Opiate modulating properties of nociceptin/orphanin FQ

Peptides

Volumn 21, Issue 1, 2000, Pages 151-172

  Harrison, Laura M ^a   Grandy, David K ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Antiopiate; Neuropeptide FF; Nociceptin; Orphanin FQ; Tyr MIF 1

Indexed keywords

CALCIUM CHANNEL; NOCICEPTIN; OPIATE RECEPTOR; POTASSIUM CHANNEL; PROTEIN KINASE C;

AMINO ACID SEQUENCE; ANALGESIA; FEEDING; HORMONE RELEASE; HUMAN; LOCOMOTION; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; REVIEW;

AMINO ACID SEQUENCE; ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; CALCIUM CHANNELS; DRUG TOLERANCE; FEMALE; HORMONES; HUMANS; MALE; MOLECULAR SEQUENCE DATA; NEUROTRANSMITTER AGENTS; OPIOID PEPTIDES; PAIN MEASUREMENT; PROTEIN KINASES; RECEPTORS, OPIOID; SUBSTANCE-RELATED DISORDERS;

EID: 0034004878     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(99)00185-0     Document Type: Review

References (193)

1. 2+ channel current in rat sensory neurons by a G-protein-independent mechanism. J Neurosci. 17:(22):1997;8721-8728.
2. Abdulla F.A., Smith P.A. Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons. J Neurosci. 18:(23):1998;9685-9694.
3. Akil H., Owens C., Gutstein H., Taylor L., Curran E., Watson S. Endogenous opioids overview and current issues . Drug Alcohol Depend. 51:1998;127-140.
4. Akil H., Watson S.J., Young E., Lewis M.E., Khachaturian H., Walker J.M. Endogenous opioids biology and function . Annu Rev Neurosci. 7:1984;223-255.
5. Allen C.A., Jiang Z.-G., Teshima K., et al. Orphanin-FQ/nociceptin (OFQ/N) modulates the activity of suprachiasmatic nucleus neurons. J Neurosci. 19:(6):1999;2152-2160.
6. Anton B., Fein J., To T., Li X., Silberstein L., Evans C.J. Immunohistochemical localization of ORL-1 in the central nervous system of the rat. J Comp Neurol. 368:1996;229-251.
7. Arndt M.L., Wu D., Soong Y., Szeto H.H. Nociceptin/orphanin FQ increases blood pressure and heart rate via sympathetic activation in sheep. Peptides. 20:(4):1999;465-470.
8. Blenis J. Signal transduction via MAP kinases proceed at your own RSK . Proc Natl Acad Sci USA. 90:1993;5889-5892.
9. Bryant W., Janik J., Baumann M., Callahan P. Orphanin FQ stimulates prolactin and growth hormone release in male and female rats. Brain Res. 807:1998;228-233.
10. Bunzow J.R., Saez C., Mortrud M., Bouvier C., Williams J.T., Low M., Grandy D.K. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ, or k opioid receptor type. FEBS Lett. 347:1994;284-288.
11. Butour J.-L., Moisand C., Mazarguil H., Mollereau C., Meunier J.-C. Recognition and activation of the opioid receptor-like ORL1 receptor by nociceptin, nociceptin analogs and opioids. Eur J Pharmacol. 321:1997;97-103.
12. Buzas B., Rosenberger J., Cox B.M. Activity and cyclic AMP-dependent regulation of nociceptin/orphanin FQ gene expression in primary neuronal and astrocyte cultures. J Neurochem. 71:1998;556-563.
13. Calo G., Rizzi A., Bodin M., Neugebauer W., Salvadori S., Guerrini R., Bianchi C., Regoli D. Pharmacological characterization of nociceptin receptor an in vitro study . Can J Physiol Pharmacol. 75:1997;713-718.
14. Candeletti S, Ferri S. Bidirectional effect of nociceptin on food intake. Int Narcotics Res Conf Ab 1998;A169. Abstract.
15. 1 receptor, has novel hypotensive activity in the rat. Life Sci. 60:(16):1997;L241-L245.
16. 1]-Nociceptin, a novel nociceptin analog, decreases systemic arterial pressure by a naloxone-insensitive mechanism in the rat. Biochem Biophys Res Commun. 234:1997;309-312.
17. 1]-Nociceptin has naloxone-insensitive vasodilator activity in the hindquarters vascular bed of the rat. Life Sci. 61:(26):1997;L403-L408.
