-
1
-
-
0023100726
-
Prevalence of asthma and hay fever in England and Wales
-
1. Flemming DM, Crombie DL. Prevalence of asthma and hay fever in England and Wales. BMJ 1987; 294: 279-83
-
(1987)
BMJ
, vol.294
, pp. 279-283
-
-
Flemming, D.M.1
Crombie, D.L.2
-
2
-
-
0021638388
-
Increases in death from asthma
-
2. Sly RM. Increases in death from asthma. Ann Allergy 1984; 53: 2-25
-
(1984)
Ann Allergy
, vol.53
, pp. 2-25
-
-
Sly, R.M.1
-
3
-
-
1842293452
-
Asthma deaths: A continuing problem
-
Sheppard M, editor. London: Bailliere Tindall
-
3. Barnes PJ. Asthma deaths: a continuing problem. In: Sheppard M, editor. Advanced medicine. London: Bailliere Tindall, 1988: 53-61
-
(1988)
Advanced Medicine
, pp. 53-61
-
-
Barnes, P.J.1
-
4
-
-
0021147863
-
Trends in the sales of drugs for asthma in New Zealand, Australia and the United Kingdom
-
4. Keating G, Mitchell EA, Jackson R, et al. Trends in the sales of drugs for asthma in New Zealand, Australia and the United Kingdom. BMJ 1983; 289: 348-51
-
(1983)
BMJ
, vol.289
, pp. 348-351
-
-
Keating, G.1
Mitchell, E.A.2
Jackson, R.3
-
5
-
-
0023651996
-
Has the management of asthma improved?
-
5. Hay IFC, Higgenbotham TW. Has the management of asthma improved? Lancet 1987; 11: 609-11
-
(1987)
Lancet
, vol.11
, pp. 609-611
-
-
Hay, I.F.C.1
Higgenbotham, T.W.2
-
6
-
-
0028136159
-
Multiple cyclic nucleotide phosphodiesterases
-
6. Beavo JA, Conti M, Heaslip RJ. Multiple cyclic nucleotide phosphodiesterases. Mol Pharmacol 1994; 46: 399-405
-
(1994)
Mol Pharmacol
, vol.46
, pp. 399-405
-
-
Beavo, J.A.1
Conti, M.2
Heaslip, R.J.3
-
7
-
-
0027164208
-
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae
-
7. Michaeli T, Bloom TJ, Martins T, et al. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J Biol Chem 1993; 268: 12925-32
-
(1993)
J Biol Chem
, vol.268
, pp. 12925-12932
-
-
Michaeli, T.1
Bloom, T.J.2
Martins, T.3
-
8
-
-
0030971045
-
Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart
-
8. Han P, Zhu X, Michaeli T. Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart. J Biol Chem 1997; 272: 16152-7
-
(1997)
J Biol Chem
, vol.272
, pp. 16152-16157
-
-
Han, P.1
Zhu, X.2
Michaeli, T.3
-
9
-
-
0030459832
-
Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants
-
9. Bloom TJ, Beavo JA. Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proc Natl Acad Sci U S A 1996; 93: 14188-92
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14188-14192
-
-
Bloom, T.J.1
Beavo, J.A.2
-
10
-
-
0032546924
-
Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases
-
10. Soderling SH, Bayuga SJ, Beavo JA. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J Biol Chem 1998; 273: 15553-8
-
(1998)
J Biol Chem
, vol.273
, pp. 15553-15558
-
-
Soderling, S.H.1
Bayuga, S.J.2
Beavo, J.A.3
-
11
-
-
0032555138
-
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
-
11. Soderling SH, Bayuga SJ, Beavo JA. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U S A 1998; 95: 8991-6
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 8991-8996
-
-
Soderling, S.H.1
Bayuga, S.J.2
Beavo, J.A.3
-
12
-
-
0033536020
-
Isolation and characterization of a dual substrate phosphodiesterase gene family: PDE10A
-
12. Soderling TR, Bayuga SJ, Beavo JA. Isolation and characterization of a dual substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci U S A 1999; 96: 7071-6
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 7071-7076
-
-
Soderling, T.R.1
Bayuga, S.J.2
Beavo, J.A.3
-
13
-
-
0032577224
-
Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase
-
13. Fisher DA, Smith JF, Pillar JS, et al. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 1998; 246: 570-7
-
(1998)
Biochem Biophys Res Commun
, vol.246
, pp. 570-577
-
-
Fisher, D.A.1
Smith, J.F.2
Pillar, J.S.3
-
14
-
-
0032546779
-
Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase
-
14. Fisher DA, Smith JF, Pillar JS, et al. Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem 1998; 273: 15559-64
-
(1998)
J Biol Chem
, vol.273
, pp. 15559-15564
-
-
Fisher, D.A.1
Smith, J.F.2
Pillar, J.S.3
-
15
-
-
0033603598
-
Cloning and characterization of a novel human phosphodiesterase that hydrolyses both cAMP and cGMP (PDE10A)
-
15. Fujishige K, Kotera J, Michibata H, et al. Cloning and characterization of a novel human phosphodiesterase that hydrolyses both cAMP and cGMP (PDE10A). J Biol Chem 1999; 274: 18438-45
-
(1999)
J Biol Chem
, vol.274
, pp. 18438-18445
-
-
Fujishige, K.1
Kotera, J.2
Michibata, H.3
-
16
-
-
0002091255
-
Theophylline and isoenzyme-selective phosphodiesterase inhibitors
-
Kay AB, editor. Oxford: Blackwell Scientific
-
16. Giembycz MA, Dent G, Souness JE. Theophylline and isoenzyme-selective phosphodiesterase inhibitors. In: Kay AB, editor. Allergy and allergic diseases. Oxford: Blackwell Scientific, 1997: 531-67
-
(1997)
Allergy and Allergic Diseases
, pp. 531-567
-
-
Giembycz, M.A.1
Dent, G.2
Souness, J.E.3
-
17
-
-
0031914520
-
Phosphodiesterase isozymes: Molecular targets for novel antiasthma agents
-
17. Torphy TJ. Phosphodiesterase isozymes: molecular targets for novel antiasthma agents. Am J Respir Crit Care Med 1998; 157: 351-70
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 351-370
-
-
Torphy, T.J.1
-
18
-
-
0025868447
-
Phosphodiesterase inhibitors: New opportunities for the treatment of asthma
-
18. Torphy TJ, Undem BJ. Phosphodiesterase inhibitors: new opportunities for the treatment of asthma. Thorax 1991; 46: 512-23
-
(1991)
Thorax
, vol.46
, pp. 512-523
-
-
Torphy, T.J.1
Undem, B.J.2
-
19
-
-
0001538864
-
Selective phosphodiesterase isoenzyme inhibitors
-
Page CP, Metzger WJ, editors. New York: Raven Press
-
19. Torphy TJ, Murray KJ, Arch JRS. Selective phosphodiesterase isoenzyme inhibitors. In: Page CP, Metzger WJ, editors. Drugs and the lung. New York: Raven Press, 1994: 397-477
-
(1994)
Drugs And the Lung
, pp. 397-477
-
-
Torphy, T.J.1
Murray, K.J.2
Arch, J.R.S.3
-
20
-
-
0026734249
-
Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilator therapy redundant in the treatment of bronchial asthma?
-
20. Giembycz MA. Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilator therapy redundant in the treatment of bronchial asthma? Biochem Pharmacol 1992; 43: 2041-51
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 2041-2051
-
-
Giembycz, M.A.1
-
21
-
-
0026607554
-
Prospects for selective cyclic nucleotide phosphodiesterase inhibitors in the treatment of bronchial asthma
-
21. Giembycz MA, Dent G. Prospects for selective cyclic nucleotide phosphodiesterase inhibitors in the treatment of bronchial asthma. Clin Exp Allergy 1992; 22: 337-44
-
(1992)
Clin Exp Allergy
, vol.22
, pp. 337-344
-
-
Giembycz, M.A.1
Dent, G.2
-
22
-
-
0027267644
-
Isoenzyme-selective cyclic nucleotide phosphodiesterase inhibitors: Biochemistry, pharmacology and therapeutic potential in asthma
-
22. Raeburn D, Souness JE, Tomkinson A, et al. Isoenzyme-selective cyclic nucleotide phosphodiesterase inhibitors: biochemistry, pharmacology and therapeutic potential in asthma. Prog Drug Res 1993; 40: 9-31
-
(1993)
Prog Drug Res
, vol.40
, pp. 9-31
-
-
Raeburn, D.1
Souness, J.E.2
Tomkinson, A.3
-
23
-
-
0029934763
-
Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma?
