Niciceptin hyperpolarises neurones in the rat ventromedial hypothalamus

Neuroscience Letters

Volumn 239, Issue 1, 1997, Pages 37-40

  Lee, K ^a   Nicholson, J R ^a   McKnight, A T ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Nociceptin; ORL1; Receptor; Ventromedial hypothalamus; Whole cell patch clamp

Indexed keywords

NALOXONE; NOCICEPTIN; TETRODOTOXIN; OPIATE PEPTIDE;

ANIMAL TISSUE; APPETITE; ARTICLE; CONTROLLED STUDY; FOOD INTAKE; HYPERPOLARIZATION; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; MALE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; ANIMAL; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG EFFECT; HYPOTHALAMUS; IN VITRO STUDY; NERVE CELL; SPRAGUE DAWLEY RAT;

ANIMALS; HYPOTHALAMUS, MIDDLE; MALE; MEMBRANE POTENTIALS; NALOXONE; NEURONS; OPIOID PEPTIDES; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; TETRODOTOXIN;

EID: 0031565822     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00875-6     Document Type: Article

References (13)

1. Boden P., Hill R.G. Effects of cholecystokinin and related peptides on neuronal activity in the ventromedial nucleus of the rat hypothalamus. Br. J. Pharmacol. 94:1988;246-252.
2. Inagaki S., Kubota Y., Kito S., Fukuda M., Ono T., Yamano M., Tohyama M. Ultrastructural evidence of enkephalinergic input to glucoreceptor neurons in ventromedial hypothalamic nucleus. Brain Res. 378:1986;420-424.
3. Matthes H., Seward E.P., Kieffer B., North R.A. Functional selectivity of Orphanin FQ for its receptor coexpressed with potassium channel subunits in Xenopus laevis oocytes. Mol. Pharmacol. 50:1996;447-450.
4. Meunier J.-C., Mollereau C., Toll L., Suandeau C., Moisand C., Alvinerie P., Butour J.-L., Guillemot J.-C., Ferrara P., Monsarrat B., Mazarguil H., Vassart G., Parmentier M., Costentin J. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature. 377:1995;532-535.
5. 1-like receptor mediates a pertussis toxin-sensitive inhibition of rat ventromedial hypothalamic neurones in vitro. Br. J. Pharmacol. 95:1988;6-8.
6. Oomura, Y., Input-output organization in the hypothalamus relating to food intake behavior. In P.J. Morgane and J. Panksepp (Eds.), Handbook of the Hypothalamus, Vol. 2, Physiology of the Hypothalamus, Marcel Dekker, New York, 1979, pp. 557-603.
7. Priestley T. The effect of baclofen and somatostatin on neuronal activity in the rat ventromedial hypothalamic nucleus in vitro. Neuropharmacology. 31:1992;103-109.
8. Reinscheid R.K., Nothacker H.-P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma F.J., Civelli O. Orphanin FQ: a neuropeptide that activates an opioid like G-protein-coupled receptor. Science, 270:1995;792-794.
9. Stratford T.R., Holahan M.R., Kelley A.E. Injections of nociceptin into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake. NeuroReport. 8:1997;423-426.
10. Stuart G.J., Dodt H.-U., Sakmann B. Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflugers Arch. 423:1993;511-518.
11. 1 receptor (opioid receptor-like 1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones. Br. J. Pharmacol. 117:1996;1609-1611.
12. 1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro. J. Neurosci. 17:1997;996-1003.
13. Wick M.J., Minnerath S.R., Lin X., Elde R., Law P.-Y., Loh H.H. Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ and κ opioid receptors. Mol. Brain Res. 27:1994;37-44.