18. Chan J.S.C., Chiu T.T., Wong Y.H. Activation of type II adenylyl cyclase by the cloned μ-opioid receptor coupling to multiple G proteins . J Neurochem. 65:1995;2682-2689.
19. 16 proteins . J Neurochem. 71:1998;2203-2210.
20. Chavkin C., Goldstein A. Specific receptor for the opioid peptide dynorphin structure-activity relationships . Proc Natl Acad Sci USA. 78:1981;6543-6547.
21. Chen Y., Fan Y., Liu J., Mestek A., Tian M., Kozak C.A., Yu L. Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family. FEBS Lett. 347:1994;279-283.
22. Chen Y., Mestek A., Liu J., Hurley J.A., Yu L. Molecular cloning and functional expression of a μ-opioid receptor from rat brain. Mol Pharmacol. 44:1993;8-12.
23. Chen Y., Mestek A., Yu L. Molecular cloning of a rat k opioid receptor reveals sequence similarities to the μ and δ opioid receptors. Biochem J. 295:1993;625-628.
24. Chu X., Xu N., Li P., Wang J.Q. Profound inhibition of cardiomotor neurons in the rat rostral ventrolateral medulla by nociceptin (orphanin FQ). NeuroReport. 9:1998;1081-1084.
25. Ciccocioppo R., Panocka I., Polidori C., Regoli D., Massi M. Effect of nociceptin on alcohol intake in alcohol-preferring rats. Psychopharmacology. 141:1999;220-224.
26. Connor M., Vaughan C.W., Chieng B., Christie M.J. Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro. Br J Pharmacol. 119:1996;1614-1618.
27. 2+ in the SH-SY5Y human neuroblastoma cell. Br J Pharmacol. 118:1996;205-207.
28. 1 receptor, has vasodilator activity in the hindquarters vascular bed of the rat. Peptides. 18:(6):1997;793-795.
29. Darland T., Grandy D.K. The orphanin FQ system an emerging target for the management of pain? British J Anaesthesia. 81:(1):1998;29-37.
30. Darland T., Heinricher M.M., Grandy D.K. Orphanin FQ/nociceptin. a role in pain and analgesia, but so much more. Trends Neurosci. 21:(5):1998;215-221.
31. Dawson-Basoa M., Gintzler A.R. Nociceptin (orphanin FQ) abolishes gestational and ovarian sex steroid-induced antinociception and induces hyperalgesia. Brain Res. 750:1997;48-52.
32. De Groot J.F., Coggeshall R.E., Carlton S.M. The reorganization of mu opioid receptors in the rat dorsal horn following peripheral axotomy. Neurosci Lett. 233:1997;113-116.
33. Devillers J.-P., Boisserie F., Laulin J.-P., Larcher A., Simonnet G. Simultaneous activation of spinal antiopioid system (neuropeptide FF) and pain facilitory circuitry by stimulation of opioid receptors in rats. Brain Res. 700:1995;173-181.
34. Devine DP, Hoversten M, Akil H. Alterations in neuronal orphanin FQ content following exposure to stress. Int Narcotics Res Conf Ab 1998;A172. Abstract.
35. Devine D.P., Reinscheid R.K., Monsma F.J., Civelli O., Akil H. The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion. Brain Res. 727:1996;225-229.
36. Devine D.P., Taylor L., Reinscheid R.K., Monsma F.J., Civelli O., Akil H. Rats rapidly develop tolerance to locomotor-inhibiting effects of the novel neuropeptide orphanin FQ. Neurochem Res. 21:(11):1996;1387-1396.
37. Di Chiara G., Imperato A. Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther. 244:1988;1067-1080.
38. Dooley C.T., Houghten R.A. Orphanin FQ receptor binding and analog structure activity relationships in rat brain . Life Sci. 59:(1):1996;L23-L29.
39. h) in immunocytochemically identified vasopressin and oxytocin neurons of guinea-pig supraoptic nucleus. J Neuroend. 2:1990;261-265.
40. Erickson R.R., Ronnekleiv O.K., Kelly M.J. Electrophysiology of guinea-pig supraoptic neurones role of a hyperpolarization-activated cation current in phasic firing . J Physiol. 460:1993;407-425.
41. Evans C.J., Keith D.E., Morrison H., Magendzo K., Edwards R.H. Cloning of a delta opioid receptor by functional expression. Science. 258:1992;1952-1955.
