Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4

British Journal of Pharmacology

Volumn 124, Issue 1, 1998, Pages 229-237

  Blease, Kate ^a   Burke Gaffney, Anne ^a   Hellewell, Paul G ^a,b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b NORTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

E selectin; Intercellular adhesion molecule 1; Leukocyte adhesion; Lung microvascular endothelium; PDE inhibitors; TNF ; Vascular cell adhesion molecule 1

Indexed keywords

6 (5,6 DIMETHOXYBENZO[B]THIEN 2 YL) 4,5 DIHYDRO 5 METHYL 3(2H) PYRIDAZINONE; ADENYLATE CYCLASE; BETA1 INTEGRIN; CD18 ANTIGEN; CELL ADHESION MOLECULE; CYCLIC AMP; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; PHOSPHODIESTERASE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; ROLIPRAM; SALBUTAMOL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG POTENTIATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; HUMAN; HUMAN CELL; LEUKOCYTE; LUNG CAPILLARY; MONOLAYER CULTURE; NEUTROPHIL; PNEUMONIA; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADRENERGIC BETA-AGONISTS; ALBUTEROL; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; EOSINOPHILS; HUMANS; LUNG; NEUTROPHILS; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINONES; ROLIPRAM; THIOPHENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031919107     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701833     Document Type: Article

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