-
23. Dent G, Giembycz MA. Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma? Thorax 1996; 51: 647-9
-
(1996)
Thorax
, vol.51
, pp. 647-649
-
-
Dent, G.1
Giembycz, M.A.2
-
24
-
-
0028314313
-
Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes: Their potential utility in the therapy of asthma
-
24. Nicholson CD, Shahid M. Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes: their potential utility in the therapy of asthma. Pulmon Pharmacol 1994; 7: 1-17
-
(1994)
Pulmon Pharmacol
, vol.7
, pp. 1-17
-
-
Nicholson, C.D.1
Shahid, M.2
-
25
-
-
0028559807
-
Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma
-
25. Torphy TJ, Barnette MS, Hay DW, et al. Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma. Environ Health Perspect 1994; 102 Suppl. 10: 79-84
-
(1994)
Environ Health Perspect
, vol.102
, Issue.SUPPL. 10
, pp. 79-84
-
-
Torphy, T.J.1
Barnette, M.S.2
Hay, D.W.3
-
26
-
-
0003338738
-
Interaction of PDE4 inhibitors with enzymes and cell functions
-
Schudt C, Dent G, Rabe K, editors. London: Academic Press
-
26. Dent G, Giembycz MA. Interaction of PDE4 inhibitors with enzymes and cell functions. In: Schudt C, Dent G, Rabe K, editors. Handbook of immunopharmacology: phosphodiesterase inhibitors. London: Academic Press, 1996: 111-26
-
(1996)
Handbook of Immunopharmacology: Phosphodiesterase Inhibitors
, pp. 111-126
-
-
Dent, G.1
Giembycz, M.A.2
-
27
-
-
0002231659
-
Phosphodiesterase IV inhibitors as potential therapeutic agents in allergic disease
-
Townley RG, Agarwal DK, editors. New York: Marcel-Dekker
-
27. Giembycz MA, Souness JE. Phosphodiesterase IV inhibitors as potential therapeutic agents in allergic disease. In: Townley RG, Agarwal DK, editors. Immunopharmacology of allergic disease. New York: Marcel-Dekker, 1996: 523-59
-
(1996)
Immunopharmacology of Allergic Disease
, pp. 523-559
-
-
Giembycz, M.A.1
Souness, J.E.2
-
28
-
-
0026581814
-
Pharmacology, mechanisms of action and uses of selective phosphodiesterase inhibitors
-
28. Skoyles JR, Sherry KM. Pharmacology, mechanisms of action and uses of selective phosphodiesterase inhibitors. Br J Anaesth 1992; 68: 293-302
-
(1992)
Br J Anaesth
, vol.68
, pp. 293-302
-
-
Skoyles, J.R.1
Sherry, K.M.2
-
29
-
-
0023197290
-
Reduction in pulmonary hypertension and in airway resistance by enoximone (MDL 17,043) in decompensated COPD
-
29. Leeman M, Lejeune P, Melot C, et al. Reduction in pulmonary hypertension and in airway resistance by enoximone (MDL 17,043) in decompensated COPD. Chest 1987; 91: 662-6
-
(1987)
Chest
, vol.91
, pp. 662-666
-
-
Leeman, M.1
Lejeune, P.2
Melot, C.3
-
30
-
-
0028888442
-
Bronchodilator and bronchoprotective effects of cilostazol in humans in vivo
-
30. Fujimura M, Kamio Y, Saito M, et al. Bronchodilator and bronchoprotective effects of cilostazol in humans in vivo. Am J Respir Crit Care Med 1995; 151: 222-5
-
(1995)
Am J Respir Crit Care Med
, vol.151
, pp. 222-225
-
-
Fujimura, M.1
Kamio, Y.2
Saito, M.3
-
31
-
-
0031885147
-
Effect of selective phosphodiesterase 3 inhibition on the early and late asthmatic responses to inhaled allergen
-
31. Bardin PG, Dorward MA, Lampe FC, et al. Effect of selective phosphodiesterase 3 inhibition on the early and late asthmatic responses to inhaled allergen. Br J Clin Pharmacol 1998; 45: 387-91
-
(1998)
Br J Clin Pharmacol
, vol.45
, pp. 387-391
-
-
Bardin, P.G.1
Dorward, M.A.2
Lampe, F.C.3
-
32
-
-
0001825786
-
Structure and function of the rolipram-sensitive, low Km cyclic AMP phosphodiesterase: A family of highly related proteins
-
Houslay MD, Beavo J, editors. New York: Wiley
-
32. Conti M, Swinnen JV. Structure and function of the rolipram-sensitive, low Km cyclic AMP phosphodiesterase: a family of highly related proteins. In: Houslay MD, Beavo J, editors. Molecular pharmacology of cell regulation: cyclic nucleotide phosphodiesterase structure and drug action. New York: Wiley, 1990: 243-66
-
(1990)
Molecular Pharmacology of Cell Regulation: Cyclic Nucleotide Phosphodiesterase Structure and Drug Action
, pp. 243-266
-
-
Conti, M.1
Swinnen, J.V.2
-
33
-
-
0027454556
-
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
-
33. Bolger G, Michaeli T, Martins T, et al. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol Cell Biol 1993; 13: 6558-71
-
(1993)
Mol Cell Biol
, vol.13
, pp. 6558-6571
-
-
Bolger, G.1
Michaeli, T.2
Martins, T.3
-
34
-
-
0024670853
-
Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase
-
34. Colicelli J, Birchmeier C, Michaeli T, et al. Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proc Natl Acad Sci U S A 1989; 86: 3599-603
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 3599-3603
-
-
Colicelli, J.1
Birchmeier, C.2
Michaeli, T.3
-
36
-
-
0344531201
-
The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP
-
36. Swinnen JV, Joseph DR, Conti M. The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP. Proc Natl Acad Sci U S A 1989; 86: 8197-201
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 8197-8201
-
-
Swinnen, J.V.1
Joseph, D.R.2
Conti, M.3
-
37
-
-
0024405251
-
Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: Evidence for a family of genes
-
37. Swinnen JV, Joseph DR, Conti M. Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. Proc Natl Acad Sci U S A 1989; 86: 5325-9
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 5325-5329
-
-
Swinnen, J.V.1
Joseph, D.R.2
Conti, M.3
-
39
-
-
0025370222
-
Cloning and expression of cDNA for a human low-km, rolipram-sensitive cyclic AMP phosphodiesterase
-
39. Livi GP, Kmetz P, McHale MM, et al. Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase. Mol Cell Biol 1990; 10: 2678-86
-
(1990)
Mol Cell Biol
, vol.10
, pp. 2678-2686
-
-
Livi, G.P.1
Kmetz, P.2
McHale, M.M.3
-
40
-
-
0027339578
-
A low-km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA
-
40. McLaughlin MM, Cieslinski LB, Burman M, et al. A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA. J Biol Chem 1993; 268: 6470-6
-
(1993)
J Biol Chem
, vol.268
, pp. 6470-6476
-
-
McLaughlin, M.M.1
Cieslinski, L.B.2
Burman, M.3
-
41
-
-
0027244894
-
The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDEIV) reveals a multigene family
-
41. Obernolte R, Bhakta S, Alvarez R, et al. The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDEIV) reveals a multigene family. Gene 1993; 129: 239-47
-
(1993)
Gene
, vol.129
, pp. 239-247
-
-
Obernolte, R.1
Bhakta, S.2
Alvarez, R.3
-
42
-
-
0028004238
-
Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)
-
42. Sullivan M, Egerton M, Shakur Y, et al. Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1). Cell Signal 1994; 6: 793-812
-
(1994)
Cell Signal
, vol.6
, pp. 793-812
-
-
Sullivan, M.1
Egerton, M.2
Shakur, Y.3
-
43
-
-
0030775103
-
Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis
-
43. Obernolte R, Ratzliff J, Baecker PA, et al. Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis. Biochim Biophys Acta 1997; 1353; 287-97
-
(1997)
Biochim Biophys Acta
, vol.1353
, pp. 287-297
-
-
Obernolte, R.1
Ratzliff, J.2
Baecker, P.A.3
-
44
-
-
0028267522
-
Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)
-
44. Baecker PA, Obernolte R, Bach C, et al. Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD). Gene 1994; 138: 253-6
-
(1994)
Gene
, vol.138
, pp. 253-256
-
-
Baecker, P.A.1
Obernolte, R.2
Bach, C.3
-
45
-
-
0028919271
-
Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)
-
45. Engels P, Sullivan M, Muller T, et al. Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C). FEBS Lett 1995; 358: 305-10
-
(1995)
FEBS Lett
, vol.358
, pp. 305-310
-
-
Engels, P.1
Sullivan, M.2
Muller, T.3
-
46
-
-
0028239635
-
Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse
-
46. Milatovich A, Bolger G, Michaeli T, et al. Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet 1994; 20: 75-86
-
(1994)
Somat Cell Mol Genet
, vol.20
, pp. 75-86
-
-
Milatovich, A.1
Bolger, G.2
Michaeli, T.3
-
47
-
-
0028872186
-
Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4
-
47. Szpirer C, Szpirer J, Riviere M, et al. Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4. Cytogenet Cell Genet 1995; 69: 11-4
-
(1995)
Cytogenet Cell Genet
, vol.69
, pp. 11-14
-
-
Szpirer, C.1
Szpirer, J.2
Riviere, M.3
-
48
-
-
0029009878
-
Recent progress in understanding the hormonal regulation of phosphodiesterases
-
48. Conti M, Nemoz G, Sette C, et al. Recent progress in understanding the hormonal regulation of phosphodiesterases. Endoer Rev 1995; 16: 370-89
-
(1995)
Endoer Rev
, vol.16
, pp. 370-389
-
-
Conti, M.1
Nemoz, G.2
Sette, C.3
-
49
-
-
0031601339
-
The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: Intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions
-
49. Houslay MD, Sullivan M, Bolger GB. The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions. Adv Pharmacol 1998; 44: 225-342
-
(1998)
Adv Pharmacol
, vol.44
, pp. 225-342
-
-
Houslay, M.D.1
Sullivan, M.2
Bolger, G.B.3
-
51
-
-
0028140251
-
Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases: Multiple mRNA variants originate from alternative splicing and multiple start sites
-
51. Monaco L, Vicini E, Conti M. Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases: multiple mRNA variants originate from alternative splicing and multiple start sites. J Biol Chem 1994; 269: 347-57
-
(1994)
J Biol Chem
, vol.269
, pp. 347-357
-
-
Monaco, L.1
Vicini, E.2
Conti, M.3
-
52
-
-
0030974622
-
Tailoring cAMP-signalling responses through isoform multiplicity
-
52. Houslay MD, Milligan G. Tailoring cAMP-signalling responses through isoform multiplicity. Trends Biochem Sci 1997; 22: 217-24
-
(1997)
Trends Biochem Sci
, vol.22
, pp. 217-224
-
-
Houslay, M.D.1
Milligan, G.2
-
53
-
-
0027295333
-
Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram
-
53. Shakur Y, Pryde JG, Houslay MD. Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram. Biochem J 1993; 292: 677-86
-
(1993)
Biochem J
, vol.292
, pp. 677-686
-
-
Shakur, Y.1
