A comparison of low-dose inhaled budesonide plus theophylline and high- dose inhaled budesonide for moderate asthma

New England Journal of Medicine

Volumn 337, Issue 20, 1997, Pages 1412-1418

  Evans, David J ^a   Taylor, David A ^a   Zetterstrom, Olle ^b   Chung, K Fan ^a   O'Connor, Brian J ^a   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; GLUCOCORTICOID; HYDROCORTISONE; THEOPHYLLINE;

ADULT; AGED; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROCORTISONE BLOOD LEVEL; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AGED; ASTHMA; BRONCHODILATOR AGENTS; BUDESONIDE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FORCED EXPIRATORY VOLUME; GLUCOCORTICOIDS; HUMANS; MALE; MIDDLE AGED; PEAK EXPIRATORY FLOW RATE; THEOPHYLLINE; VITAL CAPACITY;

EID: 0030719429     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199711133372002     Document Type: Article

References (25)

1. Barnes PJ. Inhaled glucocorticoids for asthma. N Engl J Med 1995; 332:868-75.
2. Kamada AK, Szefler SJ, Martin RJ, et al. Issues in the use of inhaled glucocorticoids. Am J Respir Crit Care Med 1996;153:1739-48.
3. Barnes PJ, Jonsson B, Klim JP. The cost of asthma. Eur Respir J 1996; 9:636-42.
4. Weinberger M, Hendeles L. Theophylline in asthma. N Engl J Med 1996;334:1380-8.
5. Barnes PJ, Pauwels RA. Theophylline in the management of asthma: time for reappraisal? Eur Respir J 1994;7:579-91.
6. Kidney J, Dominguez M, Taylor PM, Rose M, Chung KF, Barnes PJ. Immunomodulation by theophylline in asthma: demonstration by withdrawal of therapy. Am J Respir Crit Care Med 1995;151:1907-14.
7. Sullivan PJ, Bekir S, Jaffar Z, Page C, Jeffery P, Costello J. Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. Lancet 1994;343:1006-8. [Erratum, Lancet 1994;343:1512.]
8. Magnussen H, Reuss G, Jorres R. Theophylline has a dose-related effect on the airway response to inhaled histamine and methacholine in asthmatics. Am Rev Respir Dis 1987;136:1163-7.
9. Pauwels R, Van Renterghem D, Van der Straeten M, Johannesson N, Persson CGA. The effect of theophylline and enprofylline on allergen-induced bronchoconstriction. J Allergy Clin Immunol 1985;76:583-90.
10. Ward AJM, McKenniff M, Evans JM, Page CP, Costello JF. Theophylline - an immunomodulatory role in asthma? Am Rev Respir Dis 1993; 147:518-23.
11. Mary D, Aussel C, Ferrua B, Fehlmann M. Regulation of interleukin-2 synthesis by cAMP in human T cells. J Immunol 1987;139:1179-84.
12. Hatzelmann A, Tenor H, Schudt C. Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions. Br J Pharmacol 1995;114:821-31.
13. Dent G, Giembycz MA, Rabe KF, Wolf B, Barnes PJ, Magnussen H. Theophylline suppresses human alveolar macrophage respiratory burst through phosphodiesterase inhibition. Am J Respir Cell Mol Biol 1994;10: 565-72.
14. Prowse K, Walters EH. Can aminophylline reduce the need for oral corticosteroids? J Int Med Res 1979;7:Suppl 1:101-5.
15. Nassif EG, Weinberger M, Thompson R, Huntley W. The value of maintenance theophylline in steroid-dependent asthma. N Engl J Med 1981;304:71-5.
16. Rivington RN, Boulet L-P, Cote J, et al. Efficacy of uniphyl, salbutamol, and their combination in asthmatic patients on high-dose inhaled steroids. Am J Respir Crit Care Med 1995;151:325-32.
17. Guidelines on the management of asthma. Thorax 1993;48:Suppl:S1-S24. [Erratum, Thorax 1994;49:96.]
18. International Asthma Management Project. International consensus report on the diagnosis and management of asthma. Clin Exp Allergy 1992;22:Suppl 1:1-72.
19. Greening AP, Ind PW, Northfield M, Shaw G. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Lancet 1994;344:219-24.
20. Woolcock A, Lundback B, Ringdal N, Jacques LA. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroid. Am J Respir Crit Care Med 1996;153:1481-8.
21. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136: 225-44.
22. Steinijans VW, Sauter R, Bohm A, Staudinger H. Pharmacokinetic profile of a new sustained-release theophylline pellet formulation for once-daily evening administration. Arzneimittelforschung 1988;38:1241-50.
23. Crowder MJ, Hand DJ. Analysis of repeated measures. London: Chapman & Hall, 1990.
24. Dahl R, Lundback B, Malo JL, et al. A dose-ranging study of fluticasone propionate in adult patients with moderate asthma. Chest 1993;104: 1352-8.
25. Ryan G, Latimer KM, Dolovich J, Hargreave FE. Bronchial responsiveness to histamine: relationship to diurnal variation of peak flow rate, improvement after bronchodilator, and airway calibre. Thorax 1982;37:423-9.