42. Faber E.S.L., Chambers J.P., Evans R.H., Henderson G. Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro. Br J Pharmacol. 119:1996;189-190.
43. 1 receptor expressed in Chinese hamster ovary cells functional homology with opioid receptors . Eur J Pharmacol. 336:1997;233-242.
44. Florin S., Suaudeau C., Meunier J.-C., Costentin J. Nociceptin stimulates locomotion and exploratory behavior in mice. Eur J Pharmacol. 317:1996;9-13.
45. Fukada K., Kato S., Mori K., Nishi M., Takeshima H. Primary structures and expression from cDNAs of rat opioid receptor δ- and μ-subtypes. FEBS Lett. 327:1993;311-314.
46. Fukada K., Kato S., Mori K., et al. cDNA cloning and regional distribution of a novel member of the opioid receptor family. FEBS Lett. 343:1994;42-46.
47. 2 by the nociceptin receptor expressed in Chinese hamster ovary cells. J Neurochem. 71:1998;2186-2192.
48. Gaibelet G., Capeyrou R., Dietrich G., Emorine L.J. Identification in the μ-opioid receptor of cysteine residues responsible for inactivation of ligand binding by thiol alkylating and reducing reagents. FEBS Lett. 408:1997;135-140.
49. 2-adrenoceptors. Eur J Pharmacol. 298:1996;235-239.
50. 1-opioid receptor antagonist . Eur J Pharmacol. 316:1996;33-38.
51. Gherardi N., Zajac J.-M. Neuropeptide FF receptors of mouse olfactory bulb binding properties and stimulation of adenylate cyclase activity . Peptides. 18:(4):1997;577-583.
52. Gintzler A.R. Endorphin-mediated increases in pain threshold during pregnancy. Science. 210:1980;193-195.
53. Gintzler A.R., Adapa I.D., Toll L., Medina V.M., Wang L. Modulation of enkephalin release by nociceptin (orphanin FQ). Eur J Pharmacol. 325:1997;29-34.
54. Giuliani S., Maggi C.A. Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea-pig left atrium. Eur J Pharmacol. 332:1997;231-236.
55. Giuliani S., Tramontana M., Lecci A., Maggi C.A. Effect of nociceptin on heart rate and blood pressure in anaesthetized rats. Eur J Pharmacol. 333:1997;177-179.
56. Goodman C.B., Heyliger S., Emilien B., et al. Regulation of μ binding sites after chronic administration of antibodies directed against specific anti-opiate peptides. Peptides. 19:(10):1998;1703-1709.
57. Gouarderes C., Jhamandas K., Sutak M., Zajac J.-M. Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues. Br J Pharmacol. 117:1996;493-501.
58. Grisel J.E., Mogil J.S., Belknap J.K., Grandy D.K. Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. NeuroReport. 7:1996;2125-2129.
59. Guerrini R., Calo G., Rizzi A., Bigoni R., Bianchi C., Salvadori S., Regoli D. A new selective antagonist of the nociceptin receptor. Br J Pharmacol. 123:1998;163-165.
60. 1) receptors possesses systemic vasorelaxant properties . Life Sci. 60:1997;L141-L145.
61. Hao J.-X., Wiesenfeld-Hallin Z., Xu X.-J. Lack of cross-tolerance between the antinociceptive effect of intrathecal orphanin FQ and morphine in the rat. Neurosci Lett. 223:1997;49-52.
62. Hao J.-X., Xu I.S., Wiesenfeld-Hallin Z., Xu X.-J. Anti-hyperalgesic and anti-allodynic effects of intrathecal nociceptin/orphanin FQ in rats after spinal cord injury, peripheral nerve injury and inflammation. Pain. 76:1998;385-393.
63. Hara N., Minami T., Okuda-Ashitaka E., et al. Characterization of nociceptin hyperalgesia and allodynia in conscious mice. Br J Pharmacol. 121:1997;401-408.
64. Hargreaves K., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32:1988;77-88.
65. Harrison L.M., Kastin A.J., Zadina J.E. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther. 284:(2):1998;611-617.
66. i-coupled signaling pathway evidence for distinct mechanisms of agonist-mediated desensitization . J Neurochem. 71:1998;1024-1033.
67. Hayashi T., Kastin A.J., Coy D.H., Olson R.D. Tyr-MIF-1 affects passive avoidance behavior but not motor activity in rats. Brain Res Bull. 11:1983;659-662.