Pryde, J.G.2
Houslay, M.D.3
-
54
-
-
8944228921
-
1H NMR and identification of the membrane association domain using chimeric constructs
-
1H NMR and identification of the membrane association domain using chimeric constructs. J Biol Chem 1996; 271: 16703-11
-
(1996)
J Biol Chem
, vol.271
, pp. 16703-16711
-
-
Smith, K.J.1
Scotland, G.2
Beattie, J.3
-
55
-
-
0029008078
-
Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase
-
55. Scotland G, Houslay MD. Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase. Biochem J 1995; 308: 673-81
-
(1995)
Biochem J
, vol.308
, pp. 673-681
-
-
Scotland, G.1
Houslay, M.D.2
-
56
-
-
0029151222
-
Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family
-
56. McPhee I, Pooley L, Lobban M, et al. Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family. Biochem J 1995; 310: 965-74
-
(1995)
Biochem J
, vol.310
, pp. 965-974
-
-
McPhee, I.1
Pooley, L.2
Lobban, M.3
-
57
-
-
0029075310
-
Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association
-
57. Houslay MD, Scotland G, Pooley L, et al. Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association. Biochem Soc Trans 1995; 23: 393-8
-
(1995)
Biochem Soc Trans
, vol.23
, pp. 393-398
-
-
Houslay, M.D.1
Scotland, G.2
Pooley, L.3
-
58
-
-
0029959276
-
The N-terminally alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity
-
58. Houslay MD. The N-terminally alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity. Biochem Soc Trans 1996; 24: 980-6
-
(1996)
Biochem Soc Trans
, vol.24
, pp. 980-986
-
-
Houslay, M.D.1
-
59
-
-
0030947677
-
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase
-
59. Houslay MD, Scotland G, Erdogan S, et al. Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase. Biochem Soc Trans 1997; 25: 374-81
-
(1997)
Biochem Soc Trans
, vol.25
, pp. 374-381
-
-
Houslay, M.D.1
Scotland, G.2
Erdogan, S.3
-
60
-
-
0033591233
-
The RACK1 signalling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform
-
60. Yarwood SJ, Steele MR, Scotland G, et al. The RACK1 signalling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform EMBO J 1999; 274: 14909-17
-
(1999)
EMBO J
, vol.274
, pp. 14909-14917
-
-
Yarwood, S.J.1
Steele, M.R.2
Scotland, G.3
-
62
-
-
0028574848
-
Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: A diverse family of regulatory enzymes
-
62. Bolger GB. Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes. Cell Signal 1994; 6: 851-9
-
(1994)
Cell Signal
, vol.6
, pp. 851-859
-
-
Bolger, G.B.1
-
63
-
-
0027514096
-
Theophylline: An immunomodulatory role in asthma
-
63. Ward AJM, McKenniff M, Evans JM, et al. Theophylline: an immunomodulatory role in asthma. Am Rev Respir Dis 1993; 147: 518-23
-
(1993)
Am Rev Respir Dis
, vol.147
, pp. 518-523
-
-
Ward, A.J.M.1
McKenniff, M.2
Evans, J.M.3
-
64
-
-
0028344025
-
The effect of low dose theophylline on the bronchial wall infiltrate after antigen challenge
-
64. Sullivan PJ, Bekir S, Jaffar Z, et al. The effect of low dose theophylline on the bronchial wall infiltrate after antigen challenge. Lancet 1994; 343: 1006-8
-
(1994)
Lancet
, vol.343
, pp. 1006-1008
-
-
Sullivan, P.J.1
Bekir, S.2
Jaffar, Z.3
-
65
-
-
0029075748
-
The effect of theophylline on mucosal inflammation in asthmatic airways: Biopsy results
-
65. Djukanovic R, Finnerty JP, Lee C, et al. The effect of theophylline on mucosal inflammation in asthmatic airways: biopsy results. Eur Resp J 1995; 8: 831-3
-
(1995)
Eur Resp J
, vol.8
, pp. 831-833
-
-
Djukanovic, R.1
Finnerty, J.P.2
Lee, C.3
-
66
-
-
0026599811
-
LY 186655, a phosphodiesterase inhibitor, inhibits histamine release from human basophils, lung and skin fragments
-
66. Louis R, Bury T, Corhay JL, et al. LY 186655, a phosphodiesterase inhibitor, inhibits histamine release from human basophils, lung and skin fragments. Int J Immunopharmacol 1992; 14: 191-4
-
(1992)
Int J Immunopharmacol
, vol.14
, pp. 191-194
-
-
Louis, R.1
Bury, T.2
Corhay, J.L.3
-
67
-
-
0026572120
-
Preliminary identification and role of phosphodiesterase isozymes in human basophils
-
67. Peachell PT, Undem BJ, Schleimer RP, et al. Preliminary identification and role of phosphodiesterase isozymes in human basophils. J Immunol 1992; 148: 2503-10
-
(1992)
J Immunol
, vol.148
, pp. 2503-2510
-
-
Peachell, P.T.1
Undem, B.J.2
Schleimer, R.P.3
-
68
-
-
0030946351
-
Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function
-
68. Weston MC, Anderson N, Peachell PT. Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function. Br J Pharmacol 1997; 121: 287-95
-
(1997)
Br J Pharmacol
, vol.121
, pp. 287-295
-
-
Weston, M.C.1
Anderson, N.2
Peachell, P.T.3
-
69
-
-
0021795462
-
Phosphodiesterase inhibition by Ro 20-1724 reduces hyper-IgE synthesis by atopic dermatitis in vitro
-
69. Cooper KD, Kang K, Chan SC. Phosphodiesterase inhibition by Ro 20-1724 reduces hyper-IgE synthesis by atopic dermatitis in vitro. J Invest Dermatol 1985; 84: 477-82
-
(1985)
J Invest Dermatol
, vol.84
, pp. 477-482
-
-
Cooper, K.D.1
Kang, K.2
Chan, S.C.3
-
70
-
-
0025805846
-
Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors
-
70. Dent G, Giembycz MA, Rabe KF, et al. Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors. Br J Pharmacol 1991; 103: 1339-46
-
(1991)
Br J Pharmacol
, vol.103
, pp. 1339-1346
-
-
Dent, G.1
Giembycz, M.A.2
Rabe, K.F.3
-
71
-
-
0028029674
-
Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: Interaction with the beta adrenoceptor agonist albuterol
-
71. Dent G, Giembycz MA, Evans PM, et al. Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol. J Pharmacol Exp Ther 1994; 271: 1167-74
-
(1994)
J Pharmacol Exp Ther
, vol.271
, pp. 1167-1174
-
-
Dent, G.1
Giembycz, M.A.2
Evans, P.M.3
-
72
-
-
0025737579
-
Characterization of guinea-pig eosinophil phosphodiesterase activity. Assessment of its involvement in regulating superoxide generation
-
72. Souness JE, Carter CM, Diocee BK, et al. Characterization of guinea-pig eosinophil phosphodiesterase activity. Assessment of its involvement in regulating superoxide generation. Biochem Pharmacol 1991; 42: 937-45
-
(1991)
Biochem Pharmacol
, vol.42
, pp. 937-945
-
-
Souness, J.E.1
Carter, C.M.2
Diocee, B.K.3
-
73
-
-
0028329309
-
Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone
-
73. Souness JE, Villamil ME, Scott LC, et al. Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. Br J Pharmacol 1994; 111: 1081-8
-
(1994)
Br J Pharmacol
, vol.111
, pp. 1081-1088
-
-
Souness, J.E.1
Villamil, M.E.2
Scott, L.C.3
-
74
-
-
0029036931
-
Suppression of eosino-phil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: Comparison with rolipram
-
74. Souness JE, Maslen C, Webber S, et al. Suppression of eosino-phil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolipram. Br J Pharmacol 1995; 115: 39-46
-
(1995)
Br J Pharmacol
, vol.115
, pp. 39-46
-
-
Souness, J.E.1
Maslen, C.2
Webber, S.3
-
75
-
-
0028944033
-
Differential effects of nonselective and selective phosphodiesterase inhibitors on human eosinophil functions
-
75. Hatzelmann A, Tenor H, Schudt C. Differential effects of nonselective and selective phosphodiesterase inhibitors on human eosinophil functions. Br J Pharmacol 1995; 114: 821-31
-
(1995)
Br J Pharmacol
, vol.114
, pp. 821-831
-
-
Hatzelmann, A.1
Tenor, H.2
Schudt, C.3
-
76
-
-
0030922428
-
Inhibition of PAF-induced expression of CDIIb and shedding of L-selectin on human neutrophils and eosinophils by the type IV selective PDE inhibitor, rolipram
-
76. Berends C, Dijkhuizen B, Demonchy JGR, et al. Inhibition of PAF-induced expression of CDIIb and shedding of L-selectin on human neutrophils and eosinophils by the type IV selective PDE inhibitor, rolipram. Eur Respir J 1997; 10: 1000-7
-
(1997)
Eur Respir J
, vol.10
, pp. 1000-1007
-
-
Berends, C.1
Dijkhuizen, B.2
Demonchy, J.G.R.3
-
77
-
-
0029045679
-
Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils
-
77. Kaneko T, Alvarez R, Ueki IF, et al. Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell Signal 1995; 7: 527-34
-
(1995)
Cell Signal
, vol.7
, pp. 527-534
-
-
Kaneko, T.1
Alvarez, R.2
Ueki, I.F.3
-
78
-
-
0029900395
-
4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects
-
4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. Br J Pharmacol 1996; 118: 1727-35
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1727-1735
-
-
Tenor, H.1
Hatzelmann, A.2
Church, M.K.3
-
79
-
-
0029165312
-
PDE isoenzymes as targets for anti-asthma drugs
-
79. Schudt C, Tenor H, Hatzelmann A. PDE isoenzymes as targets for anti-asthma drugs. Eur Respir J 1995; 8: 1179-83
-
(1995)
Eur Respir J
, vol.8
, pp. 1179-1183
-
-
Schudt, C.1
Tenor, H.2
Hatzelmann, A.3
-
80
-
-
0028822281
-
Suppression of lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: Interaction with stimulants of adenylyl cyclase
-
80. Seldon PM, Barnes PJ, Meja K, et al. Suppression of lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase. Mol Pharmacol 1995; 48: 747-57
-
(1995)
Mol Pharmacol
, vol.48
, pp. 747-757
-
-
Seldon, P.M.1
Barnes, P.J.2
Meja, K.3
-
81
-
-
0027315234
-
The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells
-
81. Semmler J, Wachtel H, Endres S. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells. Int J Immunopharmacol 1993; 15: 409-13
-
(1993)
Int J Immunopharmacol
, vol.15
, pp. 409-413
-
-
Semmler, J.1
Wachtel, H.2
Endres, S.3
-
82
-
-
0027292201
-
Modulation of TNFα and IL-1β from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors
-
82. Molnar Kimber K, Yonno L, Heaslip R, et al. Modulation of TNFα and IL-1β from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors. Agents Actions 1993; 39: C77-9
-
(1993)
Agents Actions
, vol.39
-
-
Molnar Kimber, K.1
Yonno, L.2
Heaslip, R.3
-
83
-
-
0028134973
-
Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor
-
83. Prabhakar U, Lipshutz D, Bartus JO, et al. Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor. Int J Immunopharmacol 1994; 16: 805-16
-
(1994)
