaluation of Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66, 134-142.
17. Foulkes, E. C. (1978). Renal tubular transport of cadmium-metallothionein. Toxicol. Appl. Pharmacol. 45, 505-512.
18. Foulkes, E. C. (1990). The concept of critical levels of toxic heavy metals in target tissues. Crit. Rev. Toxicol. 20, 327-339.
19. Friberg, L., Elinder, C-G., Kjellstrom, T., and Nordberg, G. F., (Eds.) (1986). Cadmium and Health: A Toxicological and Epidemiological Appraisal, Vol. 1, pp. 103-178. CRC Press, Boca Raton, FL.
20. Goering, P. L., Waalkes, M. P., and Klaassen, C. D. (1995). Toxicology of cadmium. In Toxicology of Metals: Biochemical Aspects. Handbook of Experimental Pharmacology, Vol. 115 (R. A. Goyer and M. G. Cherian, Eds.), pp. 189-213, Springer-Verlag, New York.
21. Goyer, R. A., and Cherian, M. G. (1995). Renal effects of metals. In Metal Toxicology (R. A. Goyer, C. D. Klaassen, and M. P. Waalkes, Eds.), pp. 389-412. Academic Press, San Diego.
22. Goyer, R. A., Miller, C. R., Zhu, S-Y., and Victery, W. (1989). Non-metallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat. Toxicol. Appl. Pharmacol. 101, 232-244.
23. Groten, J. P., Koeman, J. H., van-Nesselrooij, J. H., Luten, J.B., Fentener-van-Vlissingen, J. M., Stenhuis, W. S., and van-Bladeren, P. J. (1994). Comparison of renal toxicity after long-term oral administration of cadmium chloride and cadmium-metallothionein in rats. Fundam. Appl. Toxicol. 23, 544-552.
24. Hamada, T., Nakano, S., Iwai, S., Tanimoto, A., Ariyoshi, K., and Koide, O. (1991). Pathological study on beagles after long-term oral administration of cadmium. Toxicol. Pathol. 19, 138-147.
25. Hiratsuka, O., Katsuta, O., Toyata, N., Tsuchitani, M., Umemura, T., and Marumo, F. (1996). Chronic cadmium exposure-induced renal anemia in ovariectomized rats. Toxicol. Appl. Pharmacol. 137, 228-236.
26. Jarup, L., Berglund, M., Elinder, C. G., Nordberg, G., and Vahter, M. (1998). Health effects of cadmium exposure. A review of the literature and a risk estimate. Scand. J. Work Environ. Health 24(suppl), 1-51.
27. Jarup, L., Persson, B., and Elinder, C. G. (1995). Decreased glomerular filtration rate in solderers exposed to cadmium. Occup. Environ. Med. 52, 818-822.
28. Kamiyama, T., Miyakawa, H., Li, J. P., Akiba, T., Liu, J., Liu, J. H., Marumo, F., and Sato, C. (1995). Effects of one-year cadmium exposure on livers and kidneys and their relation to glutathione levels. Res. Commun. Mol. Pathol. Pharmacol. 88, 177-186.
29. Katsuta, O., Hiratsuka, H., Matsumoto, J., Iwata, H., Toyata, N., Tsuchitani, M., Umemura, T., and Marumo, F. (1994). Cadmium-induced osteomalacic and osteopetrotic lesions in ovariectomized rats. Toxicol. Appl. Pharmacol. 126, 58-68.
30. Kayama, F., Yoshida, T., Elwell, M. R., and Luster, M. I. (1995). Cadmium-induced renal damage and proinflammatory cytokines: Possible role of IL-6 in tubular epithelial cell regeneration. Toxicol. Appl. Pharmacol. 134, 26-34.
31. Kazantzis, G. (1979). Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers. Environ. Health Perspect. 28, 155-159.
32. Kinne, R. K. H., Schutz, H., and Kinne-Saffran, E. (1995). The effect of cadmium chloride in vitro on sodium-glutamate cotransport in brush border membrane vesicles isolated from rabbit kidney. Toxicol. Appl. Pharmacol. 135, 216-221.