68. Heinricher M.M., McGaraughty S., Grandy D.K. Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla. J Neurophysiol. 78:1997;3351-3358.
69. Helyes Z., Nemeth J., Pinter E., Szolcsanyi J. Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals. Br J Pharmacol. 121:1997;613-615.
70. Henderson G., McKnight A.T. The orphan opioid receptor and its endogenous ligand - nociceptin/orphanin FQ. Trends Pharmacol Sci. 18:1997;293-300.
71. o, regulates neuronal calcium channels. Nature. 325:1987;445-447.
72. Hughes J. Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res. 88:1975;295-308.
73. Hughes J., Smith T., Morgan B., Fothergill L. Purification and properties of enkephalin - the possible endogenous ligand for the opiate receptor. Life Sci. 16:1975;1753-1758.
74. + (GIRK) channel. Mol Brain Res. 45:1997;117-126.
75. Ikeda K., Watanabe M., Ichikawa T., Kobayashi T., Yano R., Kumanishi T. Distribution of prepro-nociceptin/orphanin FQ mRNA and its receptor mRNA in developing and adult mouse central nervous systems. J Comp Neurol. 399:1998;139-151.
76. Jenck F., Moreau J.-L., Martin J.R., et al. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress. Proc Natl Acad Sci USA. 94:1997;14854-14858.
77. Jhamandas K.H., Sutak M., Henderson G. Antinociceptive and morphine modulatory actions of spinal orphanin FQ. Canadian J Physiol Pharmacol. 76:1998;314-324.
78. Jia Y.-P., Linden D.R., Serie J.R., Seybold V.S. Nociceptin/orphanin FQ binding increases in superficial laminae of the rat spinal cord during persistent peripheral inflammation. Neurosci Lett. 250:1998;21-24.
79. Kapusta D.R., Sezen S.F., Chang J.-K., Lippton H., Kenigs V.A. Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ). Life Sci. 60:1997;L15-L21.
80. Kastin A.J., Galina Z.H., Horvath A., Olson R.D. Some principles in the peptide field. J Allergy Clinical Immunol. 79:(1):1987;6-11.
81. Kastin A.J., Olson R.D., Ehrensing R.H., Berzas M.C., Schally A.V., Coy D.H. MIF-1's differential actions as an opiate antagonist. Pharmacol Biochem Behav. 11:1979;721-723.
82. Kavaliers M., Colwell D.D. Neuropeptide FF (FLQPQRFamide) and IgG from neuropeptide FF antiserum affect spatial learning in mice. Neurosci Lett. 157:1993;75-78.
83. Kieffer B.L., Befort K., Gaveriaux-Ruff C., Hirth C. The δ-opioid receptor isolation of a cDNA by expression cloning and pharmacological characteristics . Proc Natl Acad Sci USA. 89:1992;12048-12052.
84. King M.A., Rossi G.C., Chang A.H., Williams L., Pasternak G.W. Spinal analgesic activity of orphanin FQ/nociceptin and its fragments. Neurosci Lett. 223:1997;113-116.
85. Knoflach F., Reinscheid R.K., Civelli O., Kemp J.A. Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons. J Neurosci. 16:(21):1996;6657-6664.
86. 2-adrenergic and μ-opioid spinal antinociception by neuropeptide FF. Peptides. 16:(5):1995;973-977.
87. Konya H., Masuda H., Itoh K., Nagai K., Kakishita E., Matsuoka A. Modification of dopamine release by nociceptin in conscious rat striatum. Brain Res. 788:1998;341-344.
88. Lachowicz J.E., Shen Y., Monsma F.J., Sibley D.R. Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. J Neurochem. 64:1995;34-40.
89. Lake J.R., Hammond M.V., Shaddox R.C., Hunsicker L.M., Yang H.Y.-T., Malin D. IgG from neuropeptide FF antiserum reverses morphine tolerance in the rat. Neurosci Lett. 132:1991;29-32.
90. Lapalu S., Moisand C., Mazarguil H., Cambois G., Mollereau C., Meunier J.-C. Comparison of the structure-activity relationships of nociceptin and dynorphin A using chimeric peptides. FEBS Lett. 417:1997;333-336.
91. Lee K., Nicholson J.R., McKnight A.T. Nociceptin hyperpolarises neurones in the rat ventromedial hypothalamus. Neurosci Lett. 239:1997;37-40.
92. Leventhal L., Mathis J.P., Rossi G.C., Pasternak G.W., Bodnar R.J. Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia. Eur J Pharmacol. 349:1998;R1-R3.