Int J Immunopharmacol
, vol.16
, pp. 805-816
-
-
Prabhakar, U.1
Lipshutz, D.2
Bartus, J.O.3
-
84
-
-
0027325031
-
Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory responses
-
84. Griswold DE, Webb EF, Breton J, et al. Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory responses. Inflammation 1993; 17: 333-44
-
(1993)
Inflammation
, vol.17
, pp. 333-344
-
-
Griswold, D.E.1
Webb, E.F.2
Breton, J.3
-
85
-
-
0028800523
-
Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators
-
85. Derian CK, Santulli RJ, Rao PE, et al. Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators. J Immunol 1995; 154: 308-17
-
(1995)
J Immunol
, vol.154
, pp. 308-317
-
-
Derian, C.K.1
Santulli, R.J.2
Rao, P.E.3
-
86
-
-
0025181942
-
Differential inhibition of human neutrophil functions: Role of cyclic AMP-specific and cyclic GMP-insensitive phosphodiesterase
-
86. Wright CD, Kuipers PJ, Lobylarz-Singer D, et al. Differential inhibition of human neutrophil functions: role of cyclic AMP-specific and cyclic GMP-insensitive phosphodiesterase. Biochem Pharmacol 1990; 40: 699-707
-
(1990)
Biochem Pharmacol
, vol.40
, pp. 699-707
-
-
Wright, C.D.1
Kuipers, P.J.2
Lobylarz-Singer, D.3
-
88
-
-
0029131749
-
Cyclic AMP-elevating agents down-regulate the oxidative burst induced by granulocyte/macrophage colony-stimulating factor (GM-CSF) in adherent neutrophils
-
88. Ottonello L, Morone MP, Dapino P, et al. Cyclic AMP-elevating agents down-regulate the oxidative burst induced by granulocyte/macrophage colony-stimulating factor (GM-CSF) in adherent neutrophils. Clin Exp Immunol 1995; 101: 502-6
-
(1995)
Clin Exp Immunol
, vol.101
, pp. 502-506
-
-
Ottonello, L.1
Morone, M.P.2
Dapino, P.3
-
89
-
-
0028843677
-
Tumour necrosis factor α-induced oxidative burst in neutrophils adherent to fibronectin: Effects of cyclic amp-elevating agents
-
89. Ottonello L, Marone G, Dapino G, et al. Tumour necrosis factor α-induced oxidative burst in neutrophils adherent to fibronectin: effects of cyclic AMP-elevating agents. Br J Haematol 1995; 91: 566-70
-
(1995)
Br J Haematol
, vol.91
, pp. 566-570
-
-
Ottonello, L.1
Marone, G.2
Dapino, G.3
-
90
-
-
0022553144
-
Inhibition of human neutrophil degranulation by forskolin in the presence of phosphodiesterase inhibitors
-
90. Nourshargh S, Hoult JRS. Inhibition of human neutrophil degranulation by forskolin in the presence of phosphodiesterase inhibitors. Eur J Pharmacol 1986; 122: 205-12
-
(1986)
Eur J Pharmacol
, vol.122
, pp. 205-212
-
-
Nourshargh, S.1
Hoult, J.R.S.2
-
92
-
-
0031911575
-
SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: In vitro anti-inflammatory actions
-
92. Barnette MS, Christensen SB, Essayan DM, et al. SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions. J Pharmacol Exp Ther 1998; 284: 420-6
-
(1998)
J Pharmacol Exp Ther
, vol.284
, pp. 420-426
-
-
Barnette, M.S.1
Christensen, S.B.2
Essayan, D.M.3
-
93
-
-
0025225659
-
Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst
-
93. Nielson CP, Vestal RE, Sturm RJ et al. Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst. J Allergy Clin Immunol 1990; 86: 801-8
-
(1990)
J Allergy Clin Immunol
, vol.86
, pp. 801-808
-
-
Nielson, C.P.1
Vestal, R.E.2
Sturm, R.J.3
-
94
-
-
0027199723
-
Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil
-
94. Fonteh AN, Winkler JD, Torphy TJ, et al. Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil. J Immunol 1993; 151: 339-50
-
(1993)
J Immunol
, vol.151
, pp. 339-350
-
-
Fonteh, A.N.1
Winkler, J.D.2
Torphy, T.J.3
-
95
-
-
0029833842
-
+ T-lymphocytes: Role in regulating proliferation and the biosynthesis of interleukin-2
-
+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2. Br J Pharmacol 1996; 118: 1945-58
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1945-1958
-
-
Giembycz, M.A.1
Corrigan, C.J.2
Seybold, J.3
-
96
-
-
0028051721
-
Modulation of antigen-and mitogen-induced proliferative responses of peripheral blood mononuclear cells by non-selective and isozyme-selective cyclic nucleotide phosphodiesterase inhibitors
-
96. Essayan DM, Huang S, Undem BJ, et al. Modulation of antigen-and mitogen-induced proliferative responses of peripheral blood mononuclear cells by non-selective and isozyme-selective cyclic nucleotide phosphodiesterase inhibitors. J Immunol 1994; 153: 3408-13
-
(1994)
J Immunol
, vol.153
, pp. 3408-3413
-
-
Essayan, D.M.1
Huang, S.2
Undem, B.J.3
-
97
-
-
0029583309
-
Effects of non-selective and isozyme selective cyclic nucleolide phosphodiesterase inhibitors on antigen-induced cytokine gene expression in peripheral blood mononuclear cells
-
97. Essayan DM, Huang S, Kagey Sobotka A, et al. Effects of non-selective and isozyme selective cyclic nucleolide phosphodiesterase inhibitors on antigen-induced cytokine gene expression in peripheral blood mononuclear cells. Am J Respir Cell Mol Biol 1995; 13: 692-702
-
(1995)
Am J Respir Cell Mol Biol
, vol.13
, pp. 692-702
-
-
Essayan, D.M.1
Huang, S.2
Kagey Sobotka, A.3
-
98
-
-
0029560498
-
Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis
-
98. Banner KH, Roberts NM, Page CP. Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis. Br J Pharmacol 1995; 116: 3169-74
-
(1995)
Br J Pharmacol
, vol.116
, pp. 3169-3174
-
-
Banner, K.H.1
Roberts, N.M.2
Page, C.P.3
-
99
-
-
0029118881
-
Cytokine production by phytohemagglutinin-stimulated human blood cells: Effect of corticosteroids, T-cell immunosuppressants and phosphodiesterase IV inhibitors
-
99. Van Wauwe J, Aerts F, Walter H, et al. Cytokine production by phytohemagglutinin-stimulated human blood cells: effect of corticosteroids, T-cell immunosuppressants and phosphodiesterase IV inhibitors. Inflamm Res 1995; 44: 400-5
-
(1995)
Inflamm Res
, vol.44
, pp. 400-405
-
-
Van Wauwe, J.1
Aerts, F.2
Walter, H.3
-
100
-
-
0026611789
-
2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2α gene expression at multiple levels
-
2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2α gene expression at multiple levels. J Immunol 1992; 148: 2845-52
-
(1992)
J Immunol
, vol.148
, pp. 2845-2852
-
-
Anastassiou, E.D.1
Paliogianni, F.2
Balow, J.P.3
-
101
-
-
0027155666
-
Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate-phosphodiesterase activity and is reversible by phosphodiesterase inhibition
-
101. Chan SC, Li SH, Hanifin JM. Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate-phosphodiesterase activity and is reversible by phosphodiesterase inhibition. J Invest Dermatol 1993; 100: 681-4
-
(1993)
J Invest Dermatol
, vol.100
, pp. 681-684
-
-
Chan, S.C.1
Li, S.H.2
Hanifin, J.M.3
-
102
-
-
0029881921
-
Phosphodiesterase inhibitors suppress proliferation of peripheral blood mononuclear cells and interleukin-4 and -5 secretion by human T-helper type 2 cells
-
102. Crocker IC, Townley RG, Khan MM. Phosphodiesterase inhibitors suppress proliferation of peripheral blood mononuclear cells and interleukin-4 and -5 secretion by human T-helper type 2 cells. Immunopharmacol 1996; 31: 223-35
-
(1996)
Immunopharmacol
, vol.31
, pp. 223-235
-
-
Crocker, I.C.1
Townley, R.G.2
Khan, M.M.3
-
103
-
-
0031753056
-
Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors
-
103. Crocker IC, Ohia SE, Church MK, et al. Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors. J Allergy Clin Immunol 1998; 102: 797-804
-
(1998)
J Allergy Clin Immunol
, vol.102
, pp. 797-804
-
-
Crocker, I.C.1
Ohia, S.E.2
Church, M.K.3
-
104
-
-
0030919713
-
Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergen-specific human T-lymphocyte clones
-
104. Essayan DM, Kagey Sobotka A, Lichtenstein LM, et al. Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergen-specific human T-lymphocyte clones. Biochem Pharmacol 1997; 53: 1055-60
-
(1997)
Biochem Pharmacol
, vol.53
, pp. 1055-1060
-
-
Essayan, D.M.1
Kagey Sobotka, A.2
Lichtenstein, L.M.3
-
105
-
-
0031907015
-
A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cyclic AMP level and interleukin-2 production of Jurkal cells
-
105. Kaminuma O, Mori A, Wada K, et al. A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cyclic AMP level and interleukin-2 production of Jurkal cells. Immunopharmacol 1998; 38: 247-52
-
(1998)
Immunopharmacol
, vol.38
, pp. 247-252
-
-
Kaminuma, O.1
Mori, A.2
Wada, K.3
-
106
-
-
0030425431
-
Interleukin-5 production by peripheral blood mononuclear cells of asthmatic patients is suppressed by T-440: Relation to phosphodiesterase inhibition
-
106. Kaminuma O, Mori A, Suko M, et al. Interleukin-5 production by peripheral blood mononuclear cells of asthmatic patients is suppressed by T-440: relation to phosphodiesterase inhibition. J Pharmacol Exp Ther 1996; 279: 240-6
-
(1996)
J Pharmacol Exp Ther
, vol.279
, pp. 240-246
-
-
Kaminuma, O.1
Mori, A.2
Suko, M.3
-
107
-
-
0031616317
-
Interleukin-10 does not mediate the inhibitory effect of PDE4 inhibitors and other cAMP-elevating drugs on lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes
-
107. Seldon PM, Barnes PJ, Giembycz MA. Interleukin-10 does not mediate the inhibitory effect of PDE4 inhibitors and other cAMP-elevating drugs on lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes. Cell Biochem Biophys 1998; 29: 179-201
-
(1998)
Cell Biochem Biophys
, vol.29
, pp. 179-201
-
-
Seldon, P.M.1
Barnes, P.J.2
Giembycz, M.A.3
-
108
-
-
0031919107
-
Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibitors of phosphodiesterases 3 and 4
-
108. Blease K, Burke-Gaffney A, Hellewell PG. Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibitors of phosphodiesterases 3 and 4. Br J Pharmacol 1998; 124: 229-37
-
(1998)
Br J Pharmacol
, vol.124
, pp. 229-237
-
-
Blease, K.1
Burke-Gaffney, A.2
Hellewell, P.G.3
-
109
-
-
0023605191
-
Cyclic AMP-dependent regulation of lipid mediators in white cells: A unifing concept for explaining the efficacy of theophylline in asthma
-
