Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics

European Respiratory Journal

Volumn 9, Issue 3, 1996, Pages 456-462

  Jaffar, Z H ^a,b   Sullivan, P ^a   Page, C ^a   Costello, J ^a  

^a KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

asthma; bronchoalveolar lavage; immunomodulation; T lymphocytes; theophylline

Indexed keywords

ALLERGEN; PLACEBO; THEOPHYLLINE;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; IMMUNOMODULATION; LUNG LAVAGE; MALE; PRIORITY JOURNAL; PROVOCATION TEST; T LYMPHOCYTE ACTIVATION;

ADULT; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHODILATOR AGENTS; BRONCHOSCOPY; CD4-CD8 RATIO; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; PEAK EXPIRATORY FLOW RATE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THEOPHYLLINE; TREATMENT OUTCOME;

EID: 0029923004     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.96.09030456     Document Type: Article

References (43)

1. Pepys J, Hutchcroft BJ. Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Am Rev Respir Dis 1975; 12: 829-859.
2. Booij-Noord H, de Vries K, Sluiter HJ, Orie NGM. Late bronchial obstructive reaction to experimental inhalation of house dust extract. Clin Allergy 1972; 2: 43-61.
3. O'Byrne PM, Dolovich J, Hargreave FE. Late asthmatic responses. Am Rev Respir Dis 1987; 136: 740-751.
4. Casale TB, Wood D, Richerson HB, Zehr B, Zavala D, Hunninghake GW. Direct evidence of a role for mast cells in the pathogenesis of antigen-induced bronchoconstriction. J Clin Invest 1987; 80: 1507-1511.
5. Holgate ST, Finnerty JP. Recent advances in understanding the pathogenesis of asthma and its clinical implications. Q J Med 1988; 149: 5-19.
6. De Monchy JGR, Kauffman HF, Venge P, et al. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis 1985; 131: 373-376.
7. Kirby JG, Hargreave FE, Gleich GJ, O'Byrne PM. Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects. Am Rev Respir Dis 1987; 136: 379-383.
8. Beaseley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989; 139: 806-817.
9. British Thoracic Society Guidelines on the Management of Asthma. Thorax 1993; 48: S1-24.
10. Nielson CP, Crowley JJ, Cusack BJ, Vestal RE. Therapeutic concentrations of theophylline and enprofylline potentiate catecholamine effects and inhibit leukocyte activation. J Allergy Clin Immunol 1986; 78: 660-667.
11. Condino-Neto A, Vitela MMS, Cambiucci EC, et al. Theophylline therapy inhibits neutrophil and mononuclear cell chemotaxis from chronic asthmatic children. Br J Clin Pharmacol 1991; 32: 557-561.
12. Venge P, Dahl R, Karlstrom R, Pedersen B, Peterson CGB. Eosinophil and neutrophil activity in asthma in a one year double-blind trial with theophylline and two doses of inhaled budesonide. J Allergy Clin Immunol 1992; 89: A181 (Abstract).
13. Pauwels R, Van Renterghan D, Van Der Straeten M, Johannesson N, Persson CGA. The effect of theophylline and enprofylline on allergen-induced bronchoconstriction. J Allergy Clin Immunol 1985; 76: 583-590.
14. Crescioli S, Spinazzi A, Plebani M, et al. Theophylline inhibits early and late reactions induced by allergens in asthmatic subjects. Ann Allergy 1991; 66: 245-251.
15. Ward AJM, Mckenniff M, Evans JM, Page CP, Costello JF. Theophylline: an immunomodulatory role in asthma? Am Rev Respir Dis 1993; 147: 518-523.
16. Robinson DS, Hamid Q, Ying S, et al. Evidence for a predominant "TH2-type" bronchoalveolar lavage T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326: 298-304.
17. Corrigan CJ, Kay AB. T-cells and eosinophils in the pathogenesis of asthma. Immunol Today 1992; 13: 501-507.
18. Holgate ST. Mediator and cytokine mechanisms in asthma. The Altounyan Address. Thorax 1993; 48: 103-110.
19. Corrigan CJ, Hartnell A, Kay AB. T-lymphocyte activation in acute severe asthma. Lancet 1988; i: 1129-1131.