93. Levine A.S., Morley J.E., Gosnell B.A., Billington C.J., Bartness T.J. Opioids and consummatory behavior. Brain Res Bull. 14:1985;663-672.
94. Li S., Zhu J., Chen C., Chen Y.-W., Deriel J.K., Ashby B., Liu-Chen L.-Y. Molecular cloning and expression of a rat k opioid receptor. Biochem J. 295:1993;629-633.
95. Lord J.A.H., Waterfield A.A., Hughes J., Kosterlitz H.W. Endogenous opioid peptides multiple agonists and receptors . Nature. 267:1977;495-499.
96. 2+ pathway. Biochem Biophys Res Commun. 240:1997;304-308.
97. MacDonald R.L., Nelson P.G. Specific-opiate-induced depression of transmitter release from dorsal root ganglion cells in culture. Science. 199:1978;1449-1451.
98. 2-like mammalian peptide precipitates opiate-withdrawal syndrome in the rat. Peptides. 11:1990;277-280.
99. 2-like mammalian octapeptide possible role in opiate dependence and abstinence . Peptides. 11:1990;969-972.
100. Malin D.R., Zadina J.E., Lake J.R., Rogillio R.B., Leyva J.E., Benson T.M., Corriere L.S., Handunge B.P., Kastin A.J. Tyr-MIF-1 precipitates abstinence syndrome in morphine-dependent rats. Brain Res. 610:1993;169-171.
101. Mamiya T., Noda Y., Nishi M., Takeshima H., Nabeshima T. Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice. Brain Res. 783:1998;236-240.
102. Mansour A., Hoversten M.T., Taylor L.P., Watson S.J., Akil H. The cloned μ, δ, and k receptors and their endogenous ligands evidence for two opioid peptide recognition cores . Brain Res. 700:1995;89-98.
103. Meis S., Pape H.-C. Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to nociceptin/orphanin FQ. J Neurosci. 18:1998;8133-8144.
104. Mendell L.M. Physiological properties of unmyelinated fiber projection of the spinal cord. Exp Neurol. 16:1966;316-332.
105. Meng F., Taylor L.P., Hoversten M.T., et al. Moving from the orphanin FQ receptor to an opioid receptor using four point mutations. J Biol Chem. 271:(50):1996;32016-32020.
106. Meng F., Xie G.-X., Thompson R.C., Mansour A., Goldstein A., Watson S.J., Akil H. Cloning and pharmacological characterization of a rat k opioid receptor. Proc Natl Acad Sci USA. 90:1993;9954-9958.
107. Meunier J.C., Mollereau C., Toll L., et al. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature. 377:1995;532-535.
108. Meunier J.C. Nociceptin/orphenin FQ and the opioid receptor-like ORL1 receptor. Eur J Pharmacol. 340:1997;1-15.
109. Miller L.G., Kastin A.J. MIF-1 and Tyr-MIF-1 augment GABA-stimulated benzodiazepine binding. Peptides. 8:1987;751-755.
110. Minami M., Toya T., Katao Y., et al. Cloning and expression of a cDNA for the rat k-opioid receptor. FEBS Lett. 329:(3):1993;291-295.
111. Mogil J.S., Grisel J.E., Reinscheid R.K., Civelli O., Grandy D.K. Orphanin FQ is a functional anti-opioid peptide. Neuroscience. 75:1996;333-337.
112. Mogil J.S., Grisel J.E., Zhang G., Belknap J.K., Grandy D.K. Functional antagonism of μ-, δ-, and k-opioid antinociception by Orphanin FQ. Neurosci Lett. 214:1996;131-134.
113. 280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids. FEBS Lett. 395:1996;17-21.
114. Mollereau C., Parmentier M., Mailleux P., et al. ORL1, a novel member of the opioid receptor family cloning, functional expression, and localization . FEBS Lett. 341:1994;33-38.
115. Mollereau C., Simons M.-J., Soularue P., et al. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. Proc Natl Acad Sci USA. 93:1996;8666-8670.
116. Monteillet-Agius G., Fein J., Anton B., Evans C.J. ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing. J Comp Neurol. 399:1998;373-383.
117. Morgan M.M., Grisel J.E., Robbins C.S., Grandy D.K. Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ. NeuroReport. 8:1997;3431-3434.