109. Kuehl FA, Zanetti ME, Soderman DD, et al. Cyclic AMP-dependent regulation of lipid mediators in white cells: a unif-ing concept for explaining the efficacy of theophylline in asthma. Am Rev Respir Dis 1987; 136: 210-3
-
(1987)
Am Rev Respir Dis
, vol.136
, pp. 210-213
-
-
Kuehl, F.A.1
Zanetti, M.E.2
Soderman, D.D.3
-
110
-
-
0027724898
-
Pulmonary anti-allergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea-pigs
-
110. Howell RE, Sickles BD, Woeppel SL. Pulmonary anti-allergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea-pigs. J Pharmacol Exp Ther 1993; 264: 609-15
-
(1993)
J Pharmacol Exp Ther
, vol.264
, pp. 609-615
-
-
Howell, R.E.1
Sickles, B.D.2
Woeppel, S.L.3
-
111
-
-
0027496775
-
Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram
-
111. Underwood DC, Osborn RR, Novak LB, et al. Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram. J Pharmacol Exp Ther 1993; 266: 306-13
-
(1993)
J Pharmacol Exp Ther
, vol.266
, pp. 306-313
-
-
Underwood, D.C.1
Osborn, R.R.2
Novak, L.B.3
-
112
-
-
0028171498
-
Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor
-
112. Raeburn D, Underwood SL, Lewis SA, et al. Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. Br J Pharmacol 1994; 113: 1423-31
-
(1994)
Br J Pharmacol
, vol.113
, pp. 1423-1431
-
-
Raeburn, D.1
Underwood, S.L.2
Lewis, S.A.3
-
113
-
-
8944247744
-
The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP 840, a novel stereo-selective inhibitor of phosphodiesterase type 4
-
113. Hughes B, Howat D, Lisle H, et al. The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP 840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br J Pharmacol 1996; 118: 1183-91
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1183-1191
-
-
Hughes, B.1
Howat, D.2
Lisle, H.3
-
114
-
-
0029868922
-
Effect of theophylline and rolipram on antigen-induced airway responses in neonatally immunised rabbits
-
114. Gozzard N, Herd CM, Blake AM, et al. Effect of theophylline and rolipram on antigen-induced airway responses in neonatally immunised rabbits. Br J Pharmacol 1996; 117: 1405-12
-
(1996)
Br J Pharmacol
, vol.117
, pp. 1405-1412
-
-
Gozzard, N.1
Herd, C.M.2
Blake, A.M.3
-
115
-
-
0028231180
-
Effects of rolipram on responses to acute and chronic antigen exposure in monkeys
-
115. Turner CR, Andreson CJ, Smith WB, et al. Effects of rolipram on responses to acute and chronic antigen exposure in monkeys. Am J Respir Crit Care Med 1994; 149: 1153-9
-
(1994)
Am J Respir Crit Care Med
, vol.149
, pp. 1153-1159
-
-
Turner, C.R.1
Andreson, C.J.2
Smith, W.B.3
-
116
-
-
0030440965
-
The in vivo pharmacology of CP-80,633, a selective inhibitor of phosphodiesterase 4
-
116. Turner CR, Cohan VL, Cheng JB, et al. The in vivo pharmacology of CP-80,633, a selective inhibitor of phosphodiesterase 4. J Pharmacol Exp Ther 1996; 278: 1349-55
-
(1996)
J Pharmacol Exp Ther
, vol.278
, pp. 1349-1355
-
-
Turner, C.R.1
Cohan, V.L.2
Cheng, J.B.3
-
117
-
-
0028936059
-
Studies on anti-allergic activity of AH-21-132, a novel isozyme-selective phosphodiesterase inhibitor in airways
-
117. Nagai H, Takeda H, Iwama T, et al. Studies on anti-allergic activity of AH-21-132, a novel isozyme-selective phosphodiesterase inhibitor in airways. Jap J Pharmacol 1995; 67: 149-56
-
(1995)
Jap J Pharmacol
, vol.67
, pp. 149-156
-
-
Nagai, H.1
Takeda, H.2
Iwama, T.3
-
118
-
-
0031036056
-
Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration
-
118. Danahay H, Broadley KJ. Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration. Br J Pharmacol 1997; 120: 289-97
-
(1997)
Br J Pharmacol
, vol.120
, pp. 289-297
-
-
Danahay, H.1
Broadley, K.J.2
-
119
-
-
0031950276
-
PDE4 inhibition and a corticosteroid in chronically antigen exposed conscious guinea-pigs
-
119. Danahay H, Broadley KJ. PDE4 inhibition and a corticosteroid in chronically antigen exposed conscious guinea-pigs. Clin Exp Allergy 1998; 28: 513-22
-
(1998)
Clin Exp Allergy
, vol.28
, pp. 513-522
-
-
Danahay, H.1
Broadley, K.J.2
-
120
-
-
0028915252
-
Inhibition of allergen-induced lung eosinophilia by type IV and combined type III-and IV-selective phosphodiesterase inhibitors in Brown Norway rats
-
120. Elwood W, Sun J, Barnes PJ, et al. Inhibition of allergen-induced lung eosinophilia by type IV and combined type III-and IV-selective phosphodiesterase inhibitors in Brown Norway rats. Inflammation Res 1995; 44: 83-6
-
(1995)
Inflammation Res
, vol.44
, pp. 83-86
-
-
Elwood, W.1
Sun, J.2
Barnes, P.J.3
-
121
-
-
0029620892
-
Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterases types 3 or 4 in Brown Norway rats
-
121. Howell RE, Jenkins LP, Fielding LE, et al. Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterases types 3 or 4 in Brown Norway rats. Pulmon Pharmacol 1995; 8: 83-9
-
(1995)
Pulmon Pharmacol
, vol.8
, pp. 83-89
-
-
Howell, R.E.1
Jenkins, L.P.2
Fielding, L.E.3
-
122
-
-
0001607163
-
The effect of phosphodiesterase inhibitors on pulmonary inflammatory cell influx in ovalbumin-sensitized guinea-pigs
-
122. Sturm RJ, Osborne MC, Heaslip RJ. The effect of phosphodiesterase inhibitors on pulmonary inflammatory cell influx in ovalbumin-sensitized guinea-pigs. J Cell Biochem 1990; 14: 337
-
(1990)
J Cell Biochem
, vol.14
, pp. 337
-
-
Sturm, R.J.1
Osborne, M.C.2
Heaslip, R.J.3
-
123
-
-
0030892025
-
The influence of endogenous catecholamines on the inhibitory effects of rolipram against early-and late-phase response to antigen in the guinea pig
-
123. Underwood DC, Matthews JK, Osborn RR, et al. The influence of endogenous catecholamines on the inhibitory effects of rolipram against early-and late-phase response to antigen in the guinea pig. J Pharmacol Exp Ther 1997; 280; 210-9
-
(1997)
J Pharmacol Exp Ther
, vol.280
, pp. 210-219
-
-
Underwood, D.C.1
Matthews, J.K.2
Osborn, R.R.3
-
124
-
-
0032246995
-
Anti-asthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig
-
124. Underwood DC, Bochnowicz S, Osborn RR, et al. Anti-asthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig. J Pharmacol Exp Ther 1998; 287: 988-95
-
(1998)
J Pharmacol Exp Ther
, vol.287
, pp. 988-995
-
-
Underwood, D.C.1
Bochnowicz, S.2
Osborn, R.R.3
-
125
-
-
0028258454
-
Effects of isozyme-selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea-pig lung
-
125. Lagente V, Moodley I, Perrin S, et al. Effects of isozyme-selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea-pig lung. Eur J Pharmacol 1994; 255: 253-6
-
(1994)
Eur J Pharmacol
, vol.255
, pp. 253-256
-
-
Lagente, V.1
Moodley, I.2
Perrin, S.3
-
126
-
-
0029011921
-
Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors
-
126. Lagente V, Pruniaux MP, Junien JL, et al. Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors. Am J Respir Crit Care Med 1995; 151: 1720-4
-
(1995)
Am J Respir Crit Care Med
, vol.151
, pp. 1720-1724
-
-
Lagente, V.1
Pruniaux, M.P.2
Junien, J.L.3
-
127
-
-
0028900693
-
Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs
-
127. Santing RE, Olymulder CG, Van der Molen K, et al. Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs. Eur J Pharmacol 1995; 275: 75-82
-
(1995)
Eur J Pharmacol
, vol.275
, pp. 75-82
-
-
Santing, R.E.1
Olymulder, C.G.2
Van Der Molen, K.3
-
128
-
-
0029068534
-
Pulmonary antiallergic and antiinflammatory effects of a novel, orally-active phosphodiesterase IV inhibitor (WAY-127093B) in guinea pigs and rats
-
128. Howell RE, Woeppel SL, Howell DE, et al. Pulmonary antiallergic and antiinflammatory effects of a novel, orally-active phosphodiesterase IV inhibitor (WAY-127093B) in guinea pigs and rats. Inflamm Res 1995; 44 Suppl. 2: S172-3
-
(1995)
Inflamm Res
, vol.44
, Issue.SUPPL. 2
-
-
Howell, R.E.1
Woeppel, S.L.2
Howell, D.E.3
-
129
-
-
0030037738
-
Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor
-
129. Holbrook M, Gozzard N, James T, et al. Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor. Br J Pharmacol 1996; 118: 1192-200
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1192-1200
-
-
Holbrook, M.1
Gozzard, N.2
James, T.3
-
130
-
-
0027773081
-
Effect of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea-pig airways in vivo
-
130. Raeburn D, Karlsson J-A. Effect of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea-pig airways in vivo. J Pharmacol Exp Ther 1993; 267: 1147-52
-
(1993)
J Pharmacol Exp Ther
, vol.267
, pp. 1147-1152
-
-
Raeburn, D.1
Karlsson, J.-A.2
-
131
-
-
0027746243
-
Rolipram inhibits airway microvascular leakage induced by platelet-activating factor, histamine and bradykinin in guinea-pig
-
131. Ortiz J, Cortijo J, Valles JM, et al. Rolipram inhibits airway microvascular leakage induced by platelet-activating factor, histamine and bradykinin in guinea-pig. J Pharmacol 1993; 45: 1090-2
-
(1993)
J Pharmacol
, vol.45
, pp. 1090-1092
-
-
Ortiz, J.1
Cortijo, J.2
Valles, J.M.3
-
132
-
-
0030051755
-
Effects of selective phosphodiesterase inhibitors on platelet-activating factor-and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs
-
132. Ortiz JL, Valles JM, Marticabrera M, et al. Effects of selective phosphodiesterase inhibitors on platelet-activating factor-and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs. Naunyn-Schmiedeberg's Arch Pharmacol 1996; 353: 200-6
-
(1996)
Naunyn-schmiedeberg's Arch Pharmacol
, vol.353
, pp. 200-206
-
-
Ortiz, J.L.1
Valles, J.M.2
Marticabrera, M.3
-
133
-
-
0001861137
-
Cyclic nucleotide phosphodiesterases in airways smooth muscle
-
Raeburn D, Giembycz MA, editors. Basel: Birkhauser Verlag AG
-
133. Souness JE, Giembycz MA. Cyclic nucleotide phosphodiesterases in airways smooth muscle. In: Raeburn D, Giembycz MA, editors. Airways smooth muscle: biochemical control of contraction and relaxation. Basel: Birkhauser Verlag AG, 1994: 271-308
-
(1994)
Airways Smooth Muscle: Biochemical Control of Contraction and Relaxation
, pp. 271-308
-
-
Souness, J.E.1
Giembycz, M.A.2
-
134
-
-
0032845131
-
Bronchodilator effect of inhaled olprinone, a phosphodiesterase 3 inhibitor, in asthmatic patients
-
