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Volumn 81, Issue 1, 1998, Pages 29-37

The orphanin FQ system: An emerging target for the management of pain?

Author keywords

Analgesics, opioid; Orphan receptor; Orphanin; Pain

Indexed keywords

LIGAND; MESSENGER RNA; NOCICEPTIN; OPIATE RECEPTOR; PROTEIN PRECURSOR;

EID: 0031827108     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/81.1.29     Document Type: Review
Times cited : (37)

References (68)
  • 2
    • 0021288912 scopus 로고
    • Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry
    • Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annual Review of Neurosciences 1984; 7: 309-338.
    • (1984) Annual Review of Neurosciences , vol.7 , pp. 309-338
    • Basbaum, A.I.1    Fields, H.L.2
  • 3
    • 0020039181 scopus 로고
    • The organization of afferent projections to the periaqueductal gray of the rat
    • Beitz AJ. The organization of afferent projections to the periaqueductal gray of the rat. Neurosciences 1982; 7: 133-159.
    • (1982) Neurosciences , vol.7 , pp. 133-159
    • Beitz, A.J.1
  • 5
    • 0027420422 scopus 로고
    • Fiber pathways and branching patterns of biocytin-labeled olivocochlear neurons in the mouse brainstem
    • Brown MC. Fiber pathways and branching patterns of biocytin-labeled olivocochlear neurons in the mouse brainstem. Journal of Comparative Neurology 1993; 337: 600-613.
    • (1993) Journal of Comparative Neurology , vol.337 , pp. 600-613
    • Brown, M.C.1
  • 6
    • 0028284167 scopus 로고
    • Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a m, d, k opioid receptor type
    • Bunzow JR, Saez C, Mortrud M, Bouvier C, Williams JT, Low M, Grandy DK. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a m, d, k opioid receptor type. FEBS Letters 1994; 347: 284-288.
    • (1994) FEBS Letters , vol.347 , pp. 284-288
    • Bunzow, J.R.1    Saez, C.2    Mortrud, M.3    Bouvier, C.4    Williams, J.T.5    Low, M.6    Grandy, D.K.7
  • 8
    • 0019165032 scopus 로고
    • The substantia gelatinosa of the spinal cord. A critical review
    • Cervero F, Iggo A. The substantia gelatinosa of the spinal cord. A critical review. Brain 1980; 103: 717-772.
    • (1980) Brain , vol.103 , pp. 717-772
    • Cervero, F.1    Iggo, A.2
  • 9
    • 0028308020 scopus 로고
    • Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family
    • Chen Y, Fan Y, Liu J, Mestek A, Tian M, Kozak CA, Yu L. Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family. FEBS Letters 1994; 347: 279-283.
    • (1994) FEBS Letters , vol.347 , pp. 279-283
    • Chen, Y.1    Fan, Y.2    Liu, J.3    Mestek, A.4    Tian, M.5    Kozak, C.A.6    Yu, L.7
  • 10
    • 0027202213 scopus 로고
    • Molecular cloning and functional expression of a μ-opioid receptor from rat brain
    • Chen Y, Mestek A, Liu J, Hurley JA, Yu L. Molecular cloning and functional expression of a μ-opioid receptor from rat brain. Molecular Pharmacology 1993; 44: 8-12.
    • (1993) Molecular Pharmacology , vol.44 , pp. 8-12
    • Chen, Y.1    Mestek, A.2    Liu, J.3    Hurley, J.A.4    Yu, L.5
  • 11
    • 0030462638 scopus 로고    scopus 로고
    • Nociceptin recetor coupling to a potassium conductance in rat locus coeruleus neurons in vitro
    • Conner M, Vaughn CW, Chieng B, Christie MJ. Nociceptin recetor coupling to a potassium conductance in rat locus coeruleus neurons in vitro. British Journal of Pharmacology 1996; 119: 1614-1618.