118. Murase T., Arima H., Kondo K., Oiso Y. Neuropeptide FF reduces food intake in rats. Peptides. 17:(2):1996;353-354.
119. Murphy N.P., Lee Y., Maidment N.T. Orphanin FQ/nociceptin blocks acquisition of morphine place preference. Brain Res. 832:1999;168-170.
120. Murphy N.P., Ly H.T., Maidment N.T. Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats. Neuroscience. 75:(1):1996;1-4.
121. Murphy N.P., Maidment N.T. Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis. J Neurochem. 73:1999;179-186.
122. Narayanan S., Maidment N.T. Orphanin FQ and behavioral sensitization to cocaine. Pharmacol Biochem Behav. 63:(2):1999;271-277.
123. Neal M.J., Cunningham J.R., Paterson S.J., McKnight A.T. Inhibition by nociceptin of the light-evoked release of ACh from retinal cholinergic neurones. Br J Pharmacol. 120:1997;1399-1400.
124. + evoked glutamate release from rat cerebrocortical slices. Br J Pharmacol. 119:1996;1081-1083.
125. Nishi M., Takeshima H., Fukada K., Kato S., Mori K. cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for k-subtype-selective ligands. FEBS Lett. 330:(1):1993;77-80.
126. Nothacker H.-P., Reinscheid R.K., Mansour A., et al. Primary structure and tissue distribution of the orphanin FQ precursor. Proc Natl Acad Sci USA. 93:1996;8677-8682.
127. Oberling P., Stinus L., LeMoal M., Simonnet G. Biphasic effect on nociceptin and antiopiate activity of the neuropeptide FF (FLFQPQRFamide) in the rat. Peptides. 14:1993;919-924.
128. α16 couple a wide variety of receptors to phospholipase C. J Biol Chem. 270:1995;15175-15180.
129. 3-related opioid receptor using antisense oligodeoxynucleotides. Regul Peptides. 54:1994;217-218.
130. 3-related opioid receptor. Mol Pharmacol. 47:1995;1180-1188.
131. Patel H.J., Giembycz M.A., Spicuzza L., Barnes P.J., Belvisi M.G. Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin. Br J Pharmacol. 120:1997;735-736.
132. Peluso J., LaForge K.S., Matthes H.W., Kreek M.J., Kieffer B.L., Gaveriaux-Ruff C. Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells. J Neuroimmunol. 81:1998;184-192.
133. Pfeiffer A., Herz A. Endocrine actions of opioids. Horm Metab Res. 16:1984;386-397.
134. 1, stimulates feeding in rats. NeuroReport. 8:1996;369-371.
135. 2+ channels in rat spinal ganglion neurones. NeuroReport. 7:1996;2979-2981.
136. Reinscheid R.K., Ardati A., Monsma F.J. Jr, Civelli O. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J Biol Chem. 271:(24):1996;14163-14168.
137. Reinscheid R.K., Higelin J., Henningsen R.A., Monsma F.J. Jr, Civelli O. Structures that delineate orphanin FQ and dynorphin A pharmacological selectivities. J Biol Chem. 272:(3):1998;1490-1495.
138. Reinscheid R.K., Nothacker H.-P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsama F.J. Jr, Civelli O. Orphanin FQ a neuropeptide that activates an opioid-like G protein-coupled receptor . Science. 270:1995;792-794.
139. Renaud L.P., Bourque C.W. Neurophysiology and neuropharmacology of hypothalamic magnocellular neurons secreting vasopressin and oxytocin. Prog Neurobiol. 36:1991;131-169.
140. Riedl M., Shuster S., Vulchanova L., Wang J., Loh H.H., Elde R. Orphanin FQ/nociceptin-immunoreactive fibers parallel those containing endogenous opioids in rat spinal cord. NeuroReport. 7:1996;1369-1372.
141. Rossi G.C., Leventhal L., Pasternak G. Naloxone sensitive orphanin FQ-induced analgesia in mice. Eur J Pharmacol. 311:1996;R7-R8.
142. Rothman R.B. A review of the role of anti-opioid peptides in morphine tolerance and dependence. Synapse. 12:1992;129-138.
143. 2 (NPFF), downregulates mu opioid binding sites in rat brain. Peptides. 14:1993;1271-1277.
144. 2+ in mouse spinal ganglion neurons. Eur J Pharmacol. 306:1996;291-295.
145. Saito Y., Maruyama K., Kawano H., et al. Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule. J Biol Chem. 271:1996;15615-15622.