134. Myou S, Fujimura M, Kamio Y, et al. Bronchodilator effect of inhaled olprinone, a phosphodiesterase 3 inhibitor, in asthmatic patients. Am J Resir Crit Care Med 1999; 160:817-20
-
(1999)
Am J Resir Crit Care Med
, vol.160
, pp. 817-820
-
-
Myou, S.1
Fujimura, M.2
Kamio, Y.3
-
135
-
-
0026497719
-
Trials of the bronchodilator activity of the isoenzyme-selective phosphodiesterase inhibitor, AH 21-132 in healthy volunteers during methacholine challenge test
-
135. Foster RW, Rakshi K, Carpenter JR, et al. Trials of the bronchodilator activity of the isoenzyme-selective phosphodiesterase inhibitor, AH 21-132 in healthy volunteers during methacholine challenge test. Br J Clin Pharmacol 1992; 34: 527-34
-
(1992)
Br J Clin Pharmacol
, vol.34
, pp. 527-534
-
-
Foster, R.W.1
Rakshi, K.2
Carpenter, J.R.3
-
136
-
-
0026688301
-
Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma
-
136. Brunnee T, Engelstatter R, Steinijans VW, et al. Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma. Eur Respir J 1992; 5: 982-5
-
(1992)
Eur Respir J
, vol.5
, pp. 982-985
-
-
Brunnee, T.1
Engelstatter, R.2
Steinijans, V.W.3
-
137
-
-
0029067986
-
Effects of the mixed phosphodiesterase III/iV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction
-
137. Ukena D, Rentz K, Reiber C, et al. Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction. Respir Med 1995; 89: 441-4
-
(1995)
Respir Med
, vol.89
, pp. 441-444
-
-
Ukena, D.1
Rentz, K.2
Reiber, C.3
-
138
-
-
0013665026
-
Inhaled tolafentrine, a PDE III/iV inhibitor: Acute effect on histamine-and AMP-induced bronchoconstriction and exhaled NO in mild asthma
-
138. Evans DJ, Aikman SL, Kharitanov SA, et al. Inhaled tolafentrine, a PDE III/IV inhibitor: acute effect on histamine-and AMP-induced bronchoconstriction and exhaled NO in mild asthma [Abstract]. Am J Respir Crit Care Med 1996; 153: A347
-
(1996)
Am J Respir Crit Care Med
, vol.153
-
-
Evans, D.J.1
Aikman, S.L.2
Kharitanov, S.A.3
-
139
-
-
0001773047
-
LY 186655 prevents bronchospasm in asthma of moderate severity
-
139. Israel EP, Mathur PN, Tashkin D, et al. LY 186655 prevents bronchospasm in asthma of moderate severity. Chest 1988; 91: 715-8
-
(1988)
Chest
, vol.91
, pp. 715-718
-
-
Israel, E.P.1
Mathur, P.N.2
Tashkin, D.3
-
140
-
-
0002605707
-
RP 73401 (a phosphodiesterase IV inhibitor) single dose does not prevent allergen-induced bronchoconstriction during the early phase reaction in asthma
-
140. Jonker GJ, Tijhuis GJ, De Monchy JGR. RP 73401 (a phosphodiesterase IV inhibitor) single dose does not prevent allergen-induced bronchoconstriction during the early phase reaction in asthma [abstract]. Eur Respir J 1996; 9: 82S
-
(1996)
Eur Respir J
, vol.9
-
-
Jonker, G.J.1
Tijhuis, G.J.2
De Monchy, J.G.R.3
-
141
-
-
4243472809
-
Six weeks treatment with inhaled RP 73401, a PDE IV inhibitor: Effect on airway hyperresponsiveness and exhaled nitric oxide in mild to moderate asthma
-
141. McGrath JL, Aikman SL, Cook RM, et al. Six weeks treatment with inhaled RP 73401, a PDE IV inhibitor: effect on airway hyperresponsiveness and exhaled nitric oxide in mild to moderate asthma [abstract]. Am J Respir Crit Care Med 1997; 155: A660
-
(1997)
Am J Respir Crit Care Med
, vol.155
-
-
McGrath, J.L.1
Aikman, S.L.2
Cook, R.M.3
-
143
-
-
0030984905
-
The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects
-
143. Harbinson PL, MacLeod D, Hawksworth R, et al. The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects. Eur Respir J 1997; 10: 1008-14
-
(1997)
Eur Respir J
, vol.10
, pp. 1008-1014
-
-
Harbinson, P.L.1
Macleod, D.2
Hawksworth, R.3
-
144
-
-
0031841985
-
PDE4 inhibitors 1998
-
144. Norman P. PDE4 Inhibitors 1998. Exp Opin Ther Pat 1998; 8: 771-84
-
(1998)
Exp Opin Ther Pat
, vol.8
, pp. 771-784
-
-
Norman, P.1
-
145
-
-
0000951113
-
SB 207499 (Ariflo™, a second generation, selective oral phosphodiesterase type 4 (PDE4) inhibitor, attenuates exercise-induced bronchoconstriction in patients with asthma
-
145. Nieman RB, Fisher BD, Amit O, et al. SB 207499 (Ariflo™), a second generation, selective oral phosphodiesterase type 4 (PDE4) inhibitor, attenuates exercise-induced bronchoconstriction in patients with asthma [abstract]. Am J Respir Crit Care Med 1998; 157: A413
-
(1998)
Am J Respir Crit Care Med
, vol.157
-
-
Nieman, R.B.1
Fisher, B.D.2
Amit, O.3
-
146
-
-
0000006097
-
Ariflo™ improves pulmonary function in patients with asthma: Results of a study in patients taking inhaled corticosteroids
-
146. Compton CH, Cedar E, Nieman RB, et al. Ariflo™ improves pulmonary function in patients with asthma: results of a study in patients taking inhaled corticosteroids [abstract]. Am J Respir Crit Care Med 1999; 159: A522
-
(1999)
Am J Respir Crit Care Med
, vol.159
-
-
Compton, C.H.1
Cedar, E.2
Nieman, R.B.3
-
147
-
-
0023935749
-
Pharmacokinetics of rolipram in the rhesus and cynomolgous monkeys, the rat and the rabbit: Studies on species differences
-
147. Krause W, Kuhne G. Pharmacokinetics of rolipram in the rhesus and cynomolgous monkeys, the rat and the rabbit: studies on species differences. Xenobiotica 1988; 18: 561-71
-
(1988)
Xenobiotica
, vol.18
, pp. 561-571
-
-
Krause, W.1
Kuhne, G.2
-
148
-
-
0013665656
-
-
Data on file (WO9723460). Celltech Therapeutics Ltd, 1997
-
148. Data on file (WO9723460). Celltech Therapeutics Ltd, 1997
-
-
-
-
149
-
-
0013665295
-
-
Data on file (WO9723461). Celltech Therapeutics Ltd, 1997
-
149. Data on file (WO9723461). Celltech Therapeutics Ltd, 1997
-
-
-
-
151
-
-
0013691883
-
-
London: Society for Medicines Research, December
-
151. Society for Medicines Research. Trends in Medicinal Chemistry Meeting Report. London: Society for Medicines Research, December 1996
-
(1996)
Trends in Medicinal Chemistry Meeting Report
-
-
-
153
-
-
13344295098
-
3H]rolipram binding activity and their relationship to emetic behavior in the ferret
-
3H]rolipram binding activity and their relationship to emetic behavior in the ferret. J Med Chem 1996; 39: 120-5
-
(1996)
J Med Chem
, vol.39
, pp. 120-125
-
-
Duplantier, A.J.1
Biggers, M.S.2
Chambers, R.J.3
-
154
-
-
4243765716
-
Pharmacodynamic-pharmacokinetic (PD/PK profile of the phosphodiesterase (PDE) 4 inhibitor, VII294A, in human volunteers
-
154. Gale DD, Landells LJ, Spina D, et al. Pharmacodynamic-pharmacokinetic (PD/PK) profile of the phosphodiesterase (PDE) 4 inhibitor, VII294A, in human volunteers [Abstract]. Am J Respir Crit Care Med 1999; 159: A 108
-
(1999)
Am J Respir Crit Care Med
, vol.159
-
-
Gale, D.D.1
Landells, L.J.2
Spina, D.3
-
155
-
-
0001074646
-
Subtypes of the type 4 cAMP phosphodiesterases: Structure, regulation and selective inhibition
-
155. Muller T, Engels P, Fozard JR. Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition. Trends Pharmacol Sci 1996; 17: 294-8
-
(1996)
Trends Pharmacol Sci
, vol.17
, pp. 294-298
-
-
Muller, T.1
Engels, P.2
Fozard, J.R.3
-
156
-
-
0029960693
-
Role of multiple cAMP-specific phosphodiesterase variants
-
156. Bushnik T, Conti M. Role of multiple cAMP-specific phosphodiesterase variants. Biochem Soc Trans 1996; 24: 1014-9
-
(1996)
Biochem Soc Trans
, vol.24
, pp. 1014-1019
-
-
Bushnik, T.1
Conti, M.2
-
157
-
-
0032747518
-
Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B
-
157. Manning CD, Burman M, Christensen SB, et al. Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B. Br J Pharmacol 1999; 128: 1393-8
-
(1999)
Br J Pharmacol
, vol.128
, pp. 1393-1398
-
-
Manning, C.D.1
Burman, M.2
Christensen, S.B.3
-
158
-
-
0000201956
-
Molecular basis for an improved therapeutic index of SB 207499, a second generation phosphodiesterase 4 inhibitor
-
158. Torphy TJ, Christensen SB, Barnette MS, et al. Molecular basis for an improved therapeutic index of SB 207499, a second generation phosphodiesterase 4 inhibitor [abstract]. Eur Respir J 1997; 10: S313
-
(1997)
Eur Respir J
, vol.10
-
-
Torphy, T.J.1
Christensen, S.B.2
Barnette, M.S.3
-
159
-
-
0013646384
-
Activity of VI1294A, a novel phosphodiesterase 4 (PDE4) inhibitor, in cellular and animal models of asthma
-
159. Cavalla D, Gale DD, Spina D, et al. Activity of VI1294A, a novel phosphodiesterase 4 (PDE4) inhibitor, in cellular and animal models of asthma [abstract]. Am Rev Respir Crit Care Med 1997; 155: A660
-
(1997)
Am Rev Respir Crit Care Med
, vol.155
-
-
Cavalla, D.1
Gale, D.D.2
Spina, D.3
-
160
-
-
0030785390
-
A case history in successful virtual research
-
160. Cavalla D, Gale D. A case history in successful virtual research. Drugs News Perspect 1997; 10: 470-6
-
(1997)
Drugs News Perspect
, vol.10
, pp. 470-476
-
-
Cavalla, D.1
Gale, D.2
-
161
-
-
0033043309
-
Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret
-
161. Robichaud A.Taltersall FD, Choudhury I, et al. Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret. Neuropharmacol 1999; 38: 289-97
-
(1999)
Neuropharmacol
, vol.38
, pp. 289-297
-
-
Robichaud, A.1
Taltersall, F.D.2
Choudhury, I.3
-
162
-
-
0028145823
-
Expression and regulation of human and rat phosphodiesterase type IV isogenes
-
162. Engels P, Fichtel K, Lubbert H. Expression and regulation of human and rat phosphodiesterase type IV isogenes. FEBS Lett 1994; 350: 291-5
-
(1994)
FEBS Lett
, vol.350
, pp. 291-295
-
-
Engels, P.1
Fichtel, K.2
Lubbert, H.3
-
163
-
-
0030876492
-
Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study
-
163. Gantner F, Tenor H, Gekeler V, et al. Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study. J Allergy Clin Immunol 1997; 100: 527-35
-
(1997)
J Allergy Clin Immunol
, vol.100
, pp. 527-535
-
-
Gantner, F.1
Tenor, H.2
Gekeler, V.3
-
164
-
-
0031887507
-
Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation
-
164. Gantner F, Gotz C, Gekeler V, et al. Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation. Br J Pharmacol 1998; 123: 1031-8
-
(1998)
Br J Pharmacol
, vol.123
, pp. 1031-1038
-
-
Gantner, F.1
Gotz, C.2
Gekeler, V.3
-
165
-
-
0028998011
-
Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells
