Increase by the ORL1 receptor (opioid receptor-likei) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

British Journal of Pharmacology

Volumn 117, Issue 8, 1996, Pages 1609-1611

  Vaughan, Christopher W ^a,b   Christie, MacDonald J ^a  

^a University of Sydney   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Dorsal raphe nucleus; Nociceptin; Opioid receptor; ORL1 receptor; Orphan receptor; Potassium channel

Indexed keywords

BACLOFEN; DYNORPHIN A; NOCICEPTIN; OPIATE; OPIATE RECEPTOR; POTASSIUM CHANNEL; POTASSIUM ION; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; NOCICEPTIN RECEPTOR; OPIATE PEPTIDE; POTASSIUM;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; DORSAL RAPHE NUCLEUS; NERVE CELL; NERVE CELL MEMBRANE; NONHUMAN; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; ANIMAL; DOSE RESPONSE; DRUG EFFECT; METABOLISM; NERVE CONDUCTION; RAPHE NUCLEUS; SPRAGUE DAWLEY RAT;

ANIMALS; BACLOFEN; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA AGONISTS; NEURAL CONDUCTION; OPIOID PEPTIDES; POTASSIUM; POTASSIUM CHANNELS; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID;

EID: 0029658923     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15329.x     Document Type: Article

References (7)

1. LACHOWICZ, J.E., SHEN, Y., MONSMA, F.J. & SIBLEY, D.R. (1995). Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. J. Neurochem. 64, 34-40.
2. MEUNIER, J.C., MOLLEREAU, C., TOLL, L., SUAUDEAU, C., MOISAND C., ALVINERIE, P., BUTOUR, J.L., GUILLEMOT, J.C., FERRARA, P., MONSARRAT, B., MAZARGUIL, H., VASSART, G., PARMENTIER, M. & COSTENTIN, J. (1995). Isolation and structure of the endogenous agonist of opioid receptor-like ORL(1) receptor. Nature, 377, 532-535.
3. MOLLEREAU, C., PARMENTIER, M., MAILLEUX, P., BUTOUR, J.L., MOISAND C., CHALON, P., CAPUT, D., VASSART, G. & MEUNIER, J.C. (1994). ORL1, a novel member of the opioid receptor family-cloning, functional expression and localization. FEBS Lett., 341, 33-38.
4. OSBORNE, P., VAUGHAN, C.W., WILSON, H.I. & CHRISTIE, M.J. (1996). Opioid inhibition of rat periaqueductal grey neurones with identified projections to rostral ventromedial medulla in vitro. J. Physiol., 490, 383-389.
5. REINSCHEID, R.K., NOTHACKER, H.P., BOURSON, A., ARDATI, A., HENNINGSEN, R.A., BUNZOW, J.R., GRANDY, D.K., LANGEN, H., MONSMA, F.J. & CIVELLI, O. (1995). Orphanin FQ - A neuropeptide that activates an opioid like G protein-coupled receptor. Science, 270, 792-794.
6. WILLIAMS, J.T., COLMERS, W.F. & PAN, Z.Z. (1988). Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro. J. Neurosci., 8, 3499-3506.
7. ZHANG, S.W. & YU, L. (1995). Identification of dynorphins as endogenous ligands for an opioid receptor-like orphan receptor. J. Biol. Chem., 270, 22772-22776.