146. Saito Y., Maruyama K., Saido T.C., Kawashima S. Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells. J Neurosci Res. 48:1997;397-406.
147. Sandin J., Georgieva J., Schott P.A., Ogren S.O., Terenius L. Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats. Eur J Neurosci. 9:1997;194-197.
148. Sandin J., Georgieva J., Silberring J., Terenius L. In vivo metabolism of Nociceptin/orphanin FQ in rat hippocampus. NeuroReport. 10:1999;71-76.
149. Schulz S., Schreff M., NuB D., Gramsch C., Hollt V. Nociceptin/orphanin FQ and opioid peptides show overlapping distribution but not co-localization in pain-modulatory brain regions. NeuroReport. 7:1996;3021-3025.
150. Shahrestanifar M., Wang W.W., Howells R.D. Studies on inhibition of μ and δ opioid receptor binding by dithiothreitol and N-ethylmaleimide. J Biol Chem. 271:(10):1996;5505-5512.
151. Sinchak K., Hendricks D.G., Baroudi R., Micevych P.E. Orphanin FQ/nociceptin in the ventromedial nucleus facilitates lordosis in female rats. NeuroReport. 8:1997;3857-3860.
152. Sirianni M.J., Fujimoto K.I., Nelson C.S., Pellegrino M.J., Allen R.G. Cyclic AMP analogs induce synthesis, processing, and secretion of prepro-nociceptin/orphanin FQ-derived peptides by NS20Y neuroblastoma cells. DNA Cell Biol. 18:(1):1999;51-58.
153. + conductance by orphanin FQ/nociceptin in vasopressin-containing neurons. Neuroendocrinology. 69:1999;385-396.
154. Stinus L., Allard M., Gold L., Simonnet G. Changes in CNS neuropeptide FF-like material, pain sensitivity, and opiate dependence following chronic morphine treatment. Peptides. 16:1995;1235-1241.
155. Stratford T.R., Holahan M.R., Kelley A.E. Injections of nociceptin into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake. NeuroReport. 8:1997;423-426.
156. Suder P., Kotlinska J., Smoluch M.T., Sallberg M., Silberring J. Metabolic fate of nociceptin/orphanin FQ in the rat spinal cord and biological activity of its released fragment. Peptides. 20:1999;239-247.
157. Thompson R.C., Mansour A., Akil H., Watson S.J. Cloning and pharmacological characterization of a rat μ opioid receptor. Neuron. 11:1993;903-913.
158. Tian J.-H., Xu W., Fang Y., et al. Bidirectional modulatory effect of orphanin FQ in morphine-induced analgesia antagonism in brain and potentiation in spinal cord of the rat . Br J Pharmacol. 120:1997;676-680.
159. Tian J.-H., Xu W., Zhang W., et al. Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia. NeuroReport. 8:1997;497-500.
160. Tian J.-H., Zhang W., Fang Y., Xu W., Grandy D.K., Han J.-S. Endogenous orphanin FQ evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture . Br J Pharmacol. 124:1998;21-26.
161. Ueda H., Yamaguchi T., Tokuyama S., Inoue M., Nishi M., Takeshima H. Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene. Neurosci Lett. 237:1997;136-138.
162. van Biesen T., Hawes B.E., Luttrell D.K., et al. Receptor-tyrosine-kinase-, and Gβγ-mediated MAP kinase activation by a common signaling pathway. Nature. 376:1995;781-784.
163. van Biesen T., Luttrell L.M., Hawes B.E., Lefkowitz R.J. Mitogenic signaling via G protein-coupled receptors. Endocr Rev. 17:1996;698-714.
164. Van Ree J.M., De Wied D. Prolyl-leucyl-glycinamide (PLG) facilitates morphine dependence. Life Sci. 19:1976;1331-1340.
165. + conductance in dorsal raphe nucleus neurons. Br J Pharmacol. 117:1996;1609-1611.
166. 1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro. J Neurosci. 17:(3):1997;996-1003.
167. + channel. Neuroendocrinology. 67:1998;73-82.
168. Walker J.R., Spina M., Terenius L., Koob G.F. Nociceptin fails to affect heroin self-administration in the rat. NeuroReport. 9:1998;2243-2247.
169. Walter R., Ritzmann R.F., Bhargava H.N., Flexner L.B. Prolyl-leucyl-glycinamide, cyclo (leucylglycine), and derivatives block development of physical dependence on morphine in mice. Proc Natl Acad Sci USA. 76:1979;518-520.