20. Gerblich AA, Campbell AE, Schuyler MR. Changes in T-lymphocyte subpopulations after antigenic bronchial provocation in asthmatics. N Engl J Med 1984; 310: 1349-1352.
21. Gerblich AA, Salik H, Schuyler MR. Dynamic T-cell changes in peripheral blood and bronchoalveolar lavage after antigen bronchoprovocation in asthmatics. Am Rev Respir Dis 1991; 143: 533-537.
22. Gonzalez MC, Diaz P, Galleguillos FR, Ancic P, Cromwell O, Kay AB. Allergen-induced recruitment of bronchoalveolar helper (OKT4) and suppressor (OKT8) T-cells in asthma. Am Rev Respir Dis 1987; 136: 600-604.
23. Sullivan P, Bekir S, Jaffar Z, Page C, Jeffery P, Costello J. Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. Lancet 1994; 343: 1006-1008.
24. Kidney JC, Dominguez M, Rose M, Aikman S, Chung KF, Barnes PJ. Immune modulation by theophylline: the effect of withdrawal of chronic treatment in asthma. Am Rev Respir Dis 1993; 147: A772 (Abstract).
25. Kidney JC, Dominguez M, Rose M, Aikman S, Chung KF, Barnes PJ. Withdrawing chronic theophylline treatment increases airway lymphocytes in asthma. Thorax 1994; 49: 396 (Abstract).
26. Azzawi M, Bradley B, Jeffery PK, et al. Identification of activated T-lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990; 142: 1407-1413.
27. Wilson JW, Djukanovic R, Howarth PH, Holgate ST. Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma. Am Rev Respir Dis 1992; 145: 958-960.
28. Hamid Q, Azzawi M, Ying S, et al. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991; 87: 1541-1546.
29. Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in mild asthma: relationship to bronchial hyperreactivity. Am Rev Respir Dis 1988; 137: 62-69.
30. Bousquet J, Chanez P, Lacoste JY, et al. Eosinophilic inflammation in asthma. N Engl J Med 1990; 323: 1033-1039.
31. Durham SR, Kay AB. Eosinophils, bronchial hyperreactivity and late-phase asthmatic reactions. Clin Allergy 1985; 15: 411-418.
32. Rothenburg ME, Owen WF, Silberstein DS, et al. Human eosinophils have prolonged survival, enhanced functional properties and become hypodense when exposed to human interleukin-3. J Clin Invest 1988; 81: 1986-1992.
33. Lopez AF, Sanderson CJ, Gamble JR, Campbell HD, Young IG, Vadas MA. Recombinant human interleukin-5 as a selective activator of human eosinophil function. J Exp Med 1988; 167: 219-224.
34. Owen WF, Rothenburg ME, Silberstein DS, et al. Regulation of human eosinophil viability, density and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J Exp Med 1987; 166: 129-141.
35. Persson CGA. Overview of effects of theophylline. J Allergy Clin Immunol 1986; 78: 780-787.
36. Torphy TJ, Undem BJ. Phosphodiesterase inhibitors: new opportunities for the treatment of asthma. Thorax 1991; 46: 512-523.
37. Fink G, Mittleman M, Shohat B, Spitzer SA. Theophylline-induced alterations in cellular immunity in asthmatic patients. Clin Allergy 1987; 17: 313-316.
38. Pardi R, Zocchi MR, Ferrero E, Ciboddo GF, Inverardi L, Rugarli C. In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes. Clin Exp Immunol 1984; 57: 722-728.
39. Shohat B, Volovitz B, Varsano I. Induction of suppressor T-cells in asthmatic children by theophylline treatment. Clin Allergy 1983; 13; 487-493.
40. Ilfeld D, Kivity S, Feierman E, Topilsky M, Kuperman O. Effect of in vitro colchicine and oral theophylline on suppressor cell function of asthmatic patients. Clin Exp Immunol 1985; 61: 360-367.
41. Coskey LA, Bitting J, Roth MD. Inhibition of natural killer cell activity by therapeutic levels of theophylline. Am J Respir Cell Mol Biol 1993; 9: 659-665.
42. Yokoyama A, Yamashita N, Mizushima Y, Yano S. Inhibition of natural killer cell activity by oral administration of theophylline. Chest 1990; 98: 924-927.
43. Scordamaglia A, Ciprandis G, Ruffoni S, et al. Theophylline and the immune response: in vitro and in vivo effects. Clin Immunol Immunopathol 1988; 48: 238-246.