    • (1996) British Journal of Pharmacology , vol.119 , pp. 1614-1618
    • Conner, M.1    Vaughn, C.W.2    Chieng, B.3    Christie, M.J.4
  • 12
    • 0021332093 scopus 로고
    • Detection of mRNAs in sea urchin embryos by in situ hybridization using assymetric RNA probes
    • Cox KH, Deleon DV, Angerer LM, Angerer RC. Detection of mRNAs in sea urchin embryos by in situ hybridization using assymetric RNA probes. Developmental Biology 1984; 101: 485-502.
    • (1984) Developmental Biology , vol.101 , pp. 485-502
    • Cox, K.H.1    Deleon, D.V.2    Angerer, L.M.3    Angerer, R.C.4
  • 13
    • 0343150924 scopus 로고    scopus 로고
    • Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain
    • Dooley CT, Houghten RA. Orphanin FQ: receptor binding and analog structure activity relationships in rat brain. Life Sciences 1996; 59: 23-29.
    • (1996) Life Sciences , vol.59 , pp. 23-29
    • Dooley, C.T.1    Houghten, R.A.2
  • 14
    • 0022377003 scopus 로고
    • An autoradiographic study of projections ascending from the midbrain central gray, and from the region lateral to it, in the rat
    • Eberhart JA, Morrell JI, Krieger MS, Pfaff DW. An autoradiographic study of projections ascending from the midbrain central gray, and from the region lateral to it, in the rat. Journal of Comparative Neurology. 1985; 241: 285-310.
    • (1985) Journal of Comparative Neurology , vol.241 , pp. 285-310
    • Eberhart, J.A.1    Morrell, J.I.2    Krieger, M.S.3    Pfaff, D.W.4
  • 16
    • 0029818991 scopus 로고    scopus 로고
    • Depression of glutamatergic transmission by nociceptin in the neonatal rat lamisected spinal cord preparation in vitro
    • Faber ES, Chambers JP, Evans RH, Henderson G. Depression of glutamatergic transmission by nociceptin in the neonatal rat lamisected spinal cord preparation in vitro. British Journal of Pharmacology 1996; 119: 189-190.
    • (1996) British Journal of Pharmacology , vol.119 , pp. 189-190
    • Faber, E.S.1    Chambers, J.P.2    Evans, R.H.3    Henderson, G.4
  • 18
    • 0017140837 scopus 로고
    • Identification and discharge patterns of spinal sympathetic interneurons
    • Gebber GL, McCall RB. Identification and discharge patterns of spinal sympathetic interneurons. American Journal of Physiology 1976; 231: 722-733.
    • (1976) American Journal of Physiology , vol.231 , pp. 722-733
    • Gebber, G.L.1    McCall, R.B.2
  • 19
    • 0019638380 scopus 로고
    • Poracine pituiary dynorphin: Complete amino acid sequence of the biologically active heptadecapeptide
    • Goldstein A, Fischi W, Lowney LJ, Humkapiller M, Hood L. Poracine pituiary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide. PNAS 1981; 78: 7219-7223.
    • (1981) PNAS , vol.78 , pp. 7219-7223
    • Goldstein, A.1    Fischi, W.2    Lowney, L.J.3    Humkapiller, M.4    Hood, L.5
  • 20
    • 0024533314 scopus 로고
    • Ontogeny of expression of the corticotropin-releasing factor gene in the hypothalamic paraventricular nucleus and of the proopiomedanocortin gene in rat pituitary
    • Grino M, Young IWS, Burgunder JM. Ontogeny of expression of the corticotropin-releasing factor gene in the hypothalamic paraventricular nucleus and of the proopiomedanocortin gene in rat pituitary. Endocrinology 1989; 124: 60-68.
