PDE 4 inhibitors: The use of molecular cloning in the design and development of novel drugs

Drug Discovery Today

Volumn 2, Issue 3, 1997, Pages 89-101

  Hughes, Bernadette ^a   Owens, Ray ^a   Perry, Martin ^a   Warrellow, Graham ^a   Allen, Rodger ^a  

^a UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 4 [2 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 2 PHENYLETHYL]PYRIDINE; AMINOPHYLLINE; ATIZORAM; BRL 61063; CILOMILAST; CT 1731; CYCLIC AMP; DENBUFYLLINE; ISOPRENALINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PICLAMILAST; ROLIPRAM; RS 25344; SALBUTAMOL; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; BRONCHOSPASM; DRUG ACTIVITY; DRUG DESIGN; DRUG INDICATION; ENZYME LOCALIZATION; HUMAN; MOLECULAR CLONING; PROTEIN EXPRESSION; REVIEW;

EID: 0031104328     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(97)01000-3     Document Type: Review

References (55)

1. 1 Butcher, R.W. and Sutherland, E.W. (1962) J. Biol. Chem. 237, 1244-1250
2. 2 Persson, S.E. (1985) Thorax 40, 881-886
3. 3 Nemoz, G. et al. (1985) Biochem. Pharmacol. 34, 2997-3000
4. 4 Schwabe, U. et al. (1976) Mol. Pharmacol. 12, 900-910
5. 5 Hebenstriet, G.H. et al. (1989) Pharmacopsychiatry 22, 156-160
6. 6 Bobon, B. et al. (1988) Eur. Arch. Psychiatry Neurol. Sci. 238, 2-6
7. 7 Saletu, B. et al. (1992) Biol. Psychiatry 32, 668-681
8. 8 Torphy, T.J., Livi, G.P. and Chtistenson, S.B. (1993) Drug News Perspect. 6(4), 203-211
9. 9 Krishna, T. et al. (1996) in Therapeutic Immunology (Auston, K.F., Buraholf, S.J., Rosen, F.S. and Strom, T.B., eds), Blackwell Scientific
10. 10 Dudai, Y. et al. (1976) Proc. Natl. Acad. Sci. U. S. A. 73, 1684-1688
11. 11 Byers, D., Davis, R.L. and Kiger, J.A. (1981) Nature 289, 79-81
12. 12 Chen, C.N., Denome, S. and Davis, R.L. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 9313-9317
13. 13 Qiu, Y. et al. (1991) J. Mol. Biol. 222, 553-565
14. 14 Swinnen, J., Joseph, D. and Conti, M. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 5325-5329
15. 15 Bolger, G. et al. (1993) Mol. Cell. Biol. 13, 6558-6571
16. 16 Bolger, G., Rodgers, L. and Riggs, M. (1994) Gene 149, 237-244
17. 17 Jin, S.C., Swinnen, J. and Conti, M. (1992) J. Biol. Chem. 267, 18271-18274
18. 18 Sette, C., Vicini, E. and Conti, M. (1994) J. Biol. Chem. 269(28), 18271-18274
19. 19 Nemoz, G. et al. (1996) FEBS Lett. 384, 97-102
20. 20 Engels, P., Fichtel, K. and Lubbert, H. (1994) FEBS Lett. 350, 291-295
21. 21 Souness, J.E. et al. (1995) Br. J. Pbarmacol. 115, 39-46
22. 22 Torphy, T. et al. (1992) J. Biol. Chem. 267, 1798-1804
23. 23 Amegadzie, B. et al. (1995) Cell Biol. Int. 19, 477-484
24. 24 Fougier, S. et al. (1986) Biochem. Biophys. Res. Commun. 138, 205-214
25. 25 Alvarez, R. et al. (1995) Mol. Pharmacol. 48, 616-622
26. 26 Souness, J.E., Maslen, C. and Scott, L.C. (1992) FEBS Lett. 302, 181-184
27. 27 Schneider, H.H. et al. (1986) Eur. J. Pharmacol. 127, 105-115
28. 28 McLaughlin, M.M. et al. (1993) J. Biol. Chem. 268, 6470-6476
29. 29 Pillai, R. et al. (1994) Proc. Natl. Acad. Sci. U. S. A. 90, 11970-11974
30. 30 Barnette, M.S. et al. ( 1995) J. Pharmacol. Exp. Ther. 273, 674-679
31. 31 Barnette, M.S. et al. (1996) Biochem. Pharmacol. 51, 949-956
32. 32 Hatzelmann, A., Tenor, H. and Schudt, C. (1995) Br. J. Pharmacol. 114, 821-831
33. 33 Dent, G. et al. (1994) J. Pharmacol. Exp. Ther. 271, 1167-1174
34. 34 Souness, J.E. et al. (1996) Br. J. Pharmacol. 118, 649-658
35. 35 Harvath, L. et al. (1991) J. Immunol. 146, 224-232
36. 36 Barnette, M.S. et al. (1995) J. Pharmacol. Exp. Ther. 273, 1396-1402
37. 37 Raeburn, D. et al. (1994) Br. J. Pharmacol. 113, 1423-1431
38. 38 Tomkinson, A. et al. (1993) Br. J. Pharmacol. 108, 57-61
39. 39 Harris, A.L. et al. (1989) J. Pharmacol. Exp. Ther. 251, 199-206
40. 40 Underwood, D. et al. (1993) J. Pharmacol. Exp. Ther. 266, 306-313
41. 41 Undem, B.J., Meclear, S.N. and Chem, J. (1994) J. Pharmacol. Exp. Ther. 271, 811-817
42. 42 Hughes, B. et al. (1996) Br. J. Pharmacol. 118, 1183-1191
43. 43 Gozzard, N. et al. (1996) Br. J. Pharmacol. 118, 1201-1208
44. 44 Turner, C.R. et al. (1994) Am. J. Respir. Crit. Care Med. 149, 1153-1159
45. 45 Jones, T.R. et al. (1996) Am. J. Respir. Crit. Care Med. 153, A346
46. 46 Gozzard, N. et al. (1995) Br. J. Pharmacol. 117, 1405-1412
47. 47 Holbrook, M. et al. (1996) Br. J. Pharmacol. 118, 1192-1200
48. 48 Underwood, D. et al. (1994) Am. J. Respir. Crit. Care Med. 149, A762
49. 49 Qian, Y. et al. (1994) Eur. Respir. J. 7, 306-310
50. 50 Carpenter, D. et al. (1988) J. Neurophysiol. 59(2), 358-369
51. 51 Duplantier, A.J. et al. (1996) J. Med. Chem. 39, 120-125
52. 52 Brummer, T. et al. (1992) Eur. Respir. J. 5, 982-985
53. 53 Watson, J.W. et al. (1995) Allergy and Clin. Immunol., New York
54. 54 Harbinson, P.L. et al. (1996) Am. J. Resp. Crit. Care Med. 153(4), A347
55. 55 Everitt, D.E. et al. (1994) Clin. Pharmacol. Ther. 55, 1-108