Identification in the μ-opioid receptor of cysteine residues responsible for inactivation of ligand binding by thiol alkylating and reducing agents

FEBS Letters

Volumn 408, Issue 2, 1997, Pages 135-140

  Gaibelet, Gérald ^a   Capeyrou, Régine ^a   Dietrich, Gilles ^b   Emorine, Laurent J ^a  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b CHU PURPAN   (France)

Author keywords

Opioid receptor; Agonist binding site; Disulfide bond; G protein; Sulfhydryl group

Indexed keywords

DIPRENORPHINE; DITHIOTHREITOL; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MORPHINE; MU OPIATE RECEPTOR; N ETHYLMALEIMIDE; NALOXONE;

ALKYLATION; AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DISULFIDE BOND; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIGAND BINDING; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; RECEPTOR DENSITY; REDUCTION;

ALKYLATING AGENTS; ALKYLATION; ANIMALS; BINDING SITES; CLONING, MOLECULAR; COS CELLS; CYSTEINE; DIPRENORPHINE; DISULFIDES; DITHIOTHREITOL; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; ETHYLMALEIMIDE; HUMANS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; NARCOTIC ANTAGONISTS; PROTEIN BINDING; RECEPTORS, OPIOID, MU; REDUCING AGENTS; SULFHYDRYL REAGENTS; TRANSFECTION;

ANIMALIA;

EID: 0031009612     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00407-9     Document Type: Article

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