Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of γ-lactams

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 4, 1998, Pages 399-404

  Hulme, Christopher ^a,b   Moriarty, Kevin ^a   Huang, Fu Chih ^a   Mason, Jonathon ^a   McGarry, Dan ^a   Labaudiniere, Richard ^a   Souness, John ^a   Djuric, Stevan ^a  

^a SANOFI   (France)

^b Rhone Poulenc Rorer Ctrl Research   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA LACTAM DERIVATIVE; PHOSPHODIESTERASE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; LACTAMS; PHOSPHODIESTERASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032539570     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00036-5     Document Type: Article

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