33. Kjellstrom, T. (1986). Renal effects. In Cadmium and Health: A Toxicological and Epidemiological Appraisal (L. Friberg, C-G. Elinder, T. Kjellstrom, and G. F. Nordberg, Eds.), Vol. 2, pp. 21-109. CRC Press, Boca Raton, FL.
34. Klaassen, C. D., Choudhuri, S., McKim, J. M., Jr., Lehman-McKeeman, L. D., and Kershaw, W. C. (1994). In vitro and in vivo studies on the degradation of metallothionein. Environ. Health Perspect. 102(Suppl. 3), 141-146.
35. Klaassen, C. D. (1996). Heavy metals and heavy-metal antagonists. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed. (J. G. Hardman, A. Goodman Gilman, L. E. Limbird, Eds.), pp. 1649-1672. McGraw-Hill, New York.
36. Liu, J., and Klaassen, C. D. (1996). Absorption and distribution of cadmium in metallothionein-I transgenic mice. Fundam. Appl. Toxicol. 29, 294-300.
37. 2-induced nephrotoxicity: Cd-induced renal injury is not necessarily mediated by CdMT. Toxicol. Sci. (in press).
38. 2 and Cd-metallothionein in cultured rat kidney proximal tubules and LLC-PK1 cells. Toxicol. Appl. Pharmacol. 128, 264-270.
39. Maitani, T., Cuppage, F. E., and Klaassen, C.D. (1988). Nephrotoxicity of intravenously injected cadmium-metallothionein: Critical concentration and tolerance. Fundam. Appl. Toxicol. 10, 98-108.
40. Min, K-S., Onosaka, S., and Tanaka, K. (1996). Renal accumulation of cadmium and nephropathy following long-term administration of cadmium-metallothionein. Toxicol. Appl. Pharmacol. 141, 102-109.
41. Nomiyama, K., Nomiyama, H., Nomura, Y., Taguchi, T., Matsui, K., Yotoriyama, M., Akahori, F., Iwao, S., Koizumi, N., Masaoka, T., Kitamura, S., Tsuchiya, K., Suzuki, T., and Kobayashi, K. (1979). Effects of dietary cadmium on rhesus monkeys. Environ. Health Perspect. 28, 223-243.
42. Nordberg, M. (1984). General aspects of cadmium: Transport, uptake and metabolism by the kidney. Environ. Health Perspect. 54, 13-20.
43. Nordberg, G. F., Goyer, R., and Nordberg, M. (1975). Comparative toxicity of cadmium-metallothionein and cadmium chloride on mouse kidney. Arch. Pathol. 99, 192-197.
44. Prozialeck, W. C., Wellington, D. R., and Lamar, P. C. (1993). Comparison of the cytotoxic effects of cadmium chloride and cadmium-metallothionein in LLC-PK1 cells. Life Sci. 53, PL337-PL342.
45. Squibb, K. S., Pritchard, J. B., and Fowler, B. A. (1984). Cadmium-metallothionein nephropathy: Relationships between ultrastructural/biochemical alterations and intracellular cadmium binding. J. Pharmacol. Exp. Ther. 229, 311-321.
46. Tanimoto, A., Hamada, T., and Koide, O. (1993). Cell death and regeneration of renal proximal tubular cells in rats with subchronic cadmium intoxication. Toxicol. Pathol. 21, 341-352.
47. Vestergaard, P., and Shaikh, Z. A. (1994). The nephrotoxicity of intravenously administered cadmium-metallothionein: Effect of dose, mode of administration, and preexisting renal cadmium burden. Toxicol. Appl. Pharmacol. 126, 240-247.
48. Wang, X. P., Chan, H. M., Goyer, R. A., and Cherian, M. G. (1993). Nephrotoxicity of repeated injections of cadmium-metallothionein in rats. Toxicol. Appl. Pharmacol. 119, 11-16.
49. Xu, T-L., Jiang, F., Liu, X., Yang, W., and Li, G. (1998). Ultrastructural and morphometry study on the glomeruli of mice chronically intoxicated with cadmium. Chin. J. Ind. Hyg. Occup. Dis. 16, 12-14.
50. Yasuda, M., Miwa, A., and Kitagawa, M. (1995). Morphometric studies of renal lesions in Itai-itai disease: Chronic cadmium nephropathy. Nephron 69, 14-19.