    • (1989) Endocrinology , vol.124 , pp. 60-68
    • Grino, M.1    Young, I.W.S.2    Burgunder, J.M.3
  • 21
    • 0029804988 scopus 로고    scopus 로고
    • Orphanin FQ acts as a supraspinal, but not a spinal antiopioid peptide
    • Grisel JE, Mogil JS, Belknap JK, Grandy DK. Orphanin FQ acts as a supraspinal, but not a spinal antiopioid peptide. Neuroreport 1996; 7: 2125-2129.
    • (1996) Neuroreport , vol.7 , pp. 2125-2129
    • Grisel, J.E.1    Mogil, J.S.2    Belknap, J.K.3    Grandy, D.K.4
  • 22
    • 0031415767 scopus 로고    scopus 로고
    • Circuitry underlying "anti-opioid" actions of orphanin FQ (OFQ) in the rostral ventromedial medulla (RVM)
    • Heinricher MM, McGaraughty S, Grandy DK. Circuitry underlying "anti-opioid" actions of orphanin FQ (OFQ) in the rostral ventromedial medulla (RVM). Journal of Neurophysiology 1997; 78: 3351-3358.
    • (1997) Journal of Neurophysiology , vol.78 , pp. 3351-3358
    • Heinricher, M.M.1    McGaraughty, S.2    Grandy, D.K.3
  • 23
    • 0031015517 scopus 로고    scopus 로고
    • Neurocircuitry of stress: Central control of the hypothalamo-pituitary-adrenocortical axis
    • Herman JP, Cullinan WE. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends in Neurosciences 1997; 20: 78-84.
    • (1997) Trends in Neurosciences , vol.20 , pp. 78-84
    • Herman, J.P.1    Cullinan, W.E.2
  • 24
    • 0026803223 scopus 로고
    • G-protein-coupled mechanisms and nervous signaling
    • Hille B. G-protein-coupled mechanisms and nervous signaling. Neuron 1992; 9: 187-195.
    • (1992) Neuron , vol.9 , pp. 187-195
    • Hille, B.1
  • 25
    • 0017739783 scopus 로고    scopus 로고
    • Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone
    • Hosobuchi Y, Adams JE, Linchitz R. Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone. Science 1997; 197: 183-186.
    • (1997) Science , vol.197 , pp. 183-186
    • Hosobuchi, Y.1    Adams, J.E.2    Linchitz, R.3
  • 29
    • 0020048724 scopus 로고
    • Spinothalamic cells in the rat lumbar cord with collaterals to the medullary reticular formation
    • Kevetter GA, Willis WD. Spinothalamic cells in the rat lumbar cord with collaterals to the medullary reticular formation. Brain Research 1982; 238: 181-185.
    • (1982) Brain Research , vol.238 , pp. 181-185
    • Kevetter, G.A.1    Willis, W.D.2
  • 30
    • 0027052952 scopus 로고
    • The δ-opioid receptor: Isolation of a cDNA by expression cloning and pharmacological characterization
    • Kieffer BL, Befort K, Graveriaux-Ruff C, Hirth LG. The δ-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. PNAS 1992; 89: 12048-12052.
    • (1992) PNAS , vol.89 , pp. 12048-12052
    • Kieffer, B.L.1    Befort, K.2    Graveriaux-Ruff, C.3    Hirth, L.G.4
  • 32
    • 0030003320 scopus 로고    scopus 로고
    • Modulation of voltage-gated calcium channels by orphanin FQ in freshly disocciated hippocampal neurons
    • Knoflach FR. Reinscheid K, Civelli O, Kemp JA. Modulation of voltage-gated calcium channels by orphanin FQ in freshly disocciated hippocampal neurons. Journal of Neurosciences 1996; 16: 6657-6664.
    • (1996) Journal of Neurosciences , vol.16 , pp. 6657-6664
    • Knoflach, F.R.1    Reinscheid, K.2    Civelli, O.3    Kemp, J.A.4
  • 34
    • 0016415504 scopus 로고
    • In vitro models in the study of structure-activity relationships of narcotic analgesics
    • Kosterlitz, HW, Waterfield AA. In vitro models in the study of structure-activity relationships of narcotic analgesics. Annual Review of Pharmacology 1975; 15: 24-47.