170. Wang J.-L., Zhu C.-B., Cao X.-D., Wu G.-C. Distinct effect of intracerebroventricular and intrathecal injections of nociceptin/orphanin FQ in the rat formalin test. Regul Pept. 79:1999;159-163.
171. Wang J.B., Johnson P.S., Imai Y., et al. cDNA cloning of an orphan opiate receptor gene family member and its splice variant. FEBS Lett. 348:1994;75-79.
172. Wick M.J., Minnerath S.R., Lin X., Elde R., Law P.-Y., Loh H.H. Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ, and k opioid receptors. Mol Brain Res. 27:1994;37-44.
173. Wiesenfeld-Hallin Z., Xu X.-J. The role of cholecystokinin in nociception, neuropathic pain, and opiate tolerance. Regul Pept. 65:1996;23-28.
174. Xu X.-J., Hao J.-X., Wiesenfeld-Hallin Z. Nociceptin or antinociceptin potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat . NeuroReport. 7:1996;2092-2094.
175. 1 receptor agonist, and N-methyl-D-aspartate receptor antagonists on the thermal hyperalgesia induced by partial sciatic nerve injury in the rat. Anesthesiology. 87:1997;1145-1152.
176. 1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat. Neurosci Lett. 224:1997;107-110.
177. 1 receptor agonist, in the rat formalin test. Neuroscience. 81:(1):1997;249-254.
178. 1) receptor agonist, on the thermal hyperalgesia induced by carageenan injection onto the rat paw. Brain Res. 754:1997;329-332.
179. Yang H.Y.-T., Fratta W., Majane E.A., Costa E. Isolation, sequencing, synthesis and pharmacological characterization of two brain neuropeptides that modulate the actions of morphine. Proc Natl Acad Sci USA. 82:1985;7757-7761.
180. Yasuda K., Raynor K., Kong H., Breder C.D., Takeda J., Reisine T., Bell G.I. Cloning and functional comparison of k and δ opioid receptors from
181. Yuan L., Han Z., Chang J.-K., Han J.-S. Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats. Brain Res. 826:1999;330-334.
182. Zadina J.E., Chang S.L., Ge L.-J., Kastin A.J. Naloxone-reversible inhibition of cyclic AMP production by Tyr-MIF-1 in SH-SY5Y human neuroblastoma cells. Soc Neurosci Ab. 17:1991;811.
183. Zadina J.E., Kastin A.J. Interactions between the antiopiate Tyr-MIF-1 and the mu opiate morphiceptin at their respective binding sites in brain. Peptides. 6:1985;965-970.
184. Zadina JE, Kastin AJ, Ge L-J, Chang SL. Novel peptides and mechanisms of opiate tolerance. Regul Peptides 1994;Supl 1:S195-6.
185. Zadina J.E., Kastin A.J., Ge L.-J., Gluden H., Bungart K. Chronic, but not acute, administration of morphine alters antiopiate (Tyr-MIF-1) binding sites in rat brain. Life Sci. 44:1989;555-561.
186. 2). Neurosci Lett. 155:1993;220-222.
187. Zadina J.E., Kastin A.J., Kersh D., Wyatt A. Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum. Life Sci. 51:1992;869-885.
188. 2) in rat brain. Pharmacol Biochem Behav. 17:1982;1193-1198.
189. Zhang G., Murray T.F., Grandy D.K. Orphanin FQ has an inhibitory effect on the guinea pig ileum and the mouse vas deferens. Brain Res. 772:1997;102-106.
190. Zhang M., Sun Q.-L., Wan Y., Yao L., Yu Y.-X., Han J.-S. OFQ reverses the k-opioid receptor-mediated depression of calcium current in rat dorsal root ganglion neurons. NeuroReport. 9:1998;2095-2098.
191. Zhang X., Bao L., Shi T.J., Ju G., Elde R., Hokfelt T. Down regulation of mu receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy. Neuroscience. 82:1998;223-240.
192. Zhang X.-Y., Zadina J.E., Ehrlich M., Kastin A.J. Tyr-MIF-1, but not MIF-1 or morphine, decreases cyclic AMP-dependent protein kinase activity extracted from HeLa cells. Mol Cell Neurosci. 3:1992;348-353.
193. Zhu C.-B., Cao X.-D., Xu S.-F., Wu G.-C. Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats. Neurosci Lett. 235:1997;37-40.