-
165. Verghese MW, McConnell RT, Lenhard JM, et al. Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells. Mol Pharmacol 1995; 47: 1164-71
-
(1995)
Mol Pharmacol
, vol.47
, pp. 1164-1171
-
-
Verghese, M.W.1
McConnell, R.T.2
Lenhard, J.M.3
-
166
-
-
0033072681
-
Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells
-
166. Fuhrmann M, Jahn HU, Seybold J, et al. Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells. Am J Respir Cell Mol Biol 1999; 20: 292-302
-
(1999)
Am J Respir Cell Mol Biol
, vol.20
, pp. 292-302
-
-
Fuhrmann, M.1
Jahn, H.U.2
Seybold, J.3
-
167
-
-
0031723098
-
Phosphodiesterase expression in human epithelial cells
-
167. Wright LC, Seybold J, Robichaud A, et al. Phosphodiesterase expression in human epithelial cells. Am J Physiol 1998; 275: L694-700
-
(1998)
Am J Physiol
, vol.275
-
-
Wright, L.C.1
Seybold, J.2
Robichaud, A.3
-
168
-
-
0032692936
-
Impaired growth and fertility of cyclic AMP-specific phosphodiesterase PDE4D-deficient mice
-
168. Jin S-LC, Richard FJ, Kuo W-P, et al. Impaired growth and fertility of cyclic AMP-specific phosphodiesterase PDE4D-deficient mice. Proc Natl Acad Sci U S A 1999; 96: 11998-12003
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 11998-12003
-
-
Jin, S.-L.1
Richard, F.J.2
Kuo, W.-P.3
-
170
-
-
0029033752
-
Brain distribution of four rat homologues of the Drosophila dunce cAMP phosphodiesterase
-
170. Engels P, Abdel' Al S, Hulley P, et al. Brain distribution of four rat homologues of the Drosophila dunce cAMP phosphodiesterase. J Neurosci Res 1995; 41: 169-78
-
(1995)
J Neurosci Res
, vol.41
, pp. 169-178
-
-
Engels, P.1
Abdel' Al, S.2
Hulley, P.3
-
171
-
-
0030925148
-
Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases
-
171. Souness JE, Rao S. Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases. Cell Signal 1997; 9: 227-36
-
(1997)
Cell Signal
, vol.9
, pp. 227-236
-
-
Souness, J.E.1
Rao, S.2
-
172
-
-
2042433930
-
Phosphodiesterase 4: Biological underpinnings of the design of improved inhibitors
-
172. Barnette MS, Christensen SB, Underwood DC, et al. Phosphodiesterase 4: biological underpinnings of the design of improved inhibitors. Pharmacol Rev Commun 1997; 8: 65-73
-
(1997)
Pharmacol Rev Commun
, vol.8
, pp. 65-73
-
-
Barnette, M.S.1
Christensen, S.B.2
Underwood, D.C.3
-
173
-
-
0031104328
-
PDE4 inhibitors: The use of molecular cloning in the design and development of novel drugs
-
173. Hughes B, Owens R, Perry M, et al. PDE4 inhibitors: the use of molecular cloning in the design and development of novel drugs. Drug Disc Today 1997; 2: 89-101
-
(1997)
Drug Disc Today
, vol.2
, pp. 89-101
-
-
Hughes, B.1
Owens, R.2
Perry, M.3
-
174
-
-
0029075880
-
The ability of phosphodiesterase IV inhibitors to suppress Superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity
-
174. Barnette MS, Manning CD, Cieslinski LB, et al. The ability of phosphodiesterase IV inhibitors to suppress Superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity. J Pharmacol Exp Ther 1995; 273: 674-9
-
(1995)
J Pharmacol Exp Ther
, vol.273
, pp. 674-679
-
-
Barnette, M.S.1
Manning, C.D.2
Cieslinski, L.B.3
-
175
-
-
0030999319
-
Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin-2 release from murine splenocytes by interacting with a "low affinity" phosphodiesterase 4 conformer
-
175. Souness JE, Houghton C, Sardar N, et al. Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin-2 release from murine splenocytes by interacting with a "low affinity" phosphodiesterase 4 conformer. Br J Pharmacol 1997; 121: 743-50
-
(1997)
Br J Pharmacol
, vol.121
, pp. 743-750
-
-
Souness, J.E.1
Houghton, C.2
Sardar, N.3
-
176
-
-
0029982516
-
Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer
-
176. Souness JE, Griffin M, Maslen C, et al. Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer. Br J Pharmacol 1996; 118: 649-58
-
(1996)
Br J Pharmacol
, vol.118
, pp. 649-658
-
-
Souness, J.E.1
Griffin, M.2
Maslen, C.3
-
177
-
-
0029021668
-
Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: Correlation between function and interaction with a high-affinity rolipram binding site
-
177. Barnette MS, Grous M, Cieslinski LB, et al. Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site. J Pharmacol Exp Ther 1995; 273: 1396-402
-
(1995)
J Pharmacol Exp Ther
, vol.273
, pp. 1396-1402
-
-
Barnette, M.S.1
Grous, M.2
Cieslinski, L.B.3
-
178
-
-
0024743190
-
Role of low Km cyclic AMP phosphodiesterase inhibition in tracheal relaxation and bronchodilation in the guinea pig
-
178. Harris AL, Connell MJ, Ferguson EW, et al. Role of low Km cyclic AMP phosphodiesterase inhibition in tracheal relaxation and bronchodilation in the guinea pig. J Pharmacol Exp Ther 1989; 251: 199-206
-
(1989)
J Pharmacol Exp Ther
, vol.251
, pp. 199-206
-
-
Harris, A.L.1
Connell, M.J.2
Ferguson, E.W.3
-
179
-
-
14444268769
-
1,4-Cyclohexanecarboxylates: Potent and selective inhibitors of phosphodiesterase 4 for the treatment of asthma
-
179. Christensen SB, Guider A, Forster CJ, et al. 1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosphodiesterase 4 for the treatment of asthma. J Med Chem 1998; 41: 821-35
-
(1998)
J Med Chem
, vol.41
, pp. 821-835
-
-
Christensen, S.B.1
Guider, A.2
Forster, C.J.3
-
180
-
-
0000910107
-
The safety and tolerability of Ariflo™ (SB 207499), a novel and selective phosphodiesterase 4 inhibitor, in healthy male volunteers
-
180. Murdoch RD, Cowley H, Upward J, et al. The safety and tolerability of Ariflo™ (SB 207499), a novel and selective phosphodiesterase 4 inhibitor, in healthy male volunteers [abstract]. Am J Respir Crit Care Med 1998; 157: A409
-
(1998)
Am J Respir Crit Care Med
, vol.157
-
-
Murdoch, R.D.1
Cowley, H.2
Upward, J.3
-
183
-
-
0032539570
-
Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of y-lactams
-
183. Hulme C, Moriarty K, Huang FC, et al. Quaternary substituted PDE IV inhibitors II: the synthesis and in vitro evaluation of a novel series of y-lactams. Bioorg Med Chem Lett 1998; 8: 399-404
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 399-404
-
-
Hulme, C.1
Moriarty, K.2
Huang, F.C.3
-
184
-
-
0000647712
-
Potential of phosphodiesterase type 4 inhibitors in the treatment of rheumatoid arthritis
-
184. Souness JE, Foster M. Potential of phosphodiesterase type 4 inhibitors in the treatment of rheumatoid arthritis. Curr Res Rheum Arthr 1998; 2: 255-68
-
(1998)
Curr Res Rheum Arthr
, vol.2
, pp. 255-268
-
-
Souness, J.E.1
Foster, M.2
-
185
-
-
0023189396
-
Pentoxifylline: A review of its pharmaco-kinetic properties, and its therapeutic efficacy
-
185. Ward A, Clissold SP. Pentoxifylline: a review of its pharmaco-kinetic properties, and its therapeutic efficacy. Drugs 1987; 34: 50-97
-
(1987)
Drugs
, vol.34
, pp. 50-97
-
-
Ward, A.1
Clissold, S.P.2
-
186
-
-
0013684067
-
-
Data on file (Eur.Pat. 3200032). Kamijo S, Imai J, 1989
-
186. Data on file (Eur.Pat. 3200032). Kamijo S, Imai J, 1989
-
-
-
-
187
-
-
0013665657
-
-
Data on file (Eur.Pat. 319902). Kamijo S, Imai J, Kodaira H, 1989
-
187. Data on file (Eur.Pat. 319902). Kamijo S, Imai J, Kodaira H, 1989
-
-
-
-
188
-
-
0013644856
-
-
Data on file (Eur.Pat. 350913). Masakatsu K, Ohashi M, 1990
-
188. Data on file (Eur.Pat. 350913). Masakatsu K, Ohashi M, 1990
-
-
-
-
189
-
-
0025799591
-
Multiple high affinity cyclic AMP phosphodiesterases in human T-lymphocytes
-
189. Robicsek SA, Blanchard DK, Djeu JY, et al. Multiple high affinity cyclic AMP phosphodiesterases in human T-lymphocytes. Biochem Pharmacol 1991; 42: 869-77
-
(1991)
Biochem Pharmacol
, vol.42
, pp. 869-877
-
-
Robicsek, S.A.1
Blanchard, D.K.2
Djeu, J.Y.3
-
190
-
-
0002667530
-
Analysis of PDE isoenzyme profiles in cells and tissues by pharmacological methods
-
Schudt C, Dent G, Rabe K, editors. London: Academic Press
-
190. Tenor H, Schudt C. Analysis of PDE isoenzyme profiles in cells and tissues by pharmacological methods. In: Schudt C, Dent G, Rabe K, editors. Handbook of immunopharmacology: phosphodiesterase inhibitors. London: Academic Press, 1996: 21-40
-
(1996)
Handbook of Immunopharmacology: Phosphodiesterase Inhibitors.
, pp. 21-40
-
-
Tenor, H.1
Schudt, C.2
-
191
-
-
0024616409
-
Long term therapy of congestive heart failure with phosphodiesterase inhibitors
-
191. Wood MA, Hess ML. Long term therapy of congestive heart failure with phosphodiesterase inhibitors. J Am Med Sci 1989; 297: 105-13
-
(1989)
J Am Med Sci
, vol.297
, pp. 105-113
-
-
Wood, M.A.1
Hess, M.L.2
-
192
-
-
0024537314
-
Electrophysiology of phosphodiesterase inhibitors
-
192. Naccarelli GV, Goldstein RA. Electrophysiology of phosphodiesterase inhibitors. Am J Cardiol 1989; 63: 35A-40A
-
(1989)
Am J Cardiol
, vol.63
-
-
Naccarelli, G.V.1
Goldstein, R.A.2
-
193
-
-
0027219034
-
Two isoforms of cGMP-inhibited cyclic nucleotide phosphodiesterases in human tissues distinguished by their responses to vesnarinone, a new cardiotonic agent
-
193. Masuoka H, Ito M, Sugioka M, et al. Two isoforms of cGMP-inhibited cyclic nucleotide phosphodiesterases in human tissues distinguished by their responses to vesnarinone, a new cardiotonic agent. Biochem Biophys Res Commun 1993; 190: 412-7
-
(1993)
Biochem Biophys Res Commun
, vol.190
, pp. 412-417
-
-
Masuoka, H.1
Ito, M.2
Sugioka, M.3
-
194
-
-
0030053450
-
The toxicity of repeated exposures to rolipram, a type IV phosphodiesterase inhibitor, in rats
-
194. Larson JL, Pino MV, Geiger LE, et al. The toxicity of repeated exposures to rolipram, a type IV phosphodiesterase inhibitor, in rats. Pharmacol Toxiol 1996; 78: 44-9
-
(1996)
Pharmacol Toxiol
, vol.78
, pp. 44-49
-
-
Larson, J.L.1
Pino, M.V.2
Geiger, L.E.3
-
195
-
-
84990453257
-
Milrinone
-
Scriabine A, editor. New York: Raven Press
-
195. Alousi A, Fabian RJ, Baker JF, et al. Milrinone. In: Scriabine A, editor. New drugs annual: cardiovascular drugs. New York: Raven Press, 1985: 245-83
-
(1985)
New Drugs Annual: Cardiovascular Drugs.