    • (1975) Annual Review of Pharmacology , vol.15 , pp. 24-47
    • Kosterlitz, H.W.1    Waterfield, A.A.2
  • 35
    • 0030926028 scopus 로고    scopus 로고
    • Modulation of excitatory synaptic transmission by nociceptin in superficial dorsal hora neurones of the varietal rat spinal cord
    • Liebel JT, Swandulla D, Zeilhofer HU. Modulation of excitatory synaptic transmission by nociceptin in superficial dorsal hora neurones of the varietal rat spinal cord. British Journal of Pharmacology 1997; 121: 425-432.
    • (1997) British Journal of Pharmacology , vol.121 , pp. 425-432
    • Liebel, J.T.1    Swandulla, D.2    Zeilhofer, H.U.3
  • 36
    • 0028887626 scopus 로고
    • Opioid-receptor mRNA expression in the rat CNS: Anatomical and functional implications
    • Mansour A, Fox CA, Akil H, Watson SJ. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends in Neurosciences 1995; 18: 22-29.
    • (1995) Trends in Neurosciences , vol.18 , pp. 22-29
    • Mansour, A.1    Fox, C.A.2    Akil, H.3    Watson, S.J.4
  • 42
    • 0030694216 scopus 로고    scopus 로고
    • Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ
    • Morgan MM, Grisel JE, Robbins CS, Grandy DK. Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ. Neuroreport 1997; 8: 3431-3434.
    • (1997) Neuroreport , vol.8 , pp. 3431-3434
    • Morgan, M.M.1    Grisel, J.E.2    Robbins, C.S.3    Grandy, D.K.4
  • 46
    • 0030934155 scopus 로고    scopus 로고
    • Orphanin FQ, agonist of orphan opioid receptor ORL1 stimulates feeding in rats
    • Pomonis JD, Billington CJ, Levine AS. Orphanin FQ, agonist of orphan opioid receptor ORL1 stimulates feeding in rats. Neuroreport 1997; 8: 369-371.
    • (1997) Neuroreport , vol.8 , pp. 369-371
    • Pomonis, J.D.1    Billington, C.J.2    Levine, A.S.3
  • 47
    • 0031889207 scopus 로고    scopus 로고
    • Orphanin FQ 1-17 (OFQ 1-17) is the major OFQ-containing peptide produced in the rodent and monkey hypothalamus
    • Quigley DI, McDougall J, Darland T, Zhang G, Ronneklier O, Grandy DK, Allen RA. Orphanin FQ 1-17 (OFQ 1-17) is the major OFQ-containing peptide produced in the rodent and monkey hypothalamus. Peptides 1998; 19: 133-139.
    • (1998) Peptides , vol.19 , pp. 133-139
    • Quigley, D.I.1    McDougall, J.2    Darland, T.3    Zhang, G.4    Ronneklier, O.5    Grandy, D.K.6    Allen, R.A.7
  • 49
    • 0017681512 scopus 로고
    • Pain reduction by electrical brain stimulation in man
    • Richardson DE, Akil H. Pain reduction by electrical brain stimulation in man. Journal of Neurosurgery 1977; 47: 178-183.
    • (1977) Journal of Neurosurgery , vol.47 , pp. 178-183
    • Richardson, D.E.1    Akil, H.2
  • 51
    • 0027516545 scopus 로고
    • Sexual dimorphism in the romeronasal pathway and sex differences in reproductive behaviors
    • Segovia S, Guillamon A. Sexual dimorphism in the romeronasal pathway and sex differences in reproductive behaviors. Brain Research Reviews 1993; 18: 51-74.
