Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids

FEBS Letters

Volumn 395, Issue 1, 1996, Pages 17-21

  Mollereau, Catherine ^a   Moisand, Christiane ^a   Butour, Jean Luc ^a   Parmentier, Marc ^b   Meunier, Jean Claude ^a  

^a CNRS   (France)

^b ERASME HOSPITAL   (Belgium)

Author keywords

Adenylate cyclase inhibition; Agonist antagonist binding; Nociceptin orphanin FQ; Opioid receptor; Site directed mutagenesis

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ADENYLATE CYCLASE; BINDING PROTEIN; DELTAKEPHALIN; DIPRENORPHINE; DYNORPHIN A; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ETORPHINE; GUANINE NUCLEOTIDE BINDING PROTEIN; LOFENTANIL; NOCICEPTIN; NORBINALTORPHIMINE; OPIATE RECEPTOR; RECEPTOR SUBTYPE; DRUG DERIVATIVE; DYNORPHIN; FENTANYL; GLUTAMINE; HISTAMINE; LIGAND; NALTREXONE; NARCOTIC AGENT; NOCICEPTIN RECEPTOR; OPIATE PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; CONTROLLED STUDY; GENE CONSTRUCT; GENE EXPRESSION; GENE TRANSFER; HUMAN; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR AFFINITY; ANIMAL; BINDING COMPETITION; CELL MEMBRANE; CHEMISTRY; DRUG ANTAGONISM; DRUG POTENTIATION; GENETICS; HAMSTER; KINETICS; METABOLISM;

ANIMALIA;

ADENYLATE CYCLASE; ANIMALS; BINDING, COMPETITIVE; CELL MEMBRANE; CHO CELLS; CRICETINAE; DIPRENORPHINE; DYNORPHINS; ETORPHINE; FENTANYL; GLUTAMINE; HISTAMINE; HUMANS; KINETICS; LIGANDS; NALTREXONE; NARCOTICS; OPIOID PEPTIDES; RECEPTORS, OPIOID;

EID: 0030583390     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(96)00993-3     Document Type: Article

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