, pp. 245-283
-
-
Alousi, A.1
Fabian, R.J.2
Baker, J.F.3
-
196
-
-
77957178161
-
Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153, 110) to the rat
-
196. Westwood FR, Iswaran TJ, Greaves P. Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153, 110) to the rat. Fund Appl Toxicol 1990; 14: 797-809
-
(1990)
Fund Appl Toxicol
, vol.14
, pp. 797-809
-
-
Westwood, F.R.1
Iswaran, T.J.2
Greaves, P.3
-
197
-
-
0032033709
-
Assignment of the mouse PDE7A gene to the proximal region of chromosome 3 and of the human PDE7A gene lo chromosome 8q13
-
197. Han P, Fletcher CF, Copeland NG, et al. Assignment of the mouse PDE7A gene to the proximal region of chromosome 3 and of the human PDE7A gene lo chromosome 8q13. Genomics 1998; 48: 275-6
-
(1998)
Genomics
, vol.48
, pp. 275-276
-
-
Han, P.1
Fletcher, C.F.2
Copeland, N.G.3
-
198
-
-
0013668464
-
Identification of PDE VII in HUT78 T-lymphocyte cells
-
198. Bloom TJ, Beavo JA. Identification of PDE VII in HUT78 T-lymphocyte cells [abstract]. FASEB J 1994; 8: A372
-
(1994)
FASEB J
, vol.8
-
-
Bloom, T.J.1
Beavo, J.A.2
-
199
-
-
0033524977
-
CD3-and CD28-dependent induction of PDE7 required for T cell activation
-
199. Li L, Yee C, Beavo JA. CD3-and CD28-dependent induction of PDE7 required for T cell activation. Science 1999; 283: 848-51
-
(1999)
Science
, vol.283
, pp. 848-851
-
-
Li, L.1
Yee, C.2
Beavo, J.A.3
-
200
-
-
0032578624
-
Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3′,5′-cyclic nucleotide phosphodiesterase
-
200. Hayashi M, Matsushima K, Ohashi H, et al. Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3′,5′-cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun 1998; 250: 751-6
-
(1998)
Biochem Biophys Res Commun
, vol.250
, pp. 751-756
-
-
Hayashi, M.1
Matsushima, K.2
Ohashi, H.3
-
201
-
-
0032436671
-
Theophylline: A review of its potential steroid sparing effects in asthma
-
201. Markham A, Faulds D. Theophylline: a review of its potential steroid sparing effects in asthma. Drugs 1998; 56: 1081-91
-
(1998)
Drugs
, vol.56
, pp. 1081-1091
-
-
Markham, A.1
Faulds, D.2
-
202
-
-
0029990259
-
Theophylline in chronic asthma: Evidence for disease-modifying properties
-
202. Chung KF. Theophylline in chronic asthma: evidence for disease-modifying properties. Clin Exp Allergy 1996; 26 Suppl. 2: 22-7
-
(1996)
Clin Exp Allergy
, vol.26
, Issue.SUPPL. 2
, pp. 22-27
-
-
Chung, K.F.1
-
203
-
-
0022249874
-
Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children
-
203. LaHat N, Nir E, Horenstein L, et al. Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children. Allergy 1985; 40: 453-7
-
(1985)
Allergy
, vol.40
, pp. 453-457
-
-
LaHat, N.1
Nir, E.2
Horenstein, L.3
-
204
-
-
85004870467
-
Induction of suppressor T-cells in asthmatic children by theophylline treatment
-
204. Shohat B, Volovitz B, Varsano I. Induction of suppressor T-cells in asthmatic children by theophylline treatment. Clin Allergy 1983; 13: 487-93
-
(1983)
Clin Allergy
, vol.13
, pp. 487-493
-
-
Shohat, B.1
Volovitz, B.2
Varsano, I.3
-
205
-
-
85004844305
-
Need for theophylline in severe steroid-requiring asthmatics
-
205. Brenner M, Berkowitz R, Marshall N, et al. Need for theophylline in severe steroid-requiring asthmatics. Clin Allergy 1988; 18: 143-50
-
(1988)
Clin Allergy
, vol.18
, pp. 143-150
-
-
Brenner, M.1
Berkowitz, R.2
Marshall, N.3
-
206
-
-
0029050605
-
Immunomodulation by theophylline: Demonstration by withdrawal of therapy
-
206. Kidney JC, Dominguez M, Taylar P, et al. Immunomodulation by theophylline: demonstration by withdrawal of therapy. Am J Respir Crit Care Med 1995; 151: 1907-14
-
(1995)
Am J Respir Crit Care Med
, vol.151
, pp. 1907-1914
-
-
Kidney, J.C.1
Dominguez, M.2
Taylar, P.3
-
207
-
-
0030719429
-
A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma
-
207. Evans DJ, Taylor DA, Zetterstrom O, et al. A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. N Engl J Med 1997; 337: 1412-8
-
(1997)
N Engl J Med
, vol.337
, pp. 1412-1418
-
-
Evans, D.J.1
Taylor, D.A.2
Zetterstrom, O.3
-
208
-
-
0023008870
-
The pulmonary disposition of theophylline and its influence on human macrophage bactericidal function
-
208. O'Neill SJ, Sitar DS, Klass DJ, et al. The pulmonary disposition of theophylline and its influence on human macrophage bactericidal function. Am Rev Respir Dis 1986; 134: 1225-8
-
(1986)
Am Rev Respir Dis
, vol.134
, pp. 1225-1228
-
-
O'Neill, S.J.1
Sitar, D.S.2
Klass, D.J.3
-
209
-
-
0026012430
-
Theophylline therapy inhibits neutrophil and mononuclenr cell chemolaxis from chronic asthmatic children
-
209. Condino-Neto A, Vilela MM, Cambiucci EC, et al. Theophylline therapy inhibits neutrophil and mononuclenr cell chemolaxis from chronic asthmatic children. Br J Clin Pharmacol 1991; 32: 557-61
-
(1991)
Br J Clin Pharmacol
, vol.32
, pp. 557-561
-
-
Condino-Neto, A.1
Vilela, M.M.2
Cambiucci, E.C.3
-
210
-
-
0029923004
-
Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics
-
210. Jaffar Z, Sullivan P, Page C, et al. Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics. Eur Respir J 1996; 9: 456-62
-
(1996)
Eur Respir J
, vol.9
, pp. 456-462
-
-
Jaffar, Z.1
Sullivan, P.2
Page, C.3
-
211
-
-
0029972691
-
The prolonged survival of human eosinophils with interleukin-5 and its inhibition by theophylline via apoptosis
-
211. Ohta K, Sawamoto S, Nakajima M, et al. The prolonged survival of human eosinophils with interleukin-5 and its inhibition by theophylline via apoptosis. Clin Exp Allergy 1996; 26: 10-5
-
(1996)
Clin Exp Allergy
, vol.26
, pp. 10-15
-
-
Ohta, K.1
Sawamoto, S.2
Nakajima, M.3
-
212
-
-
0029739592
-
Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: A placebo-controlled parallel group study
-
212. Finnerty JP, Lee C, Wilson S, et al. Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study. Eur Respir J 1996; 9: 1672-7
-
(1996)
Eur Respir J
, vol.9
, pp. 1672-1677
-
-
Finnerty, J.P.1
Lee, C.2
Wilson, S.3
-
213
-
-
0029833439
-
Anti-inflammatory effects of theophylline: Modulation of cytokine production
-
213. Mascali JJ, Cvietusa P, Negri J, et al. Anti-inflammatory effects of theophylline: modulation of cytokine production. Ann Allergy Asthma Immunol 1996; 77: 34-8
-
(1996)
Ann Allergy Asthma Immunol
, vol.77
, pp. 34-38
-
-
Mascali, J.J.1
Cvietusa, P.2
Negri, J.3
-
214
-
-
0031880713
-
Asthma, adenosine, mast cells and theophylline
-
214. Coward WR, Sagara H, Church MK. Asthma, adenosine, mast cells and theophylline. Clin Exp Allergy 1998; 28 Suppl. 3: 42-6
-
(1998)
Clin Exp Allergy
, vol.28
, Issue.SUPPL. 3
, pp. 42-46
-
-
Coward, W.R.1
Sagara, H.2
Church, M.K.3
-
215
-
-
0031183766
-
The role of nuclear factor-κB in cytokine gene regulation
-
215. Blackwell TS, Christman JW. The role of nuclear factor-κB in cytokine gene regulation. Am J Respir Cell Mol Biol 1997; 17: 3-9
-
(1997)
Am J Respir Cell Mol Biol
, vol.17
, pp. 3-9
-
-
Blackwell, T.S.1
Christman, J.W.2
-
216
-
-
0013669884
-
-
216. LAS 31025. Clin Trials Monitor 1997; 69. 25-6
-
(1997)
Clin Trials Monitor
, vol.69
, pp. 25-26
-
-
-
217
-
-
0000876205
-
Bronchodilator activity of LAS 31025, a new selective phosphodiesterase inhibitor
-
217. Ferrer P, Dihn-Xuan T, Chanal I, et al. Bronchodilator activity of LAS 31025, a new selective phosphodiesterase inhibitor [abstract]. Am J Respir Crit Care Med 1997; 155: A660
-
(1997)
Am J Respir Crit Care Med
, vol.155
-
-
Ferrer, P.1
Dihn-Xuan, T.2
Chanal, I.3
-
218
-
-
0030056483
-
Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis
-
218. Hanifin JM, Chan SC, Cheng JB, et al. Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis. J Invest Dermatol 1996; 107: 51-6
-
(1996)
J Invest Dermatol
, vol.107
, pp. 51-56
-
-
Hanifin, J.M.1
Chan, S.C.2
Cheng, J.B.3
-
219
-
-
0032191115
-
Chronic obstructive pulmonary disease: New opportunities for drug development
-
219. Barnes PJ. Chronic obstructive pulmonary disease: new opportunities for drug development. Trends Pharmacol Sci 1998; 19: 415-23
-
(1998)
Trends Pharmacol Sci
, vol.19
, pp. 415-423
-
-
Barnes, P.J.1
-
220
-
-
0000006097
-
The efficacy of ariflo™ (SB 207499), a second generation, oral PDE4 inhibitor, in patients with COPD
-
220. Compton CH, Gubb J, Cedar E, et al. The efficacy of Ariflo™ (SB 207499), a second generation, oral PDE4 inhibitor, in patients with COPD [abstract]. Am J Respir Crit Care Med 1999; 159: A806
-
(1999)
Am J Respir Crit Care Med
, vol.159
-
-
Compton, C.H.1
Gubb, J.2
Cedar, E.3
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