    • (1993) Brain Research Reviews , vol.18 , pp. 51-74
    • Segovia, S.1    Guillamon, A.2
  • 52
    • 0024660445 scopus 로고
    • Cellular and molecular biology of neuropeptide processing and packaging
    • Sossin WS, Fisher JM, Scheller RH. Cellular and molecular biology of neuropeptide processing and packaging. Neuron 1989; 2: 1407-1417.
    • (1989) Neuron , vol.2 , pp. 1407-1417
    • Sossin, W.S.1    Fisher, J.M.2    Scheller, R.H.3
  • 53
    • 2642631769 scopus 로고    scopus 로고
    • Inhibitory action of nociceptin on spinal dorsal horn neurons of the rat, in vitro
    • Stanfa LC, Chapman V, Kerr N, Dickerson AH. Inhibitory action of nociceptin on spinal dorsal horn neurons of the rat, in vitro. British Journal of Pharmacology 1996; 117: 1609-1611.
    • (1996) British Journal of Pharmacology , vol.117 , pp. 1609-1611
    • Stanfa, L.C.1    Chapman, V.2    Kerr, N.3    Dickerson, A.H.4
  • 54
    • 0022611414 scopus 로고
    • Reticularis thalami neurons revisited: Activity changes during shifts in states of vigilance
    • Steriade M, Domich L, Oakson G. Reticularis thalami neurons revisited: activity changes during shifts in states of vigilance. Journal of Neurosciences 1986; 6: 68-81.
    • (1986) Journal of Neurosciences , vol.6 , pp. 68-81
    • Steriade, M.1    Domich, L.2    Oakson, G.3
  • 55
    • 0030933084 scopus 로고    scopus 로고
    • Injections of nociceptor into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake
    • Stratford TR, Holahan MR, Kelly AE. Injections of nociceptor into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake. Neuroreport 1997; 8: 423-426.
    • (1997) Neuroreport , vol.8 , pp. 423-426
    • Stratford, T.R.1    Holahan, M.R.2    Kelly, A.E.3
  • 56
    • 8044238345 scopus 로고    scopus 로고
    • Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: Antagonism in brain and potentiation in spinal cord of the rat
    • Tian J-H, Xu W, Fang Y, Mogil JS, Grisel JE, Grandy DK, Han J-S. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. British Journal of Pharmacology 1997; 120: 676-680.
    • (1997) British Journal of Pharmacology , vol.120 , pp. 676-680
    • Tian, J.-H.1    Xu, W.2    Fang, Y.3    Mogil, J.S.4    Grisel, J.E.5    Grandy, D.K.6    Han, J.-S.7
  • 59
    • 0030614373 scopus 로고    scopus 로고
    • Actions of the ORL1 receptor ligand nociceptin on membrane properties of the rat periaquaductal gray neurons in vitro
    • Vaughn CW, Ingram SL, Christie MJ. Actions of the ORL1 receptor ligand nociceptin on membrane properties of the rat periaquaductal gray neurons in vitro. Journal of Neurosciences 1997; 17: 996-1003.
    • (1997) Journal of Neurosciences , vol.17 , pp. 996-1003
    • Vaughn, C.W.1    Ingram, S.L.2    Christie, M.J.3
  • 60
    • 0031961878 scopus 로고    scopus 로고
    • The peptide orphanin FQ inhibits β-endorphin neurons and neurosecretory cells in the hypothalamic arcuate nucleus by activating an inwardly rectifying K conductance
    • Wagner EJ. The peptide orphanin FQ inhibits β-endorphin neurons and neurosecretory cells in the hypothalamic arcuate nucleus by activating an inwardly rectifying K conductance. Neuroendocrinology 1998; 67: 73-82.
    • (1998) Neuroendocrinology , vol.67 , pp. 73-82
    • Wagner, E.J.1
  • 62
    • 10344264470 scopus 로고    scopus 로고
    • An endogenous ligand for the ORL1 (opioid receptor-like 1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli
    • Wang XM, Zhang KM, Mokha SS. An endogenous ligand for the ORL1 (opioid receptor-like 1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli. Journal of Neurophysiology 1996; 76: 3568-3572.
