CD3- and CD28-dependent induction of PDE7 required for T cell activation

Science

Volumn 283, Issue 5403, 1999, Pages 848-849

  Li, Linsong ^a   Yee, Cassian ^b   Beavo, Joseph A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CYCLIC AMP; INTERLEUKIN 2; PHOSPHODIESTERASE;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANTIBODIES; ANTIGENS, CD28; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INDUCTION; HUMANS; INTERLEUKIN-2; ISOENZYMES; LYMPHOCYTE ACTIVATION; OLIGONUCLEOTIDES, ANTISENSE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0033524977     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.283.5403.848     Document Type: Article

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27. 3H]thymidine was then added per well. Sixteen hours later, cells were harvested for scintillation counting.
28. The three PDE7 antisense oligonucleotides were as follows: from position 1 to 24 (AS-0: 5′-CGGCAGCT-GCTAACACACTTCCAT); from position 708 to 728 (AS-708: 5′-CAGTGCATGGCCTGAGTAAC); and from position 937 to 959 (AS-959: 5′-GGCAGATGT-GAGAATAAGCCTG). For RT-PCR analysis, PDE7-specific primer pairs were as follows: 5′-GATATTTGTA-ACCCATGTCGGACG-3′ and 5′-AAAGCTTGGCGG-TACTCTATCGAT-3′. PDE4A-specific primer pairs were as follows: AAGAGGAGGAAGAAATATCAATGG and TTACAGCAACCACGAATTCCTCC.
29. We thank L. H. Li for help with RT-PCR analysis and D. Stenger for comments on the manuscript. This research is supported by NIH grant DK21723 to J.A.B. and by a grant from the Ono Pharmaceutical Company. C.Y. is the recipient of a Career Award from the Burroughs Wellcome Fund.