    • (1996) Journal of Neurophysiology , vol.76 , pp. 3568-3572
    • Wang, X.M.1    Zhang, K.M.2    Mokha, S.S.3
  • 63
    • 0029806549 scopus 로고    scopus 로고
    • Nociceptin or antinociceptin: Potent spinal antinociceptive effects of orphanin FQ/nociceptin in the rat
    • Xu XJ, Hao JX, Wiesenfeld-Hallin Z. Nociceptin or antinociceptin: potent spinal antinociceptive effects of orphanin FQ/nociceptin in the rat. Neuroreport 1997; 7: 2092-2094.
    • (1997) Neuroreport , vol.7 , pp. 2092-2094
    • Xu, X.J.1    Hao, J.X.2    Wiesenfeld-Hallin, Z.3
  • 64
    • 0026029370 scopus 로고
    • Trajectory of spinocerebellar fibers passing through the inferior and superior cerebellar peduncles in the rat spinal cord: A study using horseradish peroxidase with peduculotomy
    • Yamada J, Shirao K, Kitamura T, Sato H. Trajectory of spinocerebellar fibers passing through the inferior and superior cerebellar peduncles in the rat spinal cord: a study using horseradish peroxidase with peduculotomy. Journal of Comparative Neurology 1991; 304: 147-160.
    • (1991) Journal of Comparative Neurology , vol.304 , pp. 147-160
    • Yamada, J.1    Shirao, K.2    Kitamura, T.3    Sato, H.4
  • 65
    • 0030937927 scopus 로고    scopus 로고
    • Effects of intrathecally administered nociceptin, an opioid receptor-like (1) (ORL1) receptor agonist, on the thermal hyperalgesia induced by carageinan injection into the rat paw
    • Yamamoto T, Nozaki-Taguchi N, Kimura S. Effects of intrathecally administered nociceptin, an opioid receptor-like (1) (ORL1) receptor agonist, on the thermal hyperalgesia induced by carageinan injection into the rat paw. Brain Research 1997; 754: 329-332.
    • (1997) Brain Research , vol.754 , pp. 329-332
    • Yamamoto, T.1    Nozaki-Taguchi, N.2    Kimura, S.3
  • 66
    • 0032079958 scopus 로고    scopus 로고
    • Orphanin FQ/Nociceptin: A role in pain, analgesia and so much more
    • Darlan T, Heinricher MM, Grandy DK. Orphanin FQ/Nociceptin: A role in pain, analgesia and so much more. Trends in Neurosciences 1998; 21: 215-221.
    • (1998) Trends in Neurosciences , vol.21 , pp. 215-221
    • Darlan, T.1    Heinricher, M.M.2    Grandy, D.K.3
  • 67
    • 0031583956 scopus 로고    scopus 로고
    • Orphanin FQ/nociceptin in the ventromedial nucleus facilitates lordosis in female rats
    • Sinchak K, Hendricks DG, Baroudi R, Micerych PE. Orphanin FQ/nociceptin in the ventromedial nucleus facilitates lordosis in female rats. Neuroreport 1997; 18: 3857-3860.
    • (1997) Neuroreport , vol.18 , pp. 3857-3860
    • Sinchak, K.1    Hendricks, D.G.2    Baroudi, R.3    Micerych, P.E.4
  • 68
    • 0030728717 scopus 로고    scopus 로고
    • Orphanin FQ has an inhibitory effect on the guinea-pig ileum and the mouse vas deferens
    • Zhang G, Murray TF, Grandy DK. Orphanin FQ has an inhibitory effect on the guinea-pig ileum and the mouse vas deferens. Brain Research 1997; 772: 102-106.
    • (1997) Brain Research , vol.772 , pp. 102-106
    • Zhang, G.1    Murray, T.F.